CHIMIA 是最广泛意义上的化学科学期刊，涵盖了广泛而多样的读者群的兴趣。化学和相关领域的所有领域的贡献都被考虑以评论文章和注释的形式发表。 CHIMIA 的一个特点是主题问题，每个主题都致力于一个具有重大当前意义的领域。

CHIMIA is a journal that covers a wide range of fields within the chemical sciences, catering to a diverse readership. Contributions from all areas of chemistry and related fields are considered for publication in the form of review articles and commentaries. A notable feature of CHIMIA is its thematic issues, each dedicated to a topic of significant current relevance.

CHIMIA 是一本涵盖广泛化学科学领域的期刊，旨在满足多样化读者的兴趣。该期刊接受化学及相关领域的各类贡献，主要以评论文章和注释的形式发表。CHIMIA 的一个显著特点是其主题问题，每期专注于一个具有重要现实意义的领域。

Chimia

The core structure of a natural product was selected as scaffold for combinatorial library synthesis. The key step for the construction of the 3,9-diazabicyclo[3.3.1]non-6-ene core is a novel Dakin-West/Pictet-Spengler reaction sequence. Route selection for library synthesis was determined by solution-phase experiments. The solid-phase synthesis was developed based on the synthesis worked out in solution. A number of resins and linkers were studied to obtain the best loading and cleavage conditions. Potential target scaffolds using tryptophan, histidine and phenylalanine as building blocks were investigated. These efforts led to the development of a synthesis protocol for a tetracyclic scaffold incorporating tryptophan, useful for the preparation of a combinatorial library.

David Orain

Guido Koch

Rudolf Giger

CHIMIA International Journal for Chemistry

From Solution-Phase Studies to Solid-Phase Synthesis: A New Indole Based Scaffold for Combinatorial Chemistry

从溶液相研究到固相合成：一种用于组合化学的新型吲哚基支架

Sodium silicates are of considerable importance for many fields of inorganic chemistry and applied mineralogy, being either raw materials for synthesis or already finished products. In addition to their industrial relevance they have also been studied intensively because of their interesting physico-chemical properties including high ion-exchange capacity and selectivity or two-dimensional sodium diffusion and conductivity. Furthermore, the structural chemistry of crystalline sodium silicates offers the crystallographer challenging tasks such as polytypism, polymorphism, temperature and/or pressure-dependent phase transitions, pseudo-symmetry, complex twinning phenomena as well as incommensurately modulated structures. Many of these structural problems have been solved only recently, although in some cases they have been known for several decades. This article will provide an overview on the structurally characterized sodium silicates and their fascinating crystallochemical characteristics.

Volker Kahlenberg

Structural Chemistry of Anhydrous Sodium Silicates – A Review

无水硅酸钠的结构化学——综述

Oxidative coupling reactions are a very powerful tool for the construction of e.g. biaryl compounds, especially because typically no functionalization of the coupling partners is necessary. The use of Au for this transformation is particularly attractive since usually no special precautions to exclude moisture or air are necessary. Furthermore, the combination of oxidative coupling reactions with other Au-catalyzed reactions enables the rapid and efficient construction of molecular complexity, e.g. the constructions of dicoumarins via a domino cyclization oxidative coupling reaction.

Hermann A. Wegner

Oxidative Coupling Reactions with Gold

金催化的氧化偶联反应

We review our recent paper which resolves the long-standing dilemma of the location and nature of the six-fold coordinated aluminum in calcium aluminate silicate hydrate (C-A-S-H) samples. First principles calculations predict that at high Ca:Si and H2O ratios, aluminum is incorporated into the bridging sites of the linear silicate chains and that the stable coordination number is six. We confirm this hypothesis experimentally by one- and two-dimensional dynamic nuclear polarization enhanced 27 Al and 29 Si solid-state NMR experiments in which we correlate the distinctive six-fold coordinated aluminum NMR signal at 5 ppm to 29 Si NMR signals from silicates in C-A-S-H.

Pinelopi Moutzouri

Lyndon Emsley

The Atomic-Level Structure of Cementitious Calcium Aluminate Silicate Hydrate Determined by NMR

水泥基钙铝硅酸盐水化物的原子级结构通过核磁共振确定

This review focuses on recent developments from our laboratory in the field of radical reactions mediated by the archetypal reductive single electron transfer (SET) reagent, SmI2. Namely, we have expanded the scope of reducible carbonyl moieties to esters and amides and have exploited the resultant ketyl radicals in radical cascade reactions that generate unprecedented scaffolds. Moreover, we have taken the first steps to address the long-standing challenges of catalysis and chiral ligand control associated with the reagent.

