《中国化学杂志》是化学各领域同行评议原创研究成果的国际论坛。该杂志成立于 1983 年，当时名为 ACTA CHIMICA SINICA 英文版，并于 1990 年更名为 CHINESE JOURNAL OF CHEMISTRY，该杂志以英文出版了令人兴奋的账户、论文全文、笔记和通讯。

Acta Chimica Sinica English Edition is an international peer-reviewed journal covering all fields of chemistry, dedicated to publishing original research findings. Established in 1983 as ACTA CHIMICA SINICA English Edition, it was renamed CHINESE JOURNAL OF CHEMISTRY in 1990. The journal publishes in English and includes exciting reviews, research articles, notes, and communications.

《Acta Chimica Sinica English Edition》是一个涵盖化学各个领域的国际同行评议期刊，专注于发表原创研究成果。该杂志成立于1983年，最初名为ACTA CHIMICA SINICA英文版，并于1990年更名为CHINESE JOURNAL OF CHEMISTRY。杂志以英文出版，内容包括精彩的综述、研究论文、简报和通讯。

Acta Chimica Sinica English Edition

Summary of main observation and conclusion The direct amination of unactivated primary C—H bonds is extremely challenging due to their inert nature. Herein, we report an intramolecular primary C—H amination of sulfamate esters using an iron catalyst derived from iron(II) triflate and bipyridine. An array of oxathiazinanes were synthesized in moderate to good yields, which were further converted into biologically important azetidines by a one‐pot procedure. This research demonstrates the potential of applying simple nitrogen ligands in iron‐catalyzed C—H functionalization and offers an accessible alternative to state‐of‐the‐art iron‐nitrene chemistry.

Yan Zhang

Dayou Zhong

Muhammad Usman

Peng Xue

Wen‐Bo Liu

Chinese Journal of Chemistry

<scp>Iron‐Catalyzed</scp> Primary C—H Amination of Sulfamate Esters and Its Application in Synthesis of Azetidines†

<scp>铁催化的</scp>磺酰胺酯的C—H胺化及其在氮杂环丁烷合成中的应用†

Main observation and conclusion A redox‐neutral Fe‐catalyzed intramolecular C—H amidation of N ‐benzoyloxyureas is described. This methodology employs a simple iron complex in situ generated from Fe(OTf) 2 and bipyridine as the catalyst and N ‐benzoyloxyureas as the nitrene precursors without using exogenous oxidants. An array of cyclic ureas were synthesized via aliphatic C(sp 3 )—H amidation in excellent yields. In addition, this catalytic system is also amenable to aryl C(sp 2 )—H nitrene insertion to provide benzimidazolones in moderate yields.

Lin‐Yang Wu

Xing‐Zhen Wang

<scp>Iron‐Catalyzed</scp> Intramolecular C—H Amidation of <scp>N‐Benzoyloxyureas</scp>

铁催化的<scp>N‐苯甲酰氧基脲</scp>分子内C—H酰胺化反应

Comprehensive Summary Tumor stroma composing diverse extracellular matrixes (ECM) and stromal cells shapes a condensed physical barrier, which severely hampers the efficient accessibility of nanomedicine to tumor cells, especially these deep‐seated in the core of tumor. Such barrier significantly compromises the antitumor effects of drug‐loaded nanomedicine, revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration ability. To achieve this goal, various nanoparticle‐based strategies have been developed, including direct depleting ECM components via delivering anti‐fibrotic agents or targeting stromal cells to suppress ECM expression, dynamic regulation of nanoparticles’ physicochemical properties ( i.e ., size, surface charge, and morphology), mechanical force‐driven deep penetration, natural/biomimetic self‐driven nanomedicine, and transcytosis‐inducing nanomedicine. All these nanostrategies were systemically summarized in this review, and the design principles for obtaining admirable nanomedicine were included. With the rapid development of nanotechnology, elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies, such as chemotherapy, photodynamic therapy, and immunotherapy. Key Scientists In 2006, Chan et al. demonstrated that the size and shape of nanoparticles were important for biomedical applications, such as intracellular delivery rate and tissue penetration. In addition, the degradation of the structural collagen was confirmed to increase the diffusion of nanoparticles and macromolecules by Davies et al . in 2010. These findings reveal the importance of chemophysical properties of nanoparticles in determining their diffusion and the critical roles of stromal barrier in hindering nanoparticles penetration. On the basis of this, photoswitchable nanoparticles were developed by Kohane et al. for triggered tissue penetration and efficient drug delivery. In 2015, Nie et al . reported the targeted depletion of cancer‐associated fibroblasts by peptide assembly for enhanced antitumor drug delivery. In 2019, Shen et al . proposed the transcytosis strategy to promote the tumor penetration of nanoparticles. Very recently, Luo et al . reported the specific reversing of the biological function of cancer‐associated fibroblasts to suppress the generation of stromal matrix, greatly increasing the drug perfusion in tumor tissue. All these strategies fueled the design and construction of function‐specific nanoparticles for tumor therapy.

