研飞ivySCI (青藤学术）

Toxicology in Vitro

短名	Toxicol. In. Vitro.
Journal Impact	2.42
国际分区	TOXICOLOGY(Q3)
期刊索引	SCI Q2中科院 3 区

ISSN	0887-2333, 1879-3177
h-index	125
国内分区	医学(3区)医学毒理学(3区)

TOXICOLOGY IN VITRO 发表关于体外系统应用和使用评估或预测化学品毒性作用并阐明其作用机制的原创研究论文和评论。这些体外技术包括利用细胞或组织培养物、分离的细胞、组织切片、亚细胞部分、转基因细胞培养物和来自转基因生物的细胞，以及计算机建模。该杂志将重点关注涉及新体外方法的开发和验证的调查，例如用于基于传统和计算机模拟的毒性效应预测；关于高通量毒理学和药理学方法的使用；阐明毒性作用机制；基因组学、转录组学和蛋白质组学在毒理学中的应用，以及用于表征体外和体内发现之间关系的比较研究。该杂志强烈鼓励提交侧重于体外方法开发、实际应用和监管用途的手稿（例如，在食品成分化妆品、药物、杀虫剂和工业化学品领域）。 TOXICOLOGY IN VITRO 不鼓励那些记录有关未经化学表征的材料（例如植物提取物或草药）的毒理学影响的论文。

期刊主页投稿网址

涉及主题	化学生物生物化学遗传学医学内科学有机化学体外物理细胞生物学内分泌学细胞培养核磁共振药理学基因酶细胞凋亡免疫学毒性细胞分子生物学
出版信息	出版商: Elsevier Ltd，出版周期: Bimonthly，期刊类型: journal
基本数据	创刊年份: 1987，原创研究文献占比: 98.27%，自引率:0.00%， Gold OA占比: 25.95%
平均审稿周期	网友分享经验：平均2.0个月来源Elsevier官网：平均10.9周
平均录用比例	网友分享经验：约50%

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Impact of high (1950 MHz) and extremely low (50 Hz) frequency electromagnetic fields on DNA damage caused by occupationally relevant exposures in human derived cell lines

2024-10-1

The recovery from taxane mediated apoptosis in PC-3 castration-resistant metastatic prostate cancer cells

2024-10-1

Integrated transcriptomic and metabolomic analysis reveals the underlying mechanisms for male reproductive toxicity of polystyrene nanoplastics in mouse spermatocyte-derived GC-2spd(ts) cells

2024-10-1

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

2024-10-1

Editorial Board

2024-10-1

Engineering of gelatin scaffold by extracellular matrix of Sertoli cells for embryonic stem cell proliferation

2024-10-1

Streptococcus mitis enhances metal-induced apoptosis in reconstructed human gingiva but not skin

2024-10-1

Estrogen receptor/androgen receptor transcriptional activation of benzophenone derivatives and integrated approaches to testing and assessment (IATA) for estrogenic effects

2024-10-1

In vitro impacts of polystyrene microplastics and environmental pollutants on ethoxyresorufin-O-deethylase and glutathione S-transferase activity in Mossambica tilapia

2024-10-1

Metabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

2024-9-1

Applying cell painting in non-tumorigenic breast cells to understand impacts of common chemical exposures

2024-9-1

Chlorpyrifos-oxon induced neuronal cell death via endoplasmic reticulum stress-triggered apoptosis pathways

2024-9-1

Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes

2024-9-1

Can TK-TD modelling bridge the gap between in vitro and in vivo mammalian toxicity data?

2024-9-1

In vitro modelling of Parkinson's disease using 6-OHDA is associated with increased NQO2 activity

2024-9-1

The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines

2024-9-1

Reliability and relevance of the ES®-RHE model for in vitro skin irritation test application

2024-9-1

Corrigendum to “Novel Diphenyl urea derivative serves as an inhibitor on human lung cancer cell migration by disrupting EMT via Wnt/β-catenin and PI3K/Akt signaling” [Toxicology in Vitro 69 (2020) 105000]

2024-9-1

Effects of polystyrene micro- and nanoplastics on androgen- and estrogen receptor activity and steroidogenesis in vitro

2024-9-1

Alteration in folate carrier expression via histone deacetylase inhibition in BeWo human placental choriocarcinoma cells

2024-9-1

Unveiling the anticancer potential of Pestalotioprolide E, an unexplored macrolide: Targeting TRXR1-TRX1-ASK1-P38 signaling cascade in triple-negative breast cancer