Áron Péter

David J. Procter

Cascades, Catalysis and Chiral Ligand Control with SmI2; The Rebirth of a Reagent

SmI2的级联反应、催化作用与手性配体控制：试剂的复兴

Photon interconversion promises to alleviate thermalization losses for high energy photons and facilitates utilization of sub-bandgap photons – effectively enabling the optimal use of the entire solar spectrum. However, for solid-state device applications, the impact of intermolecular interactions on the energetic landscape underlying singlet fission and triplet-triplet annihilation upconversion cannot be neglected. In the following, the implications of molecular arrangement, intermolecular coupling strength and molecular orientation on the respective processes of solid-state singlet fission and triplet-triplet annihilation are discussed.

Lea Nienhaus

Intermolecular Interactions and their Implications in Solid-State Photon Interconversion

分子间相互作用及其在固态光子转换中的意义

This article focuses on developing artificial enzymes that utilize pnictogen bonds, a type of non-covalent σ-hole interaction, which is rarely observed in biocatalysis.The researchers designed stibine-based pnictogen-bonding catalysts, interfaced with streptavidin mutants, to catalyze transfer hydrogenation reactions.The study highlights a significant increase in catalytic activity and stereoselectivity, with deep σ-holes on the Sb(V) center enhancing transition-state recognition by more than three orders of magnitude compared to substrate recognition.The artificial enzymes showed Michaelis-Menten kinetics, confirming their enzyme-like behavior and the potential for stereoselectivity.These findings open new possibilities for using pnictogen bonds in aqueous catalysis and demonstrate the compatibility of pnictogen-bonding interactions with complex catalytic systems, expanding the toolbox of artificial enzymes for challenging reactions.

Cesare Berton

James Southwell

Simon Klingler

Jonas Genz

Stanislav Prytuliak

Fan Liu

Eda Nisli

Deborah Bäcker

Perle Hermant

Samy Kichou

Ben Boback

Dominik Ernst

Tiago Rosa de Araujo

Liam Wenger

Henrik Braband

Jason P. Holland

Swiss Science Concentrates

瑞士科学聚焦

The design of nonviral protein-based delivery systems has gained significant attention as an alternative to viral vectors and lipid nanoparticles (LNPs) for gene therapy. While viral vectors offer efficient gene delivery, they present challenges such as immunogenicity and size limitations. LNPs, though pivotal in recent advancements like messenger ribonucleic acid (mRNA)-based vaccines, cause inflammation and exhibit low endosomal escape efficiency. This article explores the development of engineered nonviral protein cages through rational design and directed evolution as an additional nanocarrier option for RNA packaging and delivery. We highlight key advances, including the design and evolution of capsidforming proteins capable of encapsulating and protecting their own encoding mRNA, a critical step in establishing a genotype-phenotype link for evolutionary optimization. Evolved protein cages, such as the I53-50-v4 and NC-4 variants, demonstrate enhanced stability and RNA protection, achieving structural transformations and packaging efficiencies akin to viral systems. The application of directed evolution has expanded the capacity of these nanocarriers enhancing their in vivo stability and biodistribution. This work underscores the potential of evolving nonviral capsids to become customizable platforms for therapeutic gene delivery, while also addressing current limitations in RNA cargo size and tissue targeting specificity. Future directions involve refining these systems to accommodate larger RNAs, and improving immunogenicity properties and dynamic control over cargo release.

Angela Steinauer

Protein Engineering and Directed Evolution for Nanocarrier Innovation&lt;sup&gt;&lt;/sup&gt;

用于纳米载体创新的蛋白质工程与定向进化

We evaluated a method to localize disulfide bonds in bovine pancreatic ribonuclease (RNase) by applying low pH trypsin protein digestion with a bottom-up LC-ESI-QTOF-MS approach. The goal was to minimize disulfide bond scrambling during sample preparation. By using N-ethylmaleimide (NEM) for alkylation of free cysteines, we achieved 92% sequence coverage and successfully identified the native disulfide bonds between specific cysteine residues. However, scrambled disulfide bonds were also observed. Our results indicate that while this low pH digestion method helps preserve native disulfide bonds, further refinement is needed to fully prevent disulfide bond rearrangement during sample preparation.

Amélie Bornex

Saša M. Miladinović

Localization of Disulfide Bonds in Ribonuclease Using Low pH Trypsin and LC-ESI-QTOF-MS

短名	CHIMIA
Journal Impact	1.03
国际分区	CHEMISTRY, MULTIDISCIPLINARY(Q3)
期刊索引	SCI Q4中科院 4 区

ISSN	0009-4293, 2673-2424
h-index	60
国内分区	化学(4区)化学化学综合(4区)

涉及主题	化学生物物理有机化学材料科学工程类生物化学量子力学计算机科学纳米技术医学
出版信息	出版商: Swiss Chemical Society，出版周期: Monthly，期刊类型: journal，开源期刊: 是
基本数据	创刊年份: 1996，原创研究文献占比: 100.00%，自引率:9.10%， Gold OA占比: 83.81%
平均审稿周期	网友分享经验：平均2月
平均录用比例	网友分享经验：约95%

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