Jordan Journal of Chemistry

Eight historical textile objects belonging to the 16th-20th centuries in the collection of the Topkapi Palace Museum in Istanbul were analyzed with the purpose of reaching improved conservation and restoration methods. The historical textiles underwent dyestuff analysis by High Performance Liquid Chromatography, morphological and elemental analysis by Scanning Electron Microscope with energy Dispersive X-ray Spectroscopy, CIEL*a*b color measurement as well as technical analysis by optical microscopy.

Recep Karadag

Silk Textiles from the Topkapi Palace Museum, Istanbul: An Analytical Study

伊斯坦布尔托普卡帕宫博物馆的丝绸纺织品：一项分析研究

Simultaneous spectrophotometric determination of captopril and hydro-chlorothiazide in pharmaceutical formulations by the H-point standard addition method (HPSAM) is described. Absorbance at 211.5 and 230.3 nm was monitored upon the addition of standard solutions of captopril. The results showed that in prepared mixtures, captopril and hydrochlorothiazide can be determined simultaneously at concentration ratios varying from 1.0:0.8 to 2.5:1.5 μg/mL, respectively. Percentage recovery was found to be 95.33–104.37% for captopril and 96.8–105% for hydrochlorothiazide, with a relative standard deviation (RSD) of 2.46%. The method was successfully used to evaluate the antihypertensive captopril drug in a binary combination of hydrochlorothiazide in real samples with high precision and accuracy within the recovery percentage.

Lazeeza Omer

Asmaa Ghanim Dawood

Nadhim Habeeb

H-point Standard Addition Method for the Simultaneous Spectrophotometric Determination of Captopril and Hydrochlorothiazide in Pharmaceutical Formulations

H点标准加入法同时测定药物制剂中卡托普利和氢氯噻嗪的紫外分光光度法

Abstract: Polyethylene glycol (PEG)/water emulsions were prepared by the flow-induced phase inversion technique using various molecular weights of PEG. The aim of this study is to investigate the effect of molecular weight on the emulsification process. A Brabender® mixer was used for dispersing the polymers in water. The stability, morphology and particle size distribution were determined for the prepared emulsions. It was found that stability increases with increasing the molecular weight of PEG, approaching 96% for PEG with a molecular weight of 600000. The polymer particle size was in the submicron scale (0.10–0.17 µm), also increasing with increased PEG molecular weight. The PEG-6000 emulsion showed a relatively small median particle size (d50 = 0.27 µm), corresponding to 50% of the particles smaller than 0.27 µm in diameter, while PEG-600000 resulted in d50 over 2.9 µm. There was a noticeable increase of water content for the emulsion of PEG with a molecular weight of 600000.

Marwa Al-Ashawy

Sahar Al-Hariri

Hussein Bakr

Polymeric Emulsions of Polyethylene Glycol in Water Prepared by Flow-induced Phase Inversion Emulsification: The Effect of Polymer Molecular Weight

聚乙二醇在水中的聚合物乳液通过流动诱导相转化乳化法制备：聚合物分子量的影响

Abstract: Four new palladium complexes of mixed phosphine and N-containing heterocyclic thiolates are synthesized and characterized. The reaction of cis-(PPh3)2PdCl2 with N-containing heterocyclic thiols (Nhet-SH) occurred in the presence of a base and produced trans-(PPh3)2Pd(κS-S-Nhet)2 (S-Nhet = SC4H5N2 (1), S2C3H3N2 (2)). However, the correspond¬ing reaction of (dppf)PdCl2 with the same thiols produced cis-(dppf)Pd(κS-SN-het)2 (dppf = 1,1'-bis(diphenylphosphino)ferrocene; SC4H5N2 (3), S2C3H3N2 (4)). Complexes 1–4 are characterized by IR, UV-Vis, 1H-NMR,13C-NMR, and 31P-NMR spectroscopy and elemental analysis.

