AIDS REVIEW 发表论文报告原始科学、临床、流行病学和社会研究，这些研究有助于获得性免疫缺陷综合征和人类逆转录病毒学领域的整体知识。目前，该期刊发表评论文章（通常是通过邀请，但也将考虑自发提交的文章）。提交给 AIDS REVIEW 的手稿将被接受，但前提是作者尚未将论文提交给另一家期刊或在其他地方发表材料。

AIDS Reviews publishes original scientific, clinical, epidemiological, and social research papers that contribute to the overall understanding of acquired immunodeficiency syndrome (AIDS) and human retrovirology. The journal currently accepts commentary articles, typically by invitation, but will also consider unsolicited submissions. Manuscripts submitted to AIDS Reviews must ensure that the authors have not submitted the paper to another journal or published the material elsewhere.

《AIDS Reviews》发表关于获得性免疫缺陷综合征（AIDS）和人类逆转录病毒（HIV）领域的原始科学、临床、流行病学和社会研究的论文。这些研究有助于深化对该领域的整体理解。目前，该期刊接受评论文章的投稿，通常是通过邀请，但也会考虑自发提交的文章。提交给《AIDS Reviews》的手稿必须确保作者未将其提交给其他期刊或在其他地方发表。

AIDS Reviews

Vicente Soriano

Ana Treviño

Aids Reviews

AIDS Rev

Sexually transmitted infections keep rising up

性传播感染持续上升

HIV epidemics still exist as a major global public health burden, especially in middle- and low-income countries. Given the lack of approved vaccines, antiretroviral therapy (ART) remains the primary approach to reduce the mortality and morbidity linked to this disease. Effective treatment for HIV-1 requires the simultaneous administration of multiple drugs. However, the virus can show resistance to antiretroviral drugs, resulting in treatment failure. Therefore, this study focused on assessing the prevalence of mutations within the Indian HIV-positive population. After assessing the data, we intended to identify the most effective highly active ART (HAART) regimens for individuals with drug-resistant variants. Furthermore, our analysis revealed a spectrum of HIV mutations, with varying effects on protein stability. The significance of this analysis lies in its potential to optimize HAART selection for HIV-positive individuals by accounting for both prevalence and stability-altering mutations. By considering mutation effects on protein stability, we can modify treatment regimens, increasing the likelihood of therapy success and diminishing the risk of resistance. Moreover, this study contributes to the broader field of drug repurposing, offering insights into the rational design of antiretroviral therapies.

Priya Kalsi

Priya Jain

Gitanjali Goyal

Himanshu Sharma

In &lt;i&gt;silico&lt;/i&gt; drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population

基于计算机药物再利用方法预测印度HIV阳性人群中流行的HIV耐药变异体的最有效HAART

Smoking among persons living with HIV infection (PLWH) is estimated to be 2-3 times greater than that in the general population. Data suggest that cigarette smoking is more common among PLWH because of several factors, including lower socioeconomic status, previous, or concurrent illicit drug and alcohol use, younger age, lower education level, and concomitant depressive symptoms. Cigarette smoking among PLWH has been associated with a higher risk of certain cancers and infections as well as lowered response to antiretroviral therapy. Randomized controlled trials on behavioral interventions for tobacco use among smokers with HIV were searched in the PubMed, Cochrane Library, EMBASE, and Web of Science databases. The retrieval period was from the inception of databases to November 2023. Network meta-analysis (NMA) was performed using the Stata 18.0 software with 19 studies (3190 subjects), of which 15 reported 7-day point prevalence abstinence and seven of which reported continuous abstinence. The NMA results showed that compared with general advice plus self-help brochure, text messaging (relative risk [RR] = 4.60, 95% confidence interval [CI], 1.12-18.81) and cell phone counseling (RR = 3.29, 95% CI, 1.71-6.32) were the most effective for 7-day point prevalence abstinence among smokers with HIV infection. Moreover, the meta-analysis showed that compared with smoking counseling and self-help brochures, continuous abstinence was statistically significantly enhanced after behavioral interventions (RR = 2.52, 95% CI, 1.51-4.20). The study revealed very low-to-high-quality evidence that text messaging, telephone counseling, and smoking cessation websites were effective for smokers with HIV infection.

