Journal of Clinical and Experimental Hematopathology

Yasunobu Sekiguchi

Hiroki Tsutsumi

Masahisa Kudo

Nobuo Maseki

Yoshie Iizaki

Machiko Kawamura

Kazuhiko Kobayashi

Yu Nishimura

Hiroaki Kanda

Daisuke Takei

Tomoya Abe

Toshiaki Nakayama

Yasumasa Shimano

Hirofumi Kobayashi

J Clin Exp Hematop

Treatment with epcoritamab in 10 patients in real-world clinical practice

真实世界临床实践中10例患者使用epcoritamab的治疗情况

A 79-year-old Japanese woman presented with exertional dyspnea. She had cardiac tamponade and urgent pericardial drainage was performed. Pathological findings from the pericardial fluid revealed non-germinal center B-cell (non-GCB) pericardial large B-cell lymphoma (CD10

Toshiki Terao

Yumiko Sato

Yoshiaki Kuroda

Tomoka Haratake

Midori Filiz Nishimura

Yasuharu Sato

Shoichi Kuyama

Discrepancy of Hans’ criteria for clonally related nodal and pericardiac fluid diffuse large B-cell lymphoma with &lt;i&gt;MYD88&lt;/i&gt; L265P mutation

Hans标准在克隆相关性结节和心包液弥漫大B细胞淋巴瘤中的差异与<i>MYD88</i> L265P突变的关系

Reactivation of hepatitis viruses during chemotherapy can be problematic in the treatment of malignant lymphomas. However, studies on reactivation of chronic hepatitis C virus (HCV) infection are limited. A 43-year-old woman presented with generalized lymphadenopathy and multiple liver tumors, and she was diagnosed with follicular lymphoma (grade 3a; clinical stage IV). Chronic HCV infection was clinically diagnosed. Immunochemotherapy (ICT), including bendamustine and obinutuzumab, was initiated with close liver function monitoring without specific treatment for hepatitis C. However, liver dysfunction worsened 17 days after ICT initiation, and ICT was interrupted. HCV-RNA and transaminase levels continued to elevate. Liver biopsy results confirmed acute exacerbation of chronic hepatitis C. Direct active antiviral (DAA) therapy was started and effective. She has maintained a sustained virologic response since DAA therapy ended. With regard to lymphoma, complete metabolic response was maintained for 4 years without additional treatment. Physicians should be aware of HCV reactivation with hepatitis flare after ICT for lymphoma and consider the indication and timing of DAA therapy for hepatitis C in this setting.

Yotaro Motomura

Kota Yoshifuji

Keisuke Tanaka

Chizuko Sakashita

Yoshihiro Umezawa

Toshikage Nagao

Sayuri Nitta

Yasuhiro Asahina

Takehiko Mori

Masahide Yamamoto

Hepatitis C virus-related hepatitis flare after immunochemotherapy in a patient with follicular lymphoma

丙型肝炎病毒相关性肝炎在滤泡性淋巴瘤患者免疫化疗后的爆发

Juvenile xanthogranuloma (JXG) is a rare benign non-Langerhans cell histiocytosis that usually occurs in cutaneous lesions on the head, neck, or upper trunk of neonates and young children. Intramuscular JXG, which invades muscle tissue, accounts for only 0.6% of all JXGs and mostly occurs in the skeletal muscles of the extremities or trunk. A 5-month-old girl was referred to our hospital. At the age of 3 months, she presented with a slow-growing lump on her left thigh. Magnetic resonance imaging (MRI) showed a 22 × 19 × 18 mm oval mass in her left thigh. First, needle biopsy results suggested deep JXG or myeloid sarcoma. Therefore, marginal resection was performed. Intraoperatively, the tumor adhered to the left tensor fasciae latae muscle and was resected together. Histopathological examination revealed a diffuse monotonous sheet-like proliferation of mononuclear histiocyte-like cells with pale, eosinophilic, foamy cytoplasm with a background of muscle and fatty tissue. Minimal mitotic figures and no nuclear atypia or multinucleated giant cells were observed. Immunohistochemical analysis was positive for CD68 (KP-1) and CD163; weakly positive for lysozyme; and negative for CD1a, S100, myeloperoxidase, and CD34. No blast proliferation was observed in the bone marrow. The patient was diagnosed with deep JXG and scheduled for periodic physical examination and MRI. Despite positive margins, the patient fared well without local recurrence 48 months after tumor removal. Understanding the unique pathology of deep JXG and detailed histological evaluation are important for decision-making.

