Advances in Virus Research

Angelika Fath‐Goodin

Jeremy Kroemer

Stacy Martin

Krista Reeves

Bruce A. Webb

Polydnavirus Genes that Enhance the Baculovirus Expression Vector System

多分DNA病毒基因增强杆状病毒表达载体系统

Felicia Goodrum

The complex biology of human cytomegalovirus latency

人巨细胞病毒潜伏的复杂生物学

Khaled Makkouk

Hanu Pappu

Safaa G. Kumari

Virus Diseases of Peas, Beans, and Faba Bean in the Mediterranean Region

地中海地区豌豆、豆类和蚕豆的病毒病害

Resistance to infection by plant viruses involves proteins encoded by plant resistance (R) genes, viz., nucleotide-binding leucine-rich repeats (NLRs), immune receptors. These sensor NLRs are activated either directly or indirectly by viral protein effectors, in effector-triggered immunity, leading to induction of defense signaling pathways, resulting in the synthesis of numerous downstream plant effector molecules that inhibit different stages of the infection cycle, as well as the induction of cell death responses mediated by helper NLRs. Early events in this process involve recognition of the activation of the R gene response by various chaperones and the transport of these complexes to the sites of subsequent events. These events include activation of several kinase cascade pathways, and the syntheses of two master transcriptional regulators, EDS1 and NPR1, as well as the phytohormones salicylic acid, jasmonic acid, and ethylene. The phytohormones, which transit from a primed, resting states to active states, regulate the remainder of the defense signaling pathways, both directly and by crosstalk with each other. This regulation results in the turnover of various suppressors of downstream events and the synthesis of various transcription factors that cooperate and/or compete to induce or suppress transcription of either other regulatory proteins, or plant effector molecules. This network of interactions results in the production of defense effectors acting alone or together with cell death in the infected region, with or without the further activation of non-specific, long-distance resistance. Here, we review the current state of knowledge regarding these processes and the components of the local responses, their interactions, regulation, and crosstalk.

Peter Palukaitis

Ju-Yeon Yoon

Adv Virus Res

Defense signaling pathways in resistance to plant viruses: Crosstalk and finger pointing

植物病毒抗性中的防御信号通路：交叉对话与指向

Said A. Ghabrial

New Developments in Fungal Virology

真菌病毒学的新进展

Avian (ortho)reovirus (ARV), which belongs to Reoviridae family, is a major domestic fowl pathogen and is the causative agent of viral tenosynovitis and chronic respiratory disease in chicken. ARV replicates within cytoplasmic inclusions, so-called viral factories, that form by phase separation and thus belong to a wider class of biological condensates. Here, we evaluate different optical imaging methods that have been developed or adapted to follow formation, fluidity and composition of viral factories and compare them with the complementary structural information obtained by well-established transmission electron microscopy and electron tomography. The molecular and cellular biology aspects for setting up and following virus infection in cells by imaging are described first. We then demonstrate that a wide-field version of fluorescence recovery after photobleaching is an effective tool to measure fluidity of mobile viral factories. A new technique, holotomographic phase microscopy, is then used for imaging of viral factory formation in live cells in three dimensions. Confocal Raman microscopy of infected cells provides "chemical" contrast for label-free segmentation of images and addresses important questions about biomolecular concentrations within viral factories and other biological condensates. Optical imaging is complemented by electron microscopy and tomography which supply higher resolution structural detail, including visualization of individual virions within the three-dimensional cellular context.

Eva Durinova

Peter Mojzes

Tomas Bily

Zdenek Franta

Tomas Fessl

Alexander Borodavka

Roman Tuma

Imaging in Virus Research

Shedding light on reovirus assembly—Multimodal imaging of viral factories

揭示呼肠孤病毒组装之谜——病毒工厂的多模态成像

Zongdi Feng

Virus Assembly and Exit Pathways

Quasi-enveloped hepatitis virus assembly and release

准包膜肝炎病毒的组装与释放

Paola Leonetti

Pascal Miesen

Ronald P. van Rij

Vitantonio Pantaleo

Viral and subviral derived small RNAs as pathogenic determinants in plants and insects

病毒和亚病毒来源的小RNA作为植物和昆虫的致病因子

短名	Adv. Virus. Res.
Journal Impact	9.81
期刊索引	中科院 2 区

ISSN	0065-3527, 1557-8399
国内分区	医学(2区)医学病毒学(2区)

涉及主题	生物遗传学医学病毒学免疫学病毒化学生物化学基因
出版信息	出版商: Academic Press Inc.，出版周期: Irregular，期刊类型: book-series，开源期刊: 否
基本数据	创刊年份: 1981，原创研究文献占比: 0.00%，自引率:N.A.， Gold OA占比: 0.00%
平均审稿周期	网友分享经验：>12周，或约稿
平均录用比例	网友分享经验：较易

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Polydnavirus Genes that Enhance the Baculovirus Expression Vector System

The complex biology of human cytomegalovirus latency

Virus Diseases of Peas, Beans, and Faba Bean in the Mediterranean Region

Defense signaling pathways in resistance to plant viruses: Crosstalk and finger pointing

New Developments in Fungal Virology

Defense signaling pathways in resistance to plant viruses: Crosstalk and finger pointing

Shedding light on reovirus assembly—Multimodal imaging of viral factories

The complex biology of human cytomegalovirus latency

Quasi-enveloped hepatitis virus assembly and release

Viral and subviral derived small RNAs as pathogenic determinants in plants and insects