CURRENT NANOSCIENCE 发表 (A) 权威/迷你评论，和 (B) 由专家撰写的原创研究和亮点，涵盖纳米科学和纳米技术的最新进展。代表了该领域的所有方面，包括纳米结构、纳米气泡、纳米液滴和纳米流体。还涵盖了纳米科学在物理学、材料科学、化学、合成、环境科学、电子学、生物医学纳米技术、生物医学工程、生物技术、医学和制药中的应用。该杂志对所有涉及纳米科学及其应用和基础科学、化学、物理、材料科学、工程和医学领域的研究都是必不可少的。CURRENT NANOSCIENCE 还欢迎提交关于纳米科学和纳米技术的以下主题的投稿：纳米电子学和光子学高级纳米材料纳米加工和测量纳米生物技术和纳米医学用于能量传感器和执行器的纳米技术计算纳米科学和技术。

Current Nanoscience publishes authoritative and mini-reviews, as well as original research and highlights written by experts, covering the latest advancements in nanoscience and nanotechnology. The journal represents all aspects of the field, including nanostructures, nanobubbles, nanodroplets, and nanofluids. It also addresses the applications of nanoscience in physics, materials science, chemistry, synthesis, environmental science, electronics, biomedical nanotechnology, biomedical engineering, biotechnology, medicine, and pharmaceuticals. This journal is essential for all research involving nanoscience and its applications, as well as foundational studies in chemistry, physics, materials science, engineering, and medicine. Current Nanoscience also welcomes submissions on the following topics related to nanoscience and nanotechnology: nanoelectronics and photonics, advanced nanomaterials, nanofabrication and measurement, nanobiotechnology and nanomedicine, nanotechnology for energy sensors and actuators, and computational nanoscience and technology.

《Current Nanoscience》发表权威性和迷你评论，以及由专家撰写的原创研究和亮点，涵盖纳米科学和纳米技术的最新进展。该期刊代表了该领域的所有方面，包括纳米结构、纳米气泡、纳米液滴和纳米流体。此外，还探讨了纳米科学在物理学、材料科学、化学、合成、环境科学、电子学、生物医学纳米技术、生物医学工程、生物技术、医学和制药中的应用。该杂志对所有涉及纳米科学及其应用的研究，以及基础科学、化学、物理、材料科学、工程和医学领域的研究都是必不可少的。《Current Nanoscience》还欢迎关于纳米科学和纳米技术的以下主题的投稿：纳米电子学和光子学、高级纳米材料、纳米加工和测量、纳米生物技术和纳米医学、用于能量传感器和执行器的纳米技术、计算纳米科学和技术。

Current Nanoscience

Introduction: With the advancement of technology, nanotechnology has emerged as a prominent research field. The Atomic Force Microscope (AFM) serves as a vital tool in nanoscience and technology, playing an indispensable role across various domains. Method: However, in the AFM photoelectric sensing system, the optical feedback noise from the beam deflection method can lead to inaccuracies in signal identification and analysis, impacting the accuracy and reliability of AFM measurements. To mitigate this interference, this study proposes a highfrequency current superposition system aimed at reducing optical feedback noise. By superimposing high-frequency currents, the semiconductor laser transitions from a single-mode to a multi-mode operational state, thereby altering its mode of operation and consequently reducing optical feedback noise during sensing. Initially, mathematical modeling and simulation analysis were conducted on the high-frequency current superposition noise reduction system to examine the impact of high-frequency current on the intensity noise of the semiconductor laser. Subsequently, the design of the high-frequency current superposition noise reduction system was outlined, encompassing the development of a constant current drive circuit, a voltage-controlled oscillator circuit, and a biasing circuit. Finally, the high-frequency current superposition noise reduction system underwent testing. Results: During the high-frequency current superposition noise reduction test, the system's Signal-to-Noise Ratio (SNR) increased from 15.57 dB to 17.81 dB, and the system's noise peak-to-peak value decreased from 8 mV to 6 mV. Analysis of the superposition frequency and noise reduction effect determined the optimal superposition frequency of the AFM photoelectric sensor system to be 400 MHz. Characterization experiments of the high-frequency superposition noise reduction system compared the clarity of Escherichia coli images before and after noise reduction. Conclusion: The aforementioned experimental results demonstrated that high-frequency current superposition is an effective noise reduction method capable of mitigating optical noise in the AFM photoelectric sensing system.

