The pharmacokinetics of dabigatran in a rat model of hyperlipidemia induced by poloxamer 407

2024-9-12

Human Keratinocyte Response to 4,4’-Methylene Diphenyl Diisocyanate-Glutathione Conjugate Exposure

2024-9-5

Meeting report of the 5th European Biotransformation Workshop

2024-9-3

Mechanism-based Inactivation of Cytochromes P450: Implications in Drug Interactions and Pharmacotherapy

2024-8-23

The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice

2024-8-10

Novel omeprazole delayed release orally disintegrating tablets for enhanced patient compliance: a case of model informed formulation development

2024-8-10

Qualitative and quantitative status of cytochrome P450s after the administration of a liposomal platelet substitute in rat liver

2024-8-9

In vitro and in vivo preclinical pharmacokinetic characterization of aficamten, a small molecule cardiac myosin inhibitor

2024-8-9

Prediction of the Liver Safety Profile of a First-in-Class Myeloperoxidase Inhibitor Using Quantitative Systems Toxicology Modeling

2024-8-8

Perspectives on the use of machine learning for ADME prediction at AstraZeneca

2024-8-8

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of [ ¹⁴ C]aficamten following single oral dose administration to rats

2024-8-7

A systematic review of allometric scaling exponents for IgG mAbs

2024-8-7

Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities

2024-8-6

Preface for Special Issue: “Emerging strategies, technologies and approaches for the next generation ADCs”

2024-7-29

Improved preclinical drug metabolism and pharmacokinetics of pibothiadine (HEC121210), a novel hepatitis B virus capsid assembly modulator

2024-7-26

Prediction of human serum concentration–time profiles of therapeutic monoclonal antibodies using common marmosets ( <i>Callithrix jacchus</i> ): initial assessment with canakinumab, adalimumab, and bevacizumab

2024-7-26

Beyond Cytotoxic Potency: Disposition Features Required to Design ADC Payload

2024-7-17

Application of quantitative pharmacology analysis to support early clinical development of oncology drugs: dose selection

2024-7-12

Study on pharmacokinetics and tissue distribution of deoxypodophyllotoxin and its metabolites in tumor-bearing mice

2024-7-1

Meeting report: DMPK optimisation strategies and quantitative translational PKPD frameworks to predict human PK and efficacious dose of Targeted protein degraders

2024-6-27

Xenobiotica Special Edition Preface

2024-6-25

Teratogenicity is more likely a Function of Primary and Secondary Pharmacology than caused by Chemically Reactive Metabolites: a critical Evaluation of 40 Years of Scientific Research

2024-6-24

An <i>in silico</i> investigation of the toxicological effects and biological activities of 3-phenoxybenzoic acid and its metabolite products

2024-6-24

Selection of a suitable animal model to evaluate secretion of drugs in the human milk: a systematic approach

2024-6-24

Three methods to optimize polymyxin B dosing using estimated AUC after first dose: Validation with the data generated by Monte-Carlo simulation

2024-6-17

<i>In vitro</i> and <i>in vivo</i> studies on the metabolism and pharmacokinetics of the selective gut microbial β-glucuronidase targeting compound Inh 1

2024-6-12

<i>lIn vitro</i> safety evaluation of (6-methoxy-9-oxo-9 <i>H</i> -xanthen-2-yl)methyl ( <i>E</i> )-3-(2,4-dimethoxyphenyl)acrylate (K-116) – the novel potential UV filter designed by means of a double chromophore strategy

2024-5-31

Assessment of P-Glycoprotein Function Using Canine Intestinal Organoid-Derived Epithelial Interfaces

2024-5-31

A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers

2024-5-13

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development

2024-5-13

Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs

2024-5-11

Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?

2024-4-30

Monomethyl Auristatin E (MMAE), a Payload for Multiple Antibody Drug Conjugates (ADCs), Demonstrates Differential Red Blood Cell Partitioning Across Human and Animal Species

2024-4-22

mRNA Expression Levels of Cytochrome P450 CYP1A2, CYP3A4, and CYP3A5 in the Epidermis: A Focus on Individual Differences Among Japanese Individuals

2024-4-22

Preparation, characterisation, pharmacokinetics and distribution of esculin microspheres administered via intravitreal injection into rabbit brain

2024-4-19

Developmental stage and infection status may affect drug distribution in the prostate of rats

2024-4-18

Pharmacokinetics and multi-peak phenomenon analysis of novel anti-Parkinson’s drug FLZ After Multi-dose in Cynomolgus Monkeys

2024-4-17

EXPLORING PRECISION-CUT LIVER SLICES FOR COMPARATIVE XENOBIOTIC METABOLISM PROFILING IN SWINE AND CATTLE

2024-4-16

Bioanalytical Approaches to Support the Development of Antibody-Oligonucleotide Conjugate (AOC) Therapeutic Proteins

2024-4-12

Academic foreign compound metabolism – ‘ <i>quo vadis</i> ’?

2024-4-12

Drug-drug interaction between danshensu and irbesartan and its potential mechanism

2024-4-9

MicroRNA-Mediated Krüppel-Like Factor 4 Upregulation Induces Alternatively Activated Macrophage-Associated Marker and Chemokine Transcription in 4,4’-Methylene Diphenyl Diisocyanate Exposed Macrophages

2024-4-3

Exploring the Pharmacokinetics of Second-Generation Cephalosporin, Cefaclor: A Systematic Review in Healthy and Diseased Populations

2024-4-2

Effects of pharmacogenetics on pharmacokinetics and toxicity of doxorubicin in Egyptian breast cancer patients

2024-3-15

Preclinical pharmacokinetic investigation of the bioavailability and skin distribution of HY-072808 ointment, a novel drug candidate for the treatment of atopic dermatitis, in minipigs by a newly LC-MS/MS method

2024-3-15

Assessment of Cytochrome P450 Induction in Canine Intestinal Organoid Models

2024-3-13

Safflower Yellow for injection enhances anti-coagulation of warfarin in rats: Implications in pharmacodynamics and pharmacokinetics

2024-3-13

Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P ₁ modulator ponesimod

2024-2-24

Rehmannioside A inhibits the activity of CYP3A4, 2C9 and 2D6 in vitro

2024-2-22

The Effects of Genetic Polymorphism on Toxicity and Pharmacokinetics of Methotrexate in Egyptian Adult Patients with Leukaemia or Lymphoma

2024-2-21