Chinese Journal of Hepatobiliary Surgery

Objective:To systematically evaluate the efficacy and clinical value of early enteral nutrition (EEN) combined with microecological agents in the treatment of severe acute pancreatitis (SAP).Methods:China National Knowledge Infrastructure, Chinese biomedical literature database, Wanfang Database, VIP, Cochrane Library, PubMed, Embase, and Web of Science were analyzed, and the retrieval time range is from the establishment of the datebase to November 1, 2019. To compare the clinical efficacy of EEN combined with microecological agents (experiment group) and single EEN treatment (control group) in SAP patients, and to compare the main outcome indicators: serum C-reactive protein level, incidence of multiple organ dysfunction syndrome, incidence of pancreatic infection necrosis, incidence of other complications, mortality, and length of hospital stay. And secondary outcome measures: plasma interleukin-8 (IL-8), tumor necrosis factor-α level, gastrointestinal score, and incidence of surgical intervention. The quality of the included literature was evaluated by using the Cochrane systematic evaluator's manual 5.1.0 risk of bias assessment tool, and meta-analysis was performed by using Stata16.0 software.Results:A total of 762 patients were enrolled in 9 RCTs. The results of meta-analysis showed that: among the main outcome indicators, C-reactive protein level [Mean Difference (
 MD)=-7.58, 95%
 CI: -23.71-8.55, P>0.05], incidence of multiple organ dysfunction syndrome [Logarithm Risk Ratio (Log
 RR)=-0.30, 95%
 CI: -0.71-0.10, P>0.05], incidence of pancreatic infection and necrosis (Log
 RR=-0.21, 95%
 CI: -0.57-0.16, P>0.05) and mortality rate (Log
 RR=0.13, 95%
 CI: -0.36-0.62, P>0.05) the differences were not statistically significant. The incidence of complications in the experimental group was significantly lower than that in the control group (Log
 RR=-0.29, 95%
 CI: -0.51-0.07, P<0.05), and the length of hospital stay in the experimental group (
 MD=-4.45, 95%
 CI: -7.47--1.43, P<0.05) was significantly shorter than that in the control group. Plasma IL-8 levels (
 MD=-7.43, 95%
 CI: -14.28--0.57, P<0.05), TNF-α level (
 MD=-38.96, 95%
 CI: -72.96--4.95, P<0.05)and gastrointestinal score (
 MD=-0.15, 95%
 CI: -0.17--0.13, P<0.05)were significantly lower in the experimental group than in the control group, and the incidence of surgical intervention was significantly lower than that of the control group (Log
 RR=-1.63, 95%
 CI: -8.96-0.57, P>0.05) no statistical significance.
 Conclusion:EEN combined with microecological preparations can reduce the length of hospital stay in SAP patients and the incidence of complications. Therefore, EEN combined with microecological agents may be beneficial for SAP patients.

Zheng Bingfeng

Ma Gang

Wang Shaoyuan

Liu Jiansheng

Zhonghua gan-dan waike zazhi

Effect of early enteral nutrition combined with microecological preparation on severe acute pancreatitis: meta-analysis

早期肠内营养联合微生态制剂对重症急性胰腺炎影响的Meta分析

Jing Tang

Jinfeng Li

Fengyong Liu

Hongjun Yuan

Xin Li

Xiaomei Tian

Kan Ji

The progress and advance on diffusion-weighted imaging in locoregional interventional treatment of hepatocellular carcinoma

肝细胞癌局部介入治疗中扩散加权成像的进展与进展

Objective:To study the influencing factors in predicting conversion of laparoscopic liver tumor resection to open surgery to provide references for selection of patients for laparoscopic hepatectomy.Methods:The clinical data of 222 patients who were planned to undergo laparoscopic liver tumor resection at Ningbo Medical Center Lihuili Hospital from December 2015 to November 2018 were analyzed retrospectively. There were 146 males and 76 females, with an average age of 58.1 years. These patients were divided into the conversion group (
 n=24) and the laparscopic group (
 n=198) according to whether intraoperative conversion to open surgery was carried out. Chi-square test was used to evaluate relevant factors of conversion. Logistic regression analysis was used for multivariate analysis and to find out independent risk factors of conversion.
 Results:The conversion rate was 10.8% (24/222). Univariate analysis showed that hypertension, history of abdominal surgery, liver cirrhosis, tumors located at posterosuperior segments and major liver resection were significantly associated with conversion (all P<0.05). Multivariate analysis showed that the risk factors which were independently associated with conversion were liver cirrhosis (
 OR=2.611, 95%
 CI: 1.018-6.701), tumors located at posterosuperior segments (
 OR=6.115, 95%
 CI: 2.207-16.941), and major liver resection (
 OR=3.361, 95%
 CI: 1.150-9.825)(all P<0.05).
 Conclusion:Patients who were planned for laparoscopic liver tumor resection with liver cirrhosis, tumors at posterosuperior segments or major liver resection were at higher risks of conversion to open surgery.

