​​​​​​器官移植的当前观点是一个不可或缺的资源，具有来自世界各地的该领域的关键、最新和重要进展。在每个部分的知名客座编辑的带领下，每双月刊《器官移植的最新观点》都提供了对干细胞移植、免疫抑制、耐受诱导以及器官保存和采购等主题的全新见解。该杂志共有 18 个部分，提供了对该领域的方便和全面的回顾，并且会引起研究人员、外科医生和其他医疗保健专业人员的兴趣。

Current Opinion in Organ Transplantation is an essential resource that presents key, up-to-date, and significant advancements in the field from around the world. Each issue, led by renowned guest editors, offers fresh insights on topics such as stem cell transplantation, immunosuppression, tolerance induction, and organ preservation and procurement. The journal consists of 18 sections, providing a convenient and comprehensive overview that will engage researchers, surgeons, and other healthcare professionals.

《Current Opinion in Organ Transplantation》是一个不可或缺的资源，提供来自全球该领域的关键、最新和重要进展。每期由知名客座编辑带领的双月刊，涵盖干细胞移植、免疫抑制、耐受诱导以及器官保存和采购等主题，提供全新的见解。该杂志共有18个部分，方便研究人员、外科医生和其他医疗保健专业人员全面回顾该领域的最新动态。

Current Opinion in Organ Transplantation

Purpose of review Molecular matching continues to be an important topic in organ transplantation. Over the years, several studies – larger and smaller – supported correlations of molecular incompatibility loads and clinical outcomes. However, their practical utility for clinical decision making remains controversial and there is no consensus on the context in which they should be used. Recent findings The recent literature on molecular matching can be divided into four main areas of research: several groups present improvements of the algorithmic pipelines (1), increasing the robustness of previous findings. Further clinical evidence is reported (2) in various cohorts and other organ transplant domains, such as liver and lung transplantation. Consideration is given to the application of molecular matching in the allocation of deceased organs (3), suggesting options to improve allocation equity and utility. Furthermore, evidence is provided for personalized immunosuppression based on immunological risk (4), including infection and post graft failure management. Summary There is ample evidence that current molecular matching algorithms add value to immunologic risk stratification for organ transplant recipients. First studies on how to translate these insights into patient management with respect to organ allocation and personalized medicine are underway and require further support.

Matthias Niemann

Benedict M. Matern

Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime?

分子匹配工具用于分配和免疫抑制优化。准备好了吗？

Purpose of review While multidisciplinary collaboration is a tenant of quality heart failure care and critical to the success of transplant programs, this essay challenges the temptation to shoehorn adult congenital heart disease (ACHD) patients into preexisting processes and paradigms. We explore the development of more relevant models, purposefully designed to improve ACHD transplant volumes and outcomes. Recent findings Globally, the rapid acceleration of ACHD patients living with and dying from HF stands in stark contrast to their access to transplant. Inferior early outcomes after ACHD transplant remain an undeniable barrier. And yet while all large registry datasets attest to this statistic, a few centers have achieved results comparable to those in acquired heart disease. This despite increases in both ACHD candidate complexity and referrals for Fontan Circulatory Failure. Perhaps something in their approach to care delivery is key?. Summary Alone, neither ACHD nor transplant programs can provide optimal management of HF in ACHD. A siloed approach is similarly inadequate. Building new ACHD-HF-Transplant teams, centered on the patient and supplemented by ad hoc expert partnerships, is an exciting approach that can improve outcomes, create a high-quality training environment, and in our experience, is a truly rewarding way of working together.

