Chinese Journal of Psychiatry

Objective To investigate the effects of clozapine on Dizocilpine maleate (MK-801)induced hypoglutamatergic schizophrenia model in mice.Methods (1) To investigate the effects of clozapine on explorative behavior and spontaneous activity, three doses of clozapine (1.0, 1.5, 2.0 mg/kg, i.p.) or vehicle was injected 30 min before the test. Locomotor activity was recorded for 30 min with an automated video tracking system, in which the components of the locomotor activity were divided into exploration (the first 10 min) and spontaneous activity (the second 20 min). (2) To examine the effects of clozapine on MK-801-induced hyperlocomotion and stereotyped behavior, mice were administered with clozapine (1.0, 1.5 and 2.0 mg/kg) or vehicle 5 min before administration of MK-801 (0.25 mg/kg). After the second injection, locomotor activity was recorded for 90 min by the video tracking system; stereotyped behavior was evaluated for 90 min with a ranked intensity scale by two raters who were blind to the drug treatment.Results Clozapine (1.5 and 2.0 mg/kg) significantly inhibited the explorative behavior and spontaneous activity (P0.001). Clozapine at 1.0 mg/kg did not affect exploration and spontaneous activity (P0.05). Clozapine (1.0-2.0 mg/kg) dose-dependently antagonized MK-801-induced hyperlocomotion. (2) Clozapine(1.5-2.0 mg/kg)dose-dependently reduced MK-801-induced stereotypy. The lowest dose (1.0 mg/kg) had no effect on stereotypy induced by MK-801. Conclusion Clozapine has the selective action on the brain region. At lower dose, clozapine selectively inhibited hyperlocomotion mediated by the mesolimbic/mesocortical system while at higher doses it inhibited hyperlocomotion and stereotypy mediated by both mesolimbic/mesocortical and nigrostriatal systems.

Zhou Dong-feng

Zhonghua jingshenke zazhi

Effects of clozapine on the hypoglutamatergic schizophrenia model in mice

氯氮平对小鼠谷氨酸能低下型精神分裂症模型的影响

Objective To evaluate the efficacy and safety of risperidone and haloperidol in treating patients with Diagnostic and Statistical Manual of Mental Disorders-Ⅳ bipolar Ⅰ disorder acute manic episodes.Methods A randomized, double-blind, controlled multicenter clinical trial was conducted. All 173 patients received 4 weeks treatment with either risperidone (n=85, averaged dosage of 4.6 mg/d) or haloperidol (n=88, 8.0 mg/d). The main efficacy measure was the change in total score of the Young Mania Rating Scale.Results The clinical response rates were 79% in risperidone and 76% in haloperidol. There were significantly higher rates of extrapyramidal symptoms in haloperidol group (58%) than that in risperidone group (44%).Conclusion The results show that risperidone has similar therapeutic effect to haloperidol in treatment of acute manic episodes, but risperidone has better tolerability.

Zhang Hong-yan

Risperidone versus haloperidol in treatment of acute manic episodes of bipolar I disorder: a randomized double-blind controlled multicenter study

利培酮与氟哌啶醇治疗双相I型障碍急性躁狂发作的随机双盲对照多中心研究

Objective To explore the key factors affecting the therapeutic effect of risperidone in Tourette′s syndrome(TS).Methods One hundred and six children with TS who were mono-treated with risperidone were involved.The efficacy was assessed with the Yale Global Tic Severity Scale(YGTSS),and response was defined as a reduction of ≥30% in the YGTSS score.The demographic and clinical characteristics were assessed with a self-compiled questionnaires and other standard instruments as the Treatment Emergent Symptom Scale(TESS),Child Behavior Checklist(CBCL),and so on.Logistic regression analysis was used to investigate the relative factors to risperidone response.Results The univariate analysis indicated that social function impairment(OR=1.340),higher total score of CBCL at baseline(OR=1.477),positive family history(OR=24.316),environmental pollution around home((OR=2.433),) younger age at onset(OR=1.594),non-democratic style of family education(OR=1.972),abnormal medical history(OR=11.468),and longer illness duation(OR=3.491) were associated with the non-response of risperidone.In multivariate analysis,the social function impairment((OR=32.258),) positive family history(OR=12.804),abnormal medical history(OR=6.459) and higher total score of CBCL at baseline(OR=1.093) were correlated to non-response of risperidone.Conclusion The results indicate that the positive family history,abnormal medical history,higher total score of CBCL at baseline and social function impairments are the key factors affecting the therapeutic effect of risperidone in treating Tourette′s syndrome.

