Advances in Space Biology and Medicine

Tana M. Hoban-Higgins

Edward L. Robinson

Charles A. Fuller

Advances in space biology and medicine

Adv Space Biol Med

Primates in Space Flight

灵长类动物在太空飞行中的研究

Stephen B. Doty

Laurence Vico

Thomas Wronski

Emily Morey-Holton

Use of Animal Models to Study Skeletal Effects of Space Flight

利用动物模型研究太空飞行对骨骼的影响

Gerald Sonnenfeld

Overview

概述

Eberhard R Horn

Gravity Effects on Life Processes in Aquatic Animals

水生动物生命过程中的重力效应

Philip J. Rijken

Johannes Boonstra

Arie J. Verkleij

Siegfried W. de Laat

Chapter 7 Effects of Gravity on the Cellular Response to Epidermal Growth Factor

第七章 重力对细胞表皮生长因子反应的影响

The hindlimb unloading rodent model is used extensively to study the response of many physiological systems to certain aspects of space flight, as well as to disuse and recovery from disuse for Earth benefits. This chapter describes the evolution of hindlimb unloading, and is divided into three sections. The first section examines the characteristics of 1064 articles using or reviewing the hindlimb unloading model, published between 1976 and April 1, 2004. The characteristics include number of publications, journals, countries, major physiological systems, method modifications, species, gender, genetic strains and ages of rodents, experiment duration, and countermeasures. The second section provides a comparison of results between space flown and hindlimb unloading animals from the 14-day Cosmos 2044 mission. The final section describes modifications to hindlimb unloading required by different experimental paradigms and a method to protect the tail harness for long duration studies. Hindlimb unloading in rodents has enabled improved understanding of the responses of the musculoskeletal, cardiovascular, immune, renal, neural, metabolic, and reproductive systems to unloading and/or to reloading on Earth with implications for both long-duration human space flight and disuse on Earth.

Ruth K. Globus

Alexander Kaplansky

Galina Durnova

Experimentation With Animal Models In Space

The Hindlimb Unloading Rat Model: Literature Overview, Technique Update and Comparison with Space Flight Data

后肢去负荷大鼠模型：文献综述、技术更新及与太空飞行数据的比较

出版信息	出版商: Elsevier，出版周期: ，期刊类型: journal，开源期刊: 否
基本数据	创刊年份: 2005，原创研究文献占比: ，自引率:， Gold OA占比:

Advances in Space Biology and Medicine

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Primates in Space Flight

Use of Animal Models to Study Skeletal Effects of Space Flight

Overview

Gravity Effects on Life Processes in Aquatic Animals

Chapter 7 Effects of Gravity on the Cellular Response to Epidermal Growth Factor

Primates in Space Flight

Use of Animal Models to Study Skeletal Effects of Space Flight

Overview

Gravity Effects on Life Processes in Aquatic Animals

The Hindlimb Unloading Rat Model: Literature Overview, Technique Update and Comparison with Space Flight Data