临床胃肠病学和肝病学 (CGH) 的使命是为读者提供临床胃肠病学和肝病学的广泛主题，包括癌症、炎症性疾病、功能性胃肠疾病、营养、吸收的诊断、内窥镜、介入和治疗进展, 和分泌物。

The mission of Clinical Gastroenterology and Hepatology is to provide readers with a wide range of topics in clinical gastroenterology and hepatology. These topics include cancer, inflammatory diseases, functional gastrointestinal disorders, nutrition, diagnostic absorption, endoscopy, interventional procedures, and therapeutic advancements.

《Clinical Gastroenterology and Hepatology》的使命是为读者提供关于临床胃肠病学和肝病学的广泛主题。这些主题包括癌症、炎症性疾病、功能性胃肠疾病、营养、吸收的诊断、内窥镜检查、介入治疗和相关进展。

Clinical Gastroenterology and Hepatology

Nonalcoholic fatty liver disease (NAFLD) and sarcopenia can be associated with advanced liver disease. Our aim was to assess the association between sarcopenia and the risk of fibrosis among patients with NAFLD.

Michael Harring

Pegah Golabi

James M Paik

Dipam Shah

Andrei Racila

Rebecca Cable

Manirath Srishord

Zobair M Younossi

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Clin Gastroenterol Hepatol

Sarcopenia Among Patients With Nonalcoholic Fatty Liver Disease (NAFLD) Is Associated With Advanced Fibrosis.

Background & AimsUltrasound-guided attenuation parameter (UGAP) is recently developed for noninvasive evaluation of steatosis. However, reports on its usefulness in clinical practice are limited. This prospective multicenter study analyzed the diagnostic accuracy of grading steatosis with reference to magnetic resonance imaging–based proton density fat fraction (MRI-PDFF), a noninvasive method with high accuracy, in a large cohort.MethodsAltogether, 1010 patients with chronic liver disease who underwent MRI-PDFF and UGAP were recruited and prospectively enrolled from 6 Japanese liver centers. Linearity was evaluated using intraclass correlation coefficients between MRI-PDFF and UGAP values. Bias, defined as the mean difference between MRI-PDFF and UGAP values, was assessed by Bland-Altman analysis. UGAP cutoffs for pairwise MRI-PDFF-based steatosis grade were determined using area under the receiver-operating characteristic curve (AUROC) analyses.ResultsUGAP values were shown to be normally distributed. However, because PDFF values were not normally distributed, they were log-transformed (MRI-logPDFF). UGAP values significantly correlated with MRI-logPDFF (intraclass correlation coefficient = 0.768). Additionally, Bland-Altman analysis showed good agreement between MRI-logPDFF and UGAP with a mean bias of 0.0002% and a narrow range of agreement (95% confidence interval [CI], –0.015 to 0.015). The AUROCs for distinguishing steatosis grade ≥1 (MRI-PDFF ≥5.2%), ≥2 (MRI-PDFF ≥11.3%), and 3 (MRI-PDFF ≥17.1%) were 0.910 (95% CI, 0.891–0.928), 0.912 (95% CI, 0.894–0.929), and 0.894 (95% CI, 0.873–0.916), respectively.ConclusionsUGAP has excellent diagnostic accuracy for grading steatosis with reference to MRI-PDFF. Additionally, UGAP has good linearity and negligible bias, suggesting that UGAP has excellent technical performance characteristics that can be widely used in clinical trials and patient care. (UMIN Clinical Trials Registry, Number: UMIN000041196). Ultrasound-guided attenuation parameter (UGAP) is recently developed for noninvasive evaluation of steatosis. However, reports on its usefulness in clinical practice are limited. This prospective multicenter study analyzed the diagnostic accuracy of grading steatosis with reference to magnetic resonance imaging–based proton density fat fraction (MRI-PDFF), a noninvasive method with high accuracy, in a large cohort. Altogether, 1010 patients with chronic liver disease who underwent MRI-PDFF and UGAP were recruited and prospectively enrolled from 6 Japanese liver centers. Linearity was evaluated using intraclass correlation coefficients between MRI-PDFF and UGAP values. Bias, defined as the mean difference between MRI-PDFF and UGAP values, was assessed by Bland-Altman analysis. UGAP cutoffs for pairwise MRI-PDFF-based steatosis grade were determined using area under the receiver-operating characteristic curve (AUROC) analyses. UGAP values were shown to be normally distributed. However, because PDFF values were not normally distributed, they were log-transformed (MRI-logPDFF). UGAP values significantly correlated with MRI-logPDFF (intraclass correlation coefficient = 0.768). Additionally, Bland-Altman analysis showed good agreement between MRI-logPDFF and UGAP with a mean bias of 0.0002% and a narrow range of agreement (95% confidence interval [CI], –0.015 to 0.015). The AUROCs for distinguishing steatosis grade ≥1 (MRI-PDFF ≥5.2%), ≥2 (MRI-PDFF ≥11.3%), and 3 (MRI-PDFF ≥17.1%) were 0.910 (95% CI, 0.891–0.928), 0.912 (95% CI, 0.894–0.929), and 0.894 (95% CI, 0.873–0.916), respectively. UGAP has excellent diagnostic accuracy for grading steatosis with reference to MRI-PDFF. Additionally, UGAP has good linearity and negligible bias, suggesting that UGAP has excellent technical performance characteristics that can be widely used in clinical trials and patient care. (UMIN Clinical Trials Registry, Number: UMIN000041196).

