ACTA NEUROPSYCHIATRICA 是一本专注于转化神经精神病学的国际期刊。它发表高质量的原创研究论文和评论。该杂志的范围特别突出了从发现到临床应用、医疗保健和全球健康的途径，可以广泛地视为标志着从发现到全球健康的途径的工作范围。

Acta Neuropsychiatrica is an international journal focused on translational neuropsychiatry, dedicated to publishing high-quality original research articles and reviews. The scope of the journal particularly emphasizes the pathways from discovery to clinical application, healthcare, and global health, broadly encompassing the work that marks the journey from discovery to global health.

《Acta Neuropsychiatrica》是一本专注于转化神经精神病学的国际期刊，致力于发表高质量的原创研究论文和评论。该期刊的范围特别强调从基础研究到临床应用、医疗保健及全球健康的各个方面，广泛涵盖了从发现到全球健康的研究工作。

Acta Neuropsychiatrica

Many patients under treatment for mood disorders, in particular patients with bipolar mood disorders, experience episodes of mood switching from one state to another. Various hypotheses have been proposed to explain the mechanism of mood switching, spontaneously or induced by drug treatment. Animal models have also been used to test the role of psychotropic drugs in the switching of mood states. We examine the possible relationship between the pharmacology of psychotropic drugs and their reported incidents of induced mood switching, with reference to the various hypotheses of mechanisms of mood switching.

Siu Wa Tang

Wayne H. Tang

Brian E. Leonard

Acta Neuropsychiatr.

Treatment-induced mood switching in affective disorders

情感障碍中的治疗诱导情绪转换

Abstract Objective: Findings from animal studies indicate that the early gut bacteriome is a potential mechanism linking maternal prenatal stress with health trajectories in offspring. However, clinical studies are scarce and the associations of maternal psychological profiles with the early infant faecal bacteriome are unknown. This study aimed to investigate the associations of prenatal stressors and distress with early infant faecal bacterial profiles in a South African birth cohort study. Methods: Associations between prenatal symptoms of depression, distress, intimate partner violence (IPV) and posttraumatic stress disorder (PTSD) and faecal bacterial profiles were evaluated in meconium and subsequent stool specimens from 84 mothers and 101 infants at birth, and longitudinally from a subset of 69 and 36 infants at 4–12 and 20–28 weeks of age, respectively, in a South African birth cohort study. Results: Infants born to mothers that were exposed to high levels of IPV had significantly higher proportions of Citrobacter and three unclassified genera, all of which belonging to the family Enterobacteriaceae detected at birth. Proportions of these Enterobacteriaceae remained significantly increased over time (birth to 20–28 weeks of life) in infants born to mothers with high levels of IPV exposure compared to infants from mothers with no/low IPV exposure. Infants born to mothers exposed to IPV also had higher proportions of the genus Weissella at 4–12 weeks compared to infants from mothers with no/low IPV exposure. Faecal specimens from mothers exposed to IPV had higher proportions of the family Lactobacillaceae and lower proportions of Peptostreptococcaceae at birth. Maternal psychological distress was associated with decreased proportions of the family Veillonellaceae in infants at 20–28 weeks and a slower decline in Gammaproteobacteria over time. No changes in beta diversity were apparent for maternal or infant faecal bacterial profiles in relation to any of the prenatal measures for psychological adversities. Conclusion: Maternal lifetime IPV and antenatal psychological distress are associated with altered bacterial profiles in infant and maternal faecal bacteria. These findings may provide insights in the involvement of the gut bacteria linking maternal psychological adversity and the maturing infant brain.

Petrus J.W. Naudé

Shantelle Claassen-Weitz

Sugnet Gardner-Lubbe

Gerrit Botha

Mamadou Kaba

Heather J. Zar

Mark P. Nicol

Dan J. Stein

Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile

母亲产前心理压力和困扰与母婴早期粪便细菌谱的关联

Abstract Objective: Psychotic disorders are characterized by abnormalities in the synchronization of neuronal responses. A 40 Hz gamma band deficit during auditory steady-state response (ASSR) measured by electroencephalogram (EEG) is a robust observation in psychosis and is associated with symptoms and functional deficits. However, the majority of ASSR studies focus on specific electrode sites, while whole scalp analysis using all channels, and the association with clinical symptoms, are rare. Methods: In this study, we use whole-scalp 40 Hz ASSR EEG measurements—power and phase locking factor—to establish deficits in early-stage psychosis (ESP) subjects, classify ESP status using an ensemble of machine learning techniques, identify correlates with principal components obtained from clinical/demographic/functioning variables, and correlate functional outcome after a short-term follow-up. Results: We identified significant spatially-distributed group level differences for power and phase locking. The performance of different machine learning techniques and interpretation of the extracted feature importance indicate that phase locking has a more predictive and parsimonious pattern than power. Phase locking is also associated with principal components composed of measures of cognitive processes. Short-term functional outcome is associated with baseline 40 Hz ASSR signals from the FCz and other channels in both phase locking and power. Conclusion: This whole scalp EEG study provides additional evidence to link deficits in 40 Hz ASSRs with cognition and functioning in ESP, and corroborates with prior studies of phase locking from a subset of EEG channels. Confirming 40 Hz ASSR deficits serves as a candidate phenotype to identify circuit dysfunctions and a biomarker for clinical outcomes in psychosis.

