Advances in neurobiology

Michy P. Kelly

Advances in Neurobiology

A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood

磷酸二酯酶11A（PDE11A）在社会记忆形成及情绪稳定中的作用

Shinji Soeda

Kosuke Aritake

Yoshihiro Urade

Hiroshi Sato

Yukihiro Shoyama

Neuroprotective Activities of Saffron and Crocin

藏红花和藏红花素的神经保护作用

D. Attili

D. J. Schill

C. J. DeLong

K. C. Lim

G. Jiang

K. F. Campbell

K. Walker

A. Laszczyk

M. G. McInnis

K. S. O’Shea

Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder

双相障碍iPSC模型中的星形胶质细胞源性外泌体

Francisco Zafra

Ignacio Ibáñez

David Bartolomé-Martín

Dolores Piniella

Marina Arribas-Blázquez

Cecilio Giménez

Glycine Transporters and Its Coupling with NMDA Receptors

甘氨酸转运体及其与NMDA受体的耦合

Anna Kruyer

Michael D. Scofield

Astrocytes in Addictive Disorders

成瘾障碍中的星形胶质细胞

Saravana Babu Chidambaram

Sunanda Tuladhar

Abid Bhat

Arehally Marappa Mahalakshmi

Bipul Ray

Musthafa Mohamed Essa

Muhammed Bishir

Srinivasa Rao Bolla

Nandakumar Dalavaikodihalli Nanjaiah

Gilles J. Guillemin

M. Walid Qoronfleh

Autism and Gut–Brain Axis: Role of Probiotics

自闭症与肠-脑轴：益生菌的作用

Noelle D. Germain

Eric S. Levine

Stormy J. Chamberlain

IPSC Models of Chromosome 15Q Imprinting Disorders: From Disease Modeling to Therapeutic Strategies

染色体15q印记障碍的iPSC模型：从疾病建模到治疗策略

Spinal muscular atrophy (SMA) is one of the major genetic disorders associated with infant mortality. More than 90% cases of SMA result from deletions or mutations of Survival Motor Neuron 1 (SMN1) gene. SMN2, a nearly identical copy of SMN1, does not compensate for the loss of SMN1 due to predominant skipping of exon 7. However, correction of SMN2 exon 7 splicing has proven to confer therapeutic benefits in SMA patients. The only approved drug for SMA is an antisense oligonucleotide (Spinraza™/Nusinersen), which corrects SMN2 exon 7 splicing by blocking intronic splicing silencer N1 (ISS-N1) located immediately downstream of exon 7. ISS-N1 is a complex regulatory element encompassing overlapping negative motifs and sequestering a cryptic splice site. More than 40 protein factors have been implicated in the regulation of SMN exon 7 splicing. There is evidence to support that multiple exons of SMN are alternatively spliced during oxidative stress, which is associated with a growing number of pathological conditions. Here, we provide the most up to date account of the mechanism of splicing regulation of the SMN genes.

Ravindra N. Singh

Natalia N. Singh

Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes

脊髓性肌萎缩基因剪接调控的机制

涉及主题	生物医学心理学内科学神经科学遗传学化学生物化学细胞生物学内分泌学计算机科学中枢神经系统细胞病理精神科物理解剖
出版信息	出版商: Springer Publishing Company，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2014，原创研究文献占比: 0.00%，自引率:N.A.， Gold OA占比: 0.00%

Advances in neurobiology

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A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood

Neuroprotective Activities of Saffron and Crocin

Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder

Glycine Transporters and Its Coupling with NMDA Receptors

Astrocytes in Addictive Disorders

Astrocytes in Addictive Disorders

Astrocyte-Derived Exosomes in an iPSC Model of Bipolar Disorder

Autism and Gut–Brain Axis: Role of Probiotics

IPSC Models of Chromosome 15Q Imprinting Disorders: From Disease Modeling to Therapeutic Strategies

Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes