Turk Jinekoloji ve Obstetrik Dernegi Dergisi

This study aimed to examine the associations between follicular distribution pattern (FDP) in polycystic ovaries and menstrual disturbances in women with infertility.A retrospective review of patients was performed (n=73). Ultrasound images from cycle day 2-5 of a spontaneous or progestin induced menstrual cycle were reviewed. Ovaries were classified as polycystic ovarian morphology (PCOM) if they contained ≥12-follicles measuring 2-9 mm in diameter. Images of PCOM ovaries were classified as having a peripheral cystic pattern (PCP) with follicles arranged at the periphery of the ovary, or general cystic pattern (GCP) if follicles were dispersed heterogeneously throughout the ovarian stroma. Menstrual disturbance was assessed by questionnaire, and oligomenorrhea was defined as cycles >35 days in length.PCP was more strongly associated with menstrual irregularity that GCP. 94% of subjects with bilateral PCP-experienced oligomenorrhea compared with 65% of women with a unilateral PCP ovary [odds ratio (OR) 9; p<0.05]. 29% of women with bilateral GCP ovaries experienced menstrual disturbances, less than bilateral PCP (OR 36; p=0.002), but similar to unilateral PCP (OR 3; p=0.07). Serum testosterone and luteinizing hormone (LH) levels were significantly correlated with the ovarian FDP.There is a relationship between menstrual irregularity or certain types of serum steroids and ovarian morphology. It remains unknown if morphology, testosterone or LH causes the menstrual disturbance or if they are co-initiated by an intervening factor.

Ginevra Mills

Bernice Goorah

Shai E Elizur

Weon-Young Son

Michael H Dahan

Journal of Turkish Society of Obstetric and Gynecology

Relationship between the follicular distribution pattern of polycystic ovaries and the degree of menstrual disturbance and serum sex steroid levels

多囊卵巢卵泡分布模式与月经紊乱程度及血清性类固醇水平的关系

ÖzAmaç: Jinekolojik maligniteler tüm dünyada kadınlarda mortalite ve morbiditenin önemli nedenleridir.Cerrahi tedavi önemli bir tedavi yöntemi olsa da gerek cerrahinin büyüklüğü, gerek hastaya bağlı faktörler postoperatif süreçleri etkilemektedir

Pınar Karabacak

Ahmet Bindal

İlyas Turan

Evrim Erdemoglu

Berit Gökçe Ceylan

The NEWS2 score predicts prolonged hospitalization in the intensive care unit in major surgery patients

NEWS2评分预测重大手术患者在重症监护病房住院时间延长

PRECIS:Continuous studies have been made to make medical treatment more successful in treating ectopic pregnancy, but sufficient results have not been obtained.In our research, we think that the levels of magnesium and potassium from maternal electrolytes and the plasma protein albumin level may help predict the success of medical treatment in the treatment of ectopic pregnancy in addition to β-hCG, which is the most used parameter in the literature.In addition, we believe that correcting blood electrolyte and albumin values and adjusting them to reference values will increase the success of TD-Mtx treatment in ectopic pregnancy treatment.

Yusuf Başkıran

Kazım Uçkan

Talip Karaçor

İzzet Çeleğen

Züat Acar

The impact of maternal electrolyte and albumin levels on the efficacy of single-dose methotrexate treatment for ectopic pregnancies

母体电解质和白蛋白水平对单剂量甲氨蝶呤治疗异位妊娠疗效的影响

Objective: To compare the short-term results of classic single-layer uterine closure and double-layer purse-string uterine closure (Turan technique) techniques in cesarean section in terms of the incidence of ischiocele formation. Materials and Methods:This was a prospective randomized controlled trial study.Participants undergoing first-time cesarean delivery were randomized into two groups.Fifty-eight participants were included in the double-layered uterine closure group (study group), while 53 participants were randomized into the classical single-layered uterine closure group (control group).For comparison of isthmocele formation, transvaginal ultrasound examination was planned in all patients 6 weeks after surgery.The operation data,the formation of isthmocele, its dimensions and volume were recorded.Results: A total of 111 women were included in the study.The incidence of ischiocele at 6 weeks after birth was not significantly different between the groups (p=0.128).Isthmosel was detected in 20.8% of single-layer closures, and this rate was determined as 10.3% in the purse technique.In the Kerr incision made during surgery, the uterine incision size did not differ in either group, but the uterine incision length after suturing was significantly smaller in the purse technique compared with the other group (p<0.001). Conclusion:The incidence of ischiocele formation after cesarean section and the depth of the ischiocele was independent of the uterotomy closure technique.

