The main aims of the Journal include collecting and generalizing the knowledge in hypertensiology; education and professional development of cardiologists and medical doctors of other specialties, who deal with different issues regarding diagnostics, management and prevention of hypertension in both clinical practice and research. The Journal also calls attention to the most urgent and up-to-date questions in hypertensiology, cardiology and related sciences. There are additional objectives, such as increasing the availability, accessibility and recognition of Russian medical scientific achievements at the international level by improving the quality of the publication and the way they are presented; enabling the exchange of opinions and information between scientists and their wider communication.    The main criteria for publication selection fit with the mentioned objectives and include currency, singularity, scientific and practical novelty, applied relevance etc.

The main aims of the journal "Arterial Hypertension (Russian Federation)" include collecting and generalizing knowledge in the field of hypertensiology, as well as promoting the education and professional development of cardiologists and medical doctors from other specialties who deal with various issues related to the diagnosis, management, and prevention of hypertension in both clinical practice and research. The journal also addresses the most urgent and contemporary questions in hypertensiology, cardiology, and related sciences. Additional objectives include increasing the availability, accessibility, and recognition of Russian medical scientific achievements at the international level by improving the quality of publications and their presentation; facilitating the exchange of opinions and information among scientists and enhancing their communication. The main criteria for publication selection align with these objectives and include currency, uniqueness, scientific and practical novelty, and applied relevance.

《Arterial Hypertension (Russian Federation)》期刊的主要目标是收集和总结高血压学领域的知识，促进心脏病学及其他相关专业医生的教育和职业发展，帮助他们处理与高血压的诊断、管理和预防相关的各种问题，无论是在临床实践还是研究中。期刊还关注高血压学、心脏病学及相关科学领域中最紧迫和最新的问题。除此之外，期刊的其他目标包括提高俄罗斯医学科学成就的国际可及性和认可度，通过提升出版质量和展示方式来实现；促进科学家之间的意见和信息交流，增强他们的沟通。期刊的出版选择标准与上述目标相符，包括时效性、独特性、科学和实践的新颖性、应用相关性等。

Arterial Hypertension (Russian Federation)

The inclusion of spironolactone in antihypertensive therapy does not provide blood pressure (BP) control in the significant proportion of patients with resistant hypertension (HTN) and is accompanied by an increased risk of developing of hyperkalemia and complications associated with blockade of male and female sex hormone receptors. In this regard, a search is underway for new drugs that are not only capable of effectively controlling BP in this population, but also have a more favorable safety profile than their predecessors. The most promising are new drugs that selectively suppress the activity of aldosterone synthase-aldosterone-mineralcorticoid receptor hormonal system, the excessive activity of which underlies the formation of resistant HTN. The review presents data on the characteristics of pharmacokinetics and the results of the clinical studies obtained in patients with resistant HTN when assessing the effectiveness and safety of the use of the new nonsteroidal mineralcorticoid receptor antagonist finerenone and the selective aldosterone synthase inhibitor baxdrostat.

O. B. Kuzmin

V. V. Belyanin

N. V. Buchneva

V. V. Zhezha

L. N. Landar

M. V. Stolbova

Arterial’naya Gipertenziya (Arterial Hypertension)

New drugs for the treatment of resistant hypertension: nonsteroidal mineralcorticoid receptor antagonist finerenone and aldosterone synthase inhibitor baxdrostat

