护理生物研究 (BRN) 是一份经过同行评审的季刊，可帮助护士研究人员、教育工作者和从业人员整合来自许多基础学科的信息；生物学、生理学、化学、卫生政策、商业、工程、教育、传播和社会科学进入护理研究、理论和临床实践。该期刊是出版伦理委员会 (COPE) 的成员

Biological Research for Nursing is a peer-reviewed quarterly journal designed to assist nurse researchers, educators, and practitioners in integrating information from various foundational disciplines, including biology, physiology, chemistry, health policy, business, engineering, education, communication, and social sciences, into nursing research, theory, and clinical practice. The journal is a member of the Committee on Publication Ethics (COPE).

《Biological Research for Nursing》是一本经过同行评审的季刊，旨在帮助护士研究人员、教育工作者和从业人员整合来自多个基础学科的信息，包括生物学、生理学、化学、卫生政策、商业、工程、教育、传播和社会科学，以促进护理研究、理论和临床实践的发展。该期刊是出版伦理委员会（COPE）的成员。

Biological Research for Nursing

Objective Approximately 24–68% of breast cancer survivors report co-occurring psychoneurological symptoms of pain, fatigue, sleep disturbance, depression, and anxiety during and after cancer treatment. This study aimed to assess the feasibility and acceptability of acupuncture for the treatment of multiple psychoneurological symptoms among breast cancer survivors and explore metabolomic changes before and after acupuncture. Methods We conducted a single-arm, prospective pilot study of breast cancer survivors with at least two moderate to severe psychoneurological symptoms (&gt;3 on a 0–10 scale). Acupuncture was administered twice weekly for 5 weeks, for 30 minutes per session. Along with Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires, a fasting serum comprehensive hydrophilic metabolites panel was analyzed at baseline and after acupuncture. Results Eight participants (mean age 52.5 ± 10.9 years; 62.5% Black) were enrolled. Feasibility was supported, with 67% recruitment, 87.5% retention, and 98% acceptability. Post intervention, PROMIS T-scores were reduced for all psychoneurological symptoms. Significant differences in serum metabolites before and after acupuncture were F-1,6/2,6-DP, glutathione disulfide, phosphorylcholine, 6-methylnicotinamide, glutathione, and putrescine (variable importance of projection values larger than 1.5 and p values &lt;0.05). Pathway analysis indicated that glutathione metabolism ( p = 0.002, q = 0.071), and arginine and proline metabolisms ( p = 0.009, q = 0.166) were potentially involved in mechanisms of acupuncture. Conclusions Acupuncture to reduce multiple psychoneurological symptoms among breast cancer survivors was feasible and acceptable. Study findings also shed light on the metabolic pathways involved in the acupuncture response and will be tested in future studies.

Hongjin Li

Judith M. Schlaeger

Crystal L. Patil

Oana C. Danciu

Yinglin Xia

Jun Sun

Ardith Z. Doorenbos

Biological Research For Nursing

Feasibility of Acupuncture and Exploration of Metabolomic Alterations for Psychoneurological Symptoms Among Breast Cancer Survivors

针灸对乳腺癌幸存者神经精神症状的可行性及代谢组学改变的探索

Background: In order to reduce the risk of leakage of cytotoxic agents, peripherally inserted central catheters (PICC) are widely used in patients diagnosed with malignancy before chemotherapy. While inflammation has been demonstrated to be associated with deep vein thrombosis (DVT), the connection between systemic immune inflammation indexes and the formation of PICC-DVT remains unclear. Purpose: This study aims to evaluate the association between PICC-DVT and systemic immune inflammation indexes including platelet-to-lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and systemic inflammatory response index (SIRI). Methods: From August 2018 to October 2021, we enrolled consecutive patients diagnosed with malignancy who underwent PICC implantation before chemotherapy. DVT was assessed using color Doppler ultrasonography. Results: Among the 513 patients, 57 patients (11.1%) developed PICC-DVT. The optimal cutoff values for PLR, SII and SIRI were 260.1, 1318.7, and 2.7, respectively. Based on the multiple logistic regression analysis, correlations were found between PICC-DVT and elevated PLR ( p = .014), SII ( p = .012), and SIRI ( p = .022). Patients with malignancy having higher values of PLR, SII or SIRI tended to be more likely to develop PICC-DVT. Conclusions: The systemic immune inflammation indexes increases the risk of PICC-DVT and could be used as auxiliary predictive tests for PICC-DVT.

