ANNALS OF HEPATOLOGY 发表了关于人类和实验模型中肝脏生物学和疾病的原始研究。投稿可以作为常规文章提交。该杂志还发表关于基础和临床主题的简明评论。

The Annals of Hepatology publishes original research on liver biology and diseases in human and experimental models. Submissions can be made as regular articles. The journal also features concise reviews on both basic and clinical topics.

《Annals of Hepatology》发表关于人类和实验模型中肝脏生物学与疾病的原创研究。投稿可作为常规文章提交。此外，该杂志还刊登有关基础和临床主题的简明评论。

Annals of Hepatology

This study aims to explore the association between Klotho and Non-Alcoholic Fatty Liver Disease (NAFLD), a condition affecting millions worldwide. Klotho may have a protective effect against NAFLD mechanisms like inflammation, oxidative stress, and fibrosis. The study will use FLI and FIB-4 score to diagnose NAFLD in a large population for investigating the link between Klotho and NAFLD. The study aimed to explore the association between Klotho and NAFLD by measuring the α-Klotho protein levels in the participants' blood using ELISA. Patients with underlying chronic liver diseases were excluded. The severity of NAFLD was evaluated using FLI and FIB-4, and logistic regression models were used to analyze the data obtained from NHANES. Subgroup analyses were conducted to study Klotho's effect on hepatic steatosis and fibrosis in diverse subpopulations. The study found that low levels of α-Klotho were associated with NAFLD, with ORs ranging from 0.72 to 0.83. However, high levels of α-Klotho were associated with NAFLD-related fibrosis. The Q4 group showed significant results in individuals aged 51 years or younger and in females. Non-Hispanic White ethnicity, education level of high school or above, non-smoking, non-hypertension, and non-diabetic groups showed negative correlations. Our study suggests a potential correlation between α-Klotho levels in the blood and NAFLD in adult patients, especially among younger individuals, females and Non-Hispanic Whites. Elevated α-Klotho levels may have therapeutic benefits in treating NAFLD. Further research is required to validate these findings, but they provide new insights for managing this condition.

Zhenfei Chi

Yun Teng

Yuting Liu

Lu Gao

Junhan Yang

Zhe Zhang

Association between klotho and non-alcoholic fatty liver disease and liver fibrosis based on the NHANES 2007–2016

基于NHANES 2007-2016的klotho与非酒精性脂肪肝及肝纤维化的关联

The impact of sleep on metabolic dysfunction-associated steatotic liver disease (MASLD) in American adults remains unclear. This study aimed to address the relationship of sleep patterns and disorders with MASLD and liver fibrosis comprehensively.

Guannan Zong

Wangjia Mao

Ming Wen

Xiaoyun Cheng

Guanghui Liu

Association of sleep patterns and disorders with metabolic dysfunction-associated steatotic liver disease and liver fibrosis in contemporary American adults

当代美国成年人睡眠模式和障碍与代谢功能障碍相关脂肪肝疾病及肝纤维化的关联

Advanced fibrosis is a crucial stage in the progression of autoimmune hepatitis (AIH), where fibrosis can either regress or advance. This study aims to leverage machine learning (ML) models for the assessment of advanced liver fibrosis in AIH patients using routine clinical features.

Qinglin Wei

Wen Li

Shubei He

Hongbo Wu

Qiaoling Xie

Ying Peng

Xingyue Zhang

An exploratory machine learning model for predicting advanced liver fibrosis in autoimmune hepatitis patients: A preliminary study

预测自身免疫性肝炎患者晚期肝纤维化的探索性机器学习模型：一项初步研究

Mario Alvares da Silva

Fatima Higuera de la Tijera

Miguel Castruita Garcia

Oscar Beltran Galvis

Ming Lung Yu

Soo Aleman

Grace Lai-Hung Wong

Javier Garcia Samaniego

Joaquin Cabezas Gonzalez

Marta Casado Martin

Mohamed Alzaabi

Aastha Chandak

Marta Martinez

Artak Khachatryan

Linda Chen

Candido Hernandez Lopez

Yu Jun Wong

P-11 REAL-WORLD DATA WITH PANGENOTYPIC DIRECT-ACTING ANTIVIRALS IN LATINAMERICA: PRELIMINARY RESULTS OF THE SVR10K STUDY

P-11 拉丁美洲泛基因型直接抗病毒药物的真实世界数据：SVR10K研究的初步结果

Liver stiffness measurement (LSM) by two-dimensional shear-wave elastography (2D SWE) is a well-established method for assessing hepatic fibrosis. Diffusion-weighted imaging (DWI) can be converted into virtual shear modulus (µ

Li Yang

Guofeng Zhou

Liheng Liu

Shengxiang Rao

Wentao Wang

Kaipu Jin

Caixia Fu

Mengsu Zeng

Ying Ding

Assessing liver fibrosis in chronic liver disease: Comparison of diffusion-weighted MR elastography and two-dimensional shear-wave elastography using histopathologic assessment as the reference standard

评估慢性肝病中的肝纤维化：以组织病理学评估为参考标准，比较扩散加权磁共振弹性成像与二维剪切波弹性成像

We aimed to compare the usefulness of the ultra-high-sensitivity hepatitis B surface antigen (iTACT-HBsAg), high-sensitivity hepatitis B core-related antigen (iTACT-HBcrAg), and anti-HBs assays in determination of cessation of nucleot(s)ide analogue (NA) treatment to prevent against hepatitis B virus (HBV) reactivation.

Takanori Suzuki

Akihiro Tamori

Kentaro Matsuura

Takako Inoue

Shigeru Kusumoto

Shinya Hagiwara

Haruka Sagi

Atsushi Kaneko

Shuko Murakami

Hayato Kawamra

Kei Fujiwara

Katsumi Aoyagi

Masaru Enomoto

Ritsuzo Kozuka

Hiromi Kataoka

Yasuhito Tanaka

Clinical usefulness of an ultra-high-sensitivity hepatitis B surface antigen assay to determine the cessation of treatment for HBV reactivation

超高灵敏度乙型肝炎表面抗原检测在确定HBV再激活治疗终止中的临床应用

Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the primary causes of chronic liver disease and may lead to liver cirrhosis and hepatocellular carcinoma. Recent reports suggested that DEAD-box RNA helicase (DDX3) acts as a sensor of free fat accumulation and may modulate the pathogenesis via miRNAs. Hence, we hypothesized that DDX3 might modulate MASLD progression via miRNA-141-mediated inhibition of Sirt-1 and autophagy.

Md Musa Hossain

Amit K Mishra

Ajay K Yadav

Md Ismail

Teja Naveen Sata

Amrendra K Sah

Arnab Banik

Gopal Sharma

Senthil K Venugopal

Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system

游离脂肪酸诱导的DDX3通过上调miR-141抑制自噬在饮食诱导的MASLD小鼠模型系统中

Abbreviation	Ann. Hepatol.
Journal Impact	3.51
Quartiles(Global)	GASTROENTEROLOGY & HEPATOLOGY(Q2)

ISSN	1665-2681, 2659-5982
h-index	66

Publication Information	Publisher: Elsevier Espana S.L.U，Publishing cycle: Quarterly，Journal Type: journal，Open Access Journals: Yes
Basic data	Year of publication: 2002，Proportion of original research papers: 86.84%，Self Citation Rate:0.00%， Gold OA Rate: 98.96%
Journal Fees	$1500Details
Average review cycle	网友分享经验：偏慢,4-8周
Average recruitment ratio	网友分享经验：较易

Annals of Hepatology

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Association between klotho and non-alcoholic fatty liver disease and liver fibrosis based on the NHANES 2007–2016

Association of sleep patterns and disorders with metabolic dysfunction-associated steatotic liver disease and liver fibrosis in contemporary American adults

An exploratory machine learning model for predicting advanced liver fibrosis in autoimmune hepatitis patients: A preliminary study

P-11 REAL-WORLD DATA WITH PANGENOTYPIC DIRECT-ACTING ANTIVIRALS IN LATINAMERICA: PRELIMINARY RESULTS OF THE SVR10K STUDY

Assessing liver fibrosis in chronic liver disease: Comparison of diffusion-weighted MR elastography and two-dimensional shear-wave elastography using histopathologic assessment as the reference standard

Clinical usefulness of an ultra-high-sensitivity hepatitis B surface antigen assay to determine the cessation of treatment for HBV reactivation

Free fatty acid-induced DDX3 inhibits autophagy via miR-141 upregulation in diet-induced MASLD mice model system

An exploratory machine learning model for predicting advanced liver fibrosis in autoimmune hepatitis patients: A preliminary study

P-11 REAL-WORLD DATA WITH PANGENOTYPIC DIRECT-ACTING ANTIVIRALS IN LATINAMERICA: PRELIMINARY RESULTS OF THE SVR10K STUDY

Assessing liver fibrosis in chronic liver disease: Comparison of diffusion-weighted MR elastography and two-dimensional shear-wave elastography using histopathologic assessment as the reference standard