Acta Physiologica et Pharmacologica Bulgarica

Markovska

Georgiev

Ankov

Acta physiologica et pharmacologica bulgarica

Influence of x-ray irradiation on the effects of apomorphine and L-dopa with respect to the dopamine level in rat brain and corpus striatum.

X射线照射对阿朴吗啡和L-多巴在大鼠脑和纹状体中多巴胺水平影响的研究。

S. Dimov

D. Popivanov

S. Moyanova

Changes in cerebral excitability under the effect of DL-C-allylglycine

DL-C-烯丙基甘氨酸对大脑兴奋性变化的影响

G. N. Gantchev

N. Draganova

S. Dunev

The role of sensory feedback in the control of postural activity

感觉反馈在姿势活动控制中的作用

Petkov

Participation of serotoninergic, GABA-ergic and opiate mechanisms in the genesis of amphetamine stereotypy.

5-羟色胺能、GABA能和阿片机制在苯丙胺刻板行为发生中的参与。

X射线照射对阿朴吗啡和L-多巴在鼠脑和纹状体多巴胺水平上作用的影响。

Using the method for passive avoidance with punishment reinforcement (step-down), it was found that the serotonin (5-HT)-receptor blockers methergoline, methysergide and ritanserin at a dose of 5 mg/kg b.w. administered i.p. 30 min before the training session as well as the M-cholinergic-receptor blocker scopolamine administered at a dose of 2 mg/kg b.w. 90 min before training impaired acquisition and retention of memory traces. The memory impairment was also manifested by the poor habituation of methergoline- and scopolamine-treated rats placed in an unfamiliar environment. Memory deficit was increased by the combination of methergoline or ritanserin with scopolamine. On multiple administration before training the nootropic drug adafenoxate completely prevented the amnestic effect of the combination methergoline plus scopolamine.

Petkov Vd

Markovska Vl

Petkov Vv

Effects of serotoninergic receptor antagonists and their combination with scopolamine on memory.

5-羟色胺能受体拮抗剂及其与东莨菪碱联合使用对记忆的影响。

The study concerns the manner in which forskolin activates the adenylate cyclase system of differentiating rabbit bone-marrow erythroid cells. The results presented show that forskolin can stimulate the basal activity of adenylate cyclase in the absence of guanine nucleotides in an in vitro assay containing plasma membranes derived from both dividing and non-dividing cells. In the presence of guanine nucleotide the activation of adenylate cyclase by forskolin is increased, but the effect is not additive and is abolished by the beta-thio analogue of GDP. Addition of forskolin to cell cultures causes a transient increase in the activity of adenylate cyclase, which is maximal by 30 minutes and disappears within 24 hours. The conclusion is made that the effect of forskolin on adenylate cyclase complex of differentiating rabbit bone-marrow erythroblasts is similar to the effect of erythropoietin (Bonanou-Tzedaki et al., 1986) and is transdusing via stimulatory guanine nucleotide-regulatory protein.

Setchenska Ms

Timanova Am

Forskolin as an activator of adenylate cyclase complex of differentiating erythroid bone-marrow cells.

毛喉素作为分化红系骨髓细胞腺苷酸环化酶复合物的激活剂。

The study deals with the changes of the excitability of CNS in the course of the ovarial cycle under the influence of long-term locomotion regimens. The excitability of the CNS was evaluated by the spontaneous EEG paroxysmal activity and by the changes in certain behavioural states (alertness, exploration and quiet wakefulness). The changes of the excitability (as assessed by EEG and behavioural features) were correlated with the effects of the locomotor regimens on the serum levels of ovarial hormones. The results suggest that long-term locomotion regimens alter the excitability of the CNS during the ovarial cycle. Running exercise was found to ameliorate the functional state of the nervous system by increasing the activation threshold, whereas restricted locomotion increases the sensitivity of the CNS.

Nikiforova As

Patchev Vk

Nikolov Nd

Long-term locomotion regimens affect EEG paroxysmal activity, behaviour and sex hormone secretion in female rats.

长期运动方案影响雌性大鼠脑电图阵发性活动、行为和性激素分泌。

The synapses in the cerebellar vermis molecular layer of 6 week old rats treated with small amounts of ethanol (9 g/kg daily) during pre- and postnatal development were examined. Quantitative analysis was made using a digitizer interfaced to a computer. Some relative and absolute (volume) parameters for synapses were calculated using respective computer programs. The results showed a decreased synaptic density as well as qualitative and quantitative changes in the pre- and postsynaptic elements. The possibility that some changes are compensatory reactions to the decreased synaptic input to the Purkinje cells following prolonged alcohol exposure is discussed.

Lolov

Lolova I

Synaptic changes in the rat cerebellum following pre- and postnatal alcohol exposure.

大鼠小脑在产前和产后酒精暴露后的突触变化。

Short-term exposure to low concentrations (4260 p. p. m.) of n-hexane or/and x-ray radiation was found to affect considerably the amount and composition of pulmonary surfactant in rats. There was a time-dependent increase of phospholipids in the broncho alveolar lavage (BAL), being more pronounced in the later period studied (15 days) and especially after irradiation alone or in combination with n-hexane. These alterations, considered to be due to the enhanced release of phospholipids, mainly phosphatidylcholine, into the alveolar spaces, led to the depletion of the lung tissue pool of its surfactant contents. The unidirectional effect of both noxious agents studied is supposed to perturb and strongly trigger the process of surfactant secretion.

Publication Information	Publisher: Universitetsko Izdatelstvo Sv. Kliment Okhridski/Publishing House of the Sofia University St. Kilment Ohridski，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2003，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

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Influence of x-ray irradiation on the effects of apomorphine and L-dopa with respect to the dopamine level in rat brain and corpus striatum.

Changes in cerebral excitability under the effect of DL-C-allylglycine

The role of sensory feedback in the control of postural activity

Participation of serotoninergic, GABA-ergic and opiate mechanisms in the genesis of amphetamine stereotypy.

Influence of x-ray irradiation on the effects of apomorphine and L-dopa with respect to the dopamine level in rat brain and corpus striatum.

Effects of serotoninergic receptor antagonists and their combination with scopolamine on memory.

Forskolin as an activator of adenylate cyclase complex of differentiating erythroid bone-marrow cells.

Long-term locomotion regimens affect EEG paroxysmal activity, behaviour and sex hormone secretion in female rats.

Synaptic changes in the rat cerebellum following pre- and postnatal alcohol exposure.

Early effects of n-hexane and irradiation on the lung surfactant system.