2024-8-22

Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells

2024-8-12

Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death

2024-8-1

Pristimerin exhibits anti-cancer activity by inducing ER stress and AKT/GSK3β pathway through increasing intracellular ROS production in human esophageal cancer cells

2024-8-1

Lack of cytotoxic and genotoxic effects of mPEG-silane coated iron(III) oxide nanoparticles doped with magnesium despite cellular uptake in cancerous and noncancerous lung cells

2024-8-1

Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes

2024-8-1

Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy

2024-8-1

Editorial Board

2024-8-1

Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor

2024-8-1

Ex vivo skin diffusion and decontamination studies of titanium dioxide nanoparticles

2024-8-1

Assessment of silver nanoparticles' antitumor effects: Insights into cell number, viability, and morphology of glioblastoma and prostate cancer cells

2024-8-1

Cytochrome P450-mediated metabolic interactions between donepezil and tadalafil in human liver microsomes

2024-8-1

Assessment of ursolic acid effect on in vitro model of cardiac fibrosis

2024-8-1

Antifungal climbazole alters androgenic pathways in mammalian cells

2024-8-1

Cannabidiol protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide25–35

2024-8-1

Exploring the combined impact of cisplatin and copper-cysteamine nanoparticles through Chemoradiation: An in-vitro study

2024-8-1

Influence of alkylthio and arylthio derivatives of tert-butylquinone on the induction of DNA damage in a human hepatocellular carcinoma cell line (HepG2)

2024-8-1

Selected phytocannabinoids inhibit SN-38- and cytokine-evoked increases in epithelial permeability and improve intestinal barrier function in vitro

2024-8-1

Amantadine mitigates the cytotoxic and genotoxic effects of doxorubicin in SH-SY5Y cells and reduces its mutagenicity

2024-8-1

Nirmatrelvir has detrimental effects on sperm function by altering the PI3K/PDK1/AKT signaling pathway

2024-8-1

Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine

2024-8-1

The microRNA miR-152 can mitigate and prevent the toxic effect of benzene on porcine ovarian cells

2024-8-1

Schisandrin B protect inner hair cells from cisplatin by inhibiting celluar oxidative stress and apoptosis

2024-8-1

Fangchinoline inhibits mouse oocyte meiosis by disturbing MPF activity

2024-8-1

1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies

2024-8-1

Three dimensional reconstruction of skin with melanoma: A model for study of invasion in vitro

2024-8-1

Evaluating the combined and individual cytotoxic effect of beauvericin, enniatin B and ochratoxin a on breast cancer cells, leukemia cells, and fresh peripheral blood mononuclear cells

2024-8-1

Effect of long-term inorganic arsenic exposure on erythropoietin production in vitro

2024-8-1

CircPDSS1 (hsa_circ_0017998) silencing induces ferroptosis in non-small-cell lung cancer cells by modulating the miR-137/SLC7A11/GPX4/GCLC axis

2024-8-1

Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells

2024-8-1

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Toxicology in Vitro

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最新文章

Impact of high (1950 MHz) and extremely low (50 Hz) frequency electromagnetic fields on DNA damage caused by occupationally relevant exposures in human derived cell lines

The recovery from taxane mediated apoptosis in PC-3 castration-resistant metastatic prostate cancer cells

Integrated transcriptomic and metabolomic analysis reveals the underlying mechanisms for male reproductive toxicity of polystyrene nanoplastics in mouse spermatocyte-derived GC-2spd(ts) cells

Knowledge infrastructure for integrated data management and analysis supporting new approach methods in predictive toxicology and risk assessment

Editorial Board

Engineering of gelatin scaffold by extracellular matrix of Sertoli cells for embryonic stem cell proliferation

Streptococcus mitis enhances metal-induced apoptosis in reconstructed human gingiva but not skin

Estrogen receptor/androgen receptor transcriptional activation of benzophenone derivatives and integrated approaches to testing and assessment (IATA) for estrogenic effects

In vitro impacts of polystyrene microplastics and environmental pollutants on ethoxyresorufin-O-deethylase and glutathione S-transferase activity in Mossambica tilapia

Metabolite of esculetin plays an important role in cytotoxic effects induced by chloroquine on porcine immature Sertoli cells

Applying cell painting in non-tumorigenic breast cells to understand impacts of common chemical exposures

Chlorpyrifos-oxon induced neuronal cell death via endoplasmic reticulum stress-triggered apoptosis pathways

Risperidone-induced bioenergetic disruption in the isolated human peripheral blood monocytes

Can TK-TD modelling bridge the gap between in vitro and in vivo mammalian toxicity data?

