Inhibitory actions of potentiating neuroactive steroids in the human α1β3γ2L GABA_Areceptor

2024-8-30

The Estrogen Receptor-Related Orphan Receptors Regulate Autophagy through TFEB

2024-8-21

<b>Rescue of Familial Lecithin:Cholesterol Acyltranferase Deficiency Mutations with an Allosteric Activator</b>

2024-8-16

<b>The impact of nanobodies on GPCR structural biology and their potential as therapeutic agents</b>

2024-8-6

Participation of Ca²⁺-Calmodulin–Dependent Protein Kinase II in the Antidepressant-Like Effects of Melatonin

2024-7-30

Aulosirazole Stimulates FOXO3a Nuclear Translocation to Regulate Apoptosis and Cell-Cycle Progression in High-Grade Serous Ovarian Cancer (HGSOC) Cells

2024-7-30

<b>Role of mitochondrial and cytosolic folylpolyglutamate synthetase in one-carbon metabolism and antitumor efficacy of mitochondrial-targeted antifolates</b>

2024-7-24

<b><b>Get ready to sharpen your tools:</b><b>A short guide to heterotrimeric G protein activity biosensors</b></b>

2024-7-11

<b>New mechanisms underlying oncogenesis in Dbl family Rho guanine nucleotide exchange factors</b>

2024-6-20

Memorial Tribute to William Albert Catterall (1946–2024)

2024-6-18

Correction to “A Brief Overview of the Toxic Sphingomyelinase Ds of Brown Recluse Spider Venom and Other Organisms and Simple Methods To Detect Production of Its Signature Cyclic Ceramide Phosphate”

2024-6-18

New perspectives and prospects of miRNA delivery in Diabetic Wound Healing

2024-6-11

<b>XOB: A novel phenylalkylamine antagonist of 5-HT_2Areceptors and voltage-gated sodium channels.</b>

2024-5-31

"Interaction of the melatonin/Ca²⁺-CaM complex with Calmodulin Kinase II: Physiological Importance"

2024-5-29

Biasing Gβγ Downstream Signaling with Gallein Inhibits Development of Morphine Tolerance and Potentiates Morphine-Induced nociception in a Tolerant State

2024-5-20

<b>Allosteric Inhibition and Pharmacochaperoning of the Serotonin Transporter by the Antidepressant Drugs Trazodone and Nefazodone</b>

2024-5-20

<b>Mechanistic understanding of dexamethasone-mediated protection</b><b>against remdesivir-induced hepatotoxicity</b>

2024-5-20

Correction to “Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation”

2024-5-17

<b>Intracellular allosteric antagonist of the olfactory receptor OR51E2</b>

2024-5-6

<b>Circumvention of Topoisomerase IIα Intron 19 Intronic Polyadenylation (IPA) in Acquired Etoposide Resistant Human Leukemia K562 Cells</b>

2024-5-6

<b>The Growing Class of Novel RNAi Therapeutics</b>

2024-5-6

<b>The M3 muscarinic acetylcholine receptor can signal through multiple G protein families</b>

2024-4-19

Deorphanization of G Protein Coupled Receptors (GPCRs): a historical perspective.

2024-4-15

Drugs Form Ternary Complexes with Human Liver Fatty Acid Binding Protein (FABP1) and FABP1 Binding Alters Drug Metabolism

2024-4-5

A Conversation with ChatGPT on Contentious Issues in Senescence and Cancer Research

2024-3-8

<b>Development of a novel assay for direct assessment of selective amylin receptor activation reveals novel differences in behaviour of selective and non-selective peptide agonists</b>

2024-3-8

2023 Julius Axelrod Symposium: Plant-Derived Molecules Acting on G Protein-Coupled Receptors

2024-3-8

Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders

2024-2-29

Special Section on Therapeutic Implications for Sphingolipids in Health and Disease—Editorial

2024-2-15

Perspective: Therapeutic Implications for Sphingolipids in Health and Disease

2024-2-15

RGS4 Actions in Mouse Prefrontal Cortex Modulate Behavioral and Transcriptomic Responses to Chronic Stress and Ketamine

2024-2-13

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3

2024-2-12

<b>Discovery and characterization of VU0542270, the first selective inhibitor of vascular Kir6.1/SUR2B K_ATPchannels</b>

2024-2-1

Prodigiosin Inhibits Transforming Growth Factor<i>β</i>Signaling by Interfering Receptor Recycling and Subcellular Translocation in Epithelial Cells

2024-1-26

<i>ent</i>-Verticilide B1 Inhibits Type 2 Ryanodine Receptor Channels and is Antiarrhythmic in<i>Casq2</i>^−/−Mice

2024-1-22

Circadian Regulation of Endocrine Fibroblast Growth Factors on Systemic Energy Metabolism

2024-1-18

Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na_V1.8 with a Unique Mechanism of Action

2024-1-9

<i>β</i>-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?

2024-1-9

Development of an LC-MS/MS method to measure sphingolipids in CSF from patients with multiple sclerosis

2024-1-5

Extrahelical Binding Site for a 1<i>H</i>-Imidazo[4,5-c]quinolin-4-amine A₃Adenosine Receptor Positive Allosteric Modulator on Helix 8 and Distal Portions of Transmembrane Domains 1 and 7

2024-1-5

Coexpressed<i>δ</i>-,<i>μ</i>-, and<i>κ</i>-Opioid Receptors Modulate Voltage-Gated Ca²⁺Channels in Gastric-Projecting Vagal Afferent Neurons

2024-1-5

Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

2023-12-21

Fanning the Flames of Endoplasmic Reticulum (ER) Stress: Can Sphingolipid Metabolism Be Targeted to Enhance ER Stress–Associated Immunogenic Cell Death in Cancer?

2023-12-21

Inhibition of Cardiac Kv4.3/KChIP2 Channels by Sulfonylurea Drug Gliquidone

2023-12-21

Drug Targeting of Acyltransferases in the Triacylglyceride and 1-O-AcylCeramide Biosynthetic Pathways

2023-12-15

Expression of Ceramide Synthases in Mice and Their Roles in Regulating Acyl-Chain Sphingolipids: A Framework for Baseline Levels and Future Implications in Aging and Disease

2023-12-15

Correction to “Gossypetin Prevents the Progression of Nonalcoholic Steatohepatitis by Regulating Oxidative Stress and AMP-Activated Protein Kinase”

2023-12-15

Signaling Specificity and Kinetics of the Human Metabotropic Glutamate Receptors

2023-12-8

Pharmacological Targeting of Senescence with Senolytics as a New Therapeutic Strategy for Neurodegeneration

2023-12-8

A Constitutive EGFR Kinase Dimer to Study Inhibitor Pharmacology

2023-12-8