INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE is a quarterly international journal publishing the finest peer-reviewed research in the field of Pharmaceutical Quality Assurance and Pharmaceutical Analysis on the basis of its originality, importance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. IJPQA also provides rapid, authoritative, insightful and arresting news and interpretation of topical and coming trends affecting science, scientists and the wider public.

The International Journal of Pharmaceutical Quality Assurance is a quarterly international journal that publishes high-quality peer-reviewed research in the fields of Pharmaceutical Quality Assurance and Pharmaceutical Analysis. The journal evaluates submissions based on originality, significance, disciplinary interest, timeliness, accessibility, elegance, and surprising conclusions. Additionally, it offers rapid, authoritative, insightful, and engaging news and interpretations of current and emerging trends affecting science, scientists, and the broader public.

《International Journal of Pharmaceutical Quality Assurance》是一本季度出版的国际期刊，专注于药品质量保证和药品分析领域的高质量同行评审研究。期刊的评审标准包括研究的原创性、重要性、学科兴趣、时效性、可及性、优雅性以及出人意料的结论。此外，《International Journal of Pharmaceutical Quality Assurance》还提供快速、权威、深刻且引人注目的新闻和对影响科学、科学家及更广泛公众的最新趋势的解读。

International Journal of Pharmaceutical Quality Assurance

This paper focuses on the cultivation of Pleurotus pulmonarius mushroom, to find the Preliminary phytochemical analysis from five different solvent extracts of P. pulmonarius. Mushrooms are white fungi that are recognized as a good food source and contain a variety of medicinal benefits. In terms of nutrition, mushrooms are better than a lot of veggies because it contain around 40 to 49% protein. The current study integrates phytochemical analysis with the production of P. pulmonarius mushroom. The mushroom grew on paddy straw, which had been used as a substrate. The Pleurotus mushroom accounts for 25% of the total edible mushroom production worldwide. Fresh mushroom fruit bodies were picked, dried, pulverized, and extracted using a soxhlet apparatus. The pH, humidity and temperature of the surroundings were maintained in between the mycelia growth. Preliminary phytochemical analysis of five different extracts from P. pulmonarius was tested using various solvents, such as alkaloids, flavonoids, terpenoids, tannins, steroids, glycosides, saponins, proteins, quinones, carbohydrates and phenols. Further research can be conducted to determine the bioactive substances from this particular mushroom.

Aswathy . S

Manjunathan . J

Phytochemical Profiling of Pleurotus Pulmonarius from Paddy Straw Substrate.

稻草基质中Pleurotus Pulmonarius的植物化学成分分析。

Molecular docking serves as a pivotal tool in comprehending drug-receptor interactions within modern-day drug design. In a previous report, new compounds 2-(4-allylpiperazin-1-yl)-1-(1-aryl-1H-tetrazol-5-yl) etalons were analyzed. Among these compounds, ‘2-(4-allylpiperazin-1-yl)-1-(1-(4-nitrophenyl)-1H-tetrazol-5-yl)ethanone’ was singled for molecular docking as it shows dual antibacterial and antifungal studies. Docking investigations revealed promising binding affinity of the compound towards Escherichia coli (1KZN), exhibiting significant antibacterial activity of docking grade -5.53 Kcal/mol, indicative of a fortified binding interaction. Conversely, the compound exhibited weaker binding affinity towards Candida albicans (1AI9) with a docking grade of -0.72 Kcal/mol. Negative binding energy signifies a robust alignment between the ligand and target protein, suggesting potential therapeutic efficacy against microbial activity. Moreover, in-silico ADMET calculations were conducted, and the synthesized compound confirms the drug-likeness within the defined parameters: molecular weight between 150 to 500 g/mol, TPSA polarity between 20 to 130 Å2 , lipophilicity ranging between -0.7 to +5.0 Log S not exceeding 6, flexibility not exceeding 9, and saturation not inferior to 0.25. The compound demonstrated compliance with these criteria, suggesting favorable in-vivo drug absorption and permeation characteristics.

Zoya . Zaidi

Mohammad Asim Khan

G. . Sundararajan

Gunjan . Sharma

In-silico ADME Evaluation and Molecular Docking of a Novel Compound’ 2-(4-Allylpiperazin-1-Yl)-1-(1-(4-Nitrophenyl)-1h-Tetrazol-5-Yl) Ethanone’ as Potential Antimicrobial Agents.

