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Biochimica et Biophysica Acta - Molecular Basis of Disease

短名
Journal Impact	4.20
国际分区	BIOPHYSICS(Q1)
期刊索引	SCI Q1中科院 2 区

ISSN	0925-4439, 1879-260X
h-index	182
国内分区	生物学(2区)生物学生化与分子生物学(2区)生物学生物物理(2区)

BBA Molecular Basis of Disease addresses the biochemistry and molecular genetics of disease processes and models of human disease. This journal covers aspects of aging, cancer, metabolic-, neurological-, and immunological-based disease. Manuscripts focused on using animal models to elucidate biochemical and mechanistic insight in each of these conditions, are particularly encouraged. Manuscripts should emphasize the underlying mechanisms of disease pathways and provide novel contributions to the understanding and/or treatment of these disorders. Highly descriptive and method development submissions may be declined without full review. The submission of uninvited reviews to BBA - Molecular Basis of Disease is strongly discouraged, and any such uninvited review should be accompanied by a coverletter outlining the compelling reasons why the review should be considered.

期刊主页投稿网址

涉及主题	生物化学生物化学医学遗传学内科学内分泌学基因细胞生物学病理有机化学物理核磁共振酶免疫学心理学受体
出版信息	出版商: Elsevier B.V.，出版周期: Monthly，期刊类型: journal
基本数据	创刊年份: 1990，原创研究文献占比: 92.55%，自引率:0.00%， Gold OA占比: 63.73%
平均审稿周期	网友分享经验：一般,3-6周来源Elsevier官网：平均8.8周
平均录用比例	网友分享经验：较难

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LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis

2024-12-1

Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury

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Nicotinamide riboside kinase 2: A unique target for skeletal muscle and cardiometabolic diseases

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Multiple myeloma exosomal miRNAs suppress cGAS-STING antiviral immunity

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Impaired IL-27 signaling aggravates macrophage senescence and sensitizes premature ovarian insufficiency induction by high-fat diet

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SLFN11 and ATR as targets for overcoming cisplatin resistance in ovarian cancer cells

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Additional statin treatment enhances the efficacy of HER2 blockade and improves prognosis in Rac1-high/HER2-positive breast cancer

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Probiotic therapy modulates the brain-gut-liver microbiota axis in a mouse model of traumatic brain injury

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Nanomolecular machines: Pioneering precision medicine for neoplastic diseases through advanced diagnosis and treatment

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TRPV4-β-catenin axis is a novel therapeutic target for dry skin-induced chronic itch

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A human microglial cell model of autosomal recessive spastic ataxia of Charlevoix-Saguenay

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PiRNA CFAPIR inhibits cardiac fibrosis by regulating the muscleblind-like protein MBNL2

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Mechanism of multifunctional adaptor protein SHARPIN regulating myocardial fibrosis and how SNP mutation affect the prognosis of myocardial infarction

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Npc1 deficiency impairs microglia function via TREM2-mTOR signaling in Niemann-Pick disease type C

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Regulation of host metabolism and defense strategies to survive neonatal infection

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Therapeutic modulation of APP-CD74 axis can activate phagocytosis of TAMs in GBM

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Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives

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25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain barrier breakdown in vitro

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Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro

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Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms

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Follicular CD8+ T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model

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Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor

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Inhibition of DDR1 promotes ferroptosis and overcomes gefitinib resistance in non-small cell lung cancer

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Pen2/ErbB4 signaling regulates stemness of pancreatic ductal carcinoma

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p85α deficiency alleviates ischemia-reperfusion injury by promoting cardiomyocyte survival

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Investigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster

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Mitigation of gestational diabetes-induced endothelial dysfunction through FGF21-NRF2 pathway activation involving L-Cystine

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Harnessing high-throughput OMICS in emerging zoonotic virus preparedness and response activities

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Host derived macrophage migration inhibitory factor expression attenuates anti-tumoral immune cell accumulation and promotes immunosuppression in the tumor microenvironment of head and neck squamous cell carcinoma

