NUCLEOSIDES、NUCLEOTIDES & NUCLEIC ACIDS 发表研究文章、简短通知以及对相关主题的简明、批判性评论，重点关注核苷、核苷酸和核酸的化学和生物学。这本全包期刊包含实验细节，强调合成、生物活性、新的和改进的合成方法，以及与新化合物相关的重要观察。

The journal "Nucleosides, Nucleotides and Nucleic Acids" publishes research articles, brief communications, and concise critical reviews on related topics, focusing on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. This comprehensive journal includes experimental details, emphasizing synthesis, bioactivity, new and improved synthetic methods, and significant observations related to new compounds.

《Nucleosides, Nucleotides and Nucleic Acids》期刊发表研究文章、简短通知以及对相关主题的简明、批判性评论，重点关注核苷、核苷酸和核酸的化学与生物学。这本综合性期刊包含实验细节，强调合成、生物活性、新的和改进的合成方法，以及与新化合物相关的重要观察。

Nucleosides, Nucleotides and Nucleic Acids

Abstract It is hypothesized that hyperuricemia in males is caused by androgen-induced urate reabsorptive transport system in the kidney. The expression of urate transporter 1 (Urat1), sodium-coupled monocarboxylate transporter 1 (Smct1) and glucose transporter 9 (Glut9) were investigated in orchiectomized mice with or without testosterone replacement. Testosterone enhanced mRNA and protein levels of Smct1 while those of Glut9 were attenuated. Although the mRNA level of Urat1 was enhanced by testosterone, the corresponding levels of Urat1 protein remained unaffected. Thus, the induction of Smct1 by testosterone is a candidate mechanism underlying hyperuricemia in males. Keywords: Uratetransporterkidneytestosterone Acknowledgments This study was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology (Grant 17590843) and the Uehara Memorial Foundation.

M. Hosoyamada

Y. Takiue

T. Shibasaki

H. Saito

Nucleosides Nucleotides & Nucleic Acids

The Effect of Testosterone Upon the Urate Reabsorptive Transport System in Mouse Kidney

睾酮对小鼠肾脏尿酸重吸收转运系统的影响

Crimean-Congo hemorrhagic fever (CCHF), an acute viral hemorrhagic fever disease, has a high mortality rate among humans. Hemorrhagic propensity is caused by coagulation malfunction and increased capillary permeability brought on by the resultant vascular injury. Vascular endothelial growth factor (VEGF) and VEGF receptor-2, or KDR (kinase insert domain containing receptor), are effective in vasculogenesis and angiogenesis. CCHF was stated to have endothelial dysfunction. This study aimed to evaluate whether the

Laleh Bahrikarehmi

Nilufer Kuruca

Umut Safiye Say Coskun

Ayse Feyda Nursal

Harun Albayrak

Serbulent Yigit

The effect of VEGF and KDR gene variants on Crimean-Congo hemorrhagic fever

VEGF 和 KDR 基因变异对克里米亚-刚果出血热的影响

Among the most prominent realizations of Morris J. Robins in the antiviral nucleoside chemistry are (i) the synthesis of 8-substituted (methyl-, amino-, bromo-, iodo) derivatives of acyclovir, (ii) xylotubercidin as an inhibitor of herpes simplex virus (HSV) infections, (iii) the anti-HIV activity of the 2',3'-dideoxyriboside of 2,6-diaminopurine (ddDAPR) and the 3'-azido- and 3'-fluoro derivatives thereof (AzddDAPR and FddDAPR, respectively), (iv) the potentiating effect of ribavirin on the anti-HIV activity of 2',3'-dideoxyinosine (ddI) and ddDAPR, (v) S-adenosylhomocysteine hydrolase (SAH) inhibitors principally active against vaccinia virus (VV) and vesicular stomatitis virus (VSV), and (vi) furo[2,3-d]pyrimidinone derivatives active against varicella-zoster virus (VZV).

Erik De Clercq

In memory of an exquisite medicinal chemist, Prof. Morris Robins

纪念杰出的药物化学家莫里斯·罗宾斯教授

Dental pulp stem cells (DPSCs) have the potential to differentiate into various types of tissues including tooth, adipose, cartilage, muscle, nerve, and also possess regenerative properties. Harmine, a beta-carboline alkaloid, has been shown to have antitumor activities and promote bone formation through the differentiation of osteoblasts. The aim of this study was to investigate the effect of harmine on the differentiation of DPSCs into odontoblast cells.