Zheng Y

The factors affecting therapeutic effect of risperidone in Tourette′s syndrome

利培酮治疗图雷特综合征疗效影响因素

Objective To investigate the incidence of internet overuse (IOU) in middle school students,and to explore the related factors to internet overuse.Methods Using the Diagnostic Questionnaire for Internet Addiction (YDQ),Strength and Difficulties Questionnaire (SDQ),Eysenck Personality Questionnaire (EPQ) the edition for children,Adolescence Time Management Disposition Scale (ATMD),we investigated 2 620 middle school students.According to the YDQ criterion and clinical interview,64 students who were diagnosed as internet overuse,and 64 students diagnosed as being normal in internet usage were included as controls.Results The incidence rate of IOU in this sample was 2.4%. IOU group had significantly higher scores on the SDQ subscales of emotional symptoms,conduct problems, hyperactivity,total difficulties and less scores on the subscales of prosocial behaviors (P＜0.05-P＜0.01), and had higher scores on the SCARED subscales of somatization/panic,general anxiety,social phobia, school phobia,and dissociative anxiety than controls (P＜0.01 ).IOU group had significantly higher scores on the EPQ subscales of neuroticism,psychoticism and less scores on the subscales of lie (P＜0.01 ),and less scores on the TAMD subscales of sense of time control,sense of time efficacy,sense of time management than controls (P＜0.05-P＜0.01).Conditioned logistic analysis showed that the factors of hyperactivity,prosocial behaviors,general anxiety were associated with IOU.Conclusion The middle school students with IOU have more behavioral and emotional problems,which may be related to internet overuse.

Gao Xue-ping

The related factors to internet overuse in middle school students

中学生网络过度使用的相关因素

Objective To investigate brain functioning during attention task in patients with schizophrenia by using functional magnetic resonance imaging.Methods Fourteen paranoid schizophrenic patients and sixteen healthy volunteers underwent fMRI when performing Stroop test.Results (1) Left inferior frontal,left superior temporal and inferior temporal gyrus was activated significantly in patients (the activated number was 11/3,6/8,6/8 respectively) than that in controls (the activated number was 6/10, 1/15,1/15 respectively) during Stroopl test (P＜0.05).Right middle frontal,left anterior eingulate gyrus (ACC) in schizophrenic patients (both activated number was 4/10 ) was activated poorly than that in controls (the activated number was 12/4,14/2 respectively) during Stroop2 test (P＜0.05).However,left superior frontal gyrus of patients (the activated number was 9/5 ) was activated significantly than that of controls (the activated number was 3/13) during Stroop2 test (P＜0.05).(2) Activation volume of right DLPFC,left ACC was significantly less during Stroopl test in patients (the activated volume was 256±579, 18±59 respectively) than that of controls (the activated volume was 298±597,67±87 respectively) (P＜0.05).Activation volume of bilateral DLPFC,left ACC during Stroop2 test was less in patients (the activated volume was 73±190,80±245,17±28 respectively) than that in controls (the activated volume was 425±800,414±703,76±98 respectively) (P＜0.05).Conclusion The findings of dysfunction in prefrontal lobe,left ACC and temporal lobe in schizophrenia give further support that these dysfunction brain areas (circuits) may be related to schizophrenic patients' attention deficit.

MU Ying-feng

Brain dysfunctioning during attention task in patients with schizophrenia:a functional magnetic resonance imaging study

精神分裂症患者注意任务中的脑功能障碍：一项功能性磁共振成像研究

目的 探讨舞蹈治疗对慢性精神分裂症患者的辅助作用.方法 在药物治疗的同时,对30 例慢性精神分裂症患者辅以舞蹈治疗( 治疗组) ,30 次为一个疗程;采用简明精神病评定量表( B P R S) 和阴性症状量( S A N S) 表于治疗前后分别进行评定,并与单纯药物治疗的30 例慢性精神分裂症患者( 对照组) 进行对照.结果 经舞蹈治疗后,治疗组 B P R S 和 S A N S评分中位数分别为26 和17 ,均低于治疗前( B P R S和 S A N S 分别为31 和27 ; P＜ 0?05 ~0?01) ,亦低于对照组( 分别为28 和19 ; P＜0?05 ~0?01) .结论 辅以舞蹈治疗对于慢性精神分裂症患者精神症状的缓解、社会功能恢复,及康复治疗均有积极意义.