Katherine Kearney

Michael McDonald

Lucy Roche

Collaborative care models in adult congenital heart disease transplant

成人先天性心脏病移植中的协作护理模式

Norihisa Shigemura

Curr Opin Organ Transplant

Interdisciplinary crosstalk for enduring and future challenges in lung transplantation

肺移植中持久与未来挑战的跨学科对话

Purpose of the review Despite significant advancements in the field of vascularized composite allotransplantation, challenges, particularly regarding the long-term viability and functionality of vascularized composite allotransplantation (VCA) grafts, persist. This paper provides a review of the current literature on the longevity of VCA grafts, focusing on factors influencing graft survival, immunological considerations and clinical outcomes. Recent findings Longevity of VCA grafts is influenced by a variety of peri- and postoperative factors including cold ischemia time, human leukocyte antigen matching, environmental exposure, psychosocial factors, adherence, immunosuppression, and complications. Due to the limited number of VCA transplants performed and heterogenous reporting, direct correlation of single factors with VCA outcomes remains inconclusive. Indirect evidence, however, supports their importance. High immunosuppressive burden, frequent occurrence of acute and accumulating cases of chronic rejection remain a significant challenge of the field. Summary Insights gained from this review aim to inform clinical practice and guide future research endeavors with the goal of ameliorating outcomes after VCA transplantation and facilitate wider use of VCA grafts for restoration of tissue defects.

Franka Messner

Claudia Sardu

Palmina Petruzzo

Grasping time – longevity of vascularized composite allografts

抓住时间——血管化复合异体移植物的寿命

Purpose of review Allograft vasculopathy in vascularized composite allografts (VCA) remains understudied. This review explores the vascular changes in VCA, focused on recent literature. Recent findings Allograft vasculopathy in VCA generally includes progressive concentric myointimal thickening and luminal narrowing of arterial vessels through endothelial deterioration and proliferation of smooth muscle cells. Microvascular changes are also noted, with thrombosis and lumen narrowing in microvessels of the skin even in the absence of large vessel vasculopathy. Histopathologic reports of skin containing VCA rejection document arteriosclerosis in deep vessels that are not always reflected in skin punch biopsies. The first revision of the Banff VCA scoring system 2022 was developed to include vascular changes in VCA. The scoring system for chronic changes and antibody mediated rejection continues to be under development. Summary The study of vascular changes in VCA continues to progress. Important data and advances in experimental and clinical VCA have been reported and continue to take place. Challenges ahead include capture of clinical data that will evolve beyond transient report forms and approaching on the problem of graft failure well grounded in sound scientific methodology.

Ethan Y. Song

Brooke E. Barrow

Linda C. Cendales

Vascular changes in vascularized composite allotransplantation

血管化复合异体移植中的血管变化

Primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD) are the leading causes of graft loss in lung transplant recipients. The development of mouse lung transplant models has allowed for the genetic dissection of cellular and molecular pathways that prevent graft survival. This review provides an overview into recent mechanistic insights into PGD and CLAD.

短名	Curr. Opin. Organ. Transplant.
Journal Impact	1.68
国际分区	TRANSPLANTATION(Q3)
期刊索引	SCI Q3中科院 4 区

ISSN	1087-2418, 1531-7013
h-index	61
国内分区	医学(4区)医学移植(3区)

涉及主题	医学内科学外科移植生物遗传学免疫学重症监护医学化学生物化学病理内分泌学
出版信息	出版商: Lippincott Williams and Wilkins Ltd.，出版周期: Quarterly，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2001，原创研究文献占比: 0.00%，自引率:5.60%， Gold OA占比: 5.65%
平均审稿周期	网友分享经验：较慢,6-12周
平均录用比例	网友分享经验：一般

Current Opinion in Organ Transplantation

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Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime?

Collaborative care models in adult congenital heart disease transplant

Interdisciplinary crosstalk for enduring and future challenges in lung transplantation

Grasping time – longevity of vascularized composite allografts

Vascular changes in vascularized composite allotransplantation

Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime?

Interdisciplinary crosstalk for enduring and future challenges in lung transplantation

Vascular changes in vascularized composite allotransplantation

Grasping time – longevity of vascularized composite allografts

Update on the immunological mechanisms of primary graft dysfunction and chronic lung allograft dysfunction