JOURNAL OF TOXICOLOGICAL SCIENCES (J. TOXICOL. SCI.) 是一本科学期刊，发表关于药物、食品添加剂、食品污染物和环境污染物等物质的毒性机制和意义的研究。一般不能接受关于含有不明化合物的提取物和混合物的毒性和影响的论文。

The Journal of Toxicological Sciences (J. TOXICOL. SCI.) is a scientific journal dedicated to publishing research on the toxic mechanisms and significance of substances such as drugs, food additives, food contaminants, and environmental pollutants. The journal generally does not accept papers on the toxicity and effects of extracts and mixtures containing unidentified compounds.

《Journal of Toxicological Sciences》（J. TOXICOL. SCI.）是一本科学期刊，专注于发表关于药物、食品添加剂、食品污染物和环境污染物等物质的毒性机制及其意义的研究。该期刊一般不接受关于含有不明化合物的提取物和混合物的毒性及其影响的论文。

Journal of Toxicological Sciences

Neuroinflammation plays a critical role in various neurological disorders. Oxycodone has anti-inflammatory properties. The purpose of this work was to look into the effect of oxycodone in controlling lipopolysaccharide (LPS)-induced neuroinflammation in microglia.

QingYun Tan

Kai Zhang

QingDong Wang

Rongjia Zang

The Journal of Toxicological Sciences

Oxycodone alleviates LPS-induced neuroinflammation by regulating the CREB/miR-181c/PDCD4 axis

羟考酮通过调节CREB/miR-181c/PDCD4轴缓解LPS诱导的神经炎症

Lidocaine has been shown to inhibit the invasion and metastasis of breast cancer, but the mechanism still remains unclear. This study explored the relationship between lidocaine and circulating seeding of breast cancer cells from the perspective of nerve fiber formation. The cell lines MDA-MB-231 and 4T1 were subcutaneously inoculated in mice to simulate the tumor self-seeding by circulating cancer cells. Lidocaine was used to treat these mice and tumor growth was observed. Silver staining was performed to observe the distribution of nerve fibers in tumor-bearing tissues, and immunohistochemical analysis was performed to observe the expression levels of nerve-related proteins. The results showed that lidocaine treatment effectively inhibited tumor growth and nerve fiber formation, and down-regulated the expression levels of protein gene product 9.5, neurofilament, nerve growth factor (NGF), and neuronatin (Nnat). Overexpression NGF and Nnat both could reverse the therapeutic effects of lidocaine. These results suggest that the effect of lidocaine on inhibiting breast cancer invasion and metastasis may be achieved by targeting Nnat, regulating the production of NGFs in cancer cells, and subsequently inhibiting the formation of nerve fibers.

Bingda Li

Hao Xu

Chongwu He

Wenxiong Zou

Yun Tu

Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation

A simple monitoring method has been proposed by measuring uranium (U) concentration and its chemical form in serum. The droplet of the 1 µL rat serum specimen was then examined by subjecting it to high energy synchrotron radiation X-ray fluorescence spectroscopy (SR-XRF) and X-ray absorption fine structure (XAFS) to determine the concentration and chemical form of U. The detection limit of U in 1 µL droplet was calculated to be 0.071 µg/g. The U concentration in the specimen obtained from the rat exposed to U was consistent with that determined by inductively coupled plasma mass spectrometry. Uranium in the rat serum was estimated to be hexavalent U based on the standard specimens of tetravalent and hexavanet U. This method developed might be used for monitoring and decorporation of patients at nuclear disasters and environmental pollution.

Akihiro Uehara

Izumi Tanaka

Hiroshi Ishihara

Daisuke Akiyama

Akira Kirishima

Shino Homma-Takeda

Monitoring method for uranium concentration and chemical form in the droplet of rat serum

大鼠血清液滴中铀浓度及化学形态的监测方法

Chlorfenapyr is a novel pyrrole compound with the chemical formula C15H11BrClF3N2O, exhibiting potent insecticidal and acaricidal effects. It primarily acts on the multi-functional oxidases in the mitochondria of insects, inhibiting the conversion of adenosine diphosphate to adenosine triphosphate, leading to cellular dysfunction due to energy depletion. With increased production and market availability, the population's exposure to chlorfenapyr has risen, resulting in a growing number of fatal poisoning incidents. This report describes the clinical presentation, disease progression, and treatment outcomes of a 2-year and 11-month-old toddler poisoned with chlorfenapyr. The child exhibited symptoms of nausea and vomiting two hours post-poisoning, received gastric lavage and fluid replacement at the local hospital, and was subsequently transferred to our facility. On admission, the child's vital signs were stable for the first two days, with normal laboratory findings. On the third day, the child showed signs of fatigue and diaphoresis, followed by high fever, profuse sweating, altered consciousness, and muscle tremors on the fourth day. By the fifth day, the child displayed rigid muscles in the limbs and trunk, respiratory and circulatory failure, despite rescue efforts proving futile, leading to eventual demise.

