BASIC AND CLINICAL ANDROLOGY 是男科领域的开放获取期刊，涵盖人类和动物模型中男性生殖和性健康的各个方面。该杂志旨在揭示国际社会男科领域的各种临床进展和研究进展。

Andrologie is an open-access journal in the field of andrology, focusing on various aspects of male reproductive and sexual health in both human and animal models. The journal aims to highlight the latest clinical advancements and research findings in the field of andrology, fostering international academic exchange.

《Andrologie》是一个开放获取的男科期刊，专注于男性生殖和性健康的各个方面，包括人类和动物模型的研究。该期刊旨在展示男科领域的最新临床进展和研究成果，促进国际学术交流。

Andrologie

Christian De Geyter

Maria De Geyter

Hermann M. Behre

Assistierte Reproduktion

辅助生殖

Eberhard Nieschlag

Ansätze zur hormonellen männlichen Kontrazeption

男性激素避孕方法的探讨

Axel Kamischke

Therapieversuche bei idiopathischer Infertilität

特发性不孕症的治疗尝试

Hermann van Ahlen

Sabine Kliesch

Störungen der Erektion, Kohabitation und Ejakulation

勃起障碍、性交和射精障碍

Claus Rolf

Michael Zitzmann

Seneszenz und Altershypogonadismus

感觉减退与老年性性腺功能减退

Abstract Background Obstructive azoospermia commonly is caused by CBAVD(Congenital Bilateral Aplasia of the Vas Deferens), mainly due to the cystic fibrosis transmembrane conductance regulator (CFTR) and adhesion G protein-coupled receptor G2(ADGRG2) mutations. The genetic landscape for Chinese CBAVD patients is unclear, leading to debates over genetic screening, counseling, and assisted reproduction strategies. This study investigates the prevalence of CFTR and ADGRG2 mutations in a southern Chinese cohort of CBAVD patients and evaluates the impact of CFTR mutations on intracytoplasmic sperm injection (ICSI) outcomes. Results CFTR mutations were identified in 71.4% (30/42) of CBAVD patients, with a total of 36 CFTR mutation sites across 13 types identified, including two novel mutations. A novel ADGRG2 mutation was also detected. Betweenthe CFTR mutation-CBAVD group and the non-CBAVD OA group, a significant difference was observed only in the 2 Pronuclei(2PN) rate (79.5% vs 86.2%, P = 0.0065), while fertilization rates, pregnancy rates, miscarriage rates, and live birth rates showed no significant differences. Between the CFTR mutation-CBAVD group and the CBAVD group without CFTR mutation, there were no significant differences in fertilization rates, 2PN rates, pregnancy rates, miscarriage rates, or live birth rates. Conclusion Chinese CBAVD patients primarily exhibit mutations in the CFTR and ADGRG2 genes. Therefore, targeted gene testing for CFTR and ADGRG2 is more suitable compared to WES for CBAVD patients. Considering that the genetic factors of approximately 30% of CBAVD patients remain unknown, it is recommended to perform massive parallel sequencing for patients who test negative for CFTR and ADGRG2 gene screening. Despite these genetic factors, ICSI outcomes were not adversely affected, except for the 2PN rate. However, genetic counseling remains crucial for Chinese CBAVD patients before undergoing assisted reproduction.

Haishan Hu

Qing Zhou

Yanlin Ma

Lingxiao Zhang

Basic and Clinical Andrology

Genetic diagnosis and outcomes of intracytoplasmic sperm injection in South Chinese patients with congenital bilateral aplasia of the vas deferens

中国南方先天性双侧输精管缺如患者胞浆内单精子注射的遗传诊断与结局

Abstract Background Affected sexual relationships affect both the quality of life of men and women. Platelet-derived therapies are becoming increasingly popular in various medical and surgical fields because of their ability to aid in tissue healing and vascular remodeling. This study aimed to assess the safety and effectiveness of platelet-rich plasma (PRP) injections in treating patients with erectile dysfunction (ED). Results Fifty-two participants with mild to moderate ED were divided into two groups: group A, who received three PRP penile injections, and group B, who received three saline injections (5 ml for each injection site). The International Index of Erectile Function (IIEF) was used to evaluate all participants. A month after the last injection, the PRP group's IIEF was 16.12 ± 1.25, while the placebo group's was 15.99 ± 1.21 ( p = 0.683). Following a 3-month period, the IIEF for the PRP group was 16.44 ± 1.17, while the placebo group's was 16.31 ± 1.06 ( p value = 0.653). Following a 6-month period, the IIEF for the PRP group was 16.35 ± 1.45, while that for the placebo group's was 16.23 ± 1.19 ( p = 0.727). In terms of IIEF, there was no significant difference between the two groups after one, three, and six months of treatment. Conclusion In brief, our research revealed no data to support the application of PRP injections in the management of mild-to-moderate ED.

