《美国高血压杂志》是一份经过同行评审的月刊，为对高血压和相关心血管疾病领域的最高标准进行科学探究提供了一个论坛。该杂志发表关于基础科学、分子生物学、临床和实验性高血压、心脏病学、流行病学、小儿高血压、内分泌学、神经生理学和肾病学的高质量原创研究和评论文章。

The American Journal of Hypertension is a peer-reviewed monthly journal that provides a high-standard forum for scientific exploration in the field of hypertension and related cardiovascular diseases. The journal publishes high-quality original research and review articles on basic science, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.

《美国高血压杂志》是一份经过同行评审的月刊，旨在为高血压及相关心血管疾病领域的科学研究提供一个高标准的论坛。该杂志发表关于基础科学、分子生物学、临床和实验性高血压、心脏病学、流行病学、小儿高血压、内分泌学、神经生理学和肾病学等领域的高质量原创研究和评论文章。

American Journal of Hypertension

Measurement of the arterial blood pressure (BP) is a time-honored, vital piece of medical information whose accuracy is seldom questioned. This review identifies the unappreciated weakness of the early validation data that compared the cuff to intra-arterial BP's. Unfortunately, the inaccuracy of the auscultatory systolic (SBP) and diastolic (DBP) measurements are necessarily transmitted to the arithmetically calculated mean (MBP) and pulse pressures (PP). The errors in cuff SBP have limited recent efforts to measure central SBP noninvasively because of the need for cuff pressure calibration of the recorded peripheral pulses. Furthermore, cuff DBP's routinely overestimate intra-arterial values adding to the error in the calculation of central PP—a recognized cardiovascular risk predictor. Validation data for the newer automatic oscillometric SBP and DBP measurements are little better. Oscillometric devices, however, offer some improvement in their recognition of the MBP, a measurement made independently of the SBP and DBP. The algorithms used to identify the SBP and DBP by the oscillometric device manufacturers are proprietary and differ from one another. Thus, the accuracy of the commercial devices cannot be compared or standardized. A data base listing those devices that have been "validated" against the inaccurate auscultatory method is available, but many commercial devices are not listed. In addition to the SBP and DBP, there is increasing interest in the information contained within the arterial and aortic pulses. Values such as pulse augmentation and amplification ratios are independent of calibration requirements and add risk assessment information beyond that of the BP itself. American Journal of Hypertension, advance online publication 24 February 2011; doi:10.1038/ajh.2011.22

H. Smulyan

M. E. Safar

Blood Pressure Measurement: Retrospective and Prospective Views

血压测量：回顾与展望

The effect of sodium intake on population health remains controversial. The objective was to investigate the incidence of all-cause mortality (ACM) and cardiovascular disease events (CVDEs) in populations exposed to dietary intakes of low sodium (<115 mmol), usual sodium (low usual sodium: 115–165 mmol; high usual sodium: 166–215 mmol), and high sodium (>215 mmol). The relationship between individual measures of dietary sodium intake vs. outcome in cohort studies and randomized controlled trials (RCTs) measured as hazard ratios (HRs) were integrated in meta-analyses. No RCTs in healthy population samples were identified. Data from 23 cohort studies and 2 follow-up studies of RCTs (n = 274,683) showed that the risks of ACM and CVDEs were decreased in usual sodium vs. low sodium intake (ACM: HR = 0.91, 95% confidence interval (CI) = 0.82–0.99; CVDEs: HR = 0.90, 95% CI = 0.82–0.99) and increased in high sodium vs. usual sodium intake (ACM: HR = 1.16, 95% CI = 1.03–1.30; CVDEs: HR = 1.12, 95% CI = 1.02–1.24). In population representative samples adjusted for multiple confounders, the HR for ACM was consistently decreased in usual sodium vs. low sodium intake (HR = 0.86; 95% CI = 0.81–0.92), but not increased in high sodium vs. usual sodium intake (HR = 1.04; 95% CI = 0.91–1.18). Within the usual sodium intake range, the number of events was stable (high usual sodium vs. low usual sodium: HR = 0.98; 95% CI = 0.92–1.03). Both low sodium intakes and high sodium intakes are associated with increased mortality, consistent with a U-shaped association between sodium intake and health outcomes.

Niels Graudal

Gesche Jürgens

Bo Baslund

Michael H. Alderman

Compared With Usual Sodium Intake, Low- and Excessive-Sodium Diets Are Associated With Increased Mortality: A Meta-Analysis

与常规钠摄入相比，低钠和高钠饮食与死亡率增加相关：一项Meta分析

Evidence for the benefits of regular exercise is irrefutable and increasing physical activity levels should be a major goal at all levels of health care. People with hypertension are less physically active than those without hypertension and there is strong evidence supporting the blood pressure–lowering ability of regular exercise, especially in hypertensive individuals. This narrative review discusses evidence relating to exercise and cardiovascular (CV) risk in people with hypertension. Comparisons between aerobic, dynamic resistance, and static resistance exercise have been made along with the merit of different exercise volumes. High-intensity interval training and isometric resistance training appear to have strong CV protective effects, but with limited data in hypertensive people, more work is needed in this area. Screening recommendations, exercise prescriptions, and special considerations are provided as a guide to decrease CV risk among hypertensive people who exercise or wish to begin. It is recommended that hypertensive individuals should aim to perform moderate intensity aerobic exercise activity for at least 30 minutes on most (preferably all) days of the week in addition to resistance exercises on 2–3 days/week. Professionals with expertise in exercise prescription may provide additional benefit to patients with high CV risk or in whom more intense exercise training is planned. Despite lay and media perceptions, CV events associated with exercise are rare and the benefits of regular exercise far outweigh the risks. In summary, current evidence supports the assertion of exercise being a cornerstone therapy in reducing CV risk and in the prevention, treatment, and control of hypertension.