Kento Imajo

Hidenori Toyoda

Satoshi Yasuda

Yasuaki Suzuki

Katsutoshi Sugimoto

Hidekatsu Kuroda

Tomoyuki Akita

Junko Tanaka

Yutaka Yasui

Nobuharu Tamaki

Masayuki Kurosaki

Namiki Izumi

Atsushi Nakajima

Takashi Kumada

Utility of Ultrasound-Guided Attenuation Parameter for Grading Steatosis With Reference to MRI-PDFF in a Large Cohort

超声引导衰减参数在大型队列中评估脂肪变性程度的应用及其与MRI-PDFF的参考价值

Among patients undergoing advanced endoscopy, unrecognized obstructive sleep apnea (OSA) could predict sedation-related complications (SRCs) and the need for airway maneuvers (AMs). By using an OSA screening tool, we sought to define the prevalence of patients at high risk for OSA and to correlate OSA with the frequency of AMs and SRCs.

Gregory A Coté

Christine E Hovis

Richard M Hovis

Lawrence Waldbaum

Dayna S Early

Steven A Edmundowicz

Riad R Azar

Daniel K Mullady

Sreenivasa S Jonnalagadda

A screening instrument for sleep apnea predicts airway maneuvers in patients undergoing advanced endoscopic procedures.

用于筛查睡眠呼吸暂停的工具可预测接受高级内镜手术患者的气道操作。

Nonalcoholic steatohepatitis (NASH) affects patients' health-related quality of life (HRQoL). Patient-reported outcomes (PROs) evaluating HRQoL were assessed in the RandomizEd Global Phase 3 Study to Evaluate the Impact on NASH with FibRosis of Obeticholic Acid TreatmEnt (REGENERATE) study, which showed that obeticholic acid (OCA) significantly improved fibrosis in patients with NASH.

Maria Stepanova

Fatema Nader

Rohit Loomba

Quentin M Anstee

Vlad Ratziu

Stephen Harrison

Arun J Sanyal

Jörn M Schattenberg

A Sidney Barritt

Mazen Noureddin

Martin Bonacci

Gail Cawkwell

Bruce Wong

Mary Rinella

Obeticholic Acid Impact on Quality of Life in Patients With Nonalcoholic Steatohepatitis: REGENERATE 18-Month Interim Analysis.

奥贝胆酸对非酒精性脂肪性肝炎患者生活质量的影响：REGENERATE 18个月中期分析。

Based largely on results from preclinical studies, the concept of a brain gut microbiome axis has been established, mediating bidirectional communication between the gut, its microbiome, and the nervous system. Limited data obtained in human beings suggest that alterations in these interactions may play a role in several brain gut disorders.We reviewed the preclinical and clinical literature related to the topic of brain gut microbiome interactions.Well-characterized bidirectional communication channels, involving neural, endocrine, and inflammatory mechanisms, exist between the gut and the brain. Communication through these channels may be modulated by variations in the permeability of the intestinal wall and the blood-brain barrier. Brain gut microbiome interactions are programmed during the first 3 years of life, including the prenatal period, but can be modulated by diet, medications, and stress throughout life. Based on correlational studies, alterations in these interactions have been implicated in the regulation of food intake, obesity, and in irritable bowel syndrome, even though causality remains to be established.Targets within the brain gut microbiome axis have the potential to become targets for novel drug development for brain gut disorders.