治疗难治性高血压的新药：非甾体类盐皮质激素受体拮抗剂非奈利酮和醛固酮合成酶抑制剂巴克洛司他

The renin-angiotensin-aldosterone system (RAAS) is involved in the regulation of kidney function and blood pressure (BP). In renal dysfunction, hyperactivation of the RAAS leads to an increase in BP and impaired permeability of the nephron glomerular filter. Blockade of the RAAS is one of the methods of nephroprotection. Objective . To compare the effect of an angiotensin-converting enzyme inhibitor (IACE), angiotensin I receptor blocker (ARB), and a selective slow calcium channel blocker (BCC) on the functional state of the microvasculature of the skin of rats with nephrectomy (NE), fed with a high-salt diet (HS). Design and methods . Five groups of Wistar rats were studied. The SO group: sham-operated animals that received a standard diet; the HS+NE group: rats with ¾ NE and HS (4 % NaCl); HS+NE+Ler-, HS+NE+Lis-, HS+NE+Los-groups: rats with ¾ NE and HS, that were treated with the BCC lerkanidipin (Ler, 3 mg/kg), IACE lisinopril (Lis, 30 mg/kg) or the ARB losartan (Los, 10 mg/kg), respectively. After 4 months, a study was performed using laser Doppler flowmetry (LDF). Results . In rats of the HS+NE group, uremia is accompanied by an increase in BP (by 16,9 % compared to the SO group). The treatment with IACE and ARB in rats with NE and HS prevents the rise in BP, while BCC does not reduce BP. The LDF-study showed that the increased intensity of initial skin perfusion in rats of the HS+NE group (7,2 ± 0,3 compared to 6,5 ± 0,2 p. u. in the SO group) is not corrected by BCC (6,9 ± 0,3 p. u.), but is reduced by the use of IACE (6,4 ± 0,2 p. u.) and ARB (6,1 ± 0,2 p. u.). Wavelet analysis showed that the increase in tonic effects on blood vessels in the endothelial, neurogenic and myogenic regulatory circuits, characteristic of renal dysfunction, decreases with the use of all studied drugs. RAAS blockade in rats with ¾ NE and HS does not prevent a decrease in the reactivity of skin microvessels to acetylcholine (ACh), and the use of BCC restores the response of skin blood flow to ACh to the control level. Conclusions . In Wistar rats, NE in combination with HS leads to an increase in BP, an increase in tonic effects on skin microvessels in the endothelial, neurogenic and myogenic ranges, as well as a decrease in the reactivity of skin blood flow to ACh. Inhibition of the RAAS by the treatment of IACE and ARB prevents the increase in BP, but does not improve the reactivity of skin microvessels. The use of BCC in rats with NE and HS does not reduce BP, but improves the reactivity of skin microvasculature to ACh.

G. T. Ivanova

M. Kh. Khasun

M. M. Parastaeva

A. Sh. Rumyantsev

O. N. Beresneva

The effect of blockade of the renin‑angiotensin‑aldosterone system on skin microcirculation in rats with impaired renal function

肾素-血管紧张素-醛固酮系统阻断对肾功能受损大鼠皮肤微循环的影响

Objective . The development of a methodology for the early detection and subsequent treatment of hypertension (HTN) in people of working age using a database of automated pre-shift and pre-trip medical examinations (APTME) indicates the purpose of the article. Design and methods . The study included the results of mandatory daily APTME of 814 male drivers. The average age of the subjects was 46,3 ± 16,6 years. The total number of medical examinations was 107 448. In all subjects the parameters of the medical examination were collected, recorded and remotely transmitted to an automated workplace to a medical worker. Based on the analyzed database of blood pressure (BP) indicators obtained during daily APTME, a risk group for HTN was formed and it comprised 285 people (35 % of the total number of employees). Results . According to the results of the analysis of the database of APTME, the following average BP values were registered in the risk group: systolic — 151 ± 6,27 mmHg, diastolic — 93 ± 3,68 mmHg. HTN of the 1st degree was detected in 82 people (60,3 %), grade 2 — in 48 people (35,3 %), 3 degrees — in 6 people (4,4 %). Only 48 employees (16,8 %) from the risk group with an established diagnosis of HTN (136 people) identified during follow-up had previously been on dispensary registration due to HTN. At the same time, regular indicators of APTME showed that these 48 employees did not achieve target BP figures, despite medical supervision. The analysis of the database of APTME and an organized set of measures made it possible to achieve the target BP in 84,7 % of drivers at risk. Conclusions . The use of APTME contributes to the early detection of elevated BP, timely referral to a doctor, diagnosis of HTN, registration at a dispensary and achievement of target BP in people at risk.

A. A. Garanin

S. A. Khasbiev

I. E. Nikolaeva

A. F. Kharasova

V. R. Kamalova

D. R. Enikeeva

The effectiveness of hypertension screening in the able-bodied population based on data from automated pre-trip medical examinations

基于自动化出航前体检数据的有劳动能力人群高血压筛查效果

This review presents current data on the epidemiology, pathogenesis, diagnosis and treatment of intracranial atherosclerosis — one of the most relevant areas of vascular neurology of the last decade. Intracranial atherosclerosis is a common cause of ischemic stroke worldwide, accounting for up to half of all ischemic strokes in South-East Asia, Latin America and Africa. Research is actively underway to assess the prevalence of intracranial atherosclerosis among the Caucasian race. New diagnostic methods for the study of intracranial atherosclerosis appear every year, in particular, the introduction of high-resolution magnetic resonance imaging of the vascular wall, the search for specific blood biomarkers broaden horizons of research in this field even at the earliest asymptomatic stages of the disease. Treatment and prevention in this cohort of patients remain ambiguous, given the high risk of recurrence of ischemic stroke. Most studies (SAMMPRIS, VISSIT, VAST) relate to the comparison of aggressive drug treatment with endovascular surgical treatment techniques. According to the latest research results, antiplatelet therapy has a significant advantage in preventing stroke.

