ACTAS ESPAÑOLAS DE PSIQUIATRÍA 将优先发表与精神病学、临床心理学和心理健康领域的临床研究相关的作品。

Actas Espanolas de Psiquiatria prioritizes the publication of clinical research related to psychiatry, clinical psychology, and mental health.

《Actas Espanolas de Psiquiatria》优先发表与精神病学、临床心理学和心理健康领域相关的临床研究作品。

Actas Espanolas de Psiquiatria

Background: Schizophrenia (SZ) is a severe mental disorder that is marked by hallucinations and cognitive impairments. Ferroptosis is a type of cell death that is associated with iron and lipid peroxidation; it may play a role in SZ etiology. The present study aimed to explore the correlations between ferroptosis-related genes and SZ in three brain regions. Methods: We used the Gene Expression Omnibus dataset GSE80655 to analyze brain samples from SZ patients and controls; specifically, we evaluated the anterior cingulate cortex (Ancg), dorsolateral prefrontal cortex (DLPFC), and nucleus accumbens (nAcc). The data were preprocessed in R, and ferroptosis-related differentially expressed genes (DEGs) were identified. Pearson correlation analysis was then performed to assess correlations between these DEGs and age at death, postmortem interval, or brain pH. To identify important ferroptosis-related genes, we created a protein–protein interaction network using the Search Tool for the Retrieval of Interacting Genes/Proteins database, and visualized it using Cytoscape software. Moreover, the pROC package was used to calculate the area under the receiver operating characteristic curves for these important genes. Finally, gene set variation analysis was used for the pathway enrichment analysis of ferroptosis-related pathways, followed by the Wilcoxon rank-sum test. Results: Nine ferroptosis-related DEGs were upregulated in the Ancg region and one was downregulated in the nAcc region. In the Ancg region, the SZ group had four ferroptosis-related DEGs that were negatively correlated with postmortem interval, and the control group had five ferroptosis-related DEGs that were negatively correlated with brain pH. The protein–protein interaction network analysis of the Ancg region revealed seven significant interacting genes; tissue inhibitor of metalloproteinases 1 (TIMP1) and galectin 3 (LGALS3) were the hub genes. Gene set variation analysis revealed substantial changes in the glycolysis pathway in the Ancg region, and in the glutamate transmembrane transport pathway and unsaturated fatty acid biosynthesis process pathway in the nAcc region, in SZ patients compared with controls. Conclusions: The correlation between ferroptosis and SZ appears to be stronger in the Ancg than in the nAcc or dorsolateral prefrontal cortex. This association may be mediated by TIMP1 and LGALS3 as well as by the glycolysis pathway, indicating that these might be possible biomarkers for SZ.

Shiqin Dai

Yong Xu

Tingting Yang

Feng Wang

Yihua Jiang

Actas Españolas de Psiquiatría

Identification and Correlation Analysis of Ferroptosis-Related Genes in Three Brain Regions of Patients with Schizophrenia

精神分裂症患者三个脑区铁死亡相关基因的鉴定与相关性分析

Background: Liquid-liquid phase separation (LLPS) has been increasingly recognized as a crucial mechanism in the pathogenesis of various neurodegenerative disorders, including Alzheimer's disease (AD). There remains a paucity of effective diagnostic biomarkers for this condition. This study aims to develop and validate a novel LLPS-related molecular signature to enhance the diagnostic accuracy and early detection of AD. Methods: LLPS-related genes were identified from online databases and subjected to bioinformatic analyses, including protein-protein interaction (PPI) network analysis and least absolute shrinkage and selection operator (LASSO) regression. Based on the optimal LLPS-related genes, a diagnosis risk model was constructed, and the diagnostic ability was evaluated using a receiver operator characteristic (ROC) curve. To elucidate the biological functions of the identified LLPS-related genes, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted. Results: A total of 149 LLPS-related genes were screened, which were found to be involved in functions related to oxidative stress, apoptosis, and cancer progression. The 149 genes were refined to six optimal candidates through PPI network analysis and LASSO regression: Activator of HSP90 ATPase Activity 1 (AHSA1), Eukaryotic Translation Initiation Factor 2 Alpha Kinase 2 (EIF2AK2), Heat Shock Protein Family A (Hsp70) Member 4 (HSPA4), Notch Receptor 1 (NOTCH1), Superoxide Dismutase 1 (SOD1), and Thioredoxin (TXN). Based on the six optimal genes, a diagnostic risk model was constructed, and the diagnostic ability was verified to be promising in AD both in training, internal validation, and two external validation datasets, with area under ROC curve (AUC) above 0.8. Furthermore, significant correlations were observed between the expression of these genes and tumor immune cell infiltration. Conclusions: A six-gene diagnosis model was constructed and verified to exhibit robust diagnostic ability in AD.

