自 1985 年出版的《细胞和发育生物学年度评论》涵盖了细胞和发育生物学领域最重要的发展，包括细胞的结构、功能和组织，细胞的发育和进化，因为它与单个和多细胞生物，以及分子生物学的模型和工具。

The Annual Review of Cell and Developmental Biology, published since 1985, covers significant developments in the field of cell and developmental biology, including the structure, function, and organization of cells, as well as their development and evolution in relation to both unicellular and multicellular organisms, utilizing models and tools from molecular biology.

《Annual Review of Cell and Developmental Biology》自1985年出版，涵盖了细胞和发育生物学领域的重要进展，包括细胞的结构、功能和组织，以及细胞的发育和进化，涉及单细胞和多细胞生物的研究，并结合分子生物学的模型和工具。

Annual Review of Cell and Developmental Biology

Reconstitution is an experimental strategy that seeks to recapitulate biological events outside their natural contexts using a reduced set of components. Classically, biochemical reconstitution has been extensively applied to identify the minimal set of molecules sufficient for recreating the basic chemistry of life. By analogy, reconstitution approaches to developmental biology recapitulate aspects of developmental events outside an embryo, with the goal of revealing the basic genetic circuits or physical cues sufficient for recreating developmental decisions. The rapidly growing repertoire of genetic, molecular, microscopic, and bioengineering tools is expanding the complexity and precision of reconstitution experiments. We review the emerging field of synthetic developmental biology, with a focus on the ways in which reconstitution strategies and new biological tools have enhanced our modern understanding of fundamental questions in developmental biology.

Gavin Schlissel

Pulin Li

Synthetic Developmental Biology: Understanding Through Reconstitution

合成发育生物学：通过重构理解

Molecular cross talk between the nervous and vascular systems is necessary to maintain the correct coupling of organ structure and function. Molecular pathways shared by both systems are emerging as major players in the communication of the neuronal compartment with the endothelium. Here we review different aspects of this cross talk and how vessels influence the development and homeostasis of the nervous system. Beyond the classical role of the vasculature as a conduit to deliver oxygen and metabolites needed for the energy-demanding neuronal compartment, vessels emerge as powerful signaling systems that control and instruct a variety of cellular processes during the development of neurons and glia, such as migration, differentiation, and structural connectivity. Moreover, a broad spectrum of mild to severe vascular dysfunctions occur in various pathologies of the nervous system, suggesting that mild structural and functional changes at the neurovascular interface may underlie cognitive decline in many of these pathological conditions.

Marta Segarra

Maria R. Aburto

Jasmin Hefendehl

Amparo Acker-Palmer

Annu. Rev. Cell Dev. Biol.

Neurovascular Interactions in the Nervous System

神经系统中的神经血管相互作用

Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary to understand the consequences of liquid-like states for biological functions.

Anthony A. Hyman

Christoph A. Weber

Frank Jülicher

Liquid-Liquid Phase Separation in Biology

生物学中的液-液相分离

Plants have evolved many systems to sense their environment and to modify their growth and development accordingly. One example is vernalization, the process by which flowering is promoted as plants sense exposure to the cold temperatures of winter. A requirement for vernalization is an adaptive trait that helps prevent flowering before winter and permits flowering in the favorable conditions of spring. In Arabidopsis and cereals, vernalization results in the suppression of genes that repress flowering. We describe recent progress in understanding the molecular basis of this suppression. In Arabidopsis, vernalization involves the recruitment of chromatin-modifying complexes to a clade of flowering repressors that are silenced epigenetically via histone modifications. We also discuss the similarities and differences in vernalization between Arabidopsis and cereals.

Dong-Hwan Kim

Mark R. Doyle

Sibum Sung

Richard M. Amasino

Vernalization: Winter and the Timing of Flowering in Plants

春化作用：冬季与植物开花时间的关系

As chimeras transform from beasts of Greek mythology into tools of contemporary bioscience, secrets of developmental biology and evolutionary divergence are being revealed. Recent advances in stem cell biology and interspecies chimerism have generated new models with extensive basic and translational applications, including generation of transplantable, patient-specific organs.

Fabian Suchy

Hiromitsu Nakauchi

Lessons from Interspecies Mammalian Chimeras

哺乳动物异种嵌合体的启示

“What makes us human?” is a central question of many research fields, notably anthropology. In this review, we focus on the development of the human neocortex, the part of the brain with a key role in cognition, to gain neurobiological insight toward answering this question. We first discuss cortical stem and progenitor cells and human-specific genes that affect their behavior. We thus aim to understand the molecular foundation of the expansion of the neocortex that occurred in the course of human evolution, as this expansion is generally thought to provide a basis for our unique cognitive abilities. We then review the emerging evidence pointing to differences in the development of the neocortex between present-day humans and Neanderthals, our closest relatives. Finally, we discuss human-specific genes that have been implicated in neuronal circuitry and offer a perspective for future studies addressing the question of what makes us human.

