关于期刊酒精和酒精中毒发表关于酒精中毒和酒精研究的生物医学、心理学和社会学方面的论文，前提是它们对该领域的知识做出了新的重大贡献。论文包括实验获得的新结果、新实验的描述（包括临床）对酒精研究和治疗领域具有重要意义的方法，或对现有结果的新解释。理论贡献与处理实验工作的论文同等考虑，前提是此类理论贡献不具有很大程度上的推测或哲学性质。

The journal "Alcohol and Alcoholism" publishes papers in the fields of biomedical, psychological, and sociological aspects of alcohol abuse and research, provided that they make significant new contributions to the knowledge in this area. The papers include new experimental results, descriptions of new experiments (including clinical studies), and methods that are of significant importance to the field of alcohol research and treatment, or new interpretations of existing results. Theoretical contributions are given equal consideration to empirical work, as long as such theoretical contributions are not overly speculative or philosophical in nature.

《Alcohol and Alcoholism》期刊发表关于酒精中毒及其研究的生物医学、心理学和社会学方面的论文，前提是这些论文对该领域的知识做出了新的重要贡献。论文内容包括实验获得的新结果、新实验的描述（包括临床研究），以及对酒精研究和治疗领域具有重要意义的方法，或对现有结果的新解释。理论贡献与实验研究的论文同等受到重视，前提是这些理论贡献不具有高度的推测性或哲学性质。

Alcohol and Alcoholism

Aims and Methods: Alcoholism may cause a range of diseases including avascular necrosis of the hip joint (AVN), cirrhosis of the liver, pancreatitis and oesophageal carcinoma. Chinese alcoholic patients diagnosed with AVN have a higher incidence of cirrhosis than of acute pancreatitis or oesophageal cancer. Thus, the aim of this study was to investigate genetic differences in polymorphisms of the alcohol-metabolizing enzymes ADH2, ADH3, ALDH2 and P4502E1 for subgroups of Chinese alcoholic patients, defined by diagnoses of AVN (n = 51), acute pancreatitis (n = 92) and liver cirrhosis (n = 159), and for 280 non-alcoholic patients. Results: Analysis revealed that ADH2*1 allele frequency was significantly lower for the alcoholic AVN than for the cirrhosis subgroup. However, no significant difference was found between the alcoholic AVN and pancreatitis subgroups. Furthermore, ALDH2*2 prevalence was not found to differ significantly between the alcoholic subgroups. When compared with our previously published data for alcoholic patients with oesophageal carcinoma, ADH2*1 carriage was significantly less frequent for the alcoholic AVN patients in the current study. Further, ALDH2*2 carriage was significantly less frequent for the alcoholic AVN subgroup than for the oesophageal carcinoma patients. Conclusions: The allele frequencies for ADH2*1 and ALDH2*2 are different when comparing subpopulations of alcoholics defined by presence of specific alcohol-induced diseases, suggesting that genetic variation in alcohol-metabolizing enzyme genes accounts for, at least in part, the specific types of organ damage observed. We also found the combination of AVN and cirrhosis to be more prevalent than that of AVN and acute pancreatitis. In contrast, the ADH2 and ALDH2 allele frequencies for the AVN subgroup were more similar to those of the acute-pancreatitis than to the cirrhosis subgroup. These data indicate the possibility that other genetic variations may also influence the type of organ-specific complications in Chinese alcoholics.