Ahmed M Ragheb

Amr M Lotfy

Mohamed Fahmy

Akrm A Elmarakbi

Safety and efficacy of platelet-rich plasma injection for treatment of erectile dysfunction: a prospective randomized controlled study

富血小板血浆注射治疗勃起功能障碍的安全性和有效性：一项前瞻性随机对照研究

Cryopreservation of human spermatozoa is a widely used technique in the assisted reproduction technology laboratory for the storage of gametes for later use, for the fertility preservation and for sperm donation programs. Cryopreservation can cause damage to membrane, cytoskeletal, acrosome and increased oxidative stress, sperm DNA damage and transcriptome changes. To assess the impact of storage time on the transcriptome of frozen human spermatozoa, semen samples were collected from 24 normospermic donors of whom 13 had cryostored semen for a short-time (1 week) and 11 had cryostored semen for a long-time (median 9 years).

Sara Stigliani

Adriana Amaro

Francesco Reggiani

Elena Maccarini

Claudia Massarotti

Matteo Lambertini

Paola Anserini

Paola Scaruffi

The storage time of cryopreserved human spermatozoa does not affect pathways involved in fertility

冷冻保存的人精子储存时间不影响与生育相关的通路

Abstract Background Primary hypogonadism is a recognised complication in survivors of testicular cancer. However, secondary hypogonadism can result from other causes that suppress the hypothalamic-pituitary axis, including obesity, high dose glucocorticoids, chronic end organ failure, and diabetes. The aim of this study was to explore low total serum testosterone in Australian survivors of testicular cancer and examine associations with body mass index, age, and prior chemotherapy use. Methods Clinical data including height, weight, diagnosis, treatment, and hormonal evaluations during follow-up were extracted from the Australian and New Zealand Urogenital and Prostate (ANZUP) Cancer Trials Group Chemocog study (2007-2012), accompanied by data from two Australian, high-volume testicular cancer centres included in the iTestis testicular cancer registry (2012-2019). Low testosterone was defined by a serum concentration of testosterone (T) &lt; 10 nmol/L, and was classified as primary by a serum concentration of luteinising hormone (LH) &gt; 8 IU/L, otherwise as secondary. Results Two hundred eighty-five individuals with either stage 1 or advanced testicular cancer were included. Of these, 105 (37%) were treated with orchidectomy and chemotherapy. Forty-nine (17%) met criteria for low testosterone during follow-up: 21 (43%) had primary and 27 (55%) had secondary low testosterone. Survivors of testicular cancer with higher body mass index were more likely to display low testosterone, both primary ( p = 0.032) and secondary ( p = 0.028). Our data did not show evidence of an association between older age or chemotherapy use and low testosterone in our cohort. Conclusions Low total serum testosterone was common in survivors of testicular cancer, and associated with a higher body mass index prior to orchidectomy, suggesting that elevated body mass index may contribute to low testosterone in this population, and that body weight, diet, and exercise should be addressed in testicular cancer follow-up.

Grace Y. Kim

Ciara Conduit

Sophie O’Haire

Chia Yuen Chong

Olivia Baenziger

Jeremy Lewin

Benjamin Thomas

Nathan Lawrentschuk

Martin R. Stockler

Ian Olver

Peter Grimison

Ben Tran

Association between low total serum testosterone and body mass index in Australian survivors of testicular cancer: a retrospective analysis

澳大利亚睾丸癌幸存者中低总血清睾酮与体重指数的关联：回顾性分析

Surgical penile prosthesis implantation (PPI) procedures have only recently been introduced to mainland China, with the overall number of such procedures having been conducted to date remaining relatively low. Accordingly, relatively little remains known with respect to the annual trends in PPI. Accordingly, this study was developed with the goal of clarifying these trends across different hospitals in mainland China, while also providing a single-center overview of post-PPI patient outcomes.

Chenwang Zhang

Haowei Bai

Chenkun Shi

Huirong Chen

Peng Li

Yuhua Huang

Huixing Chen

Fujun Zhao

Chencheng Yao

Zheng Li

Erlei Zhi

Changing trends in penile prosthesis implantation in China and an overview of postoperative outcomes from a single center

中国阴茎假体植入术的变化趋势及单中心术后结果概述

短名	Basic Clin. Androl.
Journal Impact	2.33
国际分区	ANDROLOGY(Q2)

ISSN	1166-2654, 1760-5377, 2051-4190
h-index	26

涉及主题	医学生物遗传学妇科怀孕内科学男科化学生物化学内分泌学不育解剖生殖医学哲学植物精子艺术病理人文学科
出版信息	出版商: Springer Paris，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 1991，原创研究文献占比: 73.91%，自引率:0.00%， Gold OA占比: 100.00%
平均审稿周期	网友分享经验：22 Weeks

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