Ke Xu

Wei Zheng

Reduction in Optical Feedback Noise of Atomic Force Microscopy by High-Frequency Current Modulation

高频电流调制降低原子力显微镜光学反馈噪声

This study aims to create a high-speed, low-power data transmission solution for implantable medical devices based on cutting-edge FinFET technology. The work examines the application of Binary Phase Shift Keying (BPSK) modulation through a transmission gate design, which provides an optimal blend of low resistance, high-speed performance, and minimal power consumption. Additionally, the work includes the design of a sine-to-square wave converter and a modulating signal generator. FinFET is employed owing to its high switching speed, low power consumption, low leakage current, and excellent tolerance of short channel effects. The design exhibits a steady electric field at the source end, a high electrostatic potential, and an improved ON current at low work function values using Sentaurus TCAD simulations of a 20nm FinFET, allowing high-speed data modulation in smart implants. A nonoverlapping phase generator, a low-power, current-starved gated ring oscillator, a frequency divider utilizing a True Single Phase Clock D-Flip-flop, and an XOR gate serving as a pulse counter are all featured in the design of the BPSK demodulator. This work is significant for its ability to drastically reduce power consumption to 1.75μW while retaining high data transmission speeds, making it perfect for next-generation implantable medical devices. With a 0.9 V power supply, this FinFET-based BPSK modulator and demodulator achieve a far lower power consumption than conventional CMOS-based designs, which increases device longevity and efficiency in settings with limited resources.

Lakshmi Priya G.

Biswajit Jena

Keerthana M. S.

Kasturi Priyanka

Low-Power Design of Fully Digital BPSK Modulator and Demodulator Utilizing Nanoscale FinFET for Smart Implants

用于智能植入物的纳米级FinFET全数字BPSK调制器与解调器的低功耗设计

This review explores the potential of microneedles (MNs) in enhancing the delivery of biologics vital for treating conditions, including infectious diseases, cancer, and autoimmune disorders. The COVID-19 pandemic has amplified the demand for biologics, prompting research and development. The global biologics market is expected to grow substantially due to the rise of personalized medicine. Large, complex molecules, including proteins, peptides, and vaccines, are known as biologics, and a potential technique for their delivery is microneedles. MNs come in various forms: solid, hollow, coated, dissolvable, and hydrogel MNs. Traditional drug delivery methods have limitations, while transdermal drug delivery via Microneedles offers a promising alternative. Microneedles painlessly penetrate the skin's barrier, forming temporary microchannels for effective medication administration. This minimally invasive, self-administered technique increases patient comfort and compliance and eliminates the complications of oral medications and injections, indicating a bright future for biologic drug administration. Microneedles hold the promise to reshape healthcare delivery by facilitating broader access to vaccines, insulin, and other crucial biologics.

Amit Kumar Goswami

Gadela V. Radha

Venkata Vamsi Krishna Venuganti

Transforming Biologics Delivery through Microneedles

通过微针实现生物制剂递送的转化

Objective: Melatonin has been associated with accelerated tissue regeneration and grapeseed oil has abundant unsaturated fatty acids, particularly linoleic acid that makes it a strong antioxidant, having the potential to promote wound healing by enhancing the presence of free radicals at the wound site. The study is aimed to evaluate the potential of a microemulsion gel using grapeseed oil as the organic phase and melatonin encapsulated in the vesicles to exhibit synergistic wound healing in Swiss albino rats. Materials and Method: Microemulsion containing grapeseed oil encapsulating melatonin was developed using the water-titration method. The surfactant and co-surfactant ratio (Smix) were fixed at 1:1. A pseudo-ternary diagram was used to determine the microemulsion zone and the developed microemulsion was further incorporated in carbopol 934P gel. The formulations were evaluated for their physicochemical properties and cytotoxicity assay. The optimized formulation was topically applied to cutaneous wounds of Swiss albino rat models. 30 Swiss albino rats were divided into five groups of 6 animals each: (i) Negative control group, (ii) Standard marketed formulation treated group, (iii) Optimized microemulsion containing Grapeseed oil and melatonin treated group, (iv) Grapeseed oil treated group and (v) Melatonin treated group. All the rats in each group were topically applied with the desired formulations daily for up to 14 days. Results: The treatment with a formulation comprising 10.18% Grapeseed oil, 24.88% water, and 64.94% Smix exhibited the highest entrapment efficiency of 86.65 ± 1.88% with an enhanced in vitro drug release of up to 83.02 ± 1.09%, also demonstrating first-order release kinetics. Furthermore, it did not inhibit L929 mouse fibroblast cell proliferation up to 500 μg/mL and promoted wound closure prior to other groups. Additionally, increased tissue maturation with higher collagen deposition was mostly seen by day 7. Thus demonstrating it is suitable for dermal application and sustained release of melatonin. The in vivo wound healing study and histological investigations on rat models demonstrated comparable results as observed in the marketed formulation of melatonin. Conclusion: The results showed that GSO oil based microemulsion encapsulating MEL could be a promising wound treatment option to exhibit accelerated wound healing effects.

