Acta Dermato-Venereologica, Supplement

Only a few studies, conducted in Sweden, assessed factors associated with the presence of atypical moles in the general population. We conducted a population-based, case-control study in New Hampshire, USA, to identify factors associated with atypical moles. In our study, atypical moles affected 14% of the study population. The adjusted odds ratio (OR) was 0.34 (95% confidence interval (CI) = 0.14-0.80) for those with the highest adulthood recreational sun exposure, relative to the lowest. The OR for any freckles, compared to none, was 2.24 (95% CI = 1.18-4.25). We found a linear relationship between the number of benign moles and the presence of atypical moles (p for trend = 0.0001). The OR was 7.34 (95% CI = 3.03-17.80) for > 15 benign moles, relative to 0-4. Our data indicate that freckles and benign moles, which may reflect melanocytic inducibility, are strongly associated with atypical moles. The inverse association with sun exposure should be considered with caution.

Linda Titus-Ernstoff

Jiao Ding

Ann E Perry

Steven K Spencer

Bernard F Cole

Marc S Ernstoff

Acta Dermato-Venereologica, Supplementum

Psoriasis: biomolecular, morphological and clinical considerations.

银屑病：生物分子、形态学和临床考量。

The true microcirculation is the flow of fluid and its contents through the tissues. This is controlled by blood vessels and lymphatics. Both are abnormal in psoriasis and may significantly contribute to its pathogenesis. The type of vasculature characteristic of psoriasis is common to many pathological states and probably influences the metabolism of the tissues in such a way as to maintain the pathology in status quo. It imparts to the tissue a special vulnerability but also encourages repair.

T J Ryan

The blood vessels of psoriasis.

银屑病的血管。

It is our belief that any abnormality in keratinization is secondary to an increased rate of epidermal cell production and decreased transit time and research into the underlying nature of psoriasis should concentrate on the issue of whether the stimulus to increased epidermopoietic activity is dermally or epidermally derived.

R Marks

S Barton

C S King

S Nicholls

Formation of the horny layer in psoriasis--primarily defective or secondarily affected.

银屑病角质层的形成——主要是缺陷还是次要受影响。

As demonstrated by means of an immunoperoxidase technique, the great majority of the infiltrating mononuclear cells located in the superficial and middle dermis of psoriatic skin consisted of T-lymphocytes. On the contrary, immunoglobulin bearing cells, investigated by means of both immunoperoxidase and immunofluorescence methods, were scarce; IgA and IgG cells were predominant, whilst IgM cells were scarcely represented. Macrophages and monocytic cells were observed in the superficial dermis by means of the alpha-naphtyl-acetate-esterase method, in frozen sections. The role of the above mentioned cells and the significance of their reciprocal relationships still remains in discussion.

Jannie Ausma

Gennethel Pennick

Hilde Bohets

Vera Van De Velde

Marcel Borgers

Annette Fothergill

Immunohistochemical study of dermal cell popoulation in psoriatic skin.

银屑病皮肤真皮细胞群体的免疫组化研究。

Acid mucopolysaccharides have been studied in the dermis of 40 cases of incipient psoriasis. In the upper dermis a marked reduction of the material stained with colloidal iron and with Alcian blue solutions containing 0.1 and 0.2 M MgCl2 was observed; enzymatic controls with hyaluronidase support the idea that this material consists mainly of hyaluronic acid. The intensity and the extension of this dermal alteration far beyond the limits of the above-mentioned epidermal alteration give credence to the hypothesis that in the pathogenesis of psoriasis, dermal alterations are of a primitive character.

Yi-Ju Chen

Chun-Ying Wu

Jui-Lung Shen

Acid mucopolysaccharides of the dermis in incipient psoriasis.

皮肤角质层中酸性粘多糖在早期银屑病中的作用。

In order to determine the efficacy and tolerance of two topical antiseptics, chlorhexidine vs KMn04 (diluted at 1:20,000), we compared their bacteriological and clinical effects in a randomized trial on 20 children with Atopic Dermatitis (AD) treated with topical steroids (desonide). After treatment, a clinical improvement was noted in the two groups, though without statistical differences. In vivo: Before treatment, Staphylococcus aureus (S.A.) density was high and predominant in both groups. After treatment, the decrease in S.A. was greater in the chlorhexidine group than in the KMn04 group, without significant difference. In vitro: At the clinical dilution used, there was a statistical difference (p < 0.05) between the number of killed bacteria in the chlorhexidine group (-3 log) and the number in the KMn04 group (-1 log). This study confirms the role and importance of the choice of a topical antiseptic in the treatment of AD.

J. F. Stalder

M. Fleury

M. Sourisse

T. Allavoine

C. Chalamet

P. Brosset

P. Litoux

Comparative effects of two topical antiseptics (chlorhexidine vs KMn04) on bacterial skin flora in atopic dermatitis.