Y.-C. Chao

S.-J. Wang

H.-C. Chu

W.-K. Chang

T.-Y. Hsieh

INVESTIGATION OF ALCOHOL METABOLIZING ENZYME GENES IN CHINESE ALCOHOLICS WITH AVASCULAR NECROSIS OF HIP JOINT, PANCREATITIS AND CIRRHOSIS OF THE LIVER

中国酒精性股骨头坏死、胰腺炎及肝硬化患者酒精代谢酶基因的调查研究

Aims: To systematically review the literature on the Chinese translations of the Alcohol Use Disorders Identification Test (AUDIT) and their cross-cultural applicability in Chinese language populations. Methods: We identified peer-reviewed articles published in English (n = 10) and in Chinese (n = 11) from 1980 to September 2009, with key words China, Chinese and AUDIT among PubMed, EBSCO, PsycInfo, FirstSearch electronic databases and two Chinese databases. Results: Five teams from Beijing, Tibet, Taiwan and Hong Kong reported their region-specific translation procedures, cultural adaptations, validity (0.93–0.95 in two versions) and reliability (0.63–0.99). These Chinese translations and short versions demonstrated relatively high sensitivity (0.880–0.997) and moderate specificity (0.709–0.934) for hazardous/harmful drinking and alcohol dependence, but low specificity for alcohol dependence among Min-Nan Taiwanese (0.58). The AUDIT and its adaptations were most utilized in workplace- and hospital-settings for screening and brief intervention. However, they were under-utilized in population-based surveys, primary care settings, and among women, adolescents, rural-to-urban migrants, the elderly and minorities. Among 12 studies from mainland China, four included both women and men, and only one in Tibet was published in English. Conclusion: There is a growing amount of psychometric, epidemiologic and treatment research using Chinese translations of the AUDIT, much of it still unavailable in the English-language literature. Given the increase in burden of disease and injury attributable to alcohol use in the Western Pacific region, the use of an internationally comparable instrument (such as the AUDIT) in research with Chinese populations presents a unique opportunity to expand clinical and epidemiologic knowledge about alcohol problem epidemics.

Q. Li

T. F. Babor

W. Hao

X. Chen

The Chinese Translations of Alcohol Use Disorders Identification Test (AUDIT) in China: A Systematic Review

中国酒精使用障碍筛查量表（AUDIT）中文翻译的系统综述

Abstract Aims Brain-derived neurotrophic factor (BDNF) levels may be associated with alcohol use disorders (AUD) and alcohol consumption, correlate with sleep disturbance and be influenced by sex differences and sex hormones. These associations have not been examined in a single sample accounting for all these factors. Methods Data from 190 participants (29.4% female) with AUD were utilized. Sleep quality, craving intensity, depression, anxiety and alcohol consumption were assessed using the Pittsburgh Sleep Quality Index (PSQI), Penn Alcohol Craving Scale (PACS), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7) and Timeline Follow Back for 90 days(TLFB 90). Inventory of Drug Taking Situations (IDTS) assessed the tendency to drink in positive/negative emotional states. Serum BDNF (sBDNF) and plasma sex hormones (estrogen, progesterone, testosterone, FSH and SHBG) were measured. Pearson correlation analyses were used to examine the association between sBDNF and these measures in the entire sample and in men and women separately. Higher order interaction effects between these factors were evaluated for their association with sBDNF using a backward selection model. Results No significant correlations between sBDNF levels and sex hormones, PSQI, PHQ-9, PACS, IDTS scores and alcohol consumption were found (all P-values &amp;gt; 0.05). sBDNF levels were negatively correlated with GAD-7 scores in men (r = −0.1841; P = 0.03). When considering all quadratic and two-way interactions among PSQI, PHQ-9, GAD-7, mean and max drinks/day, number of drinking days, heavy drinking days, and sex no higher order moderating effects of sBDNF levels were found. Conclusion Our study revealed no significant associations between sBDNF and alcohol measures, sleep, depression and sex hormones suggesting limited utility as a biomarker.

Bhanu Prakash Kolla

Stacey J Winham

Ada Man-Choi Ho

Meghna P Mansukhani

Larissa L Loukianova

Vanessa Pazdernik

Victor M Karpyak

The Interaction Between Brain-Derived Neurotrophic Factor Levels and Alcohol Consumption, Sleep Disturbance and Sex-Hormones in Alcohol Use Disorders

脑源性神经营养因子水平与酒精使用障碍中的酒精摄入、睡眠障碍和性激素的相互作用

A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.

