Ukrainian Journal of Cardiology

The aim – to establish markers of clinical and functional state development in patients with acute myocardial infarction inherent in wartime.Materials and methods. A cohort of 133 STEMI patients was examined (77.4 % men, 61.7±0.9 years). Part of the patients (group 1) was hospitalized from February to May 2019 (n=87), while the other part of them (group 2) was hospitalized in the period from February 24, 2022 to May 2023 (n=46) within the first 24 hours from the development of symptoms (average time of admission 5.2±0.4 hours). In order to eliminate discrepancies in indicators, which with a low probability are related to the action of wartime factors, comparable samples were made from groups 1 and 2 (52 patients and 17 patients, respectively). Comparison of groups was carried out based on clinical and anamnestic and laboratory parameters of the first day.Results and discussion. At the admission to the hospital, markers of a specific clinical and functional state in patients with STEMI due to the influence of wartime factors are: level of leukocytes &gt; 13.0 · 109/L, monocytes &gt; 0.5 · 109/L, lymphocytes &gt; 1.2 . 109/L, triglycerides &gt; 1.63 mmol/L, heart rate &gt; 76 beats/min, as well as criteria made up of these indicators (in particular, products of the level of monocytes or lymphocytes, the level of triglycerides and heart rate, as well as the 7-component scale, which takes into account heart rate, ESR, glucose and triglyceride levels, as well as the number of monocytes, lymphocytes and platelets). Moreover, the increase in the number of monocytes is not associated with hospital complications in these patients. Instead, the level of triglycerides, the number of lymphocytes and platelets are directly related both to the influence of wartime factors and to the complicated hospital course of STEMI.Conclusions. The influence of wartime factors in patients with STEMI is combined with the response to myocardial damage. It leads to an increase in the risk of a complicated course of the hospital stage, as well as to specific clinical and laboratory changes. These changes make it possible to recognize the impact of wartime factors and patients at high risk of hospital course of myocardial infarction.

O. V. Shumakov

O. M. Parkhomenko

Ya. M. Lutay

D. V. Khomiakov

M. Yu. Sokolov

Оцінка інформативності клініко-інструментальних та лабораторних показників у виявленні активності патогенетичних факторів, асоційованих зі змінами перебігу інфаркту міокарда в період воєнного стану

评估临床、器械和实验室指标在检测与战争状态下心肌梗死病程变化相关的病理发生因素活性中的信息价值

The aim – to analyze the relationship between chronic kidney disease (CKD) and cardiovascular pathology in patients with type 2 diabetes (T2D) of different ages.Materials and methods. A total of 233 patients with T2D aged 30-80 years were examined. Anthropometric indicators, blood pressure, glucose levels, glycated hemoglobin, C-peptide, total cholesterol, triglycerides, low-density and high-density lipoprotein cholesterol, creatinine, glomerular filtration rate, AST, and ALT were measured in all patients. Groups of patients were compared based on the presence of CKD and age using Student’s t-test and Pearson’s chi-squared test.Results and discussion. In patients with T2D and CKD, the incidence of coronary heart disease (CHD) (OR 1.8; 95 % CI 1.02–3.23; p=0.044), myocardial infarction (OR 2.0; 95 % CI 1.01–3.95; p=0.046), and strokes (OR 2.66; 95 % CI 1.07–6.63; p=0.036) is significantly higher compared to patients with T2D without kidney pathology. When comparing the clinical indicators of patients with T2D combined with CKD and those without it, no significant differences were found in anthropometric measurements, blood pressure, blood glucose levels, glycated hemoglobin, or C-peptide levels. The levels of total cholesterol, hemoglobin, and red blood cell count in the blood were significantly lower (р&lt;0.05), while the levels of creatinine and glomerular filtration rate were significantly higher (р&lt;0.001) in patients with kidney pathology.Conclusion. In patients with T2D, a relationship between CKD and cardiovascular pathology has been established. It can be assumed that the development of kidney pathology in patients with T2D is a significant risk factor for cardiovascular diseases.