Madhavi Gupta

Daphisha Marbaniang

Paulami Pal

Niva Rani Gogoi

Srijita Chakrabarti

Pronobesh Chattopadhyay

Subhabrata Ray

Bhaskar Mazumder

Topical Application of Melatonin in a Grapeseed Oil-based Microemulsion Accelerated Wound Healing in Rat Models

基于葡萄籽油微乳剂的褪黑素局部应用在 rat 模型中加速了伤口愈合

Dae Joon Kang

Preface

前言

Background:: Cobalt oxide nanocubes have garnered significant attention as potential supercapacitor electrodes due to their unique structural and electrochemical properties. The spent lithium-ion batteries (LiBs) are considered as zero-cost source for cobalt oxide production. Objective:: The aim of this work is to recover cobalt oxide from spent LiBs and study its electrochemical performance as a supercapacitor electrode material. Method:: This study uses an electrodeposition method to obtain cobalt oxide honeycomb-like anodes coated on Ni foam substrates from spent Li-ion batteries for supercapacitors applications. The effect of annealing temperature on the cobalt oxide anode has been carefully investigated; 450 ºC annealing temperature results in nanocubes on the surface of the cobalt oxide electrode. X-ray diffraction confirmed the formation of the Co3O4-NiO electrode. Results:: The Co3O4-NiO nanocubes electrode has shown a high specific capacitance of 1400 F g-1 at 1 A g-1 and high capacitance retention of ~96 % after 2250 cycles at a constant current density of 10 A g-1 compared to 900 F g-1 at 1 A g-1 as for prepared Co3O4 honeycomb. Conclusion:: This strategy proves that the paramount importance of Co3O4-NiO nanocubes, meticulously synthesized at elevated temperatures, as a supremely effective active material upon deposition onto transition metal foam current collectors, establishing their indispensability for supercapacitor applications.

Zinab Hassanien Bakr

Eslam Atef Abdelaziz Aboelazm

Cheng Seong Khe

Gomaa Abdelgawad Mohammed Ali

Kwok Feng Chong

Recycling the Spent Lithium-ion Battery into Nanocubes Cobalt Oxide Supercapacitor Electrode

回收废旧锂离子电池制备纳米立方体氧化钴超级电容器电极

Abbreviation	Curr. Nanosci.
Journal Impact	1.43
Quartiles(Global)	NANOSCIENCE & NANOTECHNOLOGY(Q4)

ISSN	1573-4137, 1875-6786
h-index	52

Publication Information	Publisher: Bentham Science Publishers B.V.，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2006，Proportion of original research papers: 46.77%，Self Citation Rate:0.00%， Gold OA Rate: 0.49%
Average review cycle	网友分享经验：平均3.0个月
Average recruitment ratio	网友分享经验：容易

Current Nanoscience

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Reduction in Optical Feedback Noise of Atomic Force Microscopy by High-Frequency Current Modulation

Low-Power Design of Fully Digital BPSK Modulator and Demodulator Utilizing Nanoscale FinFET for Smart Implants

Transforming Biologics Delivery through Microneedles

Topical Application of Melatonin in a Grapeseed Oil-based Microemulsion Accelerated Wound Healing in Rat Models

Preface

Low-Power Design of Fully Digital BPSK Modulator and Demodulator Utilizing Nanoscale FinFET for Smart Implants

Recycling the Spent Lithium-ion Battery into Nanocubes Cobalt Oxide Supercapacitor Electrode

Preface

Topical Application of Melatonin in a Grapeseed Oil-based Microemulsion Accelerated Wound Healing in Rat Models

Transforming Biologics Delivery through Microneedles