Allergy: European Journal of Allergy and Clinical Immunology, Supplement

A.M. Petrova

I.N. Maistrova

M.M. Zafranskaja

E.E. Sagalovich

Allergy. Supplement

The prevalence of exudative-catarrhal diathesis and immunity character in infants born in contaminated with radionuclides districts of Republic Belarus

白俄罗斯放射性污染地区出生婴儿渗出性卡他质及免疫特征的流行情况

Jean Duchateau

Alain Michils

Olivier Michel

Béatrice Gossart

Epitopic dominance of IgG antibodies against Dermatophagoides p1 antigen (Der p1) in atopic patients with perenial rhinitis and asthma

常年性鼻炎和哮喘患者中针对尘螨p1抗原（Der p1）的IgG抗体的表位优势

Georges Casimir

Jean Claude Yernault

Lung cancer induced changing profile of IgG epitopes recognized on bovine Betalactoglobulin (BLG): towards a new immune marker

肺腺癌诱导的牛β-乳球蛋白（BLG）上识别的IgG表位变化特征：迈向新的免疫标志物

Michel Mairesse

Claire Ledent

Bee venom immunotherapy changes the IgG antibody specificity

蜂毒免疫疗法改变IgG抗体特异性

Afarine Madani

Pierre-Alain Gevenois

Contact system is pre-activated in patients experiencing reactions to radio-contrast media

接触系统在经历放射造影剂反应的患者中预先激活

Allergen immunotherapy (AIT) has been documented as useful in treatment of atopic asthmatics. Some of the authors investigated relatively small effect of AIT compared with the high efficacy of inhaled corticosteroids. The aim of the study was to evaluate the beneficial effects of AIT combined with inhaled corticosteroid therapy. AIT was administered to 42 patients with perennial mild bronchial asthma monospecific sensitive to Der p1, with positive intradermal skin test to Der p, and specific IgE (RAST classes 3 and 4). Sixteen of them were receiving topical corticosteroids (200 - 400 mg/day). Changes in the specific skin reactivity, and nonspecific and specific bronchial reactivity were evaluated before the beginning of AIT, after 6 weeks, after 6 months and 1 year later. Compared to pretreatment values, specific skin reactivity and nonspecific bronchial reactivity decreased significantly after 6 months as well as after 1 year of AIT, while specific bronchial reactivity decreased but not significantly. Patients receaving AIT and corticosteroids presented significantly better improvement in skin reactivity and nonspecific bronchial reactivity than patients receaving AIT only. These findings suggest that combining AIT with inhaled topic corticosteroids increases efficacy of the treatment, improves patient compliance, in carefully selected patients.

Mirjana Kljaić-Turkalj

Branimir Čvoriščec

Neven Tudorić

Asja Stipić-Marković

In vivo reactivity changes during allergen immunotherapy and corticosteroid therapy in asthmatics

哮喘患者在过敏原免疫治疗和皮质类固醇治疗期间体内反应性的变化

The aim of the study was to correlate the NBHR with the occurrence of late allergic bronchoconstriction (LAB), change of peripheral blood eosinophil count (Eo), percent of CD25 positive CD4 T lymphocyte and total leukocyte count. The 42 allergic patients (pts) with rhinitis (R = 10) and asthma (A = 32), (mean age 25, range 15 - 37 yrs.) with mean global IgE 570 kU/L and mean specific IgE (18.25 PRU) were investigated. Bronchial challenge test was done by dosimeter method (output of nebulizer 5.8 mL/breath). Phenotypic analyses of lymphocytes were performed by flow cytometry (mAB Becton Dickinson). Distribution of NBHR severity was as follows: asthmatic range of NBHR (PD2oFEV1 met 1.8 mmola): 10 pts (5 A, 5 R). The severity of NBHR correlates statistically significant with: the occurrence of LAB, basal FEV1 (r = 0.38, p = 0.009), intensity of EAB (p = 0.00), fall in Eo 2 hours after bronchial challenge (p = 0.05), increase of Eo 48 hours after challenge (p = 0.02), the increase of CD4CD25 percent (p = 0.004) and increase in total leukocyte count in peripheral blood. LAB occurred in 17 pts (40%) with mean fall in FEV1 309%. Distribution od LAB according to severity of NBHR was: 11 pts in asthmatic range and 6 pts with mild severity of NBHR. None with normal NBHR developed LAB. The intensity of EAB did not correlate with changes of inflammatory cells. These data suggest that NBHR severity is a good marker of late allergic bronchial cascade in sensitized patients.

Neven Mičulinić

Hrvoje Klobučar

Ivan Paleček

Non-specific bronchial hyperreactivity (NBHR) and late-asthmatic reaction events after allergen-challenge

变应原激发后的非特异性气道高反应性（NBHR）及迟发型哮喘反应事件

变应原激发后的非特异性支气管高反应性（NBHR）及迟发型哮喘反应事件

出版信息	出版商: Wiley-Blackwell Publishing Ltd，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2004，原创研究文献占比: ，自引率:， Gold OA占比:

Allergy: European Journal of Allergy and Clinical Immunology, Supplement

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The prevalence of exudative-catarrhal diathesis and immunity character in infants born in contaminated with radionuclides districts of Republic Belarus

Epitopic dominance of IgG antibodies against Dermatophagoides p1 antigen (Der p1) in atopic patients with perenial rhinitis and asthma

Lung cancer induced changing profile of IgG epitopes recognized on bovine Betalactoglobulin (BLG): towards a new immune marker

Bee venom immunotherapy changes the IgG antibody specificity

Contact system is pre-activated in patients experiencing reactions to radio-contrast media

In vivo reactivity changes during allergen immunotherapy and corticosteroid therapy in asthmatics

Non-specific bronchial hyperreactivity (NBHR) and late-asthmatic reaction events after allergen-challenge

In vivo reactivity changes during allergen immunotherapy and corticosteroid therapy in asthmatics

Non-specific bronchial hyperreactivity (NBHR) and late-asthmatic reaction events after allergen-challenge

In vivo reactivity changes during allergen immunotherapy and corticosteroid therapy in asthmatics