Takashi Namba

Wieland B. Huttner

What Makes Us Human: Insights from the Evolution and Development of the Human Neocortex

什么使我们成为人类：从人类新皮层的进化和发展中获得的启示

Antibodies that gain specificity by a large insert encoding for an extra domain were described for the first time in 2016. In malaria-exposed individuals, an exon deriving from the leukocyte-associated immunoglobulin-like 1 (LAIR1) gene integrated via a copy-and-paste insertion into the immunoglobulin heavy chain encoding region. A few years later, a second example was identified, namely a dual exon integration from the leukocyte immunoglobulin-like receptor B1 (LILRB1) gene that is located in close proximity to LAIR1. A dedicated high-throughput characterization of chimeric immunoglobulin heavy chain transcripts unraveled, that insertions from distant genomic regions (including mitochondrial DNA) can contribute to human antibody diversity. This review describes the modalities of insert-containing antibodies. The role of known DNA mobility aspects, such as genomic translocation, gene conversion, and DNA fragility, is discussed in the context of insert-antibody generation. Finally, the review covers why insert antibodies were omitted from the past repertoire analyses and how insert antibodies can contribute to protective immunity or an autoreactive response.

Mikhail Lebedin

Kathrin de la Rosa

Diversification of Antibodies: From V(D)J Recombination to Somatic Exon Shuffling

抗体多样性：从V(D)J重排到体细胞外显子重排

Lipid droplets (LDs) are dynamic storage organelles with central roles in lipid and energy metabolism. They consist of a core of neutral lipids, such as triacylglycerol, which is surrounded by a monolayer of phospholipids and specialized surface proteins. The surface composition determines many of the LD properties, such as size, subcellular distribution, and interaction with partner organelles. Considering the diverse energetic and metabolic demands of various cell types, it is not surprising that LDs are highly heterogeneous within and between cell types. Despite their diversity, all LDs share a common biogenesis mechanism. However, adipocytes have evolved specific adaptations of these basic mechanisms, enabling the regulation of lipid and energy metabolism at both the cellular and organismal levels. Here, we discuss recent advances in the understanding of both the general mechanisms of LD biogenesis and the adipocyte-specific adaptations controlling these fascinating organelles.

Robin W. Klemm

Pedro Carvalho

Lipid Droplets Big and Small: Basic Mechanisms That Make Them All

大大小小的脂滴：它们的基本机制

In animals, the nervous system evolved as the primary interface between multicellular organisms and the environment. As organisms became larger and more complex, the primary functions of the nervous system expanded to include the modulation and coordination of individual responsive cells via paracrine and synaptic functions as well as to monitor and maintain the organism's own internal environment. This was initially accomplished via paracrine signaling and eventually through the assembly of multicell circuits in some lineages. Cells with similar functions and centralized nervous systems have independently arisen in several lineages. We highlight the molecular mechanisms that underlie parallel diversifications of the nervous system.

Jenks Hehmeyer

Flora Plessier

Heather Marlow

Adaptive Cellular Radiations and the Genetic Mechanisms Underlying Animal Nervous System Diversification

适应性细胞辐射与动物神经系统多样化的遗传机制

Developmental biology has greatly profited from genetic and reverse genetic approaches to indirectly studying protein function. More recently, nanobodies and other protein binders derived from different synthetic scaffolds have been used to directly dissect protein function. Protein binders have been fused to functional domains, such as to lead to protein degradation, relocalization, visualization, or posttranslational modification of the target protein upon binding. The use of such functionalized protein binders has allowed the study of the proteome during development in an unprecedented manner. In the coming years, the advent of the computational design of protein binders, together with further advances in scaffold engineering and synthetic biology, will fuel the development of novel protein binder–based technologies. Studying the proteome with increased precision will contribute to a better understanding of the immense molecular complexities hidden each step along the way to generate form and function during development.

短名	Annu. Rev. Cell Dev. Biol.
Journal Impact	11.43
国际分区	DEVELOPMENTAL BIOLOGY(Q1)
期刊索引	SCI Q1中科院 1 区

ISSN	1081-0706, 1530-8995
h-index	240
国内分区	生物学(1区)生物学发育生物学(1区)生物学细胞生物学(2区)

涉及主题	生物遗传学化学生物化学细胞生物学基因医学内科学细胞物理受体心理学进化生物学
出版信息	出版商: Annual Reviews Inc.，出版周期: Annual，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1995，原创研究文献占比: 0.00%，自引率:0.90%， Gold OA占比: 32.76%
平均审稿周期	网友分享经验：约稿?周期不定
平均录用比例	网友分享经验：约稿形式

Annual Review of Cell and Developmental Biology

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