Synthesis, biological and computational evaluation of benzoxazole hybrid analogs as potential anti-Alzheimer's agents

2024-9-13

A novel class of potent antiangiogenic and antioxidant pyrazoles: synthesis, bioactivity, docking and ADMET studies

2024-9-12

Protein-protein interactions in cGAS-STING pathway: a medicinal chemistry perspective

2024-9-12

Synthesis, anticancer activity, docking and computational studies of new pyridyl-glycosyl hybrids and acyclic analogs

2024-9-12

Discovery of novel dihydro-pyrimidine hybrids: insight into the design, synthesis, biological evaluation and absorption, distribution, metabolism and excretion studies

2024-9-12

Synthesis, crystal structure, biological and docking studies of 5-hydroxy-2-{[(2-methylpropyl)iminio]methyl}phenolate

2024-9-11

Synergistic effect of new pyrimidine derivative with oxacilin against methicillin-resistant <i>Staphylococcus aureus</i>

2024-9-5

Innovative virtual screening of PD-L1 inhibitors: the synergy of molecular similarity, neural networks and GNINA docking

2024-9-4

Synthesis, cytotoxicity and ^99m Tc-MIBI tumor cell uptake evaluation of 2-phenylbenzothiazole tagged triazole derivatives

2024-9-4

Novel 3-substituted coumarins inspire a custom pharmacology prediction pipeline: an anticancer discovery adventure

2024-9-4

New 6-nitro-4-substituted quinazoline derivatives targeting epidermal growth factor receptor: design, synthesis and <i>in vitro</i> anticancer studies

2024-9-4

Targeting EGFR with molecular degraders as a promising strategy to overcome resistance to EGFR inhibitors

2024-8-29

Pyrazine-based small molecule kinase inhibitors: clinical applications and patent review (2019–2023)

2024-8-27

Therapeutic potential of a novel pyrazolyl-pyridine derivative in the treatment of experimental colitis

2024-8-19

Design, synthesis, docking studies and bioactivity evaluation of 1,2,3-triazole eugenol derivatives

2024-8-19

Discovery of novel ULK1 inhibitors through machine learning-guided virtual screening and biological evaluation

2024-8-15

Transition metal complexes: a new generation of anticancer drugs

2024-8-9

Molecular docking, derivatization, characterization and biological assays of amantadine

2024-8-9

Design, synthesis and evaluation of novel norfloxacin analogs as potent anticancer and antioxidant agents

2024-8-8

An overview of pyridazin-3(2 <i>H</i> )-one: a core for developing bioactive agents targeting cardiovascular diseases and cancer

2024-8-6

Synthesis of quercetin derivatives as cytotoxic against breast cancer MCF-7 cell line <i>in vitro</i> and <i>in silico</i> studies

2024-8-5

Medicinal chemistry aspects of fat mass and obesity associated protein: structure, function and inhibitors

2024-8-5

Dual-target EZH2 inhibitor: latest advances in medicinal chemistry

2024-7-31

The 3D pharmacophore modeling to explore new antischistosomal agents among US FDA approved drugs

2024-7-29

Synthesis of indole-functionalized isoniazid conjugates with potent antimycobacterial and antioxidant efficacy

2024-7-23

New pyridopyrimidine derivatives as dual EGFR and CDK4/cyclin D1 inhibitors: synthesis, biological screening and molecular modeling

2024-7-18

Targeted small molecule therapy and inhibitors for lymphoma

2024-7-17

Fluorinated building blocks in drug design: new pathways and targets

2024-7-17

Barbiturate–sulfonate hybrids as potent cholinesterase inhibitors: design, synthesis and molecular modeling studies

2024-7-16

Thiourea-functionalized aminoglutethimide derivatives as anti-leishmanial agents

2024-7-2

Regulation of post-translational modification of PD-L1 and associated opportunities for novel small-molecule therapeutics

2024-7-1

A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer

2024-7-1

NMR analysis, cytotoxic activity and theoretical study of a complex between SRPIN340 and <i>p</i> -sulfonic acid calix[6]arene

2024-7-1

<i>In vitro</i> anti-breast cancer study of hybrid cinnamic acid derivatives bearing 2-thiohydantoin moiety

2024-7-1

Identification of novel benzothiazole–thiadiazole-based thiazolidinone derivative: <i>in vitro</i> and <i>in silico</i> approaches to develop promising anti-Alzheimer’s agents

2024-6-28

Synthesis, characterization and biological evaluation of aurones as potential neuroprotective agents

2024-6-28

The emerging field of senotherapeutic drugs

2024-6-27

Expanding potential of quinoline hydrazide/hydrazone derivatives as anticancer agents

2024-6-27

Structural investigations and antibacterial, antifungal and anticancer studies on zinc salicylaldimine complexes

2024-6-20

Synthesis of novel hybrids of 1,2,3-triazoles-hydrazone: targeting cholinesterases and Alzheimer's related genes

2024-6-12

Aminopyridines in the development of drug candidates against protozoan neglected tropical diseases

2024-6-10

CF ₂ H: a fascinating group for application in drug development enabling modulation of many molecular properties

2024-6-6

Novel candidates synthesis of indenopyrazole, indenoazine and indenothiophene, with anticancer and <i>in silico</i> studies

2024-6-5

Recent development of azole–sulfonamide hybrids with the anticancer potential

2024-5-30

Biological, computational evaluation of novel benzofuranyl derivatives as acetylcholinesterase and butyrylcholinesterase

2024-5-30

Thiazolidinone-linked-1,2,3-triazoles with (R)-Carvone as new potential anticancer agents

2024-5-30

Epigenetics: rethinking of drug research and development

2024-5-29

Exploring the therapeutic potential of cinnamoyl derivatives in attenuating inflammation in lipopolysaccharide-induced Caco-2 cells

2024-5-29

Design, semi-synthesis and bioevaluation of koumine-like derivatives as potential antitumor agents <i>in vitro</i> and <i>in vivo</i>

2024-5-29

Isocoumarins incorporating chalcone moieties act as isoform selective tumor-associated carbonic anhydrase inhibitors

2024-5-28