Kristina M. Holton

Amy Higgins

Austin J. Brockmeier

Mei-Hua Hall

Uncovering Key Predictive Channels and Clinical Variables in the Gamma Band Auditory Steady-State Response in Early Stage Psychosis – a Longitudinal Study

揭示早期精神病中伽马频段听觉稳态反应的关键预测通道和临床变量——一项纵向研究

Abstract Objectives: Cognitive function plays a pivotal role in assessing an individual’s quality of life. This research aimed to investigate how azelaic acid (AzA), a natural dicarboxylic acid with antioxidant and anti-inflammatory properties, affects aluminium chloride (AlCl 3 )-induced behavioural changes and biochemical alterations in the hippocampus of rats. Methods: Thirty-two male Wistar rats divided into four groups received distilled water, AzA 50 mg/kg, AlCl 3 100 mg/kg and AzA plus AlCl 3 , respectively, by oral gavage for 6 weeks. Behavioural changes were evaluated using open-field maze, elevated plus maze, novel object recognition (NOR), passive avoidance task, and Morris water maze (MWM) tests. Also, malondialdehyde (MDA), carbonyl protein, tumour necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), nuclear factor-kappa B (NF-κB), C/EBP homologous protein (CHOP), glycogen synthase kinase-3 beta (GSK-3β), brain-derived neurotrophic factor (BDNF) and acetylcholinesterase (AChE) activity were examined. Results: AzA significantly affected AlCl 3 -provoked anxiety-like behaviours and learning and memory impairments. It also reduced the toxic effect of AlCl 3 on MDA, carbonyl protein, TNF-α, IL-1β, NF-κB and GSK-3β status; however, its beneficial effects on AlCl 3 -induced changes of CHOP, BDNF and AChE activity were not significant. Conclusion: These findings disclosed that AzA could improve behavioural and cognitive function and almost limit the oxidative stress and neuroinflammation caused by AlCl 3 .

Saba Vasegh

Hakimeh Saadati

Ali Abedi

Sara Mostafalou

The effect of azelaic acid on AlCl<sub>3</sub>-induced neurocognitive impairments and molecular changes in the hippocampus of rats

壬二酸对氯化铝诱导的大鼠海马神经认知障碍及分子变化的影响

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Rodrigo Grassi-Oliveira

Exploring the intersection of metabolic and neuropsychiatric health

探索代谢与神经精神健康的交叉领域

Abstract Objective: Combining different pharmaceuticals may be beneficial when treating disorders with complex neurobiology, including alcohol use disorder (AUD). The gut-brain peptides amylin and GLP-1 may be of potential interest as they individually reduce alcohol intake in rodents. While the combination of amylin receptor (AMYR) and glucagon-like peptide-1 receptor (GLP-1R) agonists have been found to decrease feeding and body weight in obese male rats synergistically, their combined impact on alcohol intake is unknown. Methods: Therefore, the effect of the combination of an AMYR (salmon calcitonin (sCT)) and a GLP-1R (dulaglutide) agonist on alcohol intake in rats of both sexes was explored in two separate alcohol-drinking experiments. The first alcohol-drinking experiment evaluated the potential of adding sCT to an ongoing dulaglutide treatment, whereas the second alcohol-drinking experiment examined the effect when adding sCT and dulaglutide simultaneously. Results: When adding sCT to an ongoing dulaglutide treatment, a reduction in alcohol intake was observed in both male and female rats. However, when combining sCT and dulaglutide simultaneously, an initial reduction in alcohol intake was observed in rats of both sexes, whereas tolerance towards treatment was observed. In both alcohol-drinking experiments, this treatment combination consistently decreased food consumption and body weight in males and females. While the treatment combination did not affect inflammatory mediators, the gene expression of AMYR or GLP-1R, it changed fat tissue morphology. Conclusions: Further investigation needs to be done on the combination of AMYR and GLP-1R agonists to assess their combined effects on alcohol intake.

