Acta Veterinaria

Abstract Lumpy skin disease (LSD) is a contagious viral disease of cattle. This experiment aimed to study the influence of lumpy skin disease virus (LSDV) infection and farm size on hematological, biochemical parameters and cytokines in 55 beef cattle. The groups included LSDV–infected cattle from large farms (Group 1), LSDV–infected cattle from small farms (Group 2), uninfected cattle from large farms (Group 3), and uninfected cattle from small farms (Group 4). The hematological, biochemical values and cytokine profiles were measured. The results showed that red blood cells, hemoglobin, platelets, white blood cells, neutrophils, and lymphocytes were higher in infected cattle than in the uninfected cattle. The level of eosinophils of the cattle from the large farm was higher than that of the small farm. Gamma glutamyl transferase in the infected cattle was higher than in the uninfected cattle. Albumin of the cattle from the small farm was higher than that from the large farm. IFN–γ in infected cattle was higher than in uninfected cattle, while TNF–α in the infected cattle was lower than in the uninfected cattle. Our study indicated that LSDV infection altered hematological and biochemical parameters, including cytokine profiles, with farm size potentially influencing these alterations.

Thanapol Nongbua

Piyarat Srinontong

Pummarin Tippramuan

Worapol Aengwanich

Dilok Ounpomma

Zhiliang Wu

Acta veterinaria

Hematological, Biochemical and Cytokine Profiles in Cattle: Effects of Lumpy Skin Disease Virus Infection and Farm Size

牛的血液学、生化和细胞因子特征：牛结节性皮肤病病毒感染和农场规模的影响

Abstract Dogs act as definitive hosts for several diseases caused by protozoa, some of which are zoonotic. Due to their close contact with humans and other animals, they play a crucial role in the transmission of these diseases. Although infection with Neospora caninum or Leishmania infantum is not a determining factor for another, co-infection with these protozoa can aggravate clinical signs and increase the mortality rate. Though, there are reports of success in the treatment of neosporosis, the prognosis is generally considered unfavorable, especially in young dogs. The objective of this study is to report a case of infection by both protozoa in a dog treated at a university veterinary hospital, highlighting the clinical remission of nervous signs of neosporosis after treatment with the combination of sulfadoxine and clindamycin, followed by reduction of clinical signs of canine leishmaniasis (CanL) with treatment with miltefosine and allopurinol. Despite the worse prognosis for co-infection with N. caninum and L. infantum , the dog presented remission of neurological signs and a reduction in parasite load and clinicopathological signs associated with CanL.

Bianca Ribas Sena

Maria Sabrina de Freitas

Maria Natália de Freitas

Arleana do Bom Parto Ferreira de Almeida

Valéria Régia Franco Sousa

Neosporosis and Visceral Leishmaniosis in a Dog in Central–West Brazil

巴西中西部地区一例犬新孢子虫病和内脏利什曼病的病例报告

Abstract In veterinary medicine, 1% Cyclopentolate hydrochloride (CP) has emerged as an intermediate-term cycloplegic and mydriatic agent. This study evaluated the pupillary dilation time and systemic effects related to the use of 1% CP eye drops in cats. Fifteen cats, aged 1 to 6 years and weighing 2.5 to 7 kg, were included in the study. After receiving written consent from the owners, each cat was administered two drops of 1% Cyclopentolate, 10 minutes apart, into both eyes. Data on pupil dilation, systemic symptoms, and behavioral changes were collected and analyzed using frequency and descriptive statistics. Pupillary dilation was observed 30 minutes after administering the second drop of 1% CP. The duration of pupillary dilation was 36 hours for 26.6% of the eyes, 48 hours for 53.4%, and 60 hours for 20%. Within the first hour after medication administration, seven cats exhibited episodes of salivation and vomiting, and four displayed behavioral changes, including aggressiveness and increased vocalization. Results suggest that 1% CP eye drops cause mydriasis for at least 36 hours and can lead to temporary adverse effects on the gastrointestinal and nervous systems.