Vadim Osadchiy

Clair R Martin

Emeran A Mayer

The Gut–Brain Axis and the Microbiome: Mechanisms and Clinical Implications

肠道-大脑轴与微生物组：机制与临床意义

Charles J Kahi

Blue Notes

蓝调音符

Primary sclerosing cholangitis (PSC) is a known risk factor for hepatobiliary malignancies. We conducted a systematic review and meta-analysis of published studies to determine the incidence and risk factors for hepatobiliary malignancies in people with PSC.

Matheus Souza

Luan C V Lima

Lubna Al-Sharif

Daniel Q Huang

Incidence of hepatobiliary malignancies in primary sclerosing cholangitis: systematic review and meta-analysis

原发性硬化性胆管炎中肝胆恶性肿瘤的发病率：系统综述与荟萃分析

Investigate the consequences of the histological progression of metabolically associated steatohepatitis (MASH) and fibrosis on long-term survival after bariatric surgery.

Guillaume Lassailly

Robert Caiazzo

Armelle Goemans

Mikael Chetboun

Viviane Gnemmi

Julien Labreuche

Gregory Baud

Helene Verkindt

Camille Marciniak

Naima Oukhouya-Daoud

Line-Carolle Ntandja-Wandji

Massih Ningarhari

Emmanuelle Leteurtre

Violeta Raverdy

Sébastien Dharancy

Alexandre Louvet

François Pattou

Philippe Mathurin

Resolution of MASH with no worsening of fibrosis after bariatric surgery improves 15-year survival: a prospective cohort study.

减重手术后MASH缓解且纤维化无恶化可改善15年生存率：一项前瞻性队列研究。

Long-standing Inflammatory bowel disease (IBD) increases the risk of colonic neoplasia, necessitating effective screening strategies. This network meta-analysis (NMA) compared the efficacy and safety between different endoscopic modalities in the high-definition (HD) era.

Vasiliki Sinopoulou

Gaurav B Nigam

Morris Gordon

Meghana Ganeshan

Mitchell Rudo Tokonyai

Sunil Dolwani

Marietta Iacucci

Matt Rutter

Venkat Subramanian

Ana Wilson

James E East

Comparative Efficacy and Safety of Endoscopic Modalities for Colorectal Cancer Screening in Inflammatory Bowel Disease: A Systematic Review and Network Meta-Analysis

炎症性肠病结直肠癌筛查中内镜模式的比较疗效与安全性：系统综述与网络meta分析

Pojsakorn Danpanichkul

Kanokphong Suparan

Chuthatip Kaeosri

Pimtawan Jatupornpakdee

Abdelrahman M. Attia

Thanathip Suenghataiphorn

Jerapas Thongpiya

Banthoon Sukphutanan

Daniel Q. Huang

Amit G. Singal

Karn Wijarnpreecha

Ju Dong Yang

Global Trend of MASH-associated Liver Cancer A Systematic Analysis from the Global Burden of Disease 2021

全球MASH相关肝癌趋势：2021年全球疾病负担的系统分析

Abbreviation	Clin. Gastroenterol. Hepatol.
Journal Impact	11.76
Quartiles(Global)	GASTROENTEROLOGY & HEPATOLOGY(Q1)

ISSN	1542-3565, 1542-7714
h-index	208
Top Journals	Yes

Publication Information	Publisher: W.B. Saunders，Publishing cycle: Monthly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2003，Proportion of original research papers: 87.39%，Self Citation Rate:4.30%， Gold OA Rate: 28.88%
Average review cycle	网友分享经验：平均6.5月
Average recruitment ratio	网友分享经验：约37.5%

Clinical Gastroenterology and Hepatology

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