Chao Qiu

Hui Xu

A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease

用于阿尔茨海默病诊断的与液-液相分离相关的六基因标志物

Background: Intracerebral hemorrhage (ICH) is a major cause of morbidity and mortality, often leading to long-term cognitive impairment that significantly diminishes the quality of life. This study investigated the relationship between visceral fat content, obesity-related indicators, and cognitive dysfunction following ICH. Methods: A total of 388 subjects with ICH who were admitted to the Neurosurgery Department of the Hospital and met the inclusion and exclusion criteria were included in this study. Obesity-related indicators, including body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR), were measured. L3 level images were obtained by abdominal computerized tomography (CT). The visceral fat content was estimated using IMAGE J software, and adiponectin levels were assessed via enzyme-linked immunosorbent assay (ELISA). The Mini-Mental State Examination (MMSE) was used to evaluate the cognitive level of patients within 2 weeks of onset, and the shortened version of the Montreal Cognitive Assessment (miniMoCA) was used to evaluate the cognitive level of patients 6 months after ICH. Univariate and multivariate analyses were used to analyze the correlations of BMI, WC, WHtR, abdominal fat, and adiponectin with cognitive impairment after ICH. Results: BMI, WC, and WHtR were lower in the cognitive impairment group (p &lt; 0.01). Overweight patients exhibited higher MMSE scores than normal-weight patients (p &lt; 0.05) and higher miniMoCA scores than obese patients (p = 0.014). Abdominal obesity, assessed by WC and WHtR, was associated with higher MMSE scores (p = 0.022 and 0.003, respectively). Multivariate analysis indicated that WHtR was associated with cognitive impairment risk post-ICH (odds ratio (OR) = 0.233, 95% confidence interval (CI) (0.071, 0.762); p = 0.016). Although no overall association was found between adiponectin levels and cognitive impairment, subgroup analysis revealed lower adiponectin levels in overweight patients with cognitive impairment (p = 0.040). Conclusion: WHtR is independently and inversely associated with cognitive impairment after ICH. There is no significant correlation between adiponectin with cognitive impairment after ICH, while subgroup analysis indicates that adiponectin levels are lower in overweight patients with cognitive impairment.

Yuchen Wang

Xutong Zhu

Xin Zhang

Association between Visceral Fat Content and Obesity-Related Indicators with Cognitive Impairment after Intracerebral Hemorrhage

脑出血后认知障碍与内脏脂肪含量及肥胖相关指标的关联

Background: Maintaining good sleep quality is crucial for improving the efficiency of college students. Therefore, this cross-sectional study aims to elucidate the prevalence of sleep disorders among students and analyze its risk factors. Methods: A cross-sectional study was conducted on college students between March 2022 and December 2022. A well-designed questionnaire was filled out by college students from a certain university in China. Students whose scores on the Pittsburgh Sleep Quality Index (PSQI) scale exceeded 8 were included in the sleep disorder group (SD group), while those with lower were included in the non-sleep disorder group (ND group). Furthermore, single-factor analysis was used to investigate the relationship between general information and sleep disorders. Additionally, multifactor logistic regression was utilized to identify the independent risk factors contributing to the occurrence of sleep disorders among college students. Results: We observed that the total PSQI score was 7.00 ± 2.17, and the incidence of sleep disorders was 38% among 326 college students. The level of sleep disorders was low (35.89%), scoring 2 or 3 in each component. A high number of students (78.22%) did not use sleep medication in the past 1 month. The level of daytime dysfunction was low (25.76%), scoring 2 or 3 in each section. The differences between the two groups in terms of academic performance, economic level, risk of smartphone addiction, pressure level, family relationship, and physical activity were statistically significant (p &lt; 0.05). Furthermore, multifactor logistic regression analysis indicated that several factors, such as academic performance, smartphone addiction risk, pressure level, and family relationship, were independent risk factors affecting the occurrence of sleep disorders among college students (p &lt; 0.05). Conclusion: The prevalence of sleep disorders among students in a certain university is 38%. Factors affecting sleep disorders include poor academic performance, high smartphone addiction risk and stress levels, and challenging family relationship.