M. M. Tanashyan

A. S. Mazur

A. A. Raskurazhev

Intracranial atherosclerosis: the current state of the problem (literature review)

颅内动脉粥样硬化：当前问题的现状（文献综述）

The prevalence of arterial hypertension (HTN), which is one of the most important risk factors (RF) for cardiovascular diseases (CVD), is still increasing, which represents a global problem for world health, because for many decades CVD have occupied a leading position in the structure of mortality throughout the world. This article reviews the main epidemiological studies available by the end of 2023, which analyzed various indicators of HTN both in Russia and around the world, with the aim of developing an understanding of time trends in the prevalence of HTN. This article also analyzes the main RF for HTN and sex differences, because it is known that in men the prevalence of HTN is traditionally higher than in women in Russia, and special attention is paid to indicators such as adherence to therapy, effectiveness and control of HTN.

M. A. Ismailova

A. D. Afanasyeva

E. V. Garbuzova

Yu. I. Ragino

Arterial hypertension: the current state in Russia and in the world. Review. Part II

动脉高血压：俄罗斯及全球现状。综述。第二部分

Fixed-dose combinations are generally believed to be the best tool to improve patients’ adherence, thus they are recommended as a first choice for drug prescription in majority of hypertension guidelines all over the world, including Russia. At the same time real world prescription rate is rather low, especially for triple combinations. The review summarizes the treatment benefits of triple antihypertension drug combination with a focus on amlodipine + indapamide + perindopril. The benefits from studies based in real world evidence for outcome, hospitalization rate and treatment costs are presented.

A. O. Konradi

Fixed triple combinations in the treatment of arterial hypertension. Real world benefits in clinical practice

动脉高血压治疗中的固定三联组合。临床实践中的真实世界获益

The article presents the characteristics of angiotensin receptors of the central nervous system neurons, the mechanisms of penetration and formation of angiotensin in the brain, the effect of angiotensin II on neurons of various nuclei of the brain involved in the regulation of blood circulation. The ability of angiotensin receptor blockers to penetrate the blood-brain barrier and have a central effect was noted. The prospects for the use of angiotensins (1–7) and (1–9) in the treatment of hypertension are considered.

V. A. Tsyrlin

N. V. Kuzmenko

M. G. Pliss

Renin-angiotensin system and central regulation of blood circulation

肾素-血管紧张素系统和血液循环的中枢调节

Background. Ischemic stroke is the leading cause of mortality and loss of working ability. Sleep disorders and sleep-wake rhythm disorders are considered to be a potential modifiable risk factor of acute stroke. Objective. To determine the peculiarities of circadian rhythms in acute stroke by assessing the daily variation of urinary excretion of cortisol and 6-sulfatoxymelatonin. Materials and methods. We examined 27 patients with acute ischemic stroke and 9 patients admitted to the hospital with suspected but not confirmed stroke. All examinations in both groups were performed in similar settings. All patients underwent neurological assessment in acute phase and before discharge including evaluation by National Institute of Health Stroke Scale, modified Rankin scale (mRs), Barthel index and Rivermead index. Within 48–72 hours after admission, urine samples were collected at 7 a. m., 3 p. m. and 11 p. m. for cortisol and 6-sulfatoxymelatonin assessment (enzyme-linked immunosorbent assay analysis). Results. Daily urinary cortisol excretion did not differ in stroke and control subjects. However, stroke patients demonstrated the highest values in the evening while control subjects had higher levels in the morning. The rhythm of urinary 6-sulfatoxymelatonin excretion is preserved in both groups with the highest level in the morning. However, stroke patients show lower levels at all time points (by 45 %, 33 % and 72 % in the morning, afternoon and evening, respectively). There were no changes in either cortisol or 6-sulfatoxymelatonin excretion depending on stroke severity. Afternoon excretion of 6-sulfatoxymelatonin correlates with Barthel index at discharge (ρ = 0,63; p = 0,004), mRs score at discharge (ρ = –0,65; p = 0,003) and Rivermead index at admission (ρ = 0,52; p = 0,024) and at discharge (ρ = 0,49; p = 0,032). Conclusion. Patients with acute mild-moderate stroke show abnormal daily rhythm of urinary cortisol excretion with the maximum in the evening. The daily rhythm of 6-sulfatoxymelatonin excretion is preserved with the maximum excretion at night, but stroke patients have lower levels compared to control subjects.