Na Li

Jing Huang

You Feng

Hucheng Yan

Shihui Min

Xin Chen

Association Between Systemic Immune Inflammation Indexes and DVT in Patients With Malignancy Requiring PICC Insertion

恶性肿瘤患者需行PICC置管中全身免疫炎症指数与深静脉血栓的相关性

Purpose: Exposure to adversity during childhood and adolescence is associated with numerous health conditions in adulthood; telomere shortening may be a mechanism through which adversity contributes to poor outcomes. We studied three areas of adversity (parent relational instability, child household instability, and financial instability) occurring during three epochs across childhood and adolescence and their associations with telomere length during adolescence. Methods: Data were obtained from the first wave of a longitudinal cohort study of youth aged 11–17 and their primary caregiver. Caregivers completed demographic and adversity questionnaires; youth provided a saliva sample for DNA extraction for telomere analysis. Results: Of 879 youth, over half experienced some adversity. More than one third experienced parent relational instability in each age epoch, with nearly a quarter experiencing parent relational instability in all age epochs. Youth experienced a similar pattern of financial instability but lower rates of child household instability. Youth experiencing parent relational instability at two or three epochs had shorter telomeres compared to those without any parent relational instability ( p &lt; .004). Youth who experienced child household instability in two age epochs had shorter telomeres ( p = .003) and youth who experienced financial instability across all three epochs had shorter telomeres ( p = .013) compared to youth without these adversities. Conclusion: Continuing exposure to adversity in early childhood may be more likely to affect telomere length. Research is needed to further determine adversities exerting the most effect and to understand if early telomere shortening has long term health effects.

Rita H. Pickler

Jodi L. Ford

Alai Tan

Christopher Browning

Jake Tarrence

Darlene A. Kertes

Childhood Adversity and Telomere Length

童年逆境与端粒长度

Objective: The aim of this study was to explore the causal relationships between chronic pains (back pain, facial pain, general pain, headaches, knee pain, hip pain, neck/shoulder pain, stomach/abdominal pain) and analgesics (codeine, diclofenac, ibuprofen, morphine, paracetamol, tramadol) with telomere length using Mendelian randomization methods. Methods: In the study, various statistical methods including inverse variance weighted (IVW), Mendelian Randomization-Egger, weighted median, simple mode, and weighted mode were used to investigate the relationships between chronic pains, analgesics, and telomere length. Heterogeneity and pleiotropy tests were conducted to ensure the accuracy of the results. Results: The results of the IVW analysis revealed positive causal relationships between hip pain (odds ratio (OR): 1.145; 95% confidence interval (CI): 1.021–1.285; p = .020), and stomach/abdominal pain (OR: 1.100; 95% CI: 1.008–1.200; p = 0.033) with telomere length. Use of tramadol (OR: 0.074; 95% CI: 0.009–0.605; p = 0.015) had a negative causal relationships with telomere length. Conclusion: This study found positive associations between hip pain and stomach/abdominal pain with telomere length, and a negative association between tramadol and telomere length. However, no significant causal relationships were found with other types of chronic pains and analgesics. This could help develop healthier chronic pain treatments, avoiding the abuse of analgesics.

Jiahe Chen

Haotian Liu

Yulin Pang

Yubo Wang

Ziqi Ren

Jianli Liu

Yang Nan

Dan Liu

Genetic Association of Chronic Pains and Analgesics With Telomere Length: A Mendelian Randomization Study

慢性疼痛与镇痛药对端粒长度的遗传关联：一项孟德尔随机化研究

Background: Obese patients are increasingly recognized as being at higher risk for skin diseases, particularly chronic wounds. While the exact mechanisms remain unclear, obesity is suspected to influence the development of chronic injuries via inflammatory biomarkers. Single nucleotide polymorphisms (SNPs) may further influence gene expression, protein function, and levels of inflammatory biomarkers through various mechanisms, thereby modulating inflammatory responses that contribute to wound pathogenesis. Methods: A two-sample two-step Mendelian Randomization (MR) was employed to explore the causal relationship between obesity and chronic wounds, focusing on the mediating role of inflammatory biomarkers. SNPs were used as instrumental variables (IVs) to infer causality. Obesity-related genetic data were sourced from the UK Biobank and GIANT consortium. Genome-wide association studies provided data on 92 inflammatory biomarkers, involving 14,824 and 575,531 individuals. Pressure injuries, lower limb venous ulcers, and diabetic foot ulcer data were obtained from FinnGen R10 and the Pan-UK Biobank. Results: Obesity significantly increased the risk of pressure injuries, lower limb venous ulcers, and diabetic foot ulcers. CCL19, hGDNF, IL-12B, and TNFRSF9 were identified as mediators in obesity-induced lower limb venous ulcers. Conclusion: This study provides genetic evidence that obesity leads to lower limb venous ulcers via inflammatory biomarkers, suggesting potential therapeutic targets for intervention.

