CRISPR-enabled point-of-care genotyping for APOL1 genetic risk assessment

2024-9-13

ERK5 suppression overcomes FAK inhibitor resistance in mutant KRAS-driven non-small cell lung cancer

2024-9-13

An intrinsic mechanism of metabolic tuning promotes cardiac resilience to stress

2024-9-13

Multiomics reveals microbial metabolites as key actors in intestinal fibrosis in Crohn’s disease

2024-9-13

Trained immunity of intestinal tuft cells during infancy enhances host defense against enteroviral infections in mice

2024-9-11

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

2024-9-11

The influence of AHR on immune and tissue biology

2024-9-6

Author Correction: Cell-mediated exon skipping normalizes dystrophin expression and muscle function in a new mouse model of Duchenne Muscular Dystrophy

2024-9-6

Next generation of “magic bullets”, solutions from the microbial pangenome

2024-9-6

Author Correction: SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

2024-9-6

Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage?

2024-9-3

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

2024-9-2

The gray boundaries of aberrant shortening of the cellular timekeepers’ edges

2024-8-28

The evolving genetic landscape of telomere biology disorder dyskeratosis congenita

2024-8-28

Human breast tissue engineering in health and disease

2024-8-23

Novel immunotherapeutics against LGR5 to target multiple cancer types

2024-8-21

Restoration of defective oxidative phosphorylation to a subset of neurons prevents mitochondrial encephalopathy

2024-8-21

Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome

2024-8-21

Ultra-sensitive molecular residual disease detection through whole genome sequencing with single-read error correction

2024-8-20

Immunotherapies targeting the oncogenic fusion gene CLDN18-ARHGAP in gastric cancer

2024-8-20

Publisher Correction: LKB1-SIK2 loss drives uveal melanoma proliferation and hypersensitivity to SLC8A1 and ROS inhibition

2024-8-20

An enhanced intracellular delivery platform based on a distant diphtheria toxin homolog that evades pre-existing antitoxin antibodies

2024-8-19

Histidine-rich glycoprotein modulates neutrophils and thrombolysis-associated hemorrhagic transformation

2024-8-15

Comprehensive molecular characterization of collecting duct carcinoma for therapeutic vulnerability

2024-8-9

The MondoA-dependent TXNIP/GDF15 axis predicts oxaliplatin response in colorectal adenocarcinomas

2024-8-5

Experimental vaccination by single dose sporozoite injection of blood-stage attenuated malaria parasites

2024-8-5

Inhibition of GSK3α,β rescues cognitive phenotypes in a preclinical mouse model of CTNNB1 syndrome

2024-8-5

Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer

2024-7-31

The RhoB p.S73F mutation leads to cerebral palsy through dysregulation of lipid homeostasis

2024-7-30

“Cruising together”—ASC specks and SAA, a perfect match in chronic inflammation

2024-7-30

The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis

2024-7-30

Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment

2024-7-26

PD-1/LAG-3 co-signaling profiling uncovers CBL ubiquitin ligases as key immunotherapy targets

2024-7-19

LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis

2024-7-19

In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection

2024-7-15

Immune-enhancing neutrophils reprogrammed by subclinical low-dose endotoxin in cancer treatment

2024-7-15

DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells

2024-7-15

Author Correction: Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer

2024-7-12

Platelet transcription factors license the pro-inflammatory cytokine response of human monocytes

2024-7-8

Pharmacological Gq inhibition induces strong pulmonary vasorelaxation and reverses pulmonary hypertension

2024-7-8

FLT1 activation in cancer cells promotes PARP-inhibitor resistance in breast cancer

2024-7-2

FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer

2024-6-26

Minimally-invasive implantable device enhances brain cancer suppression

2024-6-20

Mutation analysis in individual circulating tumor cells depicts intratumor heterogeneity in melanoma

2024-6-19

Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease

2024-6-18

Author Correction: Mediators of necroptosis: from cell death to metabolic regulation

2024-6-18

DUSP6 inhibition overcomes neuregulin/HER3-driven therapy tolerance in HER2+ breast cancer

2024-6-17

Disrupting TSLP–TSLP receptor interactions via putative small molecule inhibitors yields a novel and efficient treatment option for atopic diseases

2024-6-14

Harnessing cholesterol uptake of malaria parasites for therapeutic applications

2024-6-11

Seeing is believing: a breakthrough to visualize necrosomes in the tissue

2024-6-10