Extrapolating Lessons from Targeted Protein Degradation to Other Proximity-Inducing Drugs

2024-9-12

An Engineered Nisin Analogue with a Hydrophobic Moiety Attached at Position 17 Selectively Inhibits <i>Enterococcus faecium</i> Strains

2024-9-10

Identification of Tunable, Environmentally Responsive Fluorogenic Dyes by High-Throughput Screening

2024-9-9

Protein Visualizer 2.0: Intuitive and Interactive Visualization of Protein Topology and Co/Post-Translational Modifications

2024-9-9

Functional Investigations of p53 Acetylation Enabled by Heterobifunctional Molecules

2024-9-9

Heterologous Biosynthesis of New Lanthipeptides Nocardiopeptins with an Unprecedented Bridging Pattern of Lanthionine and Labionin

2024-9-9

DNA-Directed Activation of Photocatalytic Labeling at Cell–Cell Contact Sites

2024-9-3

Unveiling a Potent Small Molecule Disruptor for RNA G-Quadruplexes Tougher Than DNA G-Quadruplex Disruption

2024-9-3

Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis

2024-8-29

Identification and Characterization of Novel Small-Molecule Enhancers of the CUL3^LZTR1 E3 Ligase KRAS Complex

2024-8-28

Disulfide Tethering to Map Small Molecule Binding Sites Transcriptome-wide

2024-8-28

Labeling of CC Chemokine Receptor 2 with a Versatile Intracellular Allosteric Probe

2024-8-26

Class IIb Microcin MccM Interferes with Oxidative Phosphorylation in <i>Escherichia coli</i>

2024-8-22

Identification of Cytisine Derivatives as Agonists of the Human Delta Opioid Receptor by Supercomputer-Based Virtual Drug Screening and Transcriptomics

2024-8-21

Esterase-Activated Hydrogen Sulfide Donors with Self-Reporting Fluorescence Properties and Highly Tunable Rates of Delivery

2024-8-20

<i>In Vivo</i> Injection of Reversible Optically Controlled Short Interfering RNA into Japanese Medaka Embryos (<i>Oryzias latipes</i>) to Regulate Gene Silencing

2024-8-20

Structure Prediction and Protein Engineering Yield New Insights into Microcin J25 Precursor Recognition

2024-8-20

Exploring Protein <i>S</i>-Palmitoylation: Mechanisms, Detection, and Strategies for Inhibitor Discovery

2024-8-19

Introducing Our Authors

2024-8-16

Issue Editorial Masthead

2024-8-16

A Chemical Approach to Assess the Impact of Post-translational Modification on MHC Peptide Binding and Effector Cell Engagement

2024-8-16

Issue Publication Information

2024-8-16

Heterologous Expression Facilitates the Production and Characterization of a Class III Lanthipeptide with Coupled Labionin Cross-Links in Sponge-Associated <i>Streptomyces rochei</i> MB037

2024-8-15

Facile Generation of Neutralizing Antibodies on Tyrosine Phosphorylated IRS1 by Epitope-Directed Elicitation

2024-8-13

Targeted Degradation of Protein Kinase A via a Stapled Peptide PROTAC

2024-8-13

Mitochondrial Probe for Glutathione Depletion Reveals NME3 Essentiality for Mitochondrial Redox Response

2024-8-12

Maximizing the Accuracy of Equilibrium Dissociation Constants for Affinity Complexes: From Theory to Practical Recommendations

2024-8-9

Synthesis of Plasmalogen Derivatives with Unnatural Fatty Acids as Substrates for Ferroptosis Induction

2024-8-8

MI-181 Modulates Cilia Length and Restores Cilia Length in Cells with Defective Shortened Cilia

2024-8-6

A High-Throughput Screening Platform Identifies FDA-Approved Drugs That Inhibit SREBP Pathway Activation

2024-8-6

Emissive Guanosine Analog Applicable for Real-Time Live Cell Imaging

2024-8-5

Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth

2024-8-4

Proteolytic Regulation in the Biosynthesis of Natural Product Via a ClpP Protease System

2024-8-3

Diazirine-AIOC-NAADP, a Clickable-Photoactive NAADP Analog for Sea Urchin NAADP Binding Proteins

2024-8-2

Identification of DDX5 as a Potential Therapeutic Target of Osteosarcoma Using Thiazolone Probes

2024-7-29

Organelle-Targeted Laurdans Measure Heterogeneity in Subcellular Membranes and Their Responses to Saturated Lipid Stress

2024-7-29

Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs

2024-7-25

Reversible RNA Acylation Using Bio-Orthogonal Chemistry Enables Temporal Control of CRISPR-Cas9 Nuclease Activity

2024-7-25

Regulation of Absorption and Emission in a Protein/Fluorophore Complex

2024-7-24

Activity-Based Protein Profiling of RHBDL4 Reveals Proteolysis of the Enzyme and a Distinct Inhibitor Profile

2024-7-23

Oxidation Kinetics of Fluorescent Membrane Lipid Peroxidation Indicators

2024-7-22

Issue Editorial Masthead

2024-7-19

Issue Publication Information

2024-7-19

Introducing Our Authors

2024-7-19

Correction to “Design, Synthesis, and Mechanistic Studies of (<i>R</i>)-3-Amino-5,5-difluorocyclohex-1-ene-1-carboxylic Acid as an Inactivator of Human Ornithine Aminotransferase”

2024-7-18

Imaging Interorganelle Phospholipid Transport by Extended Synaptotagmins Using Bioorthogonally Tagged Lipids

2024-7-18

Rationalizing Diverse Binding Mechanisms to the Same Protein Fold: Insights for Ligand Recognition and Biosensor Design

2024-7-17

Pseudouridine Detection and Quantification Using Bisulfite Incorporation Hindered Ligation

2024-7-16

Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRas^G12C

2024-7-11

A Repurposed Drug Interferes with Nucleic Acid to Inhibit the Dual Activities of Coronavirus Nsp13

2024-7-9