Recent insights into the causes and consequences of chromosome mis-segregation

2024-9-15

Correction: GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway

2024-9-13

Correction: Upregulated c-myc expression in multiple myeloma by internal ribosome entry results from increased interactions with and expression of PTB-1 and YB-1

2024-9-13

Multifocal, multiphenotypic tumours arising from an MTOR mutation acquired in early embryogenesis

2024-9-13

AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer

2024-9-13

ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer

2024-9-11

USP33 facilitates the ovarian cancer progression via deubiquitinating and stabilizing CBX2

2024-9-10

Elevated choline drives KLF5-dominated transcriptional reprogramming to facilitate liver cancer progression

2024-9-9

GOLM1 dictates acquired Lenvatinib resistance by a GOLM1-CSN5 positive feedback loop upon EGFR signaling activation in hepatocellular carcinoma

2024-9-9

Correction: Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma

2024-9-9

ALDH1A3 is the switch that determines the balance of ALDH+ and CD24−CD44+ cancer stem cells, EMT-MET, and glucose metabolism in breast cancer

2024-9-9

Loss of DOCK2 potentiates Inflammatory Bowel Disease–associated colorectal cancer via immune dysfunction and IFNγ induction of IDO1 expression

2024-9-7

Editorial Expression of Concern: Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

2024-9-6

Editorial Expression of Concern: RAFTK/PYK2-dependent and -independent apoptosis in multiple myeloma cells

2024-9-5

PPM1D activity promotes cellular transformation by preventing senescence and cell death

2024-9-5

Sorafenib-mediated cleavage of p62 initiates cellular senescence as a mechanism to evade its anti-hepatocellular carcinoma efficacy

2024-9-4

Bioinformatics advances in eccDNA identification and analysis

2024-8-29

Editorial Expression of Concern: p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells

2024-8-29

Synergistic effects of combined BET and FAK inhibition against Vestibular Schwannomas in NF2-related Schwannomatosis

2024-8-29

m6A modification of lipoyltransferase 1 inhibits bladder cancer progression by activating cuproptosis

2024-8-28

S-p-bromobenzyl-glutathione cyclopentyl diester (BBGC) as novel therapeutic strategy to enhance trabectedin anti-tumor effect in soft tissue sarcoma preclinical models

2024-8-28

RBM12 drives PD-L1-mediated immune evasion in hepatocellular carcinoma by increasing JAK1 mRNA translation

2024-8-26

Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours

2024-8-23

Identification of a novel alternative splicing isoform of the Hippo kinase STK3/MST2 with impaired kinase and cell growth suppressing activities

2024-8-22

Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC

2024-8-22

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

2024-8-20

Alternative splicing of ALDOA confers tamoxifen resistance in breast cancer

2024-8-20

BRD4-specific PROTAC inhibits basal-like breast cancer partially through downregulating KLF5 expression

2024-8-20

Monoacylglycerol lipase blockades the senescence-associated secretory phenotype by interfering with NF-κB activation and promotes docetaxel efficacy in prostate cancer

2024-8-18

Jumonji histone demethylases are therapeutic targets in small cell lung cancer

2024-8-18

Ac4C modification of lncRNA SIMALR promotes nasopharyngeal carcinoma progression through activating eEF1A2 to facilitate ITGB4/ITGA6 translation

2024-8-18

Engineered targeting OIP5 sensitizes bladder cancer to chemotherapy resistance via TRIP12-PPP1CB-YBX1 axis

2024-8-18

MiR-183-5p inhibits lung squamous cell carcinoma survival through disrupting hypoxia adaptation mediated by HIF-1α/NDUFA4L2 axis

2024-8-17

Cooperative genomic lesions in HRAS-mutant cancers predict resistance to farnesyltransferase inhibitors

2024-8-16

scRNA‐seq reveals the landscape of immune repertoire of PBMNCs in iMCD

2024-8-15

PrPC controls epithelial-to-mesenchymal transition in EGFR-mutated NSCLC: implications for TKI resistance and patient follow-up

2024-8-15

Hypoxia-induced LAMB2-enriched extracellular vesicles promote peritoneal metastasis in gastric cancer via the ROCK1-CAV1-Rab11 axis

2024-8-13

Spatial proteomic profiling elucidates immune determinants of neoadjuvant chemo-immunotherapy in esophageal squamous cell carcinoma

2024-8-9

CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma

2024-8-7

EZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth

2024-8-7

A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling

2024-8-7

CCL2 mediated IKZF1 expression promotes M2 polarization of glioma-associated macrophages through CD84-SHP2 pathway

2024-8-7

RHNO1: at the crossroads of DNA replication stress, DNA repair, and cancer

2024-8-6

CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A

2024-8-4

GLI1 confers resistance to PARP inhibitors by activating the DNA damage repair pathway

2024-8-3

Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer

2024-8-2

NNMT switches the proangiogenic phenotype of cancer-associated fibroblasts via epigenetically regulating ETS2/VEGFA axis

2024-7-28

GATA2 promotes castration-resistant prostate cancer development by suppressing IFN-β axis-mediated antitumor immunity

2024-7-27

Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair

2024-7-27

Single-cell profiling reveals altered immune landscape and impaired NK cell function in gastric cancer liver metastasis

2024-7-26