Touraj Zamir Nasta

Mohammad Reza Tabandeh

Ardeshir Abbasi

Hiva Moradi

Mohammad moslem Imani

Cyrus Jalili

Harmine promotes odontoblastic differentiation of dental pulp stem cells

Harmine 促进牙髓干细胞的成牙本质细胞分化

The substances that cause abnormal DNA structures are known as DNA damage-inducing factors, and their resulting DNA damage has been extensively studied and proven to be closely related to cancer, neurodegenerative diseases, and aging. Prolonged exposure to DNA damage-inducing factors can lead to a variety of difficult-to-treat diseases, yet these factors have not been well summarized. It is crucial to use a combination of environmental science and life science to gain a deep understanding of the environmental sources and biological consequences of DNA damage-inducing factors for mechanistic research and prevention of diseases such as cancer. This article selected 14 representative carcinogenic exogenous DNA damage-inducing factors and summarized them through a literature search, including both exogenous and endogenous DNA damage factors, and explored the types of DNA damage caused by the relevant damage factors.

Nian Liu

Jiahui Du

Jiani Ge

Song-Bai Liu

DNA damage-inducing endogenous and exogenous factors and research progress

DNA损伤诱导的内源性和外源性因素及研究进展

PIWI-Interacting RNAs are small non-coding RNAs derived from single-stranded RNAs which plays a crucial role in epigenetic regulation through transposon silencing and mRNA degradation via deamination. This study aimed to inhibit piR-651 and piR-823 in MDA-MB-231 triple-negative breast cancer cells and to explore their potential effects on healthy HUVEC cells. Non-target, anti-piR-651, and anti-piR-823 sequences were transfected in bothHUVEC and MDA-MB-231 cells using Lipofectamine. Proliferation and motility were assessed at 24, 48, and 72 h post-transfection in both cell lines. Based on the motility findings, MDA-MB-231 cells were underwent an invasion assay using crystal violet staining. The expressions of Ki-67, HIF-1α, MMP-2, and MMP-9 genes were measured at 48 h, when both cell lines exhibited the most significant effects of inhibition. The optimal time for proliferation of anti-piR-651 and anti-piR-823 transfected MDA-MB-231 cells was determined to be at 48 h, as indicated by decreased motility and invasion assay results (p < 0.001). NeverthelessHowever, there was no significant difference in the motility and proliferation of HUVECss transfected with anti-piR-651 and anti-piR-823 compared to the control group (p > 0.05). Asides from MMP-2 in anti-piR-823 transfected HUVECs and HIF-1α in anti-piR-823 transfected MDA-MB-231 cells, gene expressions of Ki-67, HIF-1α, MMP-2, and MMP-9 were reduced in both cell lines (p < 0.001). Inhibition of piR-651 and piR-823 decreased the survival and metastasis of cancer cells, without causing vital structural changes in healthy cells. Future research in cancer gene therapy or genetic modification may benefit from investigating piR-651 and piR-823 as possible inhibitors of breast cancer invasion and metastasis.

Çağrı Öner

Faruk Köser

Ertuğrul Çolak

The association of piR-651 and piR-823 on metastatic and invasive characteristics of triple negative breast cancer cells

piR-651 和 piR-823 在三阴性乳腺癌细胞转移和侵袭特性中的关联

Breast cancer is a heterogeneous disease that is ranked as one of the most common cancers worldwide. Currently, although there are existing molecules such as progesterone receptor and estrogen receptor for breast cancer treatment, discovering more effective drug targets is still in urgent need. In this study, we have obtained six sequencing datasets of breast cancer from GEO database and identified a set of differentially expressed molecules, including 67 miRNAs and 133 genes. Function enrichment analysis by miRPathDB database indicated that targets of 11 miRNAs could be enriched in breast cancer pathway with a p-value ≤ .05. A special miRNA-gene interaction network was constructed for analysis of the progression of breast cancer. We then ranked the importance of each molecule (i.e. miRNA and gene) by their node centrality indexes in the network and selected the top 10% of molecules. The statistical analysis of these molecules showed three miRNAs (hsa-miR-1275, hsa-miR-2392, hsa-miR-3141) have significant effects on the prognosis and survival of patients. By searching for potential drugs in Drugbank database, we have identified four candidates (phenethyl isothiocyanate, amuvatinib, theophylline, trifluridine) for targeting these genes. In conclusion, we believe that these drugs and their analogs could be used in the targeted therapy of breast cancer in the future.

