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European Journal of Medicinal Chemistry

短名	Eur. J. Med. Chem.
Journal Impact	5.94
国际分区	CHEMISTRY, MEDICINAL(Q1)
期刊索引	SCI Q1中科院 2 区

ISSN	0223-5234, 1768-3254
h-index	203
国内分区	医学(2区)医学药物化学(1区)
Top期刊	是

《欧洲药物化学杂志》是一本全球性期刊，发表关于药物化学各个方面的研究。它为发表原创论文提供了一个媒介，也欢迎评论性的论文。典型的论文将报告化合物的有机合成、表征和药理学评价。其他感兴趣的主题是药物设计、QSAR、分子建模、药物-受体相互作用、药物代谢的分子方面、前药合成和药物靶向。该杂志希望手稿能够展示研究的合理性，提供对化合物设计或机制理解的洞察力，或阐明目标。

期刊主页投稿网址

涉及主题	化学生物生物化学遗传学立体化学医学有机化学体外内科学物理药理学核磁共振基因酶组合化学细胞培养
出版信息	出版商: Elsevier Masson s.r.l.，出版周期: Monthly，期刊类型: journal
基本数据	创刊年份: 1974，原创研究文献占比: 92.61%，自引率:10.00%， Gold OA占比: 11.87%
平均审稿周期	网友分享经验：平均4.3个月来源Elsevier官网：平均7.4周
平均录用比例	网友分享经验：较易来源Elsevier官网：32%

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Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells

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Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

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Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma

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Progress in the Application of Artificial Intelligence in Molecular Generation Models based on Protein Structure

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Carbamoylation at C-8 position of natural 3-arylcoumarin scaffold for the discovery of novel PARP-1 inhibitors with potent anticancer activity

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New resorcylic acid derivatives of Lysimachia tengyuehensis against MRSA and VRE by interfering with bacterial metabolic imbalance

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Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance

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A novel theranostic strategy for myocardial infarction through neutralization of endogenous SO2 using an endoplasmic reticulum-targeted fluorescent probe

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How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents

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Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization

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Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy

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Extracellular Heat Shock Protein 90 Alpha (eHsp90α)’s Role in Cancer Progression and the Development of Therapeutic Strategies

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Discovery of novel dihydropyrrolidone-thiadiazole compound crosstalk between the YycG/F two-component regulatory pathway and cell membrane homeostasis to combat methicillin-resistant Staphylococcus aureus

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Novel pyridazinone derivatives bind to KSRP: synthesis, anti-tumor biological evaluations and modelling insights

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Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation

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Design, synthesis, and biological evaluation of oridonin derivatives as novel NLRP3 inflammasome inhibitors for the treatment of acute lung injury

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Discovery of AMPs from Random Peptides via Deep Learning-Based Model and Biological Activity Validation

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Development of fibroblast activation protein-α radiopharmaceuticals: Recent advances and perspectives

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Macrocyclic-based strategy in drug design: From lab to the clinic

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Inducing or enhancing protein-protein interaction to develop drugs: molecular glues with various biological activity

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Thioamides in medicinal chemistry and as small molecule therapeutic agents

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Synthetic Routes and Clinical Application of New Drugs Approved by EMA During 2023

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In vitro and in vivo evaluation of Bombesin-MMAE conjugates for targeted tumour therapy

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Discovery of quaternized pyridine-thiazole-ruthenium complexes as potent anti-Staphylococcus aureus agents

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Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy

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Amine-substituted heterocyclic thioamide Cu(I) and Ag(I) complexes as effective anticancer and antibacterial agents targeting the periplasm of E. coli bacteria

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Recent discovery of natural substances with cathepsin L-inhibitory activity for cancer metastasis suppression

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Indole-Core Inhibitors of Influenza A Neuraminidase: Iterative Medicinal Chemistry and Molecular Modeling

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Emerging Therapeutics: The imidazo[1,2-b]pyridazine scaffold as a novel drug candidate for eumycetoma, a neglected tropical disease

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Editorial Board

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Novel EGFR Inhibitors against Resistant L858R/T790M/C797S Mutant for Intervention of Non-Small Cell Lung Cancer

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Discovery of Novel N2-indazole Derivatives as Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Bowel Disease

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Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria

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Efficient Synthesis of Novel 1,10 Phenanthroline-Substituted Imidazolium Salts: Exploring Their Anticancer Applications

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Synthesis and biological evaluation of novel 3,6- amide and thioamide substituted- 2,3,4,9-tetrahydro-1H-carbazoles for anti-cancer activity

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Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Phosphodiesterase

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Synthesis and Evaluation of (E)-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Analogs as Competitive Partial Agonists of Butyrophilin 3A1

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Farnesyl Pyrophosphate Synthase Inhibitors with Antiosteoporosis Efficacy in Ovariectomized Rats: A Mixed Binding Approach Beyond Bisphosphonates

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Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors

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Structure-Based Discovery of Novel Piperidine-Biphenyl-DAPY Derivatives as Non-nucleoside Reverse Transcriptase Inhibitors Featuring Improved Potency, Safety, and Selectivity: From Piperazine-Biphenyl-DAPYs to Piperidine-Biphenyl-DAPYs

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European Journal of Medicinal Chemistry

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最新文章

Halogenated retinoid derivatives as dual RARα and RXRα modulators for treating acute promyelocytic leukemia cells

Development of Peptoid-Based Heteroaryl-Decorated Histone Deacetylase (HDAC) Inhibitors with Dual-Stage Antiplasmodial Activity

Discovery of Novel BCL6-Targeting PROTACs with Effective Antitumor Activities against DLBCL in Vitro and in Vivo