Ya. A. Saienko

A. V. Pisaruk

N. M. Koshel

B. M. Mankovsky

Взаємозв’язок між хронічною хворобою нирок та серцево-судинною патологією у хворих на цукровий діабет 2-го типу різного віку

2型糖尿病患者不同年龄段慢性肾脏病与心血管病理的关联

The purpose of this study was to analyse a vivid clinical case of problematic stent extraction that migrated during coronary stenting. Materials and methods. The following clinical methods of research were used: general laboratory and instrumental, which were applied in interventional cardiology. Results and discussion. A patient born in 1950 with pronounced symptoms of cardiac pathology was admitted to the cardiology department. The diagnosis of coronary heart disease in the form of class III of angina pectoris was established. Coronary angiography was recommended to the patient, where 3 vascular lesions of the coronary arteries were detected, coronary artery bypass grafting was recommended, which the patient flatly refused. Coronary stenting was performed 2 days later, but a complication occurred during the intervention – stent dislocation and migration during implantation into the mouth of the right coronary artery, which occurred during endovascular interventions for myocardial revascularisation in coronary heart disease. The causes of such complications have been identified, and the endovascular methods used in their treatment have been described. Several attempts have been made to extract the migrated stent, but the first of them were unsuccessful. Only after 5 attempts to remove the migrated stent using the ONE SNARE endovascular trap was success achieved. Conclusions. The article provides a comprehensive analysis of the problem of stent migration in various vascular systems and organs, emphasizing the seriousness and complexity of this phenomenon. It demonstrates the importance of timely diagnosis and discusses treatment approaches that can reduce the risk of complications and improve patient outcomes.

Kubanychbek S. Abdisatarov

Kairat J. Osmonaliev

Nursultan T. Nuazov

Eva T. Temirlanova

David A. Ajibaev

Coronary stent migration into the aorta during implantation in the orifice of the right coronary artery and its elimination: Review with a clinical case

右冠状动脉开口植入术中冠脉支架移位至主动脉及消除：临床病例回顾

The article presents examples of the difference in estimated GFR (eGFR) results obtained using different CKD-EPI creatinine equations (2009) and (2021). In these examples, the results were not reclassified to a higher level of renal function, but the eGFR obtained remained within the same CKD stage despite the different equations. However, it should be borne in mind that a significant reclassification to higher eGFR categories may have undesirable consequences, such as changes in the composition of the CKD population and for initiation of renoprotection measures, dosing and discontinuation of certain medications, timely referral to a nephrologist and RRT planning.The article presents validated eGFR estimating equations according to the KDIGO 2024 Guidelines for the Evaluation and Management of CKD (CKD-EPI creatinine equation (2009), CKD-EPI creatinine equation (2021), CKD-EPI creatinine-cystatin C equation (2021), EKFC equation et al.), as well as eGFR calculators available on the National Kidney Foundation (NKF) website.

S. V. Kushnirenko

L. M. Savytska

O. V. Kushnirenko

S. O. Rotova

Evaluation of renal function: choosing the right equation

肾功能评估：选择合适的公式

The term MINOCA (Myocardial Infarction with Non-Obstructive Coronary Arteries) refers to pathological conditions where there is evidence of myocardial necrosis due to a lack of blood flow but no significant coronary lesions are seen on angiography. This is working diagnosis, which requires careful investigation to identify specific causes: plaque rupture, coronary dissection, vasospasm, microvascular dysfunction, thromboembolism, etc. Angiography alone, in most cases, does not lead to an etiological diagnosis. So additional techniques like intracoronary imaging and vasomotor function tests are important, especially in younger patients. This literature review demonstrates the main pathogenic patterns and diagnostic approachs for MINOCA patients.

S. Y. Lypovetska

Інфаркт міокарда з необструктивними коронарними артеріями: патогенетичні патерни та діагностичний пошук

非阻塞性冠状动脉心肌梗死：病理发生模式与诊断探索

Publication Information	Publisher: National Scientific Center Academician M D Strazhesko Institute of Cardiology of the National Academy of Medical Sciences of Ukraine，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2019，Proportion of original research papers: ，Self Citation Rate:， Gold OA Rate:

Ukrainian Journal of Cardiology

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Взаємозв’язок між хронічною хворобою нирок та серцево-судинною патологією у хворих на цукровий діабет 2-го типу різного віку

Coronary stent migration into the aorta during implantation in the orifice of the right coronary artery and its elimination: Review with a clinical case

Evaluation of renal function: choosing the right equation

Інфаркт міокарда з необструктивними коронарними артеріями: патогенетичні патерни та діагностичний пошук

Взаємозв’язок між хронічною хворобою нирок та серцево-судинною патологією у хворих на цукровий діабет 2-го типу різного віку

Coronary stent migration into the aorta during implantation in the orifice of the right coronary artery and its elimination: Review with a clinical case

Evaluation of renal function: choosing the right equation

Інфаркт міокарда з необструктивними коронарними артеріями: патогенетичні патерни та діагностичний пошук