Design, synthesis and biological evaluation of thieno[3,2-c]pyrazol-urea derivatives as potent glycogen synthase kinase 3β inhibitors based on the DFG-out conformation

2024-11-1

Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1

2024-10-1

Editorial Board

2024-10-1

Graphical abstract TOC

2024-10-1

Repurposing antiplasmodial leads for cancer: Exploring the antiproliferative effects of N-cinnamoyl-aminoacridines

2024-10-1

A chemical platform for the efficient screening of arylazopyrazole-based photoswitchable CENP-E inhibitors using mild cyclization reactions

2024-10-1

Editorial Board

2024-9-12

Contents continued

2024-9-12

Graphical abstract TOC

2024-9-12

Graphical abstract TOC

2024-9-12

Stability studies of β-Amino- and β-Hydroxy difluoromethyl ketones in rat serum and rat liver microsomes

2024-9-1

Rational design, synthesis and pharmacological characterization of novel aminopeptidase A inhibitors

2024-9-1

Identification of isoquinolinone DHODH inhibitor isosteres

2024-9-1

Design, synthesis and structure-activity relationship of malonic acid non-nucleoside derivatives as potent CD73 inhibitors

2024-9-1

Discovery and preclinical profile of YK-2168, a differentiated selective CDK9 inhibitor in clinical development

2024-9-1

Synthesis, biochemical screening and in-silico investigations of arylsulfonamides bearing linear and cyclic tails

2024-9-1

Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines

2024-9-1

Extended voltage imaging in cardiomyocytes with a triplet state quencher-stabilized silicon rhodamine

2024-9-1

Identification of coumarin – benzimidazole hybrids as potential antibacterial agents: Synthesis, in vitro and in vivo biological assessment, and ADMET prediction

2024-9-1

Discovery of benzimidazole-2-amide BNZ-111 as new tubulin inhibitor

2024-9-1

Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities

2024-9-1

Identification of highly potent and selective HTRA1 inhibitors

2024-9-1

Machine learning-based QSAR and LB-PaCS-MD guided design of SARS-CoV-2 main protease inhibitors

2024-9-1

Identification of N-(((1S,3R,5S)-adamantan-1-yl)methyl)-3-((4-chlorophenyl)sulfonyl)benzenesulfonamide as novel Nav1.8 inhibitor with analgesic profile

2024-9-1

Graphical abstract TOC

2024-9-1

Ophiobolin A derivatives with enhanced activities under tumor-relevant acidic conditions

2024-9-1

Polyfunctionalized organoselenides: New synthetic approach from seleno-containing cyanohydrins and anti-melanoma activity

2024-9-1

Identification of triazolyl KAT6 inhibitors via a templated fragment approach

2024-9-1

Invention of novel 3-aminopiperidin-2-ones as calcitonin gene-related peptide receptor antagonists

2024-9-1

Structure elucidation, absolute configuration, and biological evaluation of cyclic peroxides from the sponge Plakinastrella sp.

2024-9-1

Novel selective proline-based peptidomimetics for human cathepsin K inhibition

2024-9-1

Pyrazolines inhibiting the activity of the early growth response-1 DNA-binding domain

2024-9-1

Michael addition-activated alkylation of G-quadruplex DNA with methylamine-protected vinyl-quinazolinone derivatives

2024-9-1

The synthesis of solid supports carrying base labile linkers to generate 3′-phosphate oligonucleotides

2024-9-1

The recent discovery of a promising pharmacological scaffold derived from carvacrol: A review

2024-9-1

Design, synthesis, and evaluation of pyranochromene derivatives as membrane targeting antibacterials against Gram-positive bacteria

2024-9-1

Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment

2024-9-1

Discovery of a potent, orally available furopyridine derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor

2024-9-1

N-methylmorpholine incorporation into the structure of biphenyl leads to the bioactive inhibitor of PD-1/PD-L1 interaction

2024-9-1

Discovery of 5-phenyl-3-ureidothiophene-2-carboxamides as protective agents for ALS patient iPSC-derived motor neurons

2024-9-1

Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase

2024-9-1

Peg-lipid-modified agonistic antibody against tumor necrosis factor receptor family elicits superior apoptosis-inducing activity against human carcinoma

2024-9-1

Assessing the inhibitory effects of some secondary amines, thioureas and 1,3-dimethyluracil conjugates of (-)-cytisine and thermopsine on the RNA-dependent RNA polymerase of SARS-CoV-1 and SARS-CoV-2

2024-9-1

Detecting 2′-5′-adenosine linked nucleic acids via acylation of secondary hydroxy functionality

2024-9-1

Structure–activity relationship study of nitrogen signaling factors

2024-9-1

Contents continued

2024-9-1

Editorial Board

2024-9-1

Plakevulin a induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells

2024-9-1

Design, synthesis, and evaluation of novel oxyacanthine derivatives for anti-SARS-CoV-2 activity

2024-9-1

The isolation of sclerotinin A as an anti-malarial compound by utilization of a global secondary metabolism regulator, laeA gene

2024-9-1