Xinyu Huang

Junjie Ren

Liying Zhou

Xu Hui

Liping Guo

Li Xu

Kehu Yang

Behavioral interventions for tobacco use in HIV-infected smokers: systematic review and pairwise, network meta-analysis of randomized trials

HIV感染吸烟者烟草使用的行为干预：随机试验的系统综述和成对、网络荟萃分析

The aim of this study was systematically review the acquired syphilis before and during follow-up of pre-exposure prophylaxis (PrEP) for HIV. We analyzed articles that studied PrEP users with the outcome of acquired syphilis. The eligibility criteria were studies retrieved from the United States National Library of Medicine (Pubmed), Latin American and Caribbean Health Sciences Literature (Lilacs), Embase and Scopus databases, published between 2012 and 2023, in English, Spanish or Portuguese. We performed the descriptive synthesis and quality analysis of selected studies using the Newcastle Ottawa scale or Cochrane scale. We also used random-effects models to generate pooled rate estimates for syphilis before PrEP and during follow-up. A total of 4412 studies were found and 35 were selected, all in English, and almost all with high or satisfactory quality. The review found a PrEP syphilis rate of 6.0%. A summary of three studies estimated a 2.34-fold increased risk of syphilis acquisition during PrEP, with an incidence rate of 8.89 cases/100 person-years. These findings warrant caution due to study heterogeneity. Compared to HIV-positive individuals, PrEP users exhibit potentially higher syphilis rates, particularly among those aged 33-38 years, and factors such as age ≥ 35 years, MSM status, prior sexually-transmitted infections, and longer PrEP duration (every 6 months) are associated. Future research should further investigate these PrEP-related factors contributing to heightened syphilis risk.

Nathália L Pedrosa

Patrícia M Pinheiro

Wildo N de Araújo

Acquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature

HIV暴露前预防背景下的获得性梅毒：科学文献的系统综述

More than two decades after introducing antiretroviral therapy (ART), several challenges still prevail in keeping well people living with HIV, even with "Test and Treat" and/or "Rapid Start of ART" initiatives, as well as the scale-up of ART worldwide to promote access and adherence to treatment. This review examined articles on ART adherence in Africa between 2016 and 2023, published in English and indexed in PubMed. A total of 16 articles out of 2415 were eligible and included for analyses. Overall, good ART adherence rates in sub-Saharan African (SSA) regions ranged from 43% to 84%. Rates in the center of the SSA region ranged from 58% to 80%, in the north from 50% to 83%, in the south from 77% to 84%, in the west from 43% to 60%, and in the east from 69% to 73%. Most African countries use self-reporting to assess treatment adherence, which is frequently unreliable. The main factors with negative influence on ART adherence were comorbidities, lack of motivation, socioeconomic difficulties, or side effects. Conclusion: Adherence to ART is a good indicator for controlling the spread of HIV in a given region. It is important to overcome the barriers that make it difficult to comply with ART and reinforce the factors that facilitate access to medication.

Pedro R S Almeida

Carlos A C Rafael

Victor Pimentel

Ana B Abecasis

Cruz S Sebastião

Joana de Morais

Adherence to antiretroviral therapy among HIV-1 patients from sub-Saharan Africa: a systematic review

撒哈拉以南非洲HIV-1患者抗逆转录病毒治疗的依从性：一项系统综述

Abbreviation	AIDS Rev.
Journal Impact	1.72
Quartiles(Global)	INFECTIOUS DISEASES(Q3)

ISSN	1139-6121, 1698-6997
h-index	62

Publication Information	Publisher: Permanyer Publications，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2000，Proportion of original research papers: 50.00%，Self Citation Rate:5.30%， Gold OA Rate: 0.00%
Average review cycle	网友分享经验：>12周，或约稿
Average recruitment ratio	网友分享经验：一般

AIDS Reviews

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Sexually transmitted infections keep rising up

In <i>silico</i> drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population

Behavioral interventions for tobacco use in HIV-infected smokers: systematic review and pairwise, network meta-analysis of randomized trials

Acquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature

Adherence to antiretroviral therapy among HIV-1 patients from sub-Saharan Africa: a systematic review

Sexually transmitted infections keep rising up

The burden of HIV-1 and HIV-2 epidemics in Ivory Coast

In <i>silico</i> drug repurposing approach to predict most effective HAART for HIV drug resistance variants prevalent in the Indian HIV-positive population

Behavioral interventions for tobacco use in HIV-infected smokers: systematic review and pairwise, network meta-analysis of randomized trials

Acquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature