Functional cardiac consequences of β-adrenergic stress-induced injury in the <i>mdx</i> mouse model of Duchenne muscular dystrophy

2024-9-13

A prioritization tool for cilia-associated genes and their <i>in vivo</i> resources unveil new avenues for ciliopathy research

2024-9-12

First person – Rebeca Piñeiro-Sabarís

2024-9-1

Deficient GATA6–CXCR7 signaling leads to bicuspid aortic valve

2024-9-1

eEF1α2 is required for actin cytoskeleton homeostasis in the aging muscle

2024-8-29

Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb

2024-8-29

Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish

2024-8-14

Sex specific emergence of trisomic <i>Dyrk1a</i>-related skeletal phenotypes in the development of a Down syndrome mouse model

2024-8-13

The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial-mesenchymal phenotype

2024-8-6

Generation and characterization of a novel mouse model of Becker Muscular Dystrophy with a deletion of exons 52 to 55

2024-8-5

Fine-tuning AMPK in physiology and disease using point-mutant mouse models

2024-8-1

Understanding the interplay between dNTP metabolism and genome stability in cancer

2024-8-1

Negative equity – the value of reporting negative results

2024-8-1

CCL2 as a potential regulator of skeletal muscle wasting in breast cancer

2024-8-1

Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy

2024-8-1

A deleterious variant of <i>INTS1</i> leads to disrupted sleep–wake cycles

2024-8-1

Macrophages directly kill bladder cancer cells through TNF signaling as an early response to BCG therapy

2024-8-1

First person – Mayra Fernanda Martínez-López

2024-8-1

A genetically small fetus impairs placental adaptations near term

2024-8-1

First person – Haimeng Lyu

2024-8-1

First person – Ionel Sandovici

2024-8-1

A single dose of radiation elicits comparable effects to fractionated radiation in a mouse model of acute salivary gland injury after head and neck cancer radiotherapy

2024-8-1

HBS1L deficiency causes retinal dystrophy in a child and a mouse model associated with defective development of photoreceptor cells

2024-7-30

Characterization of a monkey model with experimental retinal damage induced by N-methyl-D-aspartate

2024-7-26

C-C chemokine ligand 2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor mouse models

2024-7-8

First person – Hung-Ju Chiang

2024-7-1

First person – Tara Gleeson

2024-7-1

The role of the International Society for Stem Cell Research (ISSCR) guidelines in disease modeling

2024-7-1

Syngeneic mouse model of YES-driven metastatic and proliferative hepatocellular carcinoma

2024-7-1

Biological resilience in health and disease

2024-7-1

Drop the MYC: An expansion of triple-negative breast cancer driver genes

2024-7-1

The NLRP3 inflammasome is essential for IL-18 production in a model of macrophage activation syndrome

2024-7-1

Functional exploration of copy number alterations in a <i>Drosophila</i> model of triple-negative breast cancer

2024-7-1

<i>Taf1</i> knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders

2024-7-1

Human organoid model of pontocerebellar hypoplasia 2a recapitulates brain region-specific size differences

2024-7-1

The value of slow-burning science: an interview with Peter Friedl and Bettina Weigelin

2024-7-1

Functional distinction in oncogenic Ras variant activity in <i>Caenorhabditis elegans</i>

2024-7-1

Exploring host–pathogen interactions in the <i>Dictyostelium discoideum–Mycobacterium marinum</i> infection model of tuberculosis

2024-7-1

A Cas9-fusion proximity-based approach generates an <i>Irak1-Mecp2</i> tandem duplication mouse model for the study of MeCP2 duplication syndrome

2024-7-1

The preclinical gap in pancreatic cancer and radiotherapy

2024-7-1

Muscle-specific lack of GFPT1 in knock-in mice triggers ER stress to alleviate misfolded proteins

2024-6-21

Contribution of <i>Streptococcus Pseudopneumoniae</i> and <i>Salivarius</i> to vocal fold mucosal integrity and function

2024-6-21

Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus

2024-6-20

RASopathies – what they reveal about RAS/MAPK signaling in skeletal muscle development

2024-6-1

Founder mutations and rare disease in the Arab world

2024-6-1

Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning

2024-6-1

Biological and therapeutic insights from animal modeling of fusion-driven pediatric soft tissue sarcomas

2024-6-1

Translating multiscale research in rare disease

2024-6-1

First person – Eleanor McKay

2024-6-1

The missense mutation C667F in murine β-dystroglycan causes embryonic lethality, myopathy and blood-brain barrier destabilization

2024-6-1