Hai Xu

Sheyuan Ding

Yu Tong

Qiong Zhang

Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers

肥胖诱导的慢性伤口中炎症生物标志物的遗传证据

Background: The timely initiation of lactogenesis II is crucial for postpartum women, with delays having significant clinical implications. This study aimed to evaluate the determinants of delayed lactogenesis II (DOL II) in high-risk pregnant women to guide clinical interventions and postnatal care protocols. Methods: We conducted a study involving high-risk pregnant women who gave birth and were admitted to our hospital’'s obstetric intensive care unit for postpartum surveillance and treatment from February 1, 2023, to April 30, 2024. We utilized Pearson correlation analysis and logistic regression to determine factors linked to DOL II. Results: Our study included 206 high-risk pregnant women, with 85 (41.26%) experiencing DOL II. Pearson correlation analysis indicated strong associations between DOL II and maternal age (r = 0.452), gestational hypertension (r = 0.514), gestational diabetes (r = 0.487), and delayed colostrum secretion (r = 0.506), all statistically significant ( p &lt; 0.05). Logistic regression analysis identified age 35 years or older (OR = 2.115, 95%CI: 1.785–2.466), gestational hypertension (OR = 2.404, 95%CI: 2.125–3.107), gestational diabetes (OR = 2.556, 95%CI: 2.008–2.879), and colostrum secretion later than one hour postpartum (OR = 3.126, 95%CI: 2.682–3.605) as independent risk factors for DOL II, all with p &lt; 0.05. Conclusions: The incidence of DOL II is significantly elevated in high-risk pregnant women, especially those aged 35 or older, those with gestational diabetes and hypertension, and those who delay the initiation of breastfeeding. It is imperative that clinical practices prioritize enhanced prenatal care and health education, robust lactation support, and improved lactation awareness among postpartum women to reduce the prevalence of DOL II.

Qianqian Liu

Hanxiang Lin

Delayed Lactogenesis II in High-Risk Pregnancies: What Should We Care

高危妊娠中的迟发性泌乳II期：我们应关注什么

Background: This study aims to investigate the association between serum calcium levels and acute coronary syndrome (ACS) risk, examining whether this relationship differs by sex, given the known differences in calcium metabolism and hormonal influences between males and females. Methods: Utilizing the Korean Genome Epidemiology Study (KoGES) prospective cohort data, our primary exposure variables were serum calcium level and sex. The incidence of ACS served as the main outcome of interest. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression analysis. An interaction analysis was conducted to assess the interaction effect of calcium level and sex on ACS incidence. Results: After adjusting for confounding variables, high calcium intake did not significantly increase ACS incidence, with a hazard ratio (HR) of 1.07 (95% CI: 0.90–1.26). There was also no significant difference in ACS risk between females and males (HR: 0.81, 95% CI: 0.61–1.04). However, interaction effect analysis revealed that higher calcium levels were associated with an increased risk of ACS only in females (HR: 1.24, 95% CI: 1.07–1.58), whereas the association in males was not statistically significant (HR: 0.90, 95% CI: 0.71–1.15). Conclusion: Our study results indicate that elevated serum calcium levels alone did not independently increase the risk of ACS; however, high serum calcium levels were associated with an increased risk of ACS in females but not in males, underscoring the importance of sex-specific factors in assessing and managing ACS risk and highlighting the necessity for personalized medical approaches to improve cardiovascular health outcomes for women.

Eujene Jung

Dong Ki Kim

Seok Jin Ryu

Hyun Ho Ryu

Sex-Specific Impact of Serum Calcium Levels on Acute Coronary Syndrome Risk: A 19-Year Cohort Study in Korea

血清钙水平对急性冠状动脉综合征风险的性别特异性影响：一项韩国19年队列研究

Abbreviation	Biol. Res. Nurs.
Journal Impact	1.99
Quartiles(Global)	NURSING(Q2)

ISSN	1099-8004, 1552-4175
h-index	56

Publication Information	Publisher: SAGE Publications Inc.，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1999，Proportion of original research papers: 69.49%，Self Citation Rate:0.00%， Gold OA Rate: 3.21%
Average review cycle	网友分享经验：>12周，或约稿
Average recruitment ratio	网友分享经验：较易

Biological Research for Nursing

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Feasibility of Acupuncture and Exploration of Metabolomic Alterations for Psychoneurological Symptoms Among Breast Cancer Survivors

Association Between Systemic Immune Inflammation Indexes and DVT in Patients With Malignancy Requiring PICC Insertion

Childhood Adversity and Telomere Length

Genetic Association of Chronic Pains and Analgesics With Telomere Length: A Mendelian Randomization Study

Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers

Childhood Adversity and Telomere Length

Genetic Association of Chronic Pains and Analgesics With Telomere Length: A Mendelian Randomization Study

Genetic Evidence of Obesity-Induced Chronic Wounds Mediated by Inflammatory Biomarkers

Delayed Lactogenesis II in High-Risk Pregnancies: What Should We Care

Sex-Specific Impact of Serum Calcium Levels on Acute Coronary Syndrome Risk: A 19-Year Cohort Study in Korea