L. S. Korostovtseva

E. N. Zabroda

S. N. Kolomeychuk

A. D. Gordeev

V. V. Amelina

E. A. Stabrova

E. Y. Vasilieva

M. V. Bochkarev

Y. V. Sviryaev

Molecular circadian markers in acute ischemic stroke (preliminary results)

急性缺血性卒中的分子昼夜节律标志物（初步结果）

Objective . The complex assessment of clinical, functional and hemodynamic status change according to echocardiography and right heart catheterization (RHC) within 12 months after pulmonary arterial hypertension (PAH) verification in real clinical practice. Design and methods . Incident adult patients with PAH were included in a longitudinal prospective observational study with a retrospective component after PAH verification based on RHC. The data were received by patients interviewing and medical documentation analysis at enrollment and every 3 months during one-year observational period. The retrospective design was used to collect information before enrollment. Results . Thirty three patients were enrolled. 64 % of patients received monotherapy as initial PAH-specific therapy, 24 % — a double combination, while the rest received calcium channel blockers. Follow-up echocardiography was performed in 75,8 % patients. There was a significant increase in median tricuspid annular plane systolic excursion (TAPSE, p = 0,001), median left ventricular end-diastolic diameter (p = 0,004) and a decrease in the anteroposterior diameter of the left atrium (p = 0,016) during the follow-up period. There were no significant changes in the size of the right heart chambers, pulmonary artery systolic pressure, or pulmonary artery size. Follow-up RHC was performed in 16 (48,5 %) patients. There was a significant improvement in cardiac output (p = 0,006) and cardiac index (p = 0,012), venous blood oxygen saturation (p = 0,045) and significant decrease of stroke volume (p = 0,021) during the follow-up period. The initial 6-minute walk test was performed in 75,8 % patients, the median distance was 340 m. During follow-up data were available in 14 patients, the median distance was 398 m. Median time from PAH onset to PAH verification was 13,5 months with a direct correlation between the time from the PAH onset to PAH verification and WHO functional class at the time of diagnosis (ρ = 0,394, p &lt; 0,05). Within 12 months after PAH verification most patients subjectively noted the absence of positive dynamics in symptoms (88 %). Conclusions . We suppose that optimizing the treatment regimen for patients with PAH, improving access to PAH-specific therapy can improve the clinical and hemodynamics status and prognosis of patients with PAH.

V. D. Zakiev

T. V. Martynyuk

Y. V. Kotovskaya

S. V. Korkach-Romanov

Complex assessment of clinical, functional and hemodynamic status in patients with incident pulmonary arterial hypertension in real clinical practice

真实临床实践中新发肺动脉高压患者的临床、功能和血流动力学状态的综合评估

Publication Information	Publisher: All-Russian Public Organization Antihypertensive League，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2017，Proportion of original research papers: 0.00%，Self Citation Rate:N.A.， Gold OA Rate: 0.00%

Arterial Hypertension (Russian Federation)

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New drugs for the treatment of resistant hypertension: nonsteroidal mineralcorticoid receptor antagonist finerenone and aldosterone synthase inhibitor baxdrostat

The effect of blockade of the renin‑angiotensin‑aldosterone system on skin microcirculation in rats with impaired renal function

The effectiveness of hypertension screening in the able-bodied population based on data from automated pre-trip medical examinations

Intracranial atherosclerosis: the current state of the problem (literature review)

Arterial hypertension: the current state in Russia and in the world. Review. Part II

Fixed triple combinations in the treatment of arterial hypertension. Real world benefits in clinical practice

Renin-angiotensin system and central regulation of blood circulation

Molecular circadian markers in acute ischemic stroke (preliminary results)

Complex assessment of clinical, functional and hemodynamic status in patients with incident pulmonary arterial hypertension in real clinical practice

Arterial hypertension: the current state in Russia and in the world. Review. Part II

ISSN	1607-419X, 2411-8524
h-index	9