Limei Mo

Hongyan Wu

Li Zhao

Kang An

A case of infant death due to chlorfenapyr poisoning

因氯虫酰胺中毒导致婴儿死亡的案例

Numerous studies have confirmed that the apoptosis induced by the methacrylate resin monomers triethyleneglycol-dimethacrylate (TEGDMA), 2-hydroxy ethyl methacrylate (HEMA), etc., in pulp cells and odontoblast-like cells is caused mainly by oxidative stress (OS). Reactive oxygen species (ROS), recognized as the most important risk factor for apoptosis in cells of the pulp-dentin complex, are produced mainly via the mitochondrial respiratory chain. When the free resin monomers in the oral cavity and pulp reach a toxic level, the monomers induce oxidative DNA damage, activate ATM-p53 in the nucleus, and mediate the intrinsic apoptotic pathway in the presence of Bcl-2 family proteins. A vicious cycle is established between OS cellular responses and abnormalities in mitochondrial dynamics that accelerate apoptosis. Despite numerous products generated via iteration, complete polymerization of resin monomers is not currently possible. The cytotoxicity of free monomers may lead to adverse reactions, such as pulp sensitivity. This review is based on the most important papers describing the roles of resin monomers in mediating apoptosis in the pulp-dentin complex and provides an overview of the precise mechanisms related to mitochondrion-mediated cytotoxicity, suggesting ways to reduce or eliminate their cytotoxicity in the future through advancements in material technology.

Siqi Xu

Lijuan Chen

Xi Lin

Xiaoxia Yang

Lidan He

Siqi Yan

Song Luo

Xinyi Chen

Guoying Que

Resin monomers induce apoptosis of the pulp–dentin complex through the mitochondrial pathway

树脂单体通过线粒体途径诱导牙髓-牙本质复合体凋亡

Ferroptosis, a mode of cell death involving iron-dependent lipid peroxidation, has attracted widespread attention in the development of anticancer drugs and toxicological studies as a potential mechanism of chemical-induced cytotoxicity. This process is regulated by several antioxidant enzymes, of which the selenium-containing glutathione peroxidase 4 (GPx4) is the prime regulator. However, accurately and reproducibly evaluating ferroptosis in cultured cells is challenging since numerous experimental factors in in vitro setting can influence the results. In the present study, we found that the expression levels of selenoproteins, such as GPx4 and GPx1, fluctuate across several cell lines depending on the selenium content of different origin of fetal bovine serum (FBS). Cells cultured in FBS containing higher selenium concentrations exhibited elevated GPx4 expression, and were resistant to ferroptosis induced by erastin and RSL3. These findings suggest that the variability of selenium content in different FBS batches can significantly influence the susceptibility of cells to ferroptosis, highlighting the importance of standardizing these factors to enhance the reproducibility of ferroptosis-related experiments.

Hayato Takashima

Takashi Toyama

Eikan Mishima

Kei Ishida

Yinuo Wang

Atsuya Ichikawa

Junya Ito

Syunsuke Yogiashi

Stephanie Siu

Mayumi Sugawara

Satoru Shiina

Kotoko Arisawa

Marcus Conrad

Yoshiro Saito

Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells

胎牛血清中硒含量对培养细胞铁死亡敏感性和硒蛋白表达的影响

Hongbin Wang

Wei Li

Puerarin alleviates the high glucose-induced oxidative stress via the RAGE/PKC/NOX4 axis in renal mesangial cells

葛根素通过RAGE/PKC/NOX4轴减轻高糖诱导的肾小球系膜细胞氧化应激

Abbreviation	J. Toxicol. Sci.
Journal Impact	1.97
Quartiles(Global)	TOXICOLOGY(Q4)

ISSN	0388-1350, 1880-3989
h-index	59

Publication Information	Publisher: Japanese Society of Toxicology，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1976，Proportion of original research papers: 98.08%，Self Citation Rate:5.60%， Gold OA Rate: 99.43%
Average review cycle	网友分享经验：偏慢,4-8周
Average recruitment ratio	网友分享经验：容易

Journal of Toxicological Sciences

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Oxycodone alleviates LPS-induced neuroinflammation by regulating the CREB/miR-181c/PDCD4 axis

Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation

Monitoring method for uranium concentration and chemical form in the droplet of rat serum

A case of infant death due to chlorfenapyr poisoning

Resin monomers induce apoptosis of the pulp–dentin complex through the mitochondrial pathway

Monitoring method for uranium concentration and chemical form in the droplet of rat serum

A case of infant death due to chlorfenapyr poisoning

Resin monomers induce apoptosis of the pulp–dentin complex through the mitochondrial pathway

Impact of selenium content in fetal bovine serum on ferroptosis susceptibility and selenoprotein expression in cultured cells

Puerarin alleviates the high glucose-induced oxidative stress via the RAGE/PKC/NOX4 axis in renal mesangial cells