In vitro modelling of Parkinson's disease using 6-OHDA is associated with increased NQO2 activity

The role of efflux transporters in cytotoxicity and intracellular concentration of chlorpyrifos and chlorpyrifos oxon in human cell lines

Reliability and relevance of the ES®-RHE model for in vitro skin irritation test application

Corrigendum to “Novel Diphenyl urea derivative serves as an inhibitor on human lung cancer cell migration by disrupting EMT via Wnt/β-catenin and PI3K/Akt signaling” [Toxicology in Vitro 69 (2020) 105000]

Effects of polystyrene micro- and nanoplastics on androgen- and estrogen receptor activity and steroidogenesis in vitro

Alteration in folate carrier expression via histone deacetylase inhibition in BeWo human placental choriocarcinoma cells

Unveiling the anticancer potential of Pestalotioprolide E, an unexplored macrolide: Targeting TRXR1-TRX1-ASK1-P38 signaling cascade in triple-negative breast cancer

Photodynamic therapy with curcumin and near-infrared radiation as an antitumor strategy to glioblastoma cells

Construction of an in vitro simulated one compartment extravascular administration model and its comparison with classic in vitro administration model in copper chloride induced HepG2 cell death

Pristimerin exhibits anti-cancer activity by inducing ER stress and AKT/GSK3β pathway through increasing intracellular ROS production in human esophageal cancer cells

Lack of cytotoxic and genotoxic effects of mPEG-silane coated iron(III) oxide nanoparticles doped with magnesium despite cellular uptake in cancerous and noncancerous lung cells

Bisphenol a accelerates the glucolipotoxicity-induced dysfunction of rat insulinoma cell lines: An implication for a potential risk of environmental bisphenol a exposure for individuals susceptible to type 2 diabetes

Transcription Factor yin-Yang 1 augments nucleoporin 93 oncogene activity and modulates bladder Cancer malignancy

Editorial Board

Silencing Nrf2 in cisplatin resistant non-small cell lung cancer cells augments sensitivity towards EGFR inhibitor

Ex vivo skin diffusion and decontamination studies of titanium dioxide nanoparticles

Assessment of silver nanoparticles' antitumor effects: Insights into cell number, viability, and morphology of glioblastoma and prostate cancer cells

Cytochrome P450-mediated metabolic interactions between donepezil and tadalafil in human liver microsomes

Assessment of ursolic acid effect on in vitro model of cardiac fibrosis

Antifungal climbazole alters androgenic pathways in mammalian cells

Cannabidiol protects mouse hippocampal neurons from neurotoxicity induced by amyloid β-peptide25–35

Exploring the combined impact of cisplatin and copper-cysteamine nanoparticles through Chemoradiation: An in-vitro study

Influence of alkylthio and arylthio derivatives of tert-butylquinone on the induction of DNA damage in a human hepatocellular carcinoma cell line (HepG2)

Selected phytocannabinoids inhibit SN-38- and cytokine-evoked increases in epithelial permeability and improve intestinal barrier function in vitro

Amantadine mitigates the cytotoxic and genotoxic effects of doxorubicin in SH-SY5Y cells and reduces its mutagenicity

Nirmatrelvir has detrimental effects on sperm function by altering the PI3K/PDK1/AKT signaling pathway

Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine

The microRNA miR-152 can mitigate and prevent the toxic effect of benzene on porcine ovarian cells

Schisandrin B protect inner hair cells from cisplatin by inhibiting celluar oxidative stress and apoptosis

Fangchinoline inhibits mouse oocyte meiosis by disturbing MPF activity

1H NMR spectroscopic characterisation of HepG2 cells as a model metabolic system for toxicology studies

Three dimensional reconstruction of skin with melanoma: A model for study of invasion in vitro

Evaluating the combined and individual cytotoxic effect of beauvericin, enniatin B and ochratoxin a on breast cancer cells, leukemia cells, and fresh peripheral blood mononuclear cells

Effect of long-term inorganic arsenic exposure on erythropoietin production in vitro

CircPDSS1 (hsa_circ_0017998) silencing induces ferroptosis in non-small-cell lung cancer cells by modulating the miR-137/SLC7A11/GPX4/GCLC axis

Selective inhibition of HDAC6 by N-acylhydrazone derivative reduces the proliferation and induces senescence in carcinoma hepatocellular cells

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