Graphical abstract TOC

Graphical abstract TOC

GPX4 Allosteric Activators Inhibit Ferroptosis and Exert Myocardial Protection in Doxorubicin-induced Myocardial Injury Mouse Model

Discovery of novel thiophene[3,2-d]pyrimidine-based tubulin inhibitors with enhanced antitumor efficacy for combined use with anti-pd-l1 immunotherapy in melanoma

Progress in the Application of Artificial Intelligence in Molecular Generation Models based on Protein Structure

Carbamoylation at C-8 position of natural 3-arylcoumarin scaffold for the discovery of novel PARP-1 inhibitors with potent anticancer activity

New resorcylic acid derivatives of Lysimachia tengyuehensis against MRSA and VRE by interfering with bacterial metabolic imbalance

Discovery of novel pyrazolo[1,5-a]pyrimidine derivatives as potent reversal agents against ABCB1-mediated multidrug resistance

A novel theranostic strategy for myocardial infarction through neutralization of endogenous SO2 using an endoplasmic reticulum-targeted fluorescent probe

How many organic small molecules might be used to treat COVID-19? From natural products to synthetic agents

Optimization of potent, broad-spectrum, and specific anti-influenza compounds targeting RNA polymerase PA-PB1 heterodimerization

Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy

Extracellular Heat Shock Protein 90 Alpha (eHsp90α)’s Role in Cancer Progression and the Development of Therapeutic Strategies

Discovery of novel dihydropyrrolidone-thiadiazole compound crosstalk between the YycG/F two-component regulatory pathway and cell membrane homeostasis to combat methicillin-resistant Staphylococcus aureus

Novel pyridazinone derivatives bind to KSRP: synthesis, anti-tumor biological evaluations and modelling insights

Discovery of novel 2-substituted 2, 3-dihydroquinazolin-4(1H)-one derivatives as tubulin polymerization inhibitors for anticancer therapy: The in vitro and in vivo biological evaluation

Design, synthesis, and biological evaluation of oridonin derivatives as novel NLRP3 inflammasome inhibitors for the treatment of acute lung injury

Discovery of AMPs from Random Peptides via Deep Learning-Based Model and Biological Activity Validation

Development of fibroblast activation protein-α radiopharmaceuticals: Recent advances and perspectives

Macrocyclic-based strategy in drug design: From lab to the clinic

Inducing or enhancing protein-protein interaction to develop drugs: molecular glues with various biological activity

Thioamides in medicinal chemistry and as small molecule therapeutic agents

Synthetic Routes and Clinical Application of New Drugs Approved by EMA During 2023

In vitro and in vivo evaluation of Bombesin-MMAE conjugates for targeted tumour therapy

Discovery of quaternized pyridine-thiazole-ruthenium complexes as potent anti-Staphylococcus aureus agents

Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy

Amine-substituted heterocyclic thioamide Cu(I) and Ag(I) complexes as effective anticancer and antibacterial agents targeting the periplasm of E. coli bacteria

Recent discovery of natural substances with cathepsin L-inhibitory activity for cancer metastasis suppression

Indole-Core Inhibitors of Influenza A Neuraminidase: Iterative Medicinal Chemistry and Molecular Modeling

Emerging Therapeutics: The imidazo[1,2-b]pyridazine scaffold as a novel drug candidate for eumycetoma, a neglected tropical disease

Editorial Board

Novel EGFR Inhibitors against Resistant L858R/T790M/C797S Mutant for Intervention of Non-Small Cell Lung Cancer

Discovery of Novel N2-indazole Derivatives as Phosphodiesterase 4 Inhibitors for the Treatment of Inflammatory Bowel Disease

Novel pleuromutilin derivatives conjugated with phenyl-sulfide and boron-containing moieties as potent antibacterial agents against antibiotic-resistant bacteria

Efficient Synthesis of Novel 1,10 Phenanthroline-Substituted Imidazolium Salts: Exploring Their Anticancer Applications

Synthesis and biological evaluation of novel 3,6- amide and thioamide substituted- 2,3,4,9-tetrahydro-1H-carbazoles for anti-cancer activity

Synthetic Approaches and Clinical Application of Representative Small-Molecule Inhibitors of Phosphodiesterase

STATs, Promising Targets for the Treatment of Autoimmune and Inflammatory Diseases

From Lab to Clinic: The Discovery and Optimization Journey of PI3K Inhibitors

Small Molecule Agents Against Alopecia: Potential Targets and Related Pathways

Natural Products Targeting Amyloid-β Oligomer Neurotoxicity in Alzheimer's Disease

Novel Neuroprotective 5,6-Dihydropyrido[2',1':2,3]imidazo[4,5-c]quinoline Derivatives Acting Through Cholinesterase Inhibition and CB2 Signaling Modulation

Synthesis and Evaluation of (E)-4-Hydroxy-3-methyl-but-2-enyl Diphosphate Analogs as Competitive Partial Agonists of Butyrophilin 3A1

Farnesyl Pyrophosphate Synthase Inhibitors with Antiosteoporosis Efficacy in Ovariectomized Rats: A Mixed Binding Approach Beyond Bisphosphonates

Design, synthesis, and biological evaluation of novel highly selective non-carboxylic acid FABP1 inhibitors

Structure-Based Discovery of Novel Piperidine-Biphenyl-DAPY Derivatives as Non-nucleoside Reverse Transcriptase Inhibitors Featuring Improved Potency, Safety, and Selectivity: From Piperazine-Biphenyl-DAPYs to Piperidine-Biphenyl-DAPYs

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