Guo‐Feng Luo

Wei‐Hai Chen

Xian‐Zheng Zhang

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy†

纳米医学打破基质屏障以增强药物渗透，从而改善癌症治疗†

Two new phenanthrenes, named chrysotoxols A and B (1,2) and 24 known compounds were isolated from the stems of the accession species in 2010 Chinese Pharmacopoeia of "Shihu",Dendrobium chrysotoxum. All structures were elucidated by spectroscopic (NMR, MS, UV and IR) methods and the comparison with reported data in the literatures. Compound2and six known phenols were assessed for cytotoxic activity against two human tumor cell lines (A549 and HL‐60). The results indicated that erianin may have cytotoxic activity and the other six compounds lost activity at the concentration down to 10−5mol·L−1.

Jiangmiao Hu

Weiwei Fan

Fawu Dong

Zehong Miao

Jun Zhou

Chin. J. Chem.

Chemical Components of Dendrobium chrysotoxum

金钗石斛的化学成分

Abstract Nanopore sensing is developing into a powerful label‐free approach to investigate the features of biomolecules at the single‐molecule level. When a charged molecule is captured within a nanopore, it modulates the ionic current, which can be recorded in real time to reveal the properties of the target molecule. To date, nanopores have been used to sense a variety of analytes, including DNA, RNA, proteins, enzymes, small molecules, cancer cells, and metal ions, and can also provide information on biomolecular structures. In this review, we highlight the progress made in nanopore sensing over the past five years (2016—2020), and provide an outlook on future developments and directions in the field

Mengjie Cui

Yaxian Ge

Xiao Zhuge

Xin Zhou

Dongmei Xi

Shusheng Zhang

Recent Advances in Nanopore Sensing†

纳米孔传感技术的最新进展†

Comprehensive Summary Vicinal stereogenic centers are ubiquitous structural scaffolds in both natural products and synthetic compounds, yet their enantioselective construction remains a significant challenge in organic synthesis. Organoboron compounds are of paramount importance in synthetic chemistry due to their ability to undergo facile transformations, yielding diverse essential chemical bonds such as carbon‐carbon, carbon‐oxygen, carbon‐nitrogen, and carbon‐halogen bonds. Transition‐metal‐catalyzed asymmetric borylative functionalizations of internal alkenes offer a promising strategy for the enantioselective installation of two adjacent chiral centers across carbon‐carbon bonds. By leveraging the versatile transformations of the newly introduced boryl unit, this approach holds great potential for expanding the structural diversity of vicinal stereogenic scaffolds. In this concise review, we aim to highlight recent advancements in transition‐metal‐catalyzed asymmetric borylative functionalizations of internal alkenes, underscore their utility as a versatile approach for constructing vicinal stereogenic centers, and discuss unsolved challenges and future directions in this field. Key Scientists

Yu‐Shen Zhu

Jia‐Xin Li

Hao‐Tian Zhao

Bo Su

Enantioselective Borylative Functionalization of Internal Alkenes: A Platform for Constructing Vicinal Stereocenters†

内烯烃的手性选择性硼化功能化：构建邻位立体中心的平台†

Comprehensive Summary Real‐time on‐site monitoring of resorcinol (RS) concentrations is crucial for detecting hazardous levels, enabling prompt response measures to mitigate potential environmental and health risks. In this study, we developed an innovative method using CoNi@CN‐2 nanozymes to activate peroxymonosulfate (PMS) for oxidizing 3,3',5,5'‐tetramethylbenzidine (TMB). Our results show that the formation of Ni 2+ through the oxidation of Ni 0 on the CoNi@CN‐2 surface significantly enhances the electron‐donating capacity of Co 0 . The catalytic reaction of TMB is mediated by redox active species (SO 4 •− , •O 2 − , •OH and 1 O 2 ). RS drives colorimetry by transferring electrons to the benzene ring and specific nitrogen atoms in ox‐TMB, reducing ox‐TMB to TMB. Furthermore, the colorimetric assay shows a robust linear correlation between RS concentration and absorbance (Abs), described by Abs = –0.44[RS] + 0.886 (0—200 μmol/L, R 2 = 0.983). Also, we introduce a novel smartphone‐integrated autonomous detection software that can analyze RS concentration and grayscale values (GSV), yielding GSV = 0.327[RS] + 63.601 (0—200 μmol/L, R 2 = 0.990) with a detection limit of 5.29 μmol/L. Additionally, excess PMS leads to ROS attacking specific sites in ox‐TMB, forming secondary oxidation products. This study has enabled rapid and accurate detection of RS, making a significant contribution to environmental safety and protection.