Mohammad El-Khateeb

Bayan Haymoor

Qusay Tanash

Synthesis and Characterization of Mixed Phosphine/N-Containing Heterocyclic Thiolato Palladium Complexes

混合膦/含氮杂环硫醇合钯配合物的合成与表征

Abstract: A major difficulty in the treatment of mycobacterial infection is its resistance against anti-mycobacterial drugs. Exploration of diverse targets, the search for novel chemical scaffolds and different methods of tuberculosis treatment are all basic measures needed in this perspective. In the same context, mycobacterial oxidative phosphorylation has received a lot of interest. It includes the electron transport system, which encompasses the cytochrome B component of the cytochrome bc1 complex (QcrB) which is a promising therapeutic target. The anti-tubercular drug Q203 (Telacebec), which is currently in phase 2 clinical trial, inhibits cytochrome B. The present study includes virtual screening studies from the ‘Zinc15’ chemical database, taking Q203 as a reference molecule, the creation of protein using homology modeling, molecular docking as well as simulation studies. The constructed protein showed considerable reliability, as results of the Ramachandran plot showed 92.8% amino acid residues in the favoured region, ERRAT score (overall quality factor) of 92.48% with ProSA (Z score) of –5.78. The hit molecules identified by structure-based virtual screening follow the Lipinski rule of five. The docking results indicated binding affinity values ranging from –7.19 to –9.10 kcal/mol. The top three compounds were ZINC64033452, ZINC3816287 and ZINC3830215, each having a higher docking score than the reference ligand (–7.70 kcal/mol). Leu174, Pro306, Ser304, Leu180, Glu314 and Thr313 are among the residues that cover the protein’s active site. The H-bond was observed in docking studies for Q203 and top three molecules from amino acid residues Glu314 and Thr313 and was consistent throughout dynamics studies. In a dynamics run of 20 ns, a stable RMSD was found after 8 ns for hit-molecules and Q203. Based on potential findings, we report that selected candidates are more likely to be used as anti-mycobacterial agents or as starting leads for the development of novel and potent anti-tubercular agents.

Surabhi Jain

Smriti Sharma

Dhrubo Sen

Virtual Screening, Docking, ADMET and Molecular Dynamics: A Study to Find Novel Inhibitors of Mycobacterium tuberculosis Targeting QcrB

虚拟筛选、对接、ADMET和分子动力学：一项针对QcrB靶向结核分枝杆菌新型抑制剂的研究

Chromatographic and spectrophotometric methods for the quantitative determination of three antipsychotic drugs in pharmaceutical products were developed. The investigated drugs are quetiapine fumarate, olanzapine and risperidone. The flow injection analysis (FIA) method is based on the oxidation of these drugs by potassium permanganate in a basic medium. The resulting green color was monitored at 433 nm. Optimization of chemical and FI variables has been made. Under the optimized conditions, the sampling rate was about 80 injections/hour. The method is fast, simple and sensitive. For the chromatographic method, a reversed-phase Varian C8 column was used at ambient temperature. The mobile phase was a mixture of acetonitrile (ACN), acetate buffer and triethylamine (TEA), (60% ACN, 39.8% acetate buffer and 0.2% TEA, v/v/v), adjusted to pH = 4.7 with acetic acid. Tetrazolium salt was used as an internal standard. The absorption of the eluted compounds was measured using a variable-wavelength UV detector at 278 nm. The methods were applied successfully for the assay of three antipsychotic drugs in pharmaceutical products and no interferences were observed from the common excipients usually used. The proposed methods were validated for their accuracy and precision.

Idrees Al-Momani

Lubna Ababneh

Chromatographic and Automated Spectrophotometric Determination of Some Antipsychotic Drugs in Pharmaceutical Products

色谱法和自动分光光度法测定制药产品中某些抗精神病药物

PdCl2, ZnCl2 and CuCl2 complexes of three benzimidazole derivatives and two Schiff bases having the ferrocene group were synthesized and characterized. It was unexpectedly noticed that the Pd(II) and Zn(II) complexes exhibit paramagnetic characters corresponding to about one electron caused by the ferrocene moiety. For the same reason, the magnetic moment value of the Cu(II) complexes was also higher than the anticipated values. Besides, the antimicrobial activity of the complexes was investigated against six bacteria and three fungi. Comparing the ligands, the Schiff bases exhibited higher antimicrobial activity than the benzimidazole derivatives, especially on Gram+ bacteria. Among all compounds investigated in this work, [Zn(SB1)2]·2H2O showed the highest activity against S. epidermidis and S. aureus which are Gram+ bacteria.

