是一份国际、同行评审和开放获取期刊。它为发表化学所有领域和密切相关领域的原创科学研究提供了一个论坛。欢迎评论、专题、科技文章和简短的交流。

Acta Chimica Slovenica is an international, peer-reviewed, open-access journal that provides a platform for the publication of original scientific research in all areas of chemistry and closely related fields. The journal welcomes reviews, special topics, technical articles, and brief communications.

《Acta Chimica Slovenica》是一份国际同行评审的开放获取期刊，致力于为化学及其相关领域的原创科学研究提供一个发表平台。期刊欢迎各类文章，包括评论、专题研究、科技文章和简短交流。

Acta Chimica Slovenica

Modern drug discovery is mainly based on the de novo synthesis of a large number of compounds with a diversity of chemical functionalities. Though the introduction of combinatorial chemistry enabled the preparation of large libraries of compounds from so-called building blocks, the problem of successfully identifying leads remains. The introduction of a dynamic combinatorial chemistry method served as a step forward due to the involvement of biological macromolecular targets (receptors) in the synthesis of high affinity products. The major breakthrough was a synthetic method in which building blocks are irreversibly combined due to the presence of a receptor. Here we present various receptor-based combinatorial chemistry approaches. Huisgen's cycloaddition (1,3-dipolar cycloaddition of azides and alkynes) forms stabile 1,2,3-triazoles with very high receptor affinity that can reach femtomolar levels, as the case with acetylcholinesterase inhibitors shows. Huisgen's cycloaddition can be applied to various receptors including acetylcholinesterase, acetylcholine binding protein, carbonic anhydrase-II, serine/threonine-protein kinase and minor groove of DNA.

Goran Šinko

Nikola Maraković

Acta chimica slovenica

The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

锁即钥匙：基于受体组合化学的新型药物开发

The effect of heterocyclic compounds, derived from benzimidazole (BnZ), namely1-Benzyl-2-phenyl 1H-benzimidazole (BI) and 1-(4-Nitrobenzyl)-2-(4-nitrophenyl)-1H-benzimidazole (NNBI), on the carbon corrosion steel in 1M HCl medium was assessed by electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP). The effects of the concentration and the temperature were studied. The determined electrochemical parameters showed that the two inhibitors are of mixed type. The inhibition efficiency of NNBI was lesser than that of BI. The most electron-withdrawing substituent offers the lowest efficiency. The mechanism of action of these inhibitors has been defined by the thermodynamic study. Calculated ΔG° ads, Ea, ΔH° a, and ΔS° a values confirmed that BI and NNBI adsorb through a chemical and physical process. The adsorption process was found to be spontaneous and followed the Langmuir adsorption isotherm. The quantum chemical parameters calculated by density functional theory (DFT) and molecular dynamics simulation (MDS) corroborate both the experimental data and those of the literature.

Sonia Benabid

Linda Toukal

Inhibition Effect of Benzimidazole Derivatives on the Corrosion of Mild Steel in Acidic Medium: Experimental and Theoretical Studies

苯并咪唑衍生物对酸性介质中软钢腐蚀的抑制作用：实验与理论研究

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promising source of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically determined, from Aaptos sp. collected from Bunaken National Park, Indonesia, as an anticancer agent, specifically targeting colorectal cancers (CRCs). Compound 1 showed potent cytotoxicity against DLD-1 and Caco-2 with IC50 values of 30.3 and 236.8 μg/mL, respectively. In addition, the exposure of compound 1 on those colorectal cancer cells could promote cell cycle arrest and induce necrotic cell death.

Annisa Elcentia Fajarwati

Mutia Hardhiyuna

Febby Nurdiya Ningsih

Adam Hermawan

Dyaningtyas Dewi Pamungkas Putri

Nurul Fatimah

Asep Bayu

Andi Setiawan

Ucu Yanu Arbi

Tutik Murniasih

A’liyatur Rosyidah

Tri Aryono Hadi

Masteria Yunovilsa Putra

Peni Ahmadi

Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

来自布纳肯国家公园海绵Aaptos sp.的阿帕他明促进细胞周期阻滞并诱导结直肠癌细胞坏死性死亡

Two mononuclear zinc(II) complexes [ZnCl2(HL)] (1) and [ZnBr2(HL)] (2), and a polymeric zinc(II) complex [Zn(dca)L] (3), where HL is the zwitterionic form of the Schiff base 2,4-difluoro-6-(((2-pyrrolidin-1-yl)ethylimino)methyl) phenol (HL), L is the monoanionic form of HL, and dca is dicyanoamide, were prepared and characterized by elemental analysis and infrared spectroscopy, as well as X-ray single crystal determination. Complexes 1 and 2 are isostructural, in which the Zn atoms are in tetrahedral coordination. The Schiff base ligands in both complexes are coordinate to the Zn atoms through phenolate oxygen and imino nitrogen. The zinc atoms in complex 3 are in tetrahedral coordination and are bridged by dicyanoamide ligands. The Schiff base ligand in this complex is coordinates to the zinc atom through phenolate oxygen, imino nitrogen and pyrrolidine nitrogen. Molecules of the three complexes are stabilized by hydrogen bonds. The biological assay indicates that the complexes have good antimicrobial activities on the bacteria strains Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi and Staphylococcus aureus.