Elif Yıldız

Burcu Timur

Comparison of classic single-layer uterin suture and double-layer purse-string suture techniques for uterus closure in terms of postoperative short-term uterine isthmocele: A prospective randomized controlled trial

经典单层子宫缝合与双层荷包缝合技术在子宫闭合中的比较：一项关于术后短期子宫峡部憩室的前瞻性随机对照试验

PRECIS:The presence of PD-L1 expression and Microsatellite Instability in endocervical clear cell carcinomas predicts the immunotherapy may yield promising results in the treatment of endocervical clear cell carcinomas as well.

Pınar Bulutay

Özgür Can Eren

Özlem Özen

Asuman Nihan Haberal

Nilgün Kapucuoğlu

Clear cell carcinoma of the uterine cervix; an unusual HPV-independent tumor: Clinicopathological features, PD-L1 expression, and mismatch repair protein deficiency status of 16 cases

子宫颈透明细胞癌：一种罕见的HPV阴性肿瘤：16例病例的临床病理特征、PD-L1表达及错配修复蛋白缺陷状态

This study aimed to determine whether the use of human chorionic gonadotropin (hCG) as a trigger could offer a potential solution for addressing empty follicle syndrome following the administration of a trigger for gonadotropin-releasing hormone agonist.

Zeynep Ece Utkan Korun

Ayşen Yücetürk

Özge Karaosmanoğlu

Yiğit Çakıroğlu

Bülent Tıraş

Might retrigger with human chorionic gonadotropin be a solution for empty follicle syndrome after gonadotropin releasing hormone agonist trigger?

重新触发人绒毛膜促性腺激素是否是促性腺激素释放激素激动剂触发后空卵泡综合征的解决方案？

To evaluate the effect of growth hormone (GH) supplementation on outcomes of in vitro fertilization (IVF) or Intracytoplasmic sperm injection (ICSI) for women with poor ovarian response. Relevant randomized controlled trials (RCTs) were obtained through search in several databases including PubMed, Scopus, Clinicaltrials.gov, Google Scholar, and Cochrane Library. Outcome measures included live birth rate, clinical pregnancy rate, cycle cancelation rate, number of retrieved oocytes, number of transferred embryos, total dose of gonadotropin, duration of gonadotropin treatment, and peak estradiol level. Additionally, a meta-regression analysis was carried out to determine any potential linear relationships between these outcomes and IVF success. After analyzing 18 RCTs comprising of 1870 patients, the study found that GH supplementation improved the number of retrieved oocytes [standardized mean difference (SMD), 0.65; 95% confidence interval (CI), 0.29-1.00] and transferred embryos group (SMD, 0.80, 95% CI, 0.39, 1.21) as well as peak E2 level (SMD, 1.20; 95% CI, 0.59, 1.81). While reduced the total dose and duration of gonadotropin treatment (SMD, -0.82, 95% CI, -1.25, -0.39, and SMD, -0.63, 95% CI, -1.04, -0.22, respectively). The meta-regression analysis found no linear relationship between clinical pregnancy, live birth rate, or cycle cancelation rate and the outcomes measured (p>0.1). Based on the available evidence, GH supplementation appears to improve the outcomes of IVF or ICSI in women with poor response. However, there is a need for further RCTs with larger sample sizes to determine the cost-effectiveness of adding GH to conventional protocols of IVF/ICSI for treating infertility in women with poor ovarian response.