J. E. Sharman

A. La Gerche

J. S. Coombes

Exercise and Cardiovascular Risk in Patients With Hypertension

高血压患者运动与心血管风险

The association of elevated serum uric acid with the development of hypertension is established outside of pregnancy. We investigated whether first trimester uric acid was associated with the development of the following: gestational hypertension or pre-eclampsia, these outcomes stratified by presence of hyperuricemia at delivery since this denotes more severe disease,preterm birth, or small for gestational age (SGA). Uric acid was measured in 1,541 banked maternal plasma samples from a prior prospective cohort study that were collected at a mean gestational age of 9.0 (± 2.5) weeks. Polytomous regressions were performed and adjusted for parity and prepregnancy body mass index (BMI). First trimester uric acid in the highest quartile (>3.56 mg/dl) compared to lowest three quartiles was associated with an increased risk of developing pre-eclampsia (adjusted odds ratio (OR) = 1.82; 95% confidence interval (CI), 1.03–3.21) but not gestational hypertension. In women with hypertensive disease complicated by hyperuricemia at delivery, high first trimester uric acid was associated with a 3.22–fold increased risk of hyperuricemic gestational hypertension (HU) and a 3.65–fold increased risk of hyperuricemic pre-eclampsia (HPU). High first trimester uric acid was not associated with gestational hypertension or pre-eclampsia without hyperuricemia (H or HP) at delivery, preterm birth, or SGA. In women who developed hypertensive disease, elevated uric acid at delivery was only partly explained by elevated uric acid in the first trimester (r2 = 0.23). First trimester elevated uric acid was associated with later preeclampsia and more strongly with pre-eclampsia and gestational hypertension with hyperuricemia. American Journal of Hypertension advance online publication 20 January 2011; doi:10.1038/ajh.2010.262

S. K. Laughon

J. Catov

R. W. Powers

J. M. Roberts

R. E. Gandley

First Trimester Uric Acid and Adverse Pregnancy Outcomes

孕早期尿酸与不良妊娠结局

Arterial hypertension is a significant risk factor for cardiovascular (CV) morbidity and mortality. Although central blood pressure (BP) evaluation is considered the gold standard, the reliability of non-invasive measurements remains unclear. Therefore, we compared the predictive value of invasively measured central BP with non-invasively measured brachial BP and analyzed pulse pressure (PP) amplification (delta-PP; difference between central and peripheral PP) as an independent predictor of mortality.

Clara Daschner

Marcus E Kleber

Niklas Ayasse

Ksenija Stach

Gökhan Yücel

Faeq Husain-Syed

Alexander Niessner

Bernd Krüger

Winfried März

Bernhard K Krämer

Babak Yazdani

Central vs. Brachial Blood Pressure and Pulse Pressure Amplification for Mortality Risk Prediction in Patients Undergoing Coronary Angiography

中心与外周血压及脉压放大对接受冠状动脉造影患者死亡风险预测的比较

Abstract Background Clinical inertia is common when blood pressure (BP) is high in the office. Little is known about the extent of clinical inertia after ambulatory BP monitoring (ABPM). Methods This was an electronic health record-based retrospective cohort study of patients with high office BP (≥140/90 mmHg) referred for ABPM at a medical center in New York City between 2016 and 2020. Diagnostic inertia was defined as clinicians not newly diagnosing or treating hypertension in patients with high ABPM (i.e., mean awake BP ≥135/85 mmHg). Therapeutic inertia was defined as clinicians not intensifying treatment for patients with established hypertension after high ABPM. Multilevel modeling was used to assess patient and clinician characteristics associated with inertia. Results Among 329 patients without prior hypertension, 144 (44%) had high awake BP, and of these, diagnostic inertia occurred in 45 of 144 (31%). Among 239 patients taking antihypertensive medication, 141 (59%) had high awake BP, and of these, therapeutic inertia occurred in 73 of 141 (52%). In multilevel models, male gender (OR 2.81, 95%CI 1.11 – 7.08), lower awake SBP (OR 0.73 per 5 mmHg increase, 95%CI 0.53 – 1.00), and specialist vs primary care clinician type (OR 4.57, 95%CI 1.78 – 11.75) were associated with increased diagnostic inertia. Increasing age (OR 1.16 per 5-year increase, 95%CI 1.00 – 1.28) and lower awake SBP (OR 0.82 per 5 mmHg increase, 95%CI 0.66 – 0.95) were associated with increased therapeutic inertia. Conclusions Diagnostic and therapeutic inertia were common after ABPM, particularly when awake SBP was near the threshold.