H. WOELK

S. LEHRL

R. BITSCH

W. KOPCKE

BENFOTIAMINE IN TREATMENT OF ALCOHOLIC POLYNEUROPATHY: AN 8-WEEK RANDOMIZED CONTROLLED STUDY (BAP I STUDY)

贝福替尼治疗酒精性多发性神经病变：一项为期8周的随机对照研究（BAP I研究）

Abstract Aims The aim of the present study was to assess the relationship between adolescent IQ and midlife alcohol use and to explore possible mediators of this relationship. Methods Study data were from 6300 men and women who participated in the Wisconsin Longitudinal Study of high-school students graduating in 1957. IQ scores were collected during the participants’ junior year of high school. In 2004, participants reported the number of alcoholic beverages consumed (past 30 days) and the number of binge-drinking episodes. A multinomial logistic regression was conducted to determine the relationship between adolescent IQ and future drinking pattern (abstainer, moderate drinker, or heavy drinker), and Poisson regression was used to examine the number of binge-drinking episodes. Two mediators—income and education—were also explored. Results Every one-point increase in IQ score was associated with a 1.6% increase in the likelihood of reporting moderate or heavy drinking as compared to abstinence. Those with higher IQ scores also had significantly fewer binge-drinking episodes. Household income, but not education, partially mediated the relationship between IQ and drinking pattern. Conclusions The present study suggests that higher adolescent IQ may predict a higher likelihood of moderate or heavy drinking in midlife, but fewer binge-drinking episodes. The study also suggests that this relationship is mediated by other psychosocial factors, specifically income, prompting future exploration of mediators in subsequent studies.

Natalie Druffner

Donald Egan

Swetha Ramamurthy

Justin O’Brien

Allyson Folsom Davis

Jasmine Jack

Diona Symester

Kelston Thomas

Jayme M Palka

Vishal J Thakkar

Edson Sherwood Brown

IQ in high school as a predictor of midlife alcohol drinking patterns

高中智商作为中年饮酒模式预测因素

Abstract Aims Structured clinical interviewing is considered the gold standard in psychiatric diagnosis. The Diagnostic Assessment Research Tool (DART) is a novel modularized, non-copywritten, semi-structured interview; however, no studies have examined the psychometric properties of its alcohol use disorder (AUD) module. The primary aims of this study were to: (i) validate the factor structure of the DART AUD module and (ii) examine measurement invariance across several key demographic and subgroup factors. Methods Participants were community members in Hamilton, Canada and Boston, USA who self-identified as making a significant AUD recovery attempt (N = 499). Internal reliability was examined via the Kuder–Richardson 20 statistic, and correlations between symptom count and drinking quantity/frequency were examined. Then, symptom-level data were included in a confirmatory factor analysis to examine model fit of a single hypothesized factor structure. Finally, measurement invariance analyses were conducted for sex, age, ethnicity (White vs. racialized), and study site. Results This study found evidence for adequate internal reliability (rKR20 = 0.75), and symptom scores correlated with drinking quantity and frequency (r = 0.16–0.43). Confirmatory factor analysis results suggested excellent fit for the unidimensional one-factor AUD model (χ2 = 0.09, confirmatory factor index = 0.99, Tucker Lewis index = 0.99, standardized root mean square residual = 0.06, root mean square error of approximation = 0.02). Measurement invariance analyses revealed that the factor structure was equivalent between sex, age, ethnicity, and study site. Conclusions Findings provide strong evidence for the psychometric validity of the DART AUD module and support its use in research and clinical practice. The DART represents a credible alternative to other diagnostic interviewing tools for AUD.