Camila P. B. da Silveira

Dunia Y. T. Piso

Alexandre A. F. Barros Sobrinho

Roberta M. Crivelaro

Thais G. M. Abreu

Marcella R. Filezio

Marcela Aldrovani

José L. Laus

Systemic Effects Related to the Use of 1% Cyclopentolate Hydrochloride Eye Drops in Refractometry in Cats

猫眼用1%盐酸环喷托酯滴眼液在屈光测量中的全身效应

Abstract Reactive oxygen and nitrogen species (RONS) play a crucial role in the pathogenesis of various chronic diseases, including cancer, by reacting with fundamental biomolecules. While conventional anticancer treatments such as ionizing radiation and chemotherapy have significant adverse effects, some medicinal plants exhibit free radical scavenging and anticancer activities. Spilanthes acmella L., commonly known as the toothache plant, is reported to have various bioactive compounds with antioxidant and anticancer properties. The aim of this study was to investigate and evaluate antiproliferative potential of Spilanthes acmella ethanolic extract on human cervix adenocarcinoma (HeLa) and human myelogenous leukemia (K562) cancer cell lines. The stock solution of Spilanthes acmella extract was prepared in ethanol at concentration of 1 mg/mL and diluted with complete nutrient medium RPMI-1640. The medium was supplemented with 3 mM l-glutamine, 100 μg/mL streptomycin, 100 IU/mL penicillin, 10% heat-inactivated fetal bovine serum (FBS), and 25 mM Hepes, adjusted to pH 7.2. Cell survival was determined by the MTT assay 72 hours post-treatment. The IC 50 values were calculated using a dose-response growth curve. The S. acmella ethanolic extract demonstrated significant cytotoxic (antiproliferative) effects on both HeLa and K562 cancer cell lines. The extract exhibited higher cytotoxicity towards K562 cells, with an IC 50 value of 29.1 µg/mL, compared to HeLa cells, which had an IC 50 value of 48.8 µg/mL. Spilanthes acmella extract possesses considerable potential as an anticancer agent and warrants further in vivo investigations to confirm its efficacy.

Zoran Tambur

Irina Besu Žižak

Željko Žižak

Anica Joksić

Dolores Opačić

Vladimir Biočanin

Antiproliferative Effect of <i>Spilanthes Acmella</i> Extracts on Human Cervix Adenocarcinoma and Human Myelogenous Leukemia Cells

刺苋提取物对人宫颈腺癌和人类髓性白血病细胞的抗增殖作用

Abstract The osteogenic process is a complex and dynamic biological phenomenon essential for the initial formation of bones during embryonic development and the continuous remodeling and repair of bones throughout an individual’s life. It involves coordination of various cell types, signaling pathways, and environmental factors to ensure proper bone formation and maintenance. The main role in this process belongs to bone marrow cells and peripheral blood cells. This paper provides an overview of currently available literature data about different contributions of bone marrow cells and peripheral blood cells to the osteogenic process. Focusing on their differentiation, signaling pathways, and interactions within the bone microenvironment this article aims to provide a comprehensive understanding of how these cells orchestrate the osteogenic process, offering insights into their therapeutic potential. Understanding these complex cellular interactions is crucial for the development of advanced therapeutic approaches in regenerative medicine and orthopedics, which will ultimately improve outcomes in patients with bone defects and bone-related disorders.

Marija Đ. Vukelić-Nikolić

Ljubiša B. Đorđević

The Role of Bone Marrow Cells and Peripheral Blood Cells in the Osteogenic Process

骨髓细胞和外周血细胞在成骨过程中的作用

Abbreviation	ACTA VET-BEOGRAD
Journal Impact	0.63
Quartiles(Global)	VETERINARY SCIENCES(Q3)

ISSN	0567-8315, 1820-7448
h-index	22

Publication Information	Publisher: Walter de Gruyter GmbH，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1996，Proportion of original research papers: 97.50%，Self Citation Rate:14.30%， Gold OA Rate: 99.17%
Average review cycle	网友分享经验：较慢,18-36周
Average recruitment ratio	网友分享经验：容易

Acta Veterinaria

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Hematological, Biochemical and Cytokine Profiles in Cattle: Effects of Lumpy Skin Disease Virus Infection and Farm Size

Neosporosis and Visceral Leishmaniosis in a Dog in Central–West Brazil

Systemic Effects Related to the Use of 1% Cyclopentolate Hydrochloride Eye Drops in Refractometry in Cats

Antiproliferative Effect of Spilanthes Acmella Extracts on Human Cervix Adenocarcinoma and Human Myelogenous Leukemia Cells

The Role of Bone Marrow Cells and Peripheral Blood Cells in the Osteogenic Process

Hematological, Biochemical and Cytokine Profiles in Cattle: Effects of Lumpy Skin Disease Virus Infection and Farm Size

Neosporosis and Visceral Leishmaniosis in a Dog in Central–West Brazil

Systemic Effects Related to the Use of 1% Cyclopentolate Hydrochloride Eye Drops in Refractometry in Cats

Antiproliferative Effect of Spilanthes Acmella Extracts on Human Cervix Adenocarcinoma and Human Myelogenous Leukemia Cells

The Role of Bone Marrow Cells and Peripheral Blood Cells in the Osteogenic Process