Qingyong Guo

Rongsheng Xiao

Haifeng Chen

Meishuo Bao

Jingwen Qi

Qian‐qian Jia

Wuxiang Zhang

Mechanism of <scp>TMB</scp> Discoloration Catalyzed by Layered <scp>CoNi</scp>@<scp>CN</scp> Nanozymes: Application Based on Smart Phone for Resorcinol Detection

层状<scp>CoNi</scp>@<scp>CN</scp>纳米酶催化<scp>TMB</scp>褪色的机制：基于智能手机的间苯二酚检测应用

Comprehensive Summary The direct reductive coupling of carbonyl compounds with propargyl halides is a powerful and reliable tool in the synthesis of α‐allenols. However, stoichiometric metal reductants, harsh reaction conditions and a variety of additional additives are required in the traditional strategies. Additionally, the reactivity and regioselectivity control remains an elusive challenge. Herein, we developed the Ti‐catalyzed regioselective reductive coupling of readily available aldehydes and racemic propargyl bromides to rapidly access a wide range of α‐allenols. This method proceed efficiently in a reductive radical‐polar crossover manner featuring mild conditions, excellent regioselectivity control, broad substrate scope, and eco‐friendliness. Preliminary mechanistic studies support the radical‐involved catalytic cycle. And the DFT calculations demonstrate that the regioselectivity is determined by the Zimmerman‐Traxler‐type transition states.

Zulin Xiao

Wenzhe Shang

Tao Huang

Lei He

Jingyao Li

Shen Luo

Xiaoxia He

Xiang Li

Fusheng Li

Dual Photoredox and Titanium Catalyzed Regioselective Allenylation of Aldehydes via Reductive Radical‐Polar Crossover

双光氧化还原与钛催化区域选择性烯丙基化醛类化合物通过还原自由基-极性交叉反应

Comprehensive Summary Amidst the pressing environmental challenges posed by the prevalent reliance on fossil fuels, it becomes imperative to seek sustainable alternatives and prioritize energy efficiency. Electrocatalysis, which is renowned for its high efficiency and environmental friendliness, has garnered significant attention. Rare earth elements (REEs), distinguished by their unique electronic and orbital structures, play a crucial role in electrocatalysis. The strategic integration of REEs into catalysts allows for the fine‐tuning of atomic structures, which in turn, significantly boosts catalytic performance. Despite substantial advancements in rare earth‐based materials for electrocatalysis, a comprehensive overview of the regulatory mechanisms involving REEs is lacking. In this mini‐review, we systematically explore the regulatory mechanisms of REEs within electrocatalysts and their pivotal roles in essential electrocatalytic processes such as the CO 2 reduction reaction, oxygen reduction reaction, and hydrogen evolution reaction. We commence with an elucidation of REEs, proceed to delineate their regulatory impacts on electrocatalysts and delve into their applications in key electroreduction reactions. We conclude with discussions on current limitations and prospects for further advancements in this burgeoning field of research. Key Scientists

Qinlong Gao

Haoyuan Wang

Chunxiao Liu

Laihao Luo

Xu Li

Qiu jiang

Yuan Ji

Tingting Zheng

Chuan Xia

Regulatory Mechanisms and Applications of Rare Earth Elements‐Based Electrocatalysts†

