Decreased vascular contraction and changes in oxidative state in middle–aged Wistar rats after exposure to increased levels of dietary zinc

2024-10-1

The molecular signature of the peripheral cannabinoid receptor 1 antagonist AM6545 in adipose, liver and muscle tissue

2024-10-1

Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels

2024-10-1

Editorial Board

2024-10-1

Integrated network toxicology, transcriptomics and gut microbiomics reveals hepatotoxicity mechanism induced by benzo[a]pyrene exposure in mice

2024-10-1

The long-chain polyfluorinated alkyl substance perfluorohexane sulfonate (PFHxS) promotes bone marrow adipogenesis

2024-10-1

Extracellular vesicles-derived long noncoding RNAs participated in benzene hematotoxicity by mediating apoptosis and autophagy

2024-10-1

Comparison of drug-induced liver injury risk between propylthiouracil and methimazole: A quantitative systems toxicology approach

2024-10-1

Salvianolic acid B improves mitochondrial dysfunction of septic cardiomyopathy via enhancing ATF5-mediated mitochondrial unfolded protein response

2024-10-1

Ferulic acid ameliorates concanavalin A-induced hepatic fibrosis in mice via suppressing TGF-β/smad signaling

2024-9-10

VEGFR1 TK signaling protects the lungs against LPS-induced injury by suppressing the activity of alveolar macrophages and enhancing the anti-inflammatory function of monocyte-derived macrophages

2024-9-1

Azoospermia and multi-organ damage in juvenile rats exposed to α-Terpineol from weaning to sexual maturity

2024-9-1

Can we do better with Mylotarg? Model-based assessment of opportunities to improve therapeutic index

2024-9-1

Asiatic acid induces lung cancer toxicity by triggering SRC-mediated ferroptosis

2024-9-1

Gallic acid ameliorates synovial inflammation and fibrosis by regulating the intestinal flora and its metabolites

2024-9-1

Editorial Board

2024-9-1

Hydramethylnon induces mitochondria-mediated apoptosis in BEAS-2B human bronchial epithelial cells

2024-9-1

SIRT5 safeguards against T-2 toxin induced liver injury by repressing iron accumulation, oxidative stress, and the activation of NLRP3 inflammasome

2024-9-1

Do longer duration nonclinical toxicology studies provide predictive clinical safety value? The IQ consortium longer duration nonclinical to clinical translational database

2024-9-1

Chronic exposure to E-cigarette aerosols potentiates atherosclerosis in a sex-dependent manner

2024-9-1

Prediction of chemical-induced acute toxicity using in vitro assay data and chemical structure

2024-9-1

Effects of 1, 2-bis (2,4, 6-tribromophenoxy) ethane and bis (2-ethylhexyl) tetrabromophthalate on serum metabolic and lipid profiles in male rats

2024-9-1

In vitro study on the anticancer effects of oxalipalladium against PC3 human prostate carcinoma cells

2024-9-1

Metformin augments major cytoplasmic organization except for spindle organization in oocytes cultured under hyperglycemic and hyperlipidemic conditions: An in vitro study

2024-9-1

Wogonin induces mitochondrial apoptosis and synergizes with venetoclax in diffuse large B-cell lymphoma

2024-9-1

Corrigendum to “Effects of a spiroketal compound Peniciketal A and its molecular mechanisms on growth inhibition in human leukemia” [Toxicology and Applied Pharmacology, 2019, 1:366:1–9]

2024-9-1

The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafish

2024-9-1

From computational prediction to experimental validation: Hesperidin's anti-Urolithiatic activity in sodium oxalate-induced urolithiasis models in fruit flies and mice

2024-9-1

Protective effect of rupatadine on testicular ischemia/reperfusion injury in rats: Modulation of IL-6/STAT3, Akt/ mTOR signaling pathways

2024-9-1

Distinct profile of antiviral drugs effects in aortic and pulmonary endothelial cells revealed by high-content microscopy and cell painting assays

2024-9-1

Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway

2024-9-1

1,2,4-trihydroxybenzene induces non-apoptotic cell death via the structural damage of intracellular organelles

2024-9-1

Pirfenidone ameliorates ANIT-induced cholestatic liver injury via modulation of FXR, NF-кB/TNF-α, and Wnt/GSK-3β/β-catenin signaling pathways

2024-9-1

Chemotherapy-induced cognitive impairment and glia: A new take on chemobrain?

2024-9-1

Nicotinamide riboside activates SIRT3 to prevent paclitaxel-induced peripheral neuropathy

2024-8-9

The protective mechanism of sevoflurane in pulmonary arterial hypertension via downregulation of TRAF6

2024-8-8

Linagliptin mitigates cisplatin-induced kidney impairment via mitophagy regulation in rats, with emphasis on SIRT-3/PGC-1α, PINK-1 and Parkin-2

2024-8-3

Editorial Board

2024-8-1

Trifluoperazine exerts anti-osteosarcoma effect by inducing mitochondria-dependent apoptosis via AKT/TXNIP signaling pathway

2024-8-1

Potential safety implications of fatty acid-binding protein inhibition

2024-8-1

Muscarinic and nicotinic receptors stimulation by vagus nerve stimulation ameliorates trastuzumab-induced cardiotoxicity via reducing programmed cell death in rats

2024-8-1

Dapagliflozin dampens liver fibrosis induced by common bile duct ligation in rats associated with the augmentation of the hepatic Sirt1/AMPK/PGC1α/FoxO1 axis

2024-8-1

Identification of autophagy-related signatures in doxorubicin-induced cardiotoxicity

2024-8-1

Effect of aripiprazole on neural tube development in early chick embryos

2024-8-1

Biosafety assessment of novel organoselenium zidovudine derivatives in the Caenorhabditis elegans model

2024-8-1

Effect of substituents at the C3´, C3´N, C10 and C2-meta-benzoate positions of taxane derivatives on their activity against resistant cancer cells

2024-8-1

Decreasing of serine/threonine kinase 39 has tumour inhibiting effects on acute myeloid leukaemia by impacting the PI3K/AKT and Wnt/β-catenin signalling cascades

2024-8-1

Post-transplantation cyclophosphamide and cyclosporine a versus methotrexate and cyclosporine a for graft-versus-host disease prophylaxis after allogeneic peripheral stem cell transplantation in adult acute myeloid leukemia patients

2024-8-1

The impact of CYP3A4 genetic polymorphism on crizotinib metabolism and drug-drug interactions

2024-8-1

Employing a Toxic Aging Coin approach to assess hexavalent chromium (Cr[VI])-induced neurotoxic effects on behavior: Heads for age differences

2024-8-1