两种局部抗菌剂（氯己定与高锰酸钾）对特应性皮炎患者皮肤菌群的比较效果。

Twenty-three adult patients suffering from chronic atopic dermatitis (AD) have been treated by regular injections of complexes made of D. pteronyssinus allergens and specific autologous antibodies. A double-blind placebo-controlled protocol was followed for 4 months, then the patients were treated openly to complete a full year on active therapy. Preliminary results are presented for the first 8 months. Seventy-three percent of patients improved when treated with complexes, showing a mean improvement of more than 70% after 4 months. This study suggests that injections of allergen-antibody complexes is an effective treatment of at least some forms of AD and confirms that airborne allergens are significant exacerbating factors of AD.

Bernard P. Leroy

G. Boden

Marie-Antoinette Jacquemin

Jean-Marie Lachapelle

J M Saint-Remy

Allergen-antibody complexes in the treatment of atopic dermatitis: preliminary results of a double-blind placebo-controlled study.

过敏原-抗体复合物在特应性皮炎治疗中的应用：一项双盲安慰剂对照研究的初步结果。

Distribution of skin lesions was studied in 1,012 patients under 10 years of age, with atopic dermatitis. Of these, 812 (80.2%) had an atopic history; 200 did not. Both categories were divided by age into five subgroups (3-5 months, 6-11 months, 1 year, 2-4 years and 5-9 years) and the incidence of lesions in each of 52 skin regions was compared between the positive and negative history groups and between different age groups. The results were as follows. 1. There was a change in predilection site, from the head (the scalp, face and peri-auricular area) to the neck and flexures (cubital and popliteal fossae) between 1 and 2 years of age. 2. The trunk (shoulders, chest, abdomen and back) was the most common predilection site in both infants and children. 3. Only the upper arm was affected more frequently on the external side than the internal side in all age groups. 4. The nose, mamillae, palms and feet were the least affected areas in all age groups. 5. Incidences in the positive history group were no higher than in the negative group.

T Aoki

T Fukuzumi

J Adachi

K Endo

M Kojima

Re-evaluation of skin lesion distribution in atopic dermatitis. Analysis of cases 0 to 9 years of age.

特应性皮炎皮肤病变分布的再评估。0至9岁病例分析。

In a prospective computerized study, basic and minor features of atopic dermatitis were studied systematically in established cases of atopic dermatitis (AD; n = 428) and compared with subjects randomly collected from the caucasian normal population of young adults (NP; n = 659). Complete genetic data (history of AD, allergic rhinitis, allergic asthma) were obtained from the first-degree relatives of all subjects (about 9,000 family members). In young adults, atopy was found in 22.5% (AD 4.7%, allergic rhinitis 17.9%, allergic asthma 4.8%). Of 428 AD patients, 54% had 'pure' AD and 46% suffered from a 'mixed' type with concomitant respiratory allergies (RA). The general risk of developing AD and atopy increases with each first-degree family member already suffering from atopy. Our study further supports the evidence of a genetic influence on symptom specificity. Risk figures for genetic counselling are given. The complex interplay of atopic symptoms and signs in the diagnosis of AD has been analysed by a CART analysis. Compared with non-eczematous controls, the odds ratios (OR) of frequent features in AD are as follows: xerosis (OR 27.9, 95%-CI 23.2-33.8), itch when sweating (OR 25.4, 95%-CI 21. 1-30.1), white dermographism (OR 19.3, 95%-CI 16.2-23.2), wool intolerance (OR 15.8, 95%-CI 13.40-18.5), whereas the OR of elevated IgE (> 150 U/ml) was only 5.0 (95%-CI 4.3-5.8). But when comparing the AD patients with concomitant RA separately, the odds ratio is increased to 16.2.

T. L. Diepgen

M. Fartasch

Recent epidemiological and genetic studies in atopic dermatitis.

特应性皮炎的流行病学与遗传学研究进展。

Radioallergosorbent tests (RASTs) with five common foods were performed in 183 patients with atopic dermatitis. The results showed that about half of the patients had type I allergy to at least one of the five foodstuffs. The RAST results correlated roughly to the severity of dermatitis. In each group of patients with mild, moderate and severe atopic dermatitis, positive RAST reactions to common foods occurred predominantly in patients who had a personal or a family history of respiratory atopy. Positive RASTs were rare in patients with pure atopic dermatitis who had neither personal nor family history of respiratory atopy. It seems likely that type I food allergy occurs predominantly in those patients with atopic dermatitis who have a predisposition to respiratory atopy.

M. Uehara

C. Kimura

T. Uenishi

Type I allergy to foods in atopic dermatitis. Comparison between RAST-positive and RAST-negative cases.

特应性皮炎中的食物I型过敏。RAST阳性病例与RAST阴性病例的比较。

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