Cajsa Aranäs

Christian E. Edvardsson

Lindsay Zentveld

Daniel Vallöf

Sarah Witley

Maximilian Tufvesson-Alm

Olesya T. Shevchouk

Jesper Vestlund

Elisabet Jerlhag

The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats

胰高血糖素样肽-1和胰淀素受体激动剂联合使用可减少雄性和雌性大鼠的酒精摄入

Abstract Objectives: Clozapine is an atypical antipsychotic crucial for treatment-resistant schizophrenia, characterised by its multi-receptor targeting, including serotonin (5-HT2A, 5-HT2C) and dopamine (D1, D2, D3, D4) receptors, among others. This broad mechanism is effective against positive symptoms of schizophrenia with a lower incidence of extrapyramidal side effects. However, clozapine poses significant haematological risks, notably agranulocytosis, necessitating stringent blood monitoring protocols. Methods: This study examined haematological parameters in 157 patients on clozapine therapy, analysing the prevalence and clinical correlations of haematological abnormalities such as leucocytosis, thrombocytosis, and alterations in red blood cell distribution width (RDW) and mean platelet volume (MPV). Results: The findings revealed leucocytosis in 36.9% of patients, thrombocytosis in 8.9%, and elevated RDW in 23.6%. Notably, higher clozapine doses were associated with leucocytosis, though no significant correlations were found between clozapine dose, duration of use, and changes in RDW, mean corpuscular haemoglobin concentration, or MPV. Conclusion: The study’s results underscore the necessity of regular haematological monitoring to mitigate the risks of clozapine therapy while leveraging its therapeutic benefits. Additionally, the study suggests personalised dosing strategies to balance efficacy and safety, particularly in managing clozapine-induced haematological changes.

Muhammed Fatih Tabara

Cafer Baris Akar

Mehmet Kadir Atdagi

Mehmet Gurkan Gurok

Murad Atmaca

Significant haematological alterations in clozapine-treated patients: prevalence and clinical correlation

氯氮平治疗患者中显著的血常规改变：患病率与临床相关性

Abbreviation	Acta Neuropsychiatr.
Journal Impact	2.65
Quartiles(Global)	PSYCHIATRY(Q2)

ISSN	0924-2708, 1601-5215
h-index	42

Publication Information	Publisher: Cambridge University Press，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2006，Proportion of original research papers: 80.49%，Self Citation Rate:3.80%， Gold OA Rate: 37.86%

Acta Neuropsychiatrica

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Treatment-induced mood switching in affective disorders

Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile

Uncovering Key Predictive Channels and Clinical Variables in the Gamma Band Auditory Steady-State Response in Early Stage Psychosis – a Longitudinal Study

The effect of azelaic acid on AlCl₃-induced neurocognitive impairments and molecular changes in the hippocampus of rats

Exploring the intersection of metabolic and neuropsychiatric health

The effect of azelaic acid on AlCl₃-induced neurocognitive impairments and molecular changes in the hippocampus of rats

Uncovering Key Predictive Channels and Clinical Variables in the Gamma Band Auditory Steady-State Response in Early Stage Psychosis – a Longitudinal Study

The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats

Exploring the intersection of metabolic and neuropsychiatric health

Significant haematological alterations in clozapine-treated patients: prevalence and clinical correlation

Acta Neuropsychiatrica

Journal Citation Format

A journal article with 1 author

A journal article with 2 authors

A journal article with 3 authors

A journal article with 5 or more authors

Books Citation Format

Thesis Citation Format

Web sites Citation Format

Patent Citation Format

Staying up late manually editing references? ivySCI automatically matches journals and helps you generate references with a single click.

Share Submission Experience

Treatment-induced mood switching in affective disorders

Association of maternal prenatal psychological stressors and distress with maternal and early infant faecal bacterial profile

Uncovering Key Predictive Channels and Clinical Variables in the Gamma Band Auditory Steady-State Response in Early Stage Psychosis – a Longitudinal Study

The effect of azelaic acid on AlCl3-induced neurocognitive impairments and molecular changes in the hippocampus of rats

Exploring the intersection of metabolic and neuropsychiatric health

The effect of azelaic acid on AlCl3-induced neurocognitive impairments and molecular changes in the hippocampus of rats

Uncovering Key Predictive Channels and Clinical Variables in the Gamma Band Auditory Steady-State Response in Early Stage Psychosis – a Longitudinal Study

The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats

Exploring the intersection of metabolic and neuropsychiatric health

Significant haematological alterations in clozapine-treated patients: prevalence and clinical correlation

The effect of azelaic acid on AlCl₃-induced neurocognitive impairments and molecular changes in the hippocampus of rats

The effect of azelaic acid on AlCl₃-induced neurocognitive impairments and molecular changes in the hippocampus of rats