J S Flatow

R Byfield

J Singer

M J Chang

J E Schwartz

D Shimbo

I M Kronish

Clinical Inertia in the Diagnosis and Management of Hypertension Following Ambulatory Blood Pressure Monitoring

动态血压监测后高血压诊断和管理中的临床惰性

Abstract BACKGROUND Systolic blood pressure (BP) is a key factor in the outcomes of patients with acute ischemic stroke (AIS) receiving endovascular thrombectomy (EVT). However, the factors that mediate the association between BP and clinical outcome are unclear. METHODS Consecutive patients with AIS in the anterior circulation underwent continuous blood pressure monitoring for 24 hours. The 3-month modified Rankin scale (mRS) score was defined as the clinical functional outcome. The systolic BPI indices (BPIs) were successive variation (SV), standard deviation (SD), variability independent of mean blood pressure (VIM) and 24-hour mean BP. Regression analysis was used to assess the correlation between different BPIs and functional outcome, whereas mediation analysis was employed to assess the potential mediating effects of baseline risk factors through BP on functional outcome. RESULTS A total of 140 of 292 patients (47.9%) achieved functional independence, and 87 (29.8%) experienced hemorrhagic transformation (HT). A history of stroke or hypertension and NIHSS score at onset were associated with SD and VIM (P&amp;lt;0.05). BP variation (BPV) was still strongly associated with functional outcome after adjustment for different risk factors. Mediation analysis revealed that stroke affected functional outcome by affecting BPV, while the hypertension history affected functional prognosis by impacting the 24-hour mean BP and BPV. In addition, higher NIHSS scores were associated with increased BPV, whereas increased BPV was correlated with a greater proportion of unfavorable outcome. CONCLUSIONS To our knowledge, this study is the first to explore the mediating effects of different BPIs on the relationships between risk factors and functional outcome and may provide new insights and potential mechanisms for improving AIS prognosis.

Dingkang Xu

Peng Qi

Qiang He

Dezhi Shan

Guozheng Yang

Hongchun Yang

Peng Liu

Hui Liang

Shixiong Lei

Fuyou Guo

Daming Wang

Jun Lu

Systolic blood pressure modifies the effect of endovascular thrombectomy in acute ischemic stroke: a mediation analysis

收缩压对急性缺血性卒中血管内取栓治疗效果的影响：一项中介分析

Cuffless blood pressure (BP) devices are an emerging technology marketed as providing frequent, non-intrusive and reliable BP measurements. With the increasing interest in these devices, it is important for Hypertension Canada to provide a statement regarding the current place of cuffless BP measurements in hypertension management.

Céderick Landry

Lisa Dubrofsky

Sachin V Pasricha

Jennifer Ringrose

Marcel Ruzicka

Karen C Tran

Ross T Tsuyuki

Swapnil Hiremath

Rémi Goupil

Hypertension Canada Statement on the use of cuffless blood pressure monitoring devices in clinical practice

加拿大高血压声明：临床实践中无袖带血压监测设备的使用

Blood pressure (BP) is routinely measured and recorded at healthcare visits, but high BP (HBP) measurements are not always discussed in clinical notes. Our objective was to identify patient- and visit-level factors associated with discussion of HBP measurements in clinical notes, among patients without prior diagnosis of hypertension.

Cole G Chapman

Philip M Polgreen

Manish Suneja

Barry L Carter

Linnea A Polgreen

Factors associated with discussing high blood pressure readings in clinical notes

临床记录中讨论高血压读数相关因素

Abbreviation	Am. J. Hypertens.
Journal Impact	3.17
Quartiles(Global)	PERIPHERAL VASCULAR DISEASE(Q2)

ISSN	0895-7061, 1941-7225
h-index	150

Publication Information	Publisher: Oxford University Press，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1988，Proportion of original research papers: 82.42%，Self Citation Rate:3.10%， Gold OA Rate: 21.22%
Average review cycle	网友分享经验：一般,3-8周
Average recruitment ratio	网友分享经验：较易

American Journal of Hypertension

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Blood Pressure Measurement: Retrospective and Prospective Views

Compared With Usual Sodium Intake, Low- and Excessive-Sodium Diets Are Associated With Increased Mortality: A Meta-Analysis

Exercise and Cardiovascular Risk in Patients With Hypertension

First Trimester Uric Acid and Adverse Pregnancy Outcomes

Central vs. Brachial Blood Pressure and Pulse Pressure Amplification for Mortality Risk Prediction in Patients Undergoing Coronary Angiography

Clinical Inertia in the Diagnosis and Management of Hypertension Following Ambulatory Blood Pressure Monitoring

Systolic blood pressure modifies the effect of endovascular thrombectomy in acute ischemic stroke: a mediation analysis

Central vs. Brachial Blood Pressure and Pulse Pressure Amplification for Mortality Risk Prediction in Patients Undergoing Coronary Angiography

Hypertension Canada Statement on the use of cuffless blood pressure monitoring devices in clinical practice

Factors associated with discussing high blood pressure readings in clinical notes