Quinazolinone-based subchemotypes for targeting HIV-1 capsid protein: design and synthesis

2024-9-14

Medicinal significance of sp2/sp3 hybridized at C-3-substituted indole-containing lead molecules and FDA-approved drugs

2024-9-13

A review on phytochemical constituents, analytical data, and pharmacological properties of the genus Plumeria

2024-9-11

Design, synthesis, anti-tubercular activity, and computational studies of novel 3-(quinolin-3-yl)-1-phenylprop-2-en-1-one derivatives

2024-9-10

Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review

2024-9-8

Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy

2024-9-7

Structural insights into G-quadruplex binding by metal complexes: implications for drug design

2024-9-7

A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication

2024-9-3

Design, synthesis and evaluation of sesamol-derived acetamides as dual inhibitors of monoamine oxidases and cholinesterases

2024-9-3

A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies

2024-9-2

Insights into computer-aided G-quadruplex prediction in the digital age

2024-8-28

Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants

2024-8-24

Anticancer potential of delphinidin and its derivatives: therapeutic and mechanistic insights

2024-8-14

Terrein: Isolation, synthesis, and upscaling of a functional scaffold for multifaceted biomedical applications

2024-8-10

Dauricine: a review of natural observation, pharmacology, and pharmacokinetics

2024-8-9

Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents

2024-8-9

Exploration of potential antihypertensive peptides derived from farmed Chinese giant salamander (Andrias davidianus)

2024-8-8

Contrasting effect of different crowding agents on pseudoknot RNA stability

2024-8-8

Further exploration of N-4 substituents on the piperazine ring of the hybrid template 5/ 7-{[2-(4-Aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol and its analog: development of an exceptionally potent agonist for D2 & D3 receptors

2024-8-8

Novel monastrol/melatonin hybrids as a new approach for colorectal cancer intervention: design, synthesis, biological activity, and drug-likeness modeling studies

2024-8-8

Novel 2-[(8-hydroxyquinolin-7-yl)(phenyl)methylamino]benzoic acid analogs targeting the active site of botulinum neurotoxins: designing, synthesis, and biological evaluation

2024-8-3

Development of LC-MS/MS methods affording identification and measurement of active metabolites in rat and dog plasma after oral dosing of a penta-ethyl ester prodrug of diethylenetriamine pentaacetic acid

2024-7-30

Structural optimization and biological evaluation of quinoline/naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates

2024-7-30

Targeting selective inhibitors of PARPs in drug discovery and development

2024-7-28

Development of an in vitro model of the neurovascular unit for BBB permeability-linked neuroactivity screening

2024-7-28

A review of trilaciclib, a first-in-class cyclin-dependent kinase 4/6 inhibitor, for the management of metastatic small-cell lung cancer

2024-7-26

Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin I converting enzyme and dipeptidyl peptidase-IV

2024-7-25

Exploring the decadal evolution of indolizine scaffold for anticancer innovations: a comprehensive analysis

2024-7-25

Synthesis and evaluation of novel biaryl oxazolidinones effective against gram-positive bacterial infections

2024-7-24

Design and discovery of monopolar spindle kinase 1 (MPS1/TTK) inhibitors by computational approaches

2024-7-24

Synthesis and evaluation of 2-methylbenzothiazole derivatives as monoamine oxidase inhibitors

2024-7-24

Nafithromycin (MIQNAF®): ultramodern lactone ketolide designed to treat community acquired bacterial pneumonia (CABP)

2024-7-23

Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies

2024-7-20

Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer’s disease-related enzymes

2024-7-19

Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and computational studies

2024-7-17

A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy

2024-7-15

Potential therapeutic effects of ester derivatives of Ribavirin against SARS-CoV-2

2024-7-14

ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine

2024-7-13

Identification of potential natural product derivatives as CK2 inhibitors based on GA-MLR QSAR modeling, synthesis and biological evaluation

2024-7-10

Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus

2024-7-10

Synthesis and anti-leishmanial activities of uniflorol analogues

2024-7-8

Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications

2024-7-7

Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model

2024-7-7

Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans

2024-7-4

Ronald T. Borchardt: a pioneer in drug discovery and development

2024-6-28

Peptide-based therapeutics: challenges and solutions

2024-6-27

Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy

2024-6-27

Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment

2024-6-26

Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2

2024-6-26

Role of the Caco-2 cell culture model developed in Dr. Ronald T. Borchardt’s lab in modern drug research and development: a perspective from a practitioner

2024-6-25