Faezeh Zakerinasab

Qumars Behfar

Reza Parsaee

Fariba Arbab Mojeni

Arina Ansari

Niloofar Deravi

Reza Khademi

The effects of growth hormone supplementation in poor ovarian responders undergoing In vitro fertilization or Intracytoplasmic sperm injection: A systematic review and meta-analysis of randomized controlled trials

生长激素补充对体外受精或卵胞浆内单精子注射中卵巢反应不良者的影响：随机对照试验的系统评价和荟萃分析

Recurrent spontaneous abortion (RSA) is defined as two or more pregnancy losses before 24 gestational weeks, accounting for 1-3% of fertile couples. A vast majority of single-nucleotide polymorphisms (SNPs) in some

Gholamreza Bahari

Mohsen Taheri

Mojgan Mokhtari

Mahdiyeh Moudi

Mahdi Majidpour

Hossein Shahraki Ghadimi

Association between Mir-499, Mir-27a, and Mir-146a polymorphisms and their susceptibility to recurrent spontaneous abortion; in silico analysis

Mir-499、Mir-27a 和 Mir-146a 多态性与复发性自然流产易感性的关联；计算机模拟分析

High-intensity focused ultrasound (HIFU) is a non-surgical and noninvasive treatment modality that depends on external ultrasound energy sources that induce focused mass ablation and protein degeneration in the treatment area via thermal energy penetration under the intact skin. We aim in our study to collectively evaluate the safety of HIFU for the treatment of different obstetric and gynecological diseases in the literature. We searched PubMed, Scopus, and Science Direct databases, without restriction on date or language, from the inception of these databases until January 20, 2024. We also examined the references of the included studies in the Mendeley archive for eligible articles. We found a total of 706 studies. After the screening and selection process, 56 participants were included. Our dichotomous outcomes were pooled in our single-arm meta-analysis as risk ratio (RR) and with 95% confidence interval (CI) while our continuous outcomes were pooled as mean change and 95% CIs. Fixed- or random-effects models were applied depending on the heterogeneity detected. Our systematic review and meta-analysis included 56 studies including 11.740 patients. Depending on the Society of Interventional Radiology (SIR) classification for adverse effects. The results of this meta-analysis for the type A category that did not require clinical intervention found that pain in the treatment site estimated RR with 95% CI: 0.61 (0.33, 0.89), abnormal vaginal discharge 0.16 (0.073, 0.24), low-grade fever (<38 °C) 0.005 (0.002, 0.009). Sensory abnormalities of the lower limbs were examined in 3390 individuals and observed in only 19 patients who experienced gradual relief of symptoms within one month after treatment. Regarding SIR type B, 99 of a total of 6.437 patients had small vesicles and superficial burns with pooled RR and 95% CI: 0.012 (0.007, 0.018). In terms of groin or perianal and lower abdominal pain, our RRs with 95% CIs were 0.1 (0.067, 0.13) and 0.38 (0.25, 0.51). However, vaginal bleeding was detected in only 32 out of a total of 3.017. Major adverse events like lumber disc herniation, thrombocytopenia, and renal failure, were unmentionable. Additionally, our included studies did not record any deaths. HIFU, either alone or in combination with oxytocin or any other enhancing agent, is safe for patients with different gynecological and obstetric diseases. In terms of efficacy, it showed promising results compared with traditional treatment lines. To our knowledge, we are the first and most comprehensive meta-analysis in the literature that has studied the different safety outcomes related to HIFU as a treatment modality for different obstetric and gynecological diseases with a very large sample size, making our evidence strong and less attributed to errors.

Mostafa Maged Ali

Chileshe Raphael Mpehle

Esther Olusola

Phuti Khomotso Ratshabedi

Ebtehal Ali Helal Farag

How safe is high-intensity focused ultrasound? An intriguing solution for obstetric and gynecological diseases: A systematic review

高强度聚焦超声有多安全？一种有趣的妇产科疾病解决方案：系统综述

This study aimed to assess the effect of ethanol on the ovarian reserve and endometrium of rats by evaluating anti-Müllerian hormone (AMH) levels and follicle counts.

Enes Karaman

Mehmet Emin Ayağ

Negative effects of ethanol on ovarian reserve and endometrium thickness: An animal study

乙醇对卵巢储备和子宫内膜厚度的负面影响：一项动物研究

Publication Information	Publisher: Turkish Society of Obstetrics and Gynecology，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2009，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%

Turk Jinekoloji ve Obstetrik Dernegi Dergisi

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