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UVB-induced TRPS1 regulates MITF transcription activity to promote skin pigmentation

2024-10-1

Parkin R274W mutation affects muscle and mitochondrial physiology

2024-10-1

IFN-γ-responsiveness of lymphatic endothelial cells inhibits melanoma lymphatic dissemination via AMPK-mediated metabolic control

2024-10-1

EREG silencing inhibits tumorigenesis via inactivating ERK/p38 MAPK pathway in pancreatic ductal adenocarcinoma

2024-10-1

The USP10/13 inhibitor, spautin-1, attenuates the progression of glioblastoma by independently regulating RAF-ERK mediated glycolysis and SKP2.

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Next generation sequencing identifies WNT signalling as a significant pathway in Autosomal Recessive Polycystic Kidney Disease (ARPKD) manifestation and may be linked to disease severity

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RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells

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FoxO1-modulated macrophage polarization regulates osteogenesis via PPAR-γ signaling

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Ethanol promotes protease activated receptor 1: Chemokine (C-X-C motif) receptor 4 heteromerization and enhances thrombin-induced impairment of human lung endothelial cell barrier function

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N6-methyladenosine dynamics in placental development and trophoblast functions, and its potential role in placental diseases

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Inhibition of neddylation disturbs zygotic genome activation through histone modification change and leads to early development arrest in mouse embryos

2024-10-1

Na+/H+-exchange inhibition by cariporide is compensated via Na+,HCO3−-cotransport and has no net growth consequences for ErbB2-driven breast carcinomas

2024-10-1

Combined cryoablation and PD-1 inhibitor synergistically enhance antitumor immune responses in Lewis lung adenocarcinoma mice via the PI3K/AKT/mTOR pathway

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Targeting of S-phase kinase associated protein 2 stabilized tumor suppressors leading to apoptotic cell death in squamous skin cancer cells

2024-10-1

Tumor necrosis factor α receptor 1A transduces the inhibitory effect on axon regeneration triggered by IgG anti-ganglioside GD1a antibodies

2024-10-1

Metformin instigates cellular autophagy to ameliorate high-fat diet-induced pancreatic inflammation and fibrosis/EMT in mice

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Ubiquitin ligase RFWD2 promotes dendritic spine and synapse formation by activating the ERK/PEA3/c-Jun pathway in rat cerebral cortical neurons

2024-10-1

Mammary adipocytes promote breast tumor cell invasion and angiogenesis in the context of menopause and obesity

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Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease

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Current status and prospect of the DNA double-strand break repair pathway in colorectal cancer development and treatment

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Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway

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Biochimica et Biophysica Acta - Molecular Basis of Disease

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最新文章

LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis

Electroacupuncture pretreatment maintains mitochondrial quality control via HO-1/MIC60 signaling pathway to alleviate endotoxin-induced acute lung injury

Nicotinamide riboside kinase 2: A unique target for skeletal muscle and cardiometabolic diseases

Multiple myeloma exosomal miRNAs suppress cGAS-STING antiviral immunity

Impaired IL-27 signaling aggravates macrophage senescence and sensitizes premature ovarian insufficiency induction by high-fat diet

SLFN11 and ATR as targets for overcoming cisplatin resistance in ovarian cancer cells

Additional statin treatment enhances the efficacy of HER2 blockade and improves prognosis in Rac1-high/HER2-positive breast cancer

Probiotic therapy modulates the brain-gut-liver microbiota axis in a mouse model of traumatic brain injury

Nanomolecular machines: Pioneering precision medicine for neoplastic diseases through advanced diagnosis and treatment

TRPV4-β-catenin axis is a novel therapeutic target for dry skin-induced chronic itch

A human microglial cell model of autosomal recessive spastic ataxia of Charlevoix-Saguenay

PiRNA CFAPIR inhibits cardiac fibrosis by regulating the muscleblind-like protein MBNL2

Mechanism of multifunctional adaptor protein SHARPIN regulating myocardial fibrosis and how SNP mutation affect the prognosis of myocardial infarction

