Military Medical Science Letters (Vojenske Zdravotnicke Listy)

Background: Cartilage intermediate layer protein 2 (CILP2) is a monomeric glycoprotein that is mostly expressed in the intermediate zone of articular cartilage and can be detected in the extracellular matrix (ECM).The level of CILP2 in serum and its quantity on the articular cartilage surface and throughout the articular cartilage indicates the potential utility of CILP2 for investigation as a biomarker for determining cartilage deterioration in joint disorders.The CILP2 measurement of changes in cartilage biomarkers may be an effective and sensitive tool for detecting the early development of knee osteoarthritis (KOA) in people at risk for KOA.Changes in CILP2 levels may be beneficial for the early diagnosis of KOA, as CILP2 appears to be linked to cartilage thickness reduction in people who are more likely to develop KOA.Platelet rich plasma (PRP) effectiveness of transforming growth factor, platelet-derived growth factor, and the vascular endothelial growth factor is thought to be related to their release.Because of their capacity to increase matrix formation,growth factors have been widely researched for OA and cartilage regeneration.Hyaluronic acid (HA) is a glycosaminoglycan polymer composed of N-acetyl glucosamine and D-glucuronic acid disaccharide molecules.Early embryonic development, inflammatory, wound repair, cell differentiation, and viscoelasticity are all affected by HA, and other biological processes The study was aimed to evaluate effecte of CILP2 levels after intraarticular injecting pure platelet-rich plasma and hyaluronic acid into patients with early knee osteoarthritis.Materials and Methods: BT LAB kits were used to assess the serum CILP2 level.The experimental investigation included 18 control groups, 10 HA injections, and 21 pure PRP injections.age ranged from 35 to 75.The study was exluded all individuals with advanced osteoarthritis in the knee, COVID-19, diabetes, and autoimmune diseases.the time frame running from November 2021 until June 2022.Other variables in our research were age, gender, family history, use of antihypertensive medications or medications for other disorders, and body mass index (BMI).Results: The findings of this study demonstrate elevated CILP2 levels in patients with early KOA before treatments injection compared with the healthy control.After treatments injection, the level of CILP2 was decreased compared with before injection. Albdeery et al.: Defining the role of CILP2 protein in osteoarthritis 149Conclusions: CILP2 could be one of the prognostic signs of early KOA.

Ali K. Albdeery

Ajil A. Alzamily

Ihsan A. Alsalman

Military Medical Science Letters

THE ROLE OF CARTILAGE INTERMEDIATE LAYER PROTEIN2 (CILP2) IN EVALUATING THE EFFECT OF TREATMENTS (PLATELET-RICH PLASMA AND HYALURONIC ACID) ON PATIENTS WITH EARLY KNEE OSTEOARTHRITIS