Jing Huang

Yichun Gao

Jipan Liu

Zhiyuan Yang

Xiaoli Zhang

System biology analysis of miRNA-gene interaction network reveals novel drug targets in breast cancer

系统生物学分析揭示乳腺癌中miRNA-基因相互作用网络的新型药物靶点

The comprehensive advancement in DNA modification and coupling is driving DNA nanotechnology to new heights, paving the way for groundbreaking innovations in healthcare, materials science, and beyond. The ability to engineer DNA with tailored properties and functionalities underscores its immense potential in creating novel materials and devices. Utilizing a spectrum of techniques-such as amino handles, thiol groups, alkynes, azides, Diels-Alder reactions, hydrazides, and aminooxy functions-enables diverse coupling strategies, including Palladium-Catalyzed Couplings, to construct intricate DNA nanostructures. Further coupling modifications encompass hydrophobic alterations, redox-active moieties, chemical crosslinking agents, and Biotinylation. These modifications significantly broaden DNA's functional repertoire, offering precise control over interactions, structures, and features. By leveraging these advanced techniques, alongside next-generation sequencing (NGS)-based DNA modifications, researchers can design and implement DNA nanostructures with specific capabilities and applications, showcasing DNA's versatility as a programmable biomaterial. Through meticulous design and strategic implementation, DNA nanotechnology achieves unprecedented levels of precision and functionality, ushering in a new era of technological advancements and applications. These advanced DNA modification techniques hold great potential for transformative applications in nanotechnology, paving the way for innovations in drug delivery, diagnostics, and bioengineering.

Pratikeswar Panda

Rajaram Mohapatra

Revolutionizing DNA: advanced modification techniques for next-gen nanotechnology

革命性DNA：下一代纳米技术的高级修饰技术

High HMGB1 levels contribute to the development and metastasis of tumors such as colorectal cancer (CRC). The current investigation sought to evaluate the association of a functional InDel polymorphism (rs34000982) on the

Fang Wang

Zhijun Huang

Jianping Li

Xueren Gao

Clinical relevance and function of HMGB1 gene polymorphism and expression in colorectal cancer

结直肠癌中HMGB1基因多态性与表达的临床意义及功能

Determination of the different short oligonucleotide features in the full genome of fatal and mild coronavirus strains can show the researchers how these viruses evolved and became virulent strains. To this aim, at first, in the full genome of all coronavirus strains included in this study, the observed and expected frequency of dinucleotide to hexanucleotide was obtained using Markov method. Then odds ratio (observed/expected abundances) of short oligonucleotide was computed and considered as the raw data (features). Finally, ten distinct weighting algorithms approaches (Information Gain, Information Gain Ratio, Rule, Deviation, Chi Squared, Gini Index, Uncertainty, Relief, Support Vector Machine (SVM), and PCA) was employed on the features to identify oligonucleotide distribution differences across the full genome of SARS-related viruses compared to common cold coronaviruses. Totally among 5440 features (16 dinucleotides, 64 trinucleotides, 256 tetra nucleotides, 1024 penta-nucleotides, and 4096 Hexa-nucleotides), CC, CCA, CCAC, ACCAC, and CACCAC motifs were selected by 80 -90% of all weighting algorithms models to distinguish virulent strains from mild coronaviruses. These remarkable oligonucleotides might point toward the existence of some particular RNA elements that might be involved in viral virulence and thus can be targeted for viral treatment in the future.

Zahra Arab-Bafrani

Majid Nikoubin-boroujeni

Saeedeh Ebrahimi

Ali Teimoori

Elham Heidari

Elham Mousavi

Genomic determinants in pathogenicity of SARS-CoV-2 versa common cold coronaviruses

SARS-CoV-2与普通感冒冠状病毒致病性的基因组决定因素

Abbreviation	Nucleosides. Nucleotides. Nucleic. Acids.
Journal Impact	0.94
Quartiles(Global)	BIOCHEMISTRY & MOLECULAR BIOLOGY(Q4)

ISSN	0732-8311, 1525-7770, 1532-2335
h-index	53

Publication Information	Publisher: Taylor and Francis Ltd.，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2000，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Nucleosides, Nucleotides and Nucleic Acids

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