Acta Leidensia

P. Lopez Cardozo

Cestoda and the problem of individuality.

绦虫纲与个体性问题。

Van Thiel

The Identification of the Pupae of Anopheles superpicius, Anopheles bifurcatus and the different Biotypes of Anopheles maculipennis.

按蚊超按蚊、按蚊双叉按蚊及其按蚊斑点按蚊不同生物型的蛹的鉴定。

R. Bok

The presence of Spirillum minus in the parotid glands of mice.

小鼠腮腺中存在小螺菌。

The Presence of Spirillum minus in the Ear Salivary Glands of Mice.

小鼠耳唾液腺中螺旋体阴性的存在。

E. H. Hermans

Mortality-Statistics of Dutch Missionaries.

荷兰传教士死亡统计。

Trigg Pi

Acta Leiden

Drug use and design in the nineties.

九十年代的药物使用与设计。

There are several mechanisms responsible for the extensive antigenic diversity found in the asexual blood stages of Plasmodium falciparum. Failure to express antigens is a feature of many isolates cultured in vitro but probably is not a major cause of antigenic diversity in vivo. Numerous point mutations occur in allelic forms of asexual blood stage antigens and are assumed to contribute to antigenic diversity but as yet few such mutations have been mapped to antigenic epitopes. A major cause of antigenic diversity is the expression of different repetitive sequences in allelic forms of several antigens including the S-antigen and the two merozoite surface antigens, MSA-1 and MSA-2. The sequencing data indicates that S-antigen genes fall into many allelic families whereas both MSA-1 and MSA-2 are dimorphic. Further diversity has arisen as a result of intragenic recombinations between the dimorphic forms of both MSA-1 and MSA-2. In addition to this diversity reflecting the expression of different allelic genes, asexual blood stages of malaria parasites undergo antigenic variation in that clonal parasite populations can vary the form of an antigen on the surface of infected erythrocytes. Antibodies or DNA probes directed against variable repeat sequences can be used to distinguish different isolates of P. falciparum. The use of antibodies to S-antigen repeats has been particularly useful for typing the parasites causing infections. The application of S-antigen typing to field studies in Papua New Guinea has demonstrated marked diversity in the parasites causing infections in one area.

Anders Rf

Antigenic diversity in Plasmodium falciparum.

恶性疟原虫的抗原多样性。

P. Gayral

P. Loiseau

C. Bories

M. J. Brienne

M. Leclercq

J. Jacques

Development of three macrofilaricidal chemical series.

三种杀大型丝虫化学系列的发展。

O. Bain

P. N. Vuong

L. Sakka

S. Wanji

S. Kläger

U. Laukamm-Josten

Relevance of a rodent filaria with dermic microfilariae for onchocerciasis.

啮齿动物丝虫与皮肤微丝蚴在盘尾丝虫病中的相关性。

M. C. Henry

Natural and biological control of onchocerciasis focus at Kinsuka/Kinshasa, Republic of Zaire.

刚果共和国金苏卡/金沙萨地区盘尾丝虫病自然与生物防治研究。

Publication Information	Publisher: Institut Voor Tropische Geneeskunde，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1982，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Acta Leidensia

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