新型化合物“2-(4-烯丙基哌嗪-1-基)-1-(1-(4-硝基苯基)-1H-四唑-5-基)乙酮”的体内ADME评估与分子对接作为潜在抗菌剂。

In the current study, a simple and economic stability-indicating RP-HPLC method development and validation was carried out to estimate the bictegravir, emtricitabine and tenofovir from the pharmaceutical dosage form. 0.1M ammonium acetate in 0.5% v/v acetic acid solution and 1g of 1-octane sulfonic acid and adjustment of pH to 4.2 with dilute orthophosphoric acid done and methanol (40:60 v/v) was utilized as the mobile phase. The analysis was done using Inertsil ODS 3V (250 x 4.6 mm x 5 µm) column with column temperature kept at 30°C with an injection volume of 20 μL, flow rate of 1.0 ml/ minute and detection was carried out at 260 nm. The method was developed and it was validated according to ICH Q2 (R1) guidelines. The RT of bictegravir, emtricitabine and tenofovir were determined to be 12.23, 3.0 and 8.5 minutes, providing a reliable marker for its identification. The method was found linear from about 50 To 150% Of the target concentration of bictegravir emtricitabine and tenofovir with of 0.999. Significant degradation was observed in acidic, basic and peroxide stress conditions. Hence, it can be concluded that tablets are sensitive to acidic, basic and oxidation stress conditions. RSD for the peak area responses of emtricitabine, 0.03 and 0.03, respectively, indicating that the system is precise. The testing procedure was accurate from about 50 to 150%. Of the target concentration of emtricitabine, tenofovir alafenamide and bictegravir. The method was robust In relation to flow variation, column oven temperature variation, mobile phase variation and pH variation. In conclusion, our proposed RP-HPLC method provides a sensitive, accurate, and precise means of analyzing emtricitabine, tenofovir alafenamide and bictegravir from pharmaceutical dosage forms.

Nitin Mehetre

Inderbir . Singh

Advanced, Cutting-Edge RP-HPLC Methodology for the Comprehensive Quantitative Analysis of Assay of Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Co-Formulated Pharmaceutical Products.

先进的、前沿的RP-HPLC方法学用于共配方药物产品中比克替拉韦、恩曲他滨和替诺福韦艾拉酚胺的综合定量分析。

The experienced of pain amid labor is women’s most extreme event, which causes intemperate stress. Assorted in strength, every woman bears intensity of labor is varied. Entonox is one of the non-invasive analgesic methods used during the process and identifying its potency is the foremost article’s purpose. A hospital-based prospective case control-single-centered study was done. The subject’s information and feedback on entonox use were gathered and analyzed with suitable statistical SPSS. The explicit parameters of parturient were interpreted by descriptive frequencies comparison between the different variables were calculated using the T-test. Many entonox users showed positive responses with reduced pain compared to non-users. The Apgar score showed no significant variation in both I and II groups, which proves no alliance of entonox with neonatal outcomes. Entonox is a choice alternative for managing pain during the initial labor phases. The success of this preferable technique (Entonox) can be attributed to most females choosing non-intrusive methods during labor.

Pathan Amanulla Khan

Ayesha . Samreen

Sofia . Sadaf

D Naga Latha

D . Varun

Evaluating the Efficacy of Entonox in Reducing Labor Pain During Active Labor: A Case-Control Study.

评估笑气在活跃期分娩中减轻产痛的有效性：一项病例对照研究。

Trianthema portulacastrum Linn. is an ancient Indian medicinal plant widely used in the treatment of ulcers, wounds, inflammation and pain. The leaves, flowers, and roots are the most important parts that are used traditionally. In the present investigation, antiulcer screening of etOH and aqueous leaves extract was screened in ethanol-induced gastric ulcers in rats at the selected doses. The results thus obtained were compared with standard drugs and it was found that EATPL exhibited significant results when compared with AETPL.

ISSN	0975-9506
h-index	12

Publication Information	Publisher: Dr. Yashwant Research Labs Pvt. Ltd.，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2013，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%

International Journal of Pharmaceutical Quality Assurance

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Phytochemical Profiling of Pleurotus Pulmonarius from Paddy Straw Substrate.

In-silico ADME Evaluation and Molecular Docking of a Novel Compound’ 2-(4-Allylpiperazin-1-Yl)-1-(1-(4-Nitrophenyl)-1h-Tetrazol-5-Yl) Ethanone’ as Potential Antimicrobial Agents.

Advanced, Cutting-Edge RP-HPLC Methodology for the Comprehensive Quantitative Analysis of Assay of Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Co-Formulated Pharmaceutical Products.

Evaluating the Efficacy of Entonox in Reducing Labor Pain During Active Labor: A Case-Control Study.

EAntiulcer Activity of Trianthema portulacastrum Linn. in Gastric Ulcers.

Phytochemical Profiling of Pleurotus Pulmonarius from Paddy Straw Substrate.

In-silico ADME Evaluation and Molecular Docking of a Novel Compound’ 2-(4-Allylpiperazin-1-Yl)-1-(1-(4-Nitrophenyl)-1h-Tetrazol-5-Yl) Ethanone’ as Potential Antimicrobial Agents.

Advanced, Cutting-Edge RP-HPLC Methodology for the Comprehensive Quantitative Analysis of Assay of Bictegravir, Emtricitabine, and Tenofovir Alafenamide in Co-Formulated Pharmaceutical Products.

Evaluating the Efficacy of Entonox in Reducing Labor Pain During Active Labor: A Case-Control Study.

EAntiulcer Activity of Trianthema portulacastrum Linn. in Gastric Ulcers.