苏琳

樊作树

屈英

江涛

刘津

王育新

詹凰

马永恒

中华精神科杂志

对慢性精神分裂症患者辅以舞蹈治疗的疗效观察

【Abstract】 After the epidemic of COVID‑19 has been basically under control interiorly, China is under the situation of regular epidemic prevention and control. Hence a reflection on the problems about the risk of gaming disorder in the epidemic period can be helpful to mental health professionals who prevent and control gaming disorder. The authors clarified the improper publicity of the gaming industry and false media report, and also reviewed the trend of game using was rapidly rising and game market was rapidly expanding. Consequently, as the author addressed, the health risks due to excessive gaming patterns were increasing. This review also pointed out and analyzed some new trend of the expansion of female game users during the epidemic, and the further in-depth integration of games and gambling. Finally, some advice was provided to the mental health workers to cope with the increasing risk of gaming disorder during a post-epidemic era. © Chinese Journal of Psychiatry 2021.

Y. Ming

S. Hongxian

H. Wei

COVID‑19 and the risk of gaming disorder: a reflection in the situation of regular epidemic prevention and control

COVID-19与游戏障碍风险：常态化疫情防控下的反思

Three patients diagnosed with COVID-19 were all young women in their thirties who have suffered from Internet violence in their personal life after hospitalization. They showed significant emotional distress such as, depression state, acute stress disorder, and dissociative disorder. The current study adopts short-term, individualized and comprehensive psychological interventions, including psychological support, encouragement, listening, safety confirmation, catharsis, psychological suggestion, and stimulation of internal potential to treat patients. The third case was provided with psychological interventions combined with antipsychotic treatment. After timely psychological interventions all three patients achieved sound results. © 2021 Chinese Medical Journals Publishing House Co.Ltd.

L. Yang

X. Wang

T. Sun

Psychological intervention for three COVID patients who suffered online violence

三名遭受网络暴力的COVID患者的心理干预

Objective
To investigate the differences of socio-demographics and smartphone use features among Chinese college students between problematic smartphone user (PSU) and non-PSU, and to clarify the link between PSU and psychopathological symptoms (anxiety and depression).


Methods
A total of 1 205 undergraduates from 35 classes of 8 universities or colleges, stratified with different school levels, were selected using the cluster random sampling strategy. The Problematic Cellular Phone Use Questionnaire (PCPUQ) was used to identify problematic use of smartphone use, and Zung Self-Rating Anxiety Scale (SAS) and Zung Self-Rating Depression Scale (SDS) were used to measure anxiety and depression symptoms.


Results
The prevalence of PSU among undergraduates was estimated to be 20.6%(207/1 006). There were significant differences between PSU and non-PSU on their major of either science category or humanities category (χ2=11.424, P<0.01), grade (χ2=5.868, P<0.05), monthly living expense supported by their family (χ2=12.713, P<0.01), daily time spent on their smartphones (χ2=20.052, P<0.01),frequency of changing the mobile phones (χ2=14.511, P<0.01) and monthly smartphone bill (χ2=13.107, P<0.01). Furthermore, the self rated anxiety (34.8% (72/207) vs. 14.6% (117/799), χ2=43.704, P<0.01) and depression (36.2% (75/207) vs. 15.4% (123/799), χ2=45.159, P<0.01) were both found more elevated in PSU than non-PSU.


Conclusion
Some common sociodemographic variables and smartphone usage patterns were identified in undergraduates displaying PSU. Moreover, PSU is associated with more elevated anxiety and depression symptoms.


Key words: 
Behavior, addiction; Anxiety; Depression; Problematic smartphone use

Yueheng Liu

Jiang Long

Joël Billieux

Chang Qi

Haoyu He

Shubao Chen

Qiuxia Wu

Yifan Xiong

Tieqiao Liu

Problematic smartphone use and its relation with anxiety and depression: a survey in a large sample of undergraduates

问题性智能手机使用及其与焦虑和抑郁的关系：一项针对大量本科生的调查

出版信息	出版商: Chinese Medical Journals Publishing House Co.Ltd，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2019，原创研究文献占比: ，自引率:， Gold OA占比:

Chinese Journal of Psychiatry

期刊引文格式

有 1 位以上作者的期刊

有 2 位作者的期刊

有 3 位作者的期刊

有 5 位以上作者的期刊

书籍引用格式

学位论文引用格式

网页引用格式

专利引用格式

手工熬夜修改参考文献？研飞自动匹配期刊，一键轻松成稿，支持 Word/WPS

投稿经验分享