Npc1 deficiency impairs microglia function via TREM2-mTOR signaling in Niemann-Pick disease type C

Regulation of host metabolism and defense strategies to survive neonatal infection

Therapeutic modulation of APP-CD74 axis can activate phagocytosis of TAMs in GBM

Aspartate in tumor microenvironment and beyond: Metabolic interactions and therapeutic perspectives

25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain barrier breakdown in vitro

Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro

Inhibition of Mettl3 ameliorates osteoblastic senescence by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent mechanisms

Follicular CD8+ T cells promote immunoglobulin production and demyelination in multiple sclerosis and a murine model

Harlequin mice exhibit cognitive impairment, severe loss of Purkinje cells and a compromised bioenergetic status due to the absence of Apoptosis Inducing Factor

Inhibition of DDR1 promotes ferroptosis and overcomes gefitinib resistance in non-small cell lung cancer

Pen2/ErbB4 signaling regulates stemness of pancreatic ductal carcinoma

p85α deficiency alleviates ischemia-reperfusion injury by promoting cardiomyocyte survival

Investigating SARS-CoV-2 virus-host interactions and mRNA expression: Insights using three models of D. melanogaster

Mitigation of gestational diabetes-induced endothelial dysfunction through FGF21-NRF2 pathway activation involving L-Cystine

Harnessing high-throughput OMICS in emerging zoonotic virus preparedness and response activities

Host derived macrophage migration inhibitory factor expression attenuates anti-tumoral immune cell accumulation and promotes immunosuppression in the tumor microenvironment of head and neck squamous cell carcinoma

UVB-induced TRPS1 regulates MITF transcription activity to promote skin pigmentation

Parkin R274W mutation affects muscle and mitochondrial physiology

IFN-γ-responsiveness of lymphatic endothelial cells inhibits melanoma lymphatic dissemination via AMPK-mediated metabolic control

EREG silencing inhibits tumorigenesis via inactivating ERK/p38 MAPK pathway in pancreatic ductal adenocarcinoma

The USP10/13 inhibitor, spautin-1, attenuates the progression of glioblastoma by independently regulating RAF-ERK mediated glycolysis and SKP2.

Next generation sequencing identifies WNT signalling as a significant pathway in Autosomal Recessive Polycystic Kidney Disease (ARPKD) manifestation and may be linked to disease severity

RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells

FoxO1-modulated macrophage polarization regulates osteogenesis via PPAR-γ signaling

Ethanol promotes protease activated receptor 1: Chemokine (C-X-C motif) receptor 4 heteromerization and enhances thrombin-induced impairment of human lung endothelial cell barrier function

N6-methyladenosine dynamics in placental development and trophoblast functions, and its potential role in placental diseases

Inhibition of neddylation disturbs zygotic genome activation through histone modification change and leads to early development arrest in mouse embryos

Na+/H+-exchange inhibition by cariporide is compensated via Na+,HCO3−-cotransport and has no net growth consequences for ErbB2-driven breast carcinomas

Combined cryoablation and PD-1 inhibitor synergistically enhance antitumor immune responses in Lewis lung adenocarcinoma mice via the PI3K/AKT/mTOR pathway

Targeting of S-phase kinase associated protein 2 stabilized tumor suppressors leading to apoptotic cell death in squamous skin cancer cells

Tumor necrosis factor α receptor 1A transduces the inhibitory effect on axon regeneration triggered by IgG anti-ganglioside GD1a antibodies

Metformin instigates cellular autophagy to ameliorate high-fat diet-induced pancreatic inflammation and fibrosis/EMT in mice

Ubiquitin ligase RFWD2 promotes dendritic spine and synapse formation by activating the ERK/PEA3/c-Jun pathway in rat cerebral cortical neurons

Mammary adipocytes promote breast tumor cell invasion and angiogenesis in the context of menopause and obesity

Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease

Current status and prospect of the DNA double-strand break repair pathway in colorectal cancer development and treatment

Low-dose radiation promotes high-fat diet-induced atherosclerosis by activating cGAS signal pathway

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