Chinese Journal of Integrated Traditional and Western Medicine

Being the unique core of traditional Chinese medicine (TCM), pattern classification exerts a direct effect on the efficacy and safety of herbal interventions. In this article, the authors integrated the pattern classification and disease diagnosis with many approaches from systems biology. Integration of pattern classification with biomedical diagnosis by systems biology is not only a new direction of personalized medicine development, but also provides a new drug development model. In the further study, the pattern classifications of major diseases will be the focus of research.

Ai-ping Lu

Zhao-xiang Bian

Ke-ji Chen

Chinese journal of integrative medicine

Chin J Integr Med

Bridging the traditional Chinese medicine pattern classification and biomedical disease diagnosis with systems biology.

It has been well known that insomnia and sleep deprivation can lead to many metabolic diseases such as type 2 diabete mellitus (T2DM). Chinese medicine (CM) has been used to improve insomnia and showed many good therapeutic effects. Some Coptidis Rhizoma-contained traditional formulae have been found to exert obvious effects on insomnia, such as Jiaotai Pill (), Huanglian Ejiao Decoction (), Huanglian Wendan Decoction (), Niuhuang Qingxin Pill (), and Zhusha Anshen Pill (). Coptidis Rhizoma, a traditional herbal medicine which can purge Xin (Heart) fire, is the most important component of these formulas. Studies have found that these formulae could improve T2DM symptoms. We hypothesized that treating insomnia theoretically may help to prevent diabetes and organized many experimental studies in this review and concluded that Coptidis Rhizoma-contained traditional formulae for insomnia might be a potential to prevent diabetes.

Wen-Ya Huang

Hui Dong

Coptidis Rhizoma-Contained Traditional Formulae for Insomnia: A Potential to Prevent Diabetes?

Chinese medicine (CM) is usually prescribed as CM formula to treat disease. The lack of effective research approach makes it difficult to elucidate the molecular mechanisms of CM formula owing to its complicated chemical compounds. Network pharmacology is increasingly applied in CM formula research in recent years, which is identified suitable for the study of CM formula. In this review, we summarized the methodology of network pharmacology, including network construction, network analysis and network verification. The aim of constructing a network is to achieve the interaction between the bioactive compounds and targets and the interaction between various targets, and then find out and validate the key nodes via network analysis and network verification. Besides, we reviewed the application in CM formula research, mainly including targets discovery, bioactive compounds screening, toxicity evaluation, mechanism research and quality control research. Finally, we proposed prospective in the future and limitations of network pharmacology, expecting to provide new strategy and thinking on study for CM formula.

Ting-Ting Luo

Yuan Lu

Shi-Kai Yan

Xue Xiao

Xiang-Lu Rong

Jiao Guo

Network Pharmacology in Research of Chinese Medicine Formula: Methodology, Application and Prospective.

To assess whether adjuvant Chinese patent medicines (CPMs) to standard treatment could reduce recurrent bleeding after variceal bleeding in cirrhotic patients.

Qun Zhang

Yu-Xin Li

Yao Liu

Yi-Xin Hou

Bing-Bing Zhu

Yun-Yi Huang

Ke Shi

Xian-Bo Wang

Effects of Adjuvant Chinese Patent Medicine Therapy on Prevention of Variceal Rebleeding: A Retrospective Cohort Study.

中药辅助治疗对预防食管静脉曲张再出血的影响：一项回顾性队列研究。

To investigate the efficacy of integrated Chinese and Western medicine extending the progression-free survival (PFS) and overall survival (OS) of limited-stage small cell lung cancer (LS-SCLC) patients after the first-line chemoradiotherapy.

Run-Zhi Qi

Shu-Lin He

Yue Li

Yu-Wei Zhao

Liang Geng

Jie He

Meng-Qi Cheng

Jia-Qi Hu

Cong-Huang Li

Bao-Jin Hua

Retrospective Clinical Study on Integrated Chinese and Western Medicine in Treatment of Limited-Stage Small Cell Lung Cancer.

中西医结合治疗局限期小细胞肺癌的回顾性临床研究

Qing-yun Jia

Yi-ru Wang

Da-wei Sun

Jian-chun Mao

Luan Xue

Xiao-hua Gu

Xiang Yu

Xue-mei Piao

Hao Xu

Qian-qian Liang

Chinese Journal of Integrative Medicine

Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis: A 48-Week, Multicentre, Randomized, Double-Blind, Placebo-Controlled Trial

加用甲氨蝶呤的蠲痹丸治疗活动性类风湿关节炎的疗效和安全性：一项48周、多中心、随机、双盲、安慰剂对照试验

Xing-chen Zhou

Shuang Wu

Kai-zheng Wang

Long-hao Chen

Zi-cheng Wei

Tao Li

Zi-han Hua

Qiong Xia

Zhi-zhen Lyu

Li-jiang Lyu

Impact of Spinal Manipulative Therapy on Brain Function and Pain Alleviation in Lumbar Disc Herniation: A Resting-State fMRI Study

腰椎间盘突出症的脊椎手法治疗对脑功能和疼痛缓解的影响：一项静息态fMRI研究

To evaluate the protective effects of gentiopicroside (GPS) against reactive oxygen species (ROS)-induced NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation in endothelial cells, aiming to reduce atherosclerosis.

Zhu-Qing Li

Feng Zhang

Qi Li

Li Wang

Xiao-Qiang Sun

Chao Li

Xue-Mei Yin

Chun-Lei Liu

Yan-Xin Wang

Xiao-Yu Du

Cheng-Zhi Lu

Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway

京尼平苷通过SIRT1/Nrf2途径抑制血管内皮细胞中依赖活性氧的NLRP3炎症小体激活来减轻动脉粥样硬化

To evaluate the therapeutic effect of Yu Melody relaxation training (YMRT) combined with Jianpi Jieyu Decoction (JJD) in treating patients with insomnia disorders (ID).

Hao-Yu Pang

Xu Chen

Ling-Yun Xi

Qian-Lin Jia

Yang Bai

Jing Cao

Xia Hong

Therapeutic Effect of Yu Melody Relaxation Training Combined with Jianpi Jieyu Decoction in Insomnia Patients: A Randomized Controlled Trial

玉音放松训练联合健脾解郁汤治疗失眠患者的疗效：一项随机对照试验

Jie-qiong Zeng

Hui-fen Zhou

Hai-xia Du

Yu-jia Wu

Qian-ping Mao

Jun-jun Yin

Hai-tong Wan

Jie-hong Yang

Tongmai Hypoglycemic Capsule Attenuates Myocardial Oxidative Stress and Fibrosis in the Development of Diabetic Cardiomyopathy in Rats

通脉降糖胶囊减轻大鼠糖尿病心肌病发展中的心肌氧化应激和纤维化

Publication Information	Publisher: Chinese Association of the Integration of Traditional and Western Medicine, China Academy of Traditional Chinese Medicine，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1995，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Chinese Journal of Integrated Traditional and Western Medicine

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