Molly L Garber

Kyla Belisario

Emily E Levitt

Randi E McCabe

John Kelly

James MacKillop

Psychometric validation of the <i>Diagnostic Assessment Research Tool</i>: Alcohol use disorder module

《诊断评估研究工具》的心理测量学验证：酒精使用障碍模块

Abstract Aims The study investigated relationships between how youth and young adults access alcohol and their binge drinking behaviors. Methods Data from the Rhode Island Student Survey (11- to 18-year-olds) and the Mobile Screen Time project (18- to 24-year-old) were included. Participants were asked whether they access alcohol through several different methods (e.g. gifts, purchase, theft), and a latent class analysis was conducted to identify patterns of behavior. Logistic regression models were used to determine if class assignment was associated with binge drinking, after adjusting for age, sexual/gender status, and identification as a Black, Indigenous, and other Person of Color. Results Among youth, participants who primarily accessed alcohol through friends had 6 times the odds of binge drinking (OR[95%CI] = 6.22 [4.08,9.49]), and those who accessed alcohol through all available sources had 23 times the odds (OR[95%CI] = 23.1 [9.08,58.6]). In young adults, participants who actively purchased alcohol had 3.7 times the odds of binge drinking (OR [95%CI] = 3.69 [1.62,8.37]). Conclusions Distinct means of accessing alcohol in youth and young adult populations can be identified, and different methods of access may be associated with increased binge drinking. Strong availability and ID checking policies are needed for on- and off-premise locations, and the implementation of parent-centered programs should be considered.

Jonathan K Noel

Steve Jacob

Samantha K Borden

Kelsey A Gately

Samantha R Rosenthal

Method of accessing alcohol and binge drinking status in youth and young adults

青少年和年轻成年人饮酒及酗酒状况的评估方法

This study assessed the association between exposure to alcohol adverts on social media and alcohol use among university students in Uganda since alcohol consumption has severe effects, especially in countries with weak regulations for alcohol marketing.

Edwinah Atusingwize

Maria Nilsson

Annika Egan Sjölander

Nazarius Mbona Tumwesigye

David Musoke

Evelina Landstedt

Exploring links—exposure to alcohol adverts on social media in relation to alcohol use among university students in Uganda

探索关联——乌干达大学生社交媒体酒精广告接触与饮酒行为的关系

The COVID-19 pandemic increased alcohol consumption in the USA as a result of widespread individual changes in drinking patterns. Few studies have utilized longitudinal data allowing the prediction of increased or decreased drinking from COVID-19 economic, social, and health impacts.

William C Kerr

Yu Ye

Priscilla Martinez

Katherine J Karriker-Jaffe

Deidre Patterson

Thomas K Greenfield

Nina Mulia

Changes in US drinking and alcohol use disorders associated with social, health, and economic impacts of COVID-19

COVID-19社会、健康和经济影响下的美国饮酒及酒精使用障碍变化

Abstract In an analytical sample of 462 UK-based trans and non-binary respondents to a co-produced survey, 23.2% reported drinking with a higher risk of dependence (AUDIT scores ≥16), and 26.2% reported that they mostly drank at home alone. Pre-drinking and drinking mostly at home alone were associated with high-risk drinking and may be appropriate behaviours to address in harm reduction interventions.

Dean J Connolly

Ivan Ezquerra-Romano

Stewart O’Callaghan

Jacob Bayliss

Beth Thayne

Zhi Holloway

Emma Davies

Pre-drinking is Associated with Possible Alcohol Dependence in UK Trans and Non-Binary Communities

预饮酒与英国跨性别和非二元性别群体可能的酒精依赖相关

Abbreviation	Alcohol. Alcohol.
Journal Impact	2.03
Quartiles(Global)	SUBSTANCE ABUSE(Q3)

ISSN	0735-0414, 1464-3502
h-index	109

Publication Information	Publisher: Oxford University Press，Publishing cycle: Bimonthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1965，Proportion of original research papers: 84.38%，Self Citation Rate:4.80%， Gold OA Rate: 22.34%
Average review cycle	网友分享经验：偏慢,4-8周
Average recruitment ratio	网友分享经验：较易

Alcohol and Alcoholism

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