Atsushi Maejima

Keisuke Okuno

Masanori Miyaishi

Daisuke Kawaba

Sosuke Kakee

Kensaku Yamaga

Noriyuki Namba

Deep juvenile xanthogranuloma invading the left tensor fasciae latae muscle: a case report and a literature review

左阔筋膜张肌侵袭性深部幼年黄色肉芽肿：病例报告及文献综述

Cluster of Differentiation 54 (CD54), also known as intracellular adhesion molecule-1 (ICAM-1), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Although CD54 has been shown to be involved in cell-to-cell adhesion and proliferation of B-cell lymphoma cell lines, the clinical significance of its expression has not yet been elucidated. We analyzed Ki-67 indices, the expression status of CD54 and its receptor (CD11a), and the intercellular distance of tumor cells in 40 diffuse large B-cell lymphoma (DLBCL) cases with vascular invasion to analyze the association of cell adhesion and proliferation status. CD54 and CD11a were simultaneously expressed (double-positive) in extra/intravascular tumor cells in 14 (35%) of the cases. Histologically, lymphoma cells of the double positive cases exhibited significantly higher Ki-67 index in extravascular tumor cells than that in the intravascular ones, while no difference was observed in lymphoma cells of the non-double positive cases. The significantly shorter extravascular intercellular distance compared with the intravascular intercellular distance suggested the association between cell-cell adhesion mediated by CD54 and cell proliferation. We further confirmed that the treatment of the recombinant LFA1 (CD11a/CD18) showed the adhesion of human DLBCL-derived cell line HBL-2 to LFA1 and increased cell viability. These findings suggest that cell-to-cell adhesion via CD54 maintains the cell proliferative activity of a subset of DLBCL. This study provides a valuable foundation upon which further research may be conducted to determine detailed mechanisms of cell-to-cell-associated and adhesion-independent cell proliferation.

Satoshi Kawana

Osamu Suzuki

Yuko Hashimoto

Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases

弥漫大B细胞淋巴瘤病例中通过CD54（细胞间粘附分子-1）相关细胞粘附介导的细胞增殖

Abbreviation	J Clin Exp Hematopathol
Journal Impact	0.89
Quartiles(Global)	HEMATOLOGY(Q4)

ISSN	1346-4280, 1880-9952
h-index	34

Publication Information	Publisher: Nihon Rinpa Monaikei Gakkai，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2019，Proportion of original research papers: 74.42%，Self Citation Rate:11.10%， Gold OA Rate: 99.04%
Average review cycle	网友分享经验：11 Weeks

Journal of Clinical and Experimental Hematopathology

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Treatment with epcoritamab in 10 patients in real-world clinical practice

Discrepancy of Hans’ criteria for clonally related nodal and pericardiac fluid diffuse large B-cell lymphoma with <i>MYD88</i> L265P mutation

Hepatitis C virus-related hepatitis flare after immunochemotherapy in a patient with follicular lymphoma

Deep juvenile xanthogranuloma invading the left tensor fasciae latae muscle: a case report and a literature review

Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases

Treatment with epcoritamab in 10 patients in real-world clinical practice

Discrepancy of Hans’ criteria for clonally related nodal and pericardiac fluid diffuse large B-cell lymphoma with <i>MYD88</i> L265P mutation

Hepatitis C virus-related hepatitis flare after immunochemotherapy in a patient with follicular lymphoma

Deep juvenile xanthogranuloma invading the left tensor fasciae latae muscle: a case report and a literature review

Cell-to-cell adhesion via CD54 (intercellular adhesion molecule-1)-associated cell proliferation in diffuse large B-cell lymphoma cases