稀土元素基电催化剂的调控机制与应用†

Comprehensive Summary As a class of organic dyes, boron‐containing compounds play an important role in organic luminescent materials. They have attracted considerable attention due to their unique photophysical properties. Chiral luminescent systems have a wide range of practical applications in biological imaging, optoelectronic devices, information storage and 3D display. Boron‐containing chiral luminescent materials can not only effectively improve the luminescent properties of CPL materials, but also bring unique properties to the system, which enables them to be used as favorable CPL emitting materials for an expanded range of applications. Here, we review the research progress of boron‐containing chiral luminescent materials by the detailed discuss according to different chiral skeletons, such as point chirality, 1,1’‐binaphthyl, [ n ]helicenes, [2,2]paracyclophane and pillar[5]arenes. We believe that this review is of significance for the development of boron‐containing compounds and CPL materials. Key Scientists The studies of circularly polarized luminescence (CPL) based on small organic molecules have advanced significantly. However, boron‐containing chiral luminescent materials have gained attention only in recent years. In 2019, Zhao's group prepared a binaphthalene derivative modified with triarylborane, representing the organic small molecule luminescent material to exhibit CPL characteristics responsive to both solvent and fluoride ions. In 2020, the Chen's group used the unique luminescence properties and steric effects of triarylborane and triphenylamine to prepare CPL materials based on the planar chiral pillar[5]arenes. In 2021, Wang's group developed a new class of B,N‐embedded double hetero[7]helicenes molecules that exhibit strong chiroptical responses in the UV‐visible region. In the same year, He's group used asymmetric reactions to synthesize boron‐based point‐chirality compounds with high efficiency and enantioselectivity. In 2023, Ravat synthesized 1,4‐B,N‐embedded helicenes exhibiting narrow‐band fluorescence and CPL. During this period, Matthias Wagner et al obtained (BO) 2 ‐doped tetrathia[7]helicene via an efficient four‐step synthesis, and Zheng reported the nearly pure green circularly polarized electroluminescent device (CP‐OLED). In 2024, Chen's group prepared B,N‐embedded hetero‐[9]helicenes offering a pathway towards significantly enhanced efficiency in helicene‐based CPEL.

Jiaqi Di

Shuran Han

Pangkuan Chen

Recent Advances of Boron‐Containing Chiral Luminescent Materials†

含硼手性发光材料的最新进展†

短名	Chin. J. Chem.
Journal Impact	5.56
国际分区	CHEMISTRY, MULTIDISCIPLINARY(Q2)
期刊索引	SCI Q2中科院 1 区中国科学引文数据库中国科技核心期刊目录

ISSN	0256-7660, 1001-604X, 1614-7065
h-index	58
国内分区	化学(1区)化学化学综合(2区)

出版信息	出版商: Wiley-Blackwell，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1983，原创研究文献占比: ，自引率:， Gold OA占比:

Acta Chimica Sinica English Edition

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Iron‐Catalyzed Primary C—H Amination of Sulfamate Esters and Its Application in Synthesis of Azetidines^†

Iron‐Catalyzed Intramolecular C—H Amidation of N‐Benzoyloxyureas

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy^†

Chemical Components of Dendrobium chrysotoxum

Recent Advances in Nanopore Sensing†

Enantioselective Borylative Functionalization of Internal Alkenes: A Platform for Constructing Vicinal Stereocenters^†

Mechanism of TMB Discoloration Catalyzed by Layered CoNi@CN Nanozymes: Application Based on Smart Phone for Resorcinol Detection

Dual Photoredox and Titanium Catalyzed Regioselective Allenylation of Aldehydes via Reductive Radical‐Polar Crossover

Regulatory Mechanisms and Applications of Rare Earth Elements‐Based Electrocatalysts^†

Recent Advances of Boron‐Containing Chiral Luminescent Materials^†

Acta Chimica Sinica English Edition

期刊引文格式

有 1 位以上作者的期刊

有 2 位作者的期刊

有 3 位作者的期刊

有 5 位以上作者的期刊

书籍引用格式

学位论文引用格式

网页引用格式

专利引用格式

手工熬夜修改参考文献？研飞自动匹配期刊，一键轻松成稿，支持 Word/WPS

投稿经验分享

Iron‐Catalyzed Primary C—H Amination of Sulfamate Esters and Its Application in Synthesis of Azetidines†

Iron‐Catalyzed Intramolecular C—H Amidation of N‐Benzoyloxyureas

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy†

Chemical Components of Dendrobium chrysotoxum

Recent Advances in Nanopore Sensing†

Enantioselective Borylative Functionalization of Internal Alkenes: A Platform for Constructing Vicinal Stereocenters†

Mechanism of TMB Discoloration Catalyzed by Layered CoNi@CN Nanozymes: Application Based on Smart Phone for Resorcinol Detection

Dual Photoredox and Titanium Catalyzed Regioselective Allenylation of Aldehydes via Reductive Radical‐Polar Crossover

Regulatory Mechanisms and Applications of Rare Earth Elements‐Based Electrocatalysts†

Recent Advances of Boron‐Containing Chiral Luminescent Materials†

Iron‐Catalyzed Primary C—H Amination of Sulfamate Esters and Its Application in Synthesis of Azetidines^†

Nanomedicine Disrupts Stromal Barriers to Augment Drug Penetration for Improved Cancer Therapy^†

Enantioselective Borylative Functionalization of Internal Alkenes: A Platform for Constructing Vicinal Stereocenters^†

Regulatory Mechanisms and Applications of Rare Earth Elements‐Based Electrocatalysts^†

Recent Advances of Boron‐Containing Chiral Luminescent Materials^†