European Journal of Heart Failure, Supplement

González Juanatey

José Ramón

European Journal of Heart Failure Supplements

Interstitial collagen, apoptosis and diastolic function in essential hypertension

间质胶原、细胞凋亡与原发性高血压舒张功能

V. Moiseev

A. Potapenko

O. Abdulasisov

L. Dyatchuk

I. Meray

G. Kiyakbaev

Z. Kobalava

Efficacy of Ivabradine in patients with chronic heart failure after myocardial infarction

伊伐布雷定对心肌梗死后慢性心力衰竭患者疗效的研究

Purpose: Heart failure is a major cause of mortality and morbidity, while anemia is a frequent comorbidity in chronic heart failure with significant impact on the long-term outcome. Our aim was to assess the prognostic value of anemia on short-term outcome in acute worsening of advanced, but prior stable chronic heart failure. Methods: We performed retrospective study of 263 consecutive patients hospitalised for acute exacerbation of decompensated chronic heart failure, New York Heart Association functional class 3 and 4, whose ejection fraction measured by echocardiography was ≤ 40%. All of these patients were stable more than 30 days prior to hospitalisation. Among these patients 138 (73 female) had anemia and 125 were without anemia (64 female). Anemia was defined by WHO criteria, as hemoglobin at admission <120 g/l for women and <130 g/l for men. Statistical analysis included comparison of demographic, clinical, laboratory and therapeutic data between these two groups, with an emphasis on 30-days mortality rate. All patients had optimal therapy in accordance with the actual ESC guidelines and anemia was treated if indicated. Results: Patients in both groups were similar age (77, 5 ±8 vs. 75±9, 8 years, p=0, 067) and had average length of hospital stay around 8 days (8 [95% C.I. 89-93]vs.8 [95% C.I. 90-94], P=0.817). Although 30-days mortality rate was higher in anemic patients, that difference was not statistically significant (11.4% vs. 9.5%, P=0.764). Hemoglobin concentration at admission is not in corelation with 30-days mortality in male (P=0.472) neither female (P=0.767) patients. The group of anemic patients had significantly wider QRS complex (118ms [95% C.I. 96-124] vs. 92ms [95% C.I. 84-109], P=0.013), higher concentration of urea (11.8 mmol/l [95% C.I. 10.2-13.5] vs. 9.2 mmol/l [95% C.I. 8.6], P=0.015) and creatinine (139μmol/l [95% C.I. 128-155] vs. 111 μmol/l [95% C.I. 107-125], P<0.001) than nonanemic patients. Oxygen saturation slightly differed between the groups (88, 67% vs. 88, 48% P=0.817). Conclusion: In according to our results anemia does not affect the short-term outcome in patients hospitalised for acute worsening of advanced chronic heart failure.

Lea Skorup

Teodora Zaninovic-Jurjevic

Alen Ruzic

Nikolina Jurjevic

Ksenija Bazdaric

Luka Zaputovic

Zarko Mavric

Anemia does not affect the short-term outcome in acute exacerbation of advanced chronic heart failure

贫血不会影响重度慢性心力衰竭急性加重的短期预后

Purpose: We performed a study to evaluate the accuracy of admission UA serum level as a predictor of major adverse cardiac events (MACE) in the context of acute myocardial infarction (AMI). Methods: We evaluated results of cohort of 210 patients hospitalized in our center from January till December 2010 for ischemic chest discomfort within first 12 hours from the onset of symptoms and diagnosed with either non-ST segment elevation MI or ST segment elevation MI. None of the patients has been previously diagnosed with CAD. Exclusion criteria included previously documented elevated UA levels, chronic kidney disease, malignancy and chronic alcoholism. Follow up was achieved by means of standard hospital database and chart reviews and telephone calls at 30th day post admission. Measured MACE conditions were acute heart failure, new symptoms of CAD that required treatment, and cardiac death. The ROC curve analyses was used in order to determine optimal UA gender specific cut-off values for prediction of MACE during 30 days of follow-up. Cox proportional hazards regression model was employed to calculated the risk of adverse outcomes with elevated UA after adjusting for sex, age, body mass index, hypertension, diabetes, hyperlipidaemia, smoking, diuretics, angiotensin converting enzyme inhibitors and statins. Results: The mean age was 63 years with 20% of patient at least 75 years old. Women accounted for 26.4% of the study population. The index diagnosis was STEMI in 80.5% and NSTEMI in 19.5%. Most patients underwent PCI (75%) during the index hospitalization (mean days in hospital 7.2). The mean left ventricular EF was 45.6%, Killip class II-IV in 19.0% patients, eGFR median value was 87.4 ml/min/1.73 m2 with 9.5% lower than 60 ml/mi/1.73 m2. Patients were classified into two subgroups, having serum UA level under or above the gender specific ROC determined cut off value (360 μmol/l for men and 309 μmol/l for women). The incidence of total MACE was 35.2% with significant differences between two groups 23% vs. 49% p < 0.001 (acute cardiac failure 14% vs. 31%, p = 0.004, new symptoms of CAD 6% vs. 9%, p=0.298 and cardiac death 4% vs. 9%, p = 0.149). The instantaneus relative risk of MACE during the 30-day period with respect to the UA level measured at admittance to the hospital is 2.52 with 95% CI 1.57- 4.06. Conclusion: Our results suggest that the patient having serum UA at admittance above the gender specified value is more likely to develop AMI related complications in 30-days period therefore elevated serum uric acid level can be considered a reliable marker for predicting adverse events in AMI.

Zeljko Madzar

Zlatko Cubranic

Sanja Matijevic

Vjekoslav Tomulic

Štefica Dvornik

Marta Zuvic Butorac

Uric acid as a predictive biomarker of 30-day outcomes after acute myocardial infarction: a retrospective cohort study

尿酸作为急性心肌梗死后30天预后预测标志物的回顾性队列研究

M.L. Mamalyga

Influence of heart failure severity on the autoregulation of cerebral circulation and manifestation of convulsive readiness

心力衰竭严重程度对脑循环自主调节及惊厥 readiness 表现的影响

出版信息	出版商: Oxford University Press，出版周期: ，期刊类型: journal，开源期刊: 否
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European Journal of Heart Failure, Supplement

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Interstitial collagen, apoptosis and diastolic function in essential hypertension

Efficacy of Ivabradine in patients with chronic heart failure after myocardial infarction

Anemia does not affect the short-term outcome in acute exacerbation of advanced chronic heart failure

Uric acid as a predictive biomarker of 30-day outcomes after acute myocardial infarction: a retrospective cohort study

Influence of heart failure severity on the autoregulation of cerebral circulation and manifestation of convulsive readiness

Pharmacokinetics of ubiqinol, administrered intravenously

Pharmacokinetics of ubiqinol, administrered intravenously

Pharmacokinetics of ubiqinol, administrered intravenously

Pharmacokinetics of ubiqinol, administrered intravenously

Pharmacokinetics of ubiqinol, administrered intravenously