Lin Rongfeng

Hua Yongfei

LU Changjiang

LU Caide

Influencing factors in predicting conversion of laparoscopic liver tumor resection to open surgery

腹腔镜肝肿瘤切除术转为开腹手术的预测影响因素

Objective
To investigate the effect of microRNA-128 (miR-128) on the proliferation, apoptosis on the hepatoma cells.


Methods
The target genes of miR-128 were analyzed by using bioinformatics and dual luciferase reporter assay system. We overexpressed miR-128 in the MHCC97H cells and also infected the GP73 gene with virus in the cell. Cell proliferation was detected by cell counting kit and apoptosis was detected by TUNEL and apoptosis index was calculated. Thirty 6-8 weeks Balb/c nude mice were randomly divided into miR-128 overexpression group (n=15) and control group (n=15).


Results
The results of bioinformatics and dual luciferase reporter assay showed that GP73 was the target gene of miR-128. Compared with the negative control group, cell proliferation in miR-128 overexpression group was decreased significantly; compared with miR-128+ empty plasmid group, cell in miR-128+ GP73 group was significantly increased (P<0.05). Compared with the negative control group, the apoptosis index in miR-128 overexpression group was significantly increased (P<0.05). Compared with miR-128 + empty plasmid group, the apoptosis index of miR-128 + GP73 group was significantly increased (P<0.05). Tumor volume of the overexpression group was higher than that of the control group. 5 weeks later, tumor volume of the miR-128 overexpression group (1 209±108)mm3 was significantly higher than that of the control group (1 985±298)mm3, the difference was statistically significant (P<0.05).


Conclusion
miR-128 can promote the proliferation and inhibit the apoptosis of hepatoma cells by regulating GP73, which provide a reference for the prognosis evaluation of hepatoma.


Key words: 
Liver neoplasms; MicroRNA-128; Golgi protein-73; Cell proliferation; Apoptosis

Jianhua Li

Ling Han

Effect and mechanism of microRNA-128 on proliferation and apoptosis of hepatocelluar carcinoma cells

微RNA-128对肝细胞癌细胞增殖和凋亡的影响及机制

早期肠内营养联合微生态制剂对重症急性胰腺炎的影响：Meta分析

涉及主题	医学内科学生物外科胃肠病学遗传学化学病理生物化学放射科内分泌学免疫学癌症研究
出版信息	出版商: Chinese Medical Journals Publishing House Co.Ltd，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2020，原创研究文献占比: 0.00%，自引率:N.A.， Gold OA占比: 0.00%

Chinese Journal of Hepatobiliary Surgery

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Effect of early enteral nutrition combined with microecological preparation on severe acute pancreatitis: meta-analysis

The progress and advance on diffusion-weighted imaging in locoregional interventional treatment of hepatocellular carcinoma

Influencing factors in predicting conversion of laparoscopic liver tumor resection to open surgery

Effect and mechanism of microRNA-128 on proliferation and apoptosis of hepatocelluar carcinoma cells

Effect of early enteral nutrition combined with microecological preparation on severe acute pancreatitis: meta-analysis

Effect of early enteral nutrition combined with microecological preparation on severe acute pancreatitis: meta-analysis

The progress and advance on diffusion-weighted imaging in locoregional interventional treatment of hepatocellular carcinoma

Influencing factors in predicting conversion of laparoscopic liver tumor resection to open surgery

Effect of early enteral nutrition combined with microecological preparation on severe acute pancreatitis: meta-analysis

The progress and advance on diffusion-weighted imaging in locoregional interventional treatment of hepatocellular carcinoma

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期刊索引	北大核心中国科学引文数据库中国科技核心期刊目录

ISSN	1007-8118
h-index	3