Lingjia Hu

Kun Wang

Guihua Fu

Hongjuan Wei

Yu Wu

Cross-Sectional Study on Analysis of the Prevalence and Influencing Factors of Sleep Disorders among College Students in a Certain University in China

中国某大学大学生睡眠障碍流行情况及影响因素的横断面研究

Background: University life is a phase of developing personal and professional skills, but it brings challenges such as distancing from family and supporting networks, difficulties with academic tasks, loneliness, new relationships, competitiveness, and social, socioeconomic, and psychological vulnerability, among others. These conditions can lead to the development of illnesses such as anxiety, depression, sleeping disorders, suicide, self-harming, and excessive drug use, including psychotropic medications. Therefore, this study aimed to evaluate the use of psychotropic medications and its association with sociodemographic, academic, behavioral, and health variables in Brazilian university students. Methods: A cross-sectional, quantitative research, with a sampling of 524 students from a Brazilian public Higher Education Institution (Federal University of Mato Grosso - UFMT). The collection took place from October 10th to December 30th, 2022. An online questionnaire was applied with sociodemographic and clinical questions—the General Anxiety Disorder Questionnaire-7 (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9). The data were descriptively and inferentially analyzed; in the descriptive analysis, the absolute (FA) and relative (FR) frequencies of each category investigated were presented; and for bi- and multivariate analyses, Poisson regression with robust estimation was used. Results: The participants were at the median age of 22 years old, the majority were female (69.7%), heterosexual (68.1%), with medium/high subjective social status (82.4%) and without being involved in a romantic relationship (54%). The prevalence of psychotropic medication use was 26.1%, considering that 17.5% was not prescribed by a medical professional. The most used class of medications was antidepressants (91 participants), followed by natural medicines (38 participants). Among the segments associated with the use of psychotropic drugs were female individuals, romantic relationships, perception of academic performance by postgraduate students, and previous diagnoses of mental or mood disorders (depression and anxiety). Conclusions: The results obtained highlight the importance of research on mental health among university students, especially regarding the use of psychotropic drugs, which must be monitored by a qualified professional. At the university, these data can be important for the development of policies aimed at health and life quality, in addition to contributing to the strengthening of national and international partnerships, and promoting the scientific production in the area.

Cássia Regina Primila Cardoso Berti

Alice Milani Nespollo

Moises Kogien

Evelyn Kelly Das Neves Abreu

Samira Reschetti Marcon

Tatiane Lebre Dias

Variables Associated with the Use of Psychotropic Medications by Brazilian University Students

巴西大学生使用精神药物相关变量

Abbreviation	Actas. Esp. Psiquiatr.
Journal Impact	1.01
Quartiles(Global)	PSYCHIATRY(Q4)

ISSN	1139-9287, 1578-2735
h-index	39

Publication Information	Publisher: STM Editores S.A，Publishing cycle: Bimonthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 1996，Proportion of original research papers: 82.76%，Self Citation Rate:0.00%， Gold OA Rate: 0.00%
Average review cycle	网友分享经验：>12周，或约稿
Average recruitment ratio	网友分享经验：容易

Actas Espanolas de Psiquiatria

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Identification and Correlation Analysis of Ferroptosis-Related Genes in Three Brain Regions of Patients with Schizophrenia

A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease

Association between Visceral Fat Content and Obesity-Related Indicators with Cognitive Impairment after Intracerebral Hemorrhage

Cross-Sectional Study on Analysis of the Prevalence and Influencing Factors of Sleep Disorders among College Students in a Certain University in China

Variables Associated with the Use of Psychotropic Medications by Brazilian University Students

Identification and Correlation Analysis of Ferroptosis-Related Genes in Three Brain Regions of Patients with Schizophrenia

A Six-Gene Signature Related to Liquid-Liquid Phase Separation for Diagnosis of Alzheimer's Disease

Association between Visceral Fat Content and Obesity-Related Indicators with Cognitive Impairment after Intracerebral Hemorrhage

Cross-Sectional Study on Analysis of the Prevalence and Influencing Factors of Sleep Disorders among College Students in a Certain University in China

Variables Associated with the Use of Psychotropic Medications by Brazilian University Students