评估治疗（富血小板血浆和透明质酸）对早期膝关节骨性关节炎患者效果中软骨中间层蛋白2 (CILP2) 的作用

Jan Páleník

Michal Soták

Karel Roubík

Mikuláš Kosák

Martin Pochop

Adéla Bubeníková

Tomáš Tyll

THE IMPACT OF SIMULATION METHOD AND ENVIRONMENT ON STRESS LEVELS AND PERFORMANCE IN MILITARY PARAMEDICS: A PILOT STUDY

模拟方法和环境对军事护理人员压力水平及表现的影响：一项初步研究

Petr Malý

Leona Chrastinová

Martin Malý

Jan M. Horáček

CAROTID ARTERY DISSECTION AND CONNECTIVE TISSUE DISORDERS: A REVIEW OF KNOWN GENE/PROTEIN MUTATION FINDINGS

颈动脉夹层与结缔组织疾病：已知基因/蛋白质突变发现的综述

Markéta Čápová

Kateřina Horáčková

Marie Holubová

DELIRIUM AND ITS MANAGEMENT IN NURSING INTERVENTIONS

谵妄及其在护理干预中的管理

The aim of the current pilot study is to depict the pattern of management of autism spectrum disorder (ASD) in Saudi Arabia, focusing on the efficacy of risperidone in reducing the target symptoms of ASD compared to only behavioral therapy.A cross-sectional study was conducted at two main centers for 10 months.On a convenience basis, prospective visits were scheduled for children, who had received regular behavioral therapy and/or antipsychotics¬ (mainly risperidone), and their parents to assess the efficacy and side-effects of the treatment.The improvement of symptoms of ASD was assessed using the Aberrant Behavior Checklist-Community Version (ABC-CV) including five subdomains: Irritability, Lethargy, Stereotypic behavior, Hyperactivity, and Inappropriate speech.Twenty-nine children (26 boys and 3 girls) with a mean age of 8.96 years (range: 5-15 years) were included in this study.The distribution of management strategy was: risperidone (11, 37.9%), behavioral therapy only (9, 31.0%),risperidone and behavioral therapy (9, 31.0%).The use of a combination of antipsychotics and psychostimulants (17.24%) was less common than in a previous American study (38%).Surprisingly, scores for all ABC subdomains were higher than those of previous studies, indicating less efficacy of risperidone in this group.Additionally, for the Lethargy subdomain, the score was 74.3±24.3.Interestingly, children who received behavioral therapy only, had lower scores compared to their counterparts who received risperidone only in all ABC subdomains and the total score.Consistent with other reports, this study highlighted the efficacy of risperidone alongside behavioral therapy on reducing hyperactivity symptoms and total ABC score.Despite the published data regarding the efficacy and safety of risperidone, supporting that it may have an important role in the management of ASD in children, further prospective design studies in Saudi Arabia are warranted to confirm the findings or encourage its continuous employment as long-term maintenance therapy.

Sireen Abdul Rahim Shilbayeh

Iman Sharaf Adeen

MANAGEMENT OF AUTISM SPECTRUM DISORDER: A PILOT STUDY IN SAUDI PAEDIATRICS

自闭症谱系障碍的管理：沙特儿科的一项试点研究

Vojtěch Humlíček

Josef Fusek

USABILITY OF MILITARY HEALTH SERVICE TO SUPPORT AN INTEGRATED RESCUE SYSTEM

军事医疗服务支持综合救援系统的可用性

Vendula Hepnarova

Martina Hrabinova

Jakub Opravil

Mojmir Vanek

Eva Mezeiova

Lukas Gorecki

Tomas Kucera

Daniel Jun

Ondrej Soukup

Lubica Muckova

Jan Korabecny

DESIGN, CHEMICAL SYNTHESIS, AND IN VITRO EVALUATION OF NOVEL UNCHARGED CHOLINESTERASE REACTIVATOR

新型非带电胆碱酯酶重活化剂的设计、化学合成及体外评价

Publication Information	Publisher: University of Defence, Faculty of Military Health Sciences，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2018，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%

Military Medical Science Letters (Vojenske Zdravotnicke Listy)

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THE ROLE OF CARTILAGE INTERMEDIATE LAYER PROTEIN2 (CILP2) IN EVALUATING THE EFFECT OF TREATMENTS (PLATELET-RICH PLASMA AND HYALURONIC ACID) ON PATIENTS WITH EARLY KNEE OSTEOARTHRITIS

THE IMPACT OF SIMULATION METHOD AND ENVIRONMENT ON STRESS LEVELS AND PERFORMANCE IN MILITARY PARAMEDICS: A PILOT STUDY

CAROTID ARTERY DISSECTION AND CONNECTIVE TISSUE DISORDERS: A REVIEW OF KNOWN GENE/PROTEIN MUTATION FINDINGS

DELIRIUM AND ITS MANAGEMENT IN NURSING INTERVENTIONS

MANAGEMENT OF AUTISM SPECTRUM DISORDER: A PILOT STUDY IN SAUDI PAEDIATRICS

THE IMPACT OF SIMULATION METHOD AND ENVIRONMENT ON STRESS LEVELS AND PERFORMANCE IN MILITARY PARAMEDICS: A PILOT STUDY

DELIRIUM AND ITS MANAGEMENT IN NURSING INTERVENTIONS

CAROTID ARTERY DISSECTION AND CONNECTIVE TISSUE DISORDERS: A REVIEW OF KNOWN GENE/PROTEIN MUTATION FINDINGS

USABILITY OF MILITARY HEALTH SERVICE TO SUPPORT AN INTEGRATED RESCUE SYSTEM

DESIGN, CHEMICAL SYNTHESIS, AND IN VITRO EVALUATION OF NOVEL UNCHARGED CHOLINESTERASE REACTIVATOR

ISSN	0372-7025, 2571-113X
h-index	6