Gentamicin and clindamycin antibiotic-eluting depot technology eradicates <i>S. aureus</i> in an implant-associated osteomyelitis pig model without systemic antibiotics

2024-9-17

Novel humanized anti-PcrV monoclonal antibody COT-143 protects mice from lethal <i>Pseudomonas aeruginosa</i> infection via inhibition of toxin translocation by the type III secretion system

2024-9-13

<i>In vitro</i> antimalarial susceptibility profile of <i>Plasmodium falciparum</i> isolates in the BEI Resources repository

2024-9-13

Recent increase in <i>Candida auris</i> frequency in the SENTRY surveillance program: antifungal activity and genotypic characterization

2024-9-12

An adaptable, fit-for-purpose screening approach with high-throughput capability to determine speed of action and stage specificity of anti-malarial compounds

2024-9-12

Anti-echinococcal effect of metformin in advanced experimental cystic echinococcosis: reprogrammed intermediary carbon metabolism in the parasite

2024-9-12

The OprF porin as a potential target for the restoration of carbapenem susceptibility in <i>Pseudomonas aeruginosa</i> expressing acquired carbapenemases

2024-9-12

Erratum for Yang et al., “A phase I study of the safety, tolerability, and pharmacokinetics of contezolid acefosamil after intravenous and oral administration in healthy Chinese subjects”

2024-9-12

Evolution toward extremely high imipenem resistance in <i>Mycobacterium abscessus</i> outbreak strains

2024-9-10

Synergistic antimicrobial combination of third-generation cephalosporins and polymyxin B against carbapenem-polymyxin-resistant <i>Klebsiella pneumoniae:</i> an <i>in vitro</i> and <i>in vivo</i> analysis

2024-9-10

Molecular characterization of clinically isolated <i>Pseudomonas aeruginosa</i> with varying resistance to ceftazidime-avibactam and ceftolozane-tazobactam collected as a part of the ATLAS global surveillance program from 2020 to 2021

2024-9-10

A high content imaging assay for identification of specific inhibitors of native <i>Plasmodium</i> liver stage protein synthesis

2024-9-10

Zebrafish as an effective model for evaluating phage therapy in bacterial infections: a promising strategy against human pathogens

2024-9-9

Polymyxins retain <i>in vitro</i> activity and <i>in vivo</i> efficacy against “resistant” <i>Acinetobacter baumannii</i> strains when tested in physiological conditions

2024-9-6

Oral pharmacokinetics and efficacy of oral phospholipid remdesivir nucleoside prodrugs against SARS-CoV-2 in mice

2024-9-6

High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in <i>Helicobacter pylori</i>

2024-9-6

Incidence of serotonin syndrome in patients receiving tedizolid and concomitant serotonergic agents

2024-9-5

IMT-P8 potentiates Gram-positive specific antibiotics in intrinsically resistant Gram-negative bacteria

2024-9-5

Clinical outcomes and emergence of resistance of <i>Pseudomonas aeruginosa</i> infections treated with ceftolozane-tazobactam versus ceftazidime-avibactam

2024-9-4

Discovery of new acetamide derivatives of 5-indole-1,3,4-oxadiazol-2-thiol as inhibitors of HIV-1 Tat-mediated viral transcription

2024-9-4

Evaluating nephrotoxicity reduction in a novel polymyxin B formulation: insights from a 3D kidney-on-a-chip model

2024-9-3

Design of novel and highly selective SARS-CoV-2 main protease inhibitors

2024-9-3

The fungal natural product fusidic acid demonstrates potent activity against <i>Mycoplasma genitalium</i>

2024-8-29

Efficacy of ensitrelvir for cough due to COVID-19 Omicron variant in medical healthcare workers

2024-8-29

Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries

2024-8-28

Onametostat, a PfPRMT5 inhibitor, exhibits antimalarial activity to <i>Plasmodium falciparum</i>

2024-8-28

Dose-fractionation studies of a <i>Plasmodium</i> phosphatidylinositol 4-kinase inhibitor in a humanized mouse model of malaria

2024-8-28

Loss of glycerol catabolism confers carbon-source-dependent artemisinin resistance in <i>Mycobacterium tuberculosis</i>

2024-8-28

Zidovudine in synergistic combination with nitrofurantoin or omadacycline: <i>in vitro</i> and in murine urinary tract or lung infection evaluation against multidrug-resistant <i>Klebsiella pneumoniae</i>

2024-8-28

Application of machine-learning models to predict the ganciclovir and valganciclovir exposure in children using a limited sampling strategy

2024-8-28

The novel MFS efflux pump SxtP, regulated by the LysR-type transcriptional activator SxtR, is involved in the susceptibility to sulfamethoxazole/trimethoprim (SXT) and the pathogenesis of <i>Acinetobacter baumannii</i>

2024-8-28

Pharmacokinetics and safety of TBAJ-876, a novel antimycobacterial diarylquinoline, in healthy subjects

2024-8-28

Osteomyelitis-relevant antibiotics at clinical concentrations show limited effectivity against acute and chronic intracellular <i>S. aureus</i> infections in osteocytes

2024-8-28

Automated calculation and reporting of vancomycin area under the concentration–time curve: a simplified single-trough concentration-based equation approach

2024-8-28

IncC plasmid genome rearrangements influence the vertical and horizontal transmission tradeoff in <i>Escherichia coli</i>

2024-8-28

Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination

2024-8-28

Retrospective validation study of a machine learning-based software for empirical and organism-targeted antibiotic therapy selection

2024-8-28

<i>Acinetobacter baumannii</i> transformants expressing oxacillinases and metallo-β-lactamases that confer resistance to meropenem: new tools for anti- <i>Acinetobacter</i> drug development and AMR preparedness

2024-8-27

Deoxyshikonin: a promising lead drug grass against drug resistance or sensitivity to <i>Helicobacter pylori</i> in an acidic environment

2024-8-22

Use of frozen native feces for fecal microbiota transplantation in recurrent <i>Clostridioides difficile</i> infection: a simple way to improve the efficiency of donor feces preparation

2024-8-21

A molecular analysis of meropenem–vaborbactam non-susceptible KPC-producing <i>Klebsiella pneumoniae</i>

2024-8-20

Structural basis of paramyxo- and pneumovirus polymerase inhibition by non-nucleoside small-molecule antivirals

2024-8-20

Multicenter evaluation of activity of aztreonam in combination with avibactam, relebactam, and vaborbactam against metallo-β-lactamase-producing carbapenem-resistant gram-negative bacilli

2024-8-19

Systemic absorption and safety of topical terbinafine hydrochloride 10% solution (MOB015B): a phase 1 maximal usage trial in patients with moderate-to-severe onychomycosis

2024-8-19

Zap the clap with DNA: a novel microbicide for preventing <i>Neisseria gonorrhoeae</i> infection

2024-8-16

Development of non-sedating benzodiazepines with <i>in vivo</i> antischistosomal activity

2024-8-13

Bacteriophage therapy reduces <i>Staphylococcus aureus</i> in a porcine and human <i>ex vivo</i> burn wound infection model

2024-8-13

<i>In vitro</i> efficacy of next-generation dihydrotriazines and biguanides against babesiosis and malaria parasites

2024-8-13

Prevalence and dynamics of antimalarial drug resistance mutations among the <i>Plasmodium falciparum</i> isolates in TAK Province, Thailand, during the period of 1998–2001

2024-8-13

A retrospective analysis of <i>P. falciparum</i> drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda

2024-8-13