Yu-Hui Wu

Wan-Lin Wei

Wei Li

Zhonglu You

Synthesis, Characterization and X-Ray Crystal Structures of Schiff Base Zinc(II) Complexes with Antibacterial Activity

合成、表征及具有抗菌活性的希夫碱锌(II)配合物的X射线晶体结构

Endothelial dysfunction is an important risk factor for the development of cardiovascular diseases, and its condition is further aggravated by oxidative stress. Biliverdin (BV) and bilirubin (BR) are potent antioxidants that protect endothelial cells, with biliverdin reductase (BVR) converting BV to BR to maintain redox balance. This study explored BVR’s role in mediating these protective effects under normoxic and hypoxia-reoxygenation conditions. Pharmacological inhibition of BVR reduced the protective effects of BV and BR, as evidenced by the decreased cell viability, cellular antioxidant activity, and intracellular bilirubin levels. Activation of ERK1/2 reduced BVR’s protective function, while its inhibition enhanced it. Additionally, disruption of the BVR-ERK interaction further modulated these effects, highlighting BVR-ERK1/2 interaction sites as potential therapeutic targets for oxidative stress-induced endothelial dysfunction.

Kuldeepak Sharma

Irena Zajc

Alen Albreht

Lovro Žiberna

Inhibition of Biliverdin Reductase Diminished the Protective Activity of Bilirubin and Biliverdin Against Oxidative Stress-Induced Injury in Human Vascular Endothelium

胆绿素还原酶抑制减弱胆红素和胆绿素对人类血管内皮氧化应激诱导损伤的保护作用

Schiff bases have various pharmacological activities due to the azomethine (–C=N–) group. Usnic acid is the most famous lichen metabolite and it contains two carbonyl groups to synthesize the Schiff base derivatives with primary amines. Therefore, in the current study, the known Schiff base derivatives 2–5 of usnic acid (1) were synthesized to explore their antidiabetic, neuroprotective, antioxidant, antidepressant and anti-Parkinson’s disease properties. Among the tested compounds, compound 4 exhibited the strongest antidiabetic and antidepressant activities, inhibiting α-glycosidase, α-amylase and MAO-A enzyme activities, respectively. Moreover, all of the tested compounds strongly scavenged the ABTS and DPPH radicals and the ABTS radical scavenging activities of 3 and 4 were found to be higher than the commercial antioxidants BHA and trolox. None of the tested compounds showed any significant anti-Parkinson’s disease activity or neuroprotective action. In conclusion, compound 4 can be suggested as a drug candidate molecule for further studies due to its strong antioxidant, antidiabetic and antidepressant properties.

Lawali Yabo-Dambagi

Ahmet Cakir

Mehmet Akyuz

Aysegul Karakucuk-Iyidogan

Ali Aslan

Synthesis of Schiff Bases of Usnic Acid and Investigation of Their Antidiabetic, Antidepressant, Anti-Parkinson’s Disease, Neuroprotective and Antioxidant Potentials

松萝酸席夫碱的合成及其抗糖尿病、抗抑郁、抗帕金森病、神经保护和抗氧化潜能研究

Abbreviation	Acta Chim. Slov.
Journal Impact	1.28
Quartiles(Global)	CHEMISTRY, MULTIDISCIPLINARY(Q3)

ISSN	1318-0207, 1580-3155
h-index	53

Publication Information	Publisher: Slovensko Kemijsko Drustvo，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 1996，Proportion of original research papers: 98.63%，Self Citation Rate:25.00%， Gold OA Rate: 90.94%
Average review cycle	网友分享经验：平均1.0个月
Average recruitment ratio	网友分享经验：容易

Acta Chimica Slovenica

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The Lock is the Key: Development of Novel Drugs through Receptor Based Combinatorial Chemistry

Inhibition Effect of Benzimidazole Derivatives on the Corrosion of Mild Steel in Acidic Medium: Experimental and Theoretical Studies

Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

Synthesis, Characterization and X-Ray Crystal Structures of Schiff Base Zinc(II) Complexes with Antibacterial Activity

Inhibition of Biliverdin Reductase Diminished the Protective Activity of Bilirubin and Biliverdin Against Oxidative Stress-Induced Injury in Human Vascular Endothelium

Inhibition Effect of Benzimidazole Derivatives on the Corrosion of Mild Steel in Acidic Medium: Experimental and Theoretical Studies

Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

Synthesis, Characterization and X-Ray Crystal Structures of Schiff Base Zinc(II) Complexes with Antibacterial Activity

Inhibition of Biliverdin Reductase Diminished the Protective Activity of Bilirubin and Biliverdin Against Oxidative Stress-Induced Injury in Human Vascular Endothelium

Synthesis of Schiff Bases of Usnic Acid and Investigation of Their Antidiabetic, Antidepressant, Anti-Parkinson’s Disease, Neuroprotective and Antioxidant Potentials