Aydin Tavman

Elham Alterhoni

Mayram Hacioglu

Demet Gürbüz

Ayshe Seher

Birteksöz Tan

Preparation, Characterization and Antimicrobial Activity of Pd(II), Zn(II) and Cu(II) Complexes of Benzimidazoles and Schiff Bases Including Ferrocene Group

苯并咪唑和含二茂铁基团的席夫碱的Pd(II)、Zn(II)和Cu(II)配合物的制备、表征及抗菌活性

Gmelina arborea Roxb. (Family: Verbenaceae) is a medicinal plant that has been used in the treatment of diabetes mellitus (DM) since ancient times. Decoctions prepared from various parts of G. arborea are used in traditional systems of medicine as a remedy against DM and various other diseases. The present review describes the antidiabetic, antioxidant and anti-inflammatory properties of G. arborea extracts and their bioactive phytoconstituents that are likely to contribute to antidiabetic properties and their therapeutic importance in the management of diabetes. A comprehensive literature search was conducted using PubMed, ScienceDirect, Semantic Scholar and Google Scholar databases. Studies published from 1970 to 2021 were considered in this review. Out of the 157 results, 34 articles were excluded being duplications and 58 articles were excluded being outside the scope of this review. The remaining 65 articles were considered in this review. The in vitro and in vivo assays reveal the therapeutic potential of G. arborea in terms of antidiabetic, antioxidant and anti-inflammatory properties, indicating that the plant is a valuable source for developing non-toxic herbal formulations to manage DM.

Anoja Attanayake

Ransika Wadasinghe

Pabasara Kalansuriya

B Bandara

Ethnomedicinal Uses, Antidiabetic, Antioxidant and Anti-inflammatory Activity of Gmelina arborea Roxb. and Its Bioactive Compounds: A Review

Gmelina arborea Roxb. 的民族药用、抗糖尿病、抗氧化和抗炎活性及其生物活性化合物综述

A novel compound 2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methyl piperidin-4-one (II) has been synthesized by a previously well-known reaction between (E)-3-(2-ethoxyphenyl)-1-(2-methyloxiran-2-yl)prop-2-en-1-one (I) and ethanol amine. The compound was used to synthesize (Z)-2-((2S,5S)-2-(2-ethoxyphenyl)-5-hydroxy-1-(2-hydroxyethyl)-5-methylpiperidin-4-ylidene)hydrazine-1-carbothioamide (III) through con-den¬sation with thiosemicarbazide in acidic medium. Structures were confirmed by spectral data (IR,1H-NMR and LC-MS). Potential antimicrobial efficiency of the newly synthesized piperidin-4-one derivatives was studied against a Gram-positive bacterial strain (Staphylococcus aureus) and a Gram-negative bacterial strain (Enterobacter sp.) applying the agar dilution method. The results showed that compound (III) has a higher antimicrobial activity than compound (II).

Synthesis and Antimicrobial Activity of Some Piperid-4-one Derivatives against Bacterial Strains

一些哌啶-4-酮衍生物的合成及其对细菌菌株的抗菌活性

It is possible to classify various propolis samples based on their botanical or geographic origins, since environmental conditions and the harvest season have an impact on the chemical ingredients that make up propolis. In the current research, the determination and geographical classification of propolis samples according to their mineral/metal content are addressed. Acid digestion was employed for mineral/metal recovery and inductively-coupled plasma-optical emission spectrometry was used for accurate quantification. Multivariate techniques, PCA and PLS-DA, were applied for unsupervised and supervised classification for different propolis samples. The measured analytical data can be simply manipulated using chemometric tools, like PCA and PLS-DA. Adequate results were reported by PLS-DA to separate propolis samples that were obtained from industrial and agricultural, but not desert regions. The variations in mineral/metal contents present in propolis were helpful for discrimination purposes. Minerals, like Ca, Na, and K, were the most significant variables for propolis discrimination according to their geographical origins. Based on mineral and metal content, PLS-DA model was effective to classify propolis samples with 92% accuracy as estimated from the confusion matrix.

Basel Al-Saida

Eyad Abu-Nameh

Amal Al-Abbadi

Determination and Classification of Jordanian Propolis Samples According to Their Elemental Profile

约旦蜂胶样品元素成分的测定与分类

Abbreviation	JJC
Journal Impact	0.48
Quartiles(Global)	CHEMISTRY, MULTIDISCIPLINARY(Q4)

Publication Information	Publisher: Yarmouk University，Publishing cycle: ，Journal Type: journal，Open Access Journals: No
Basic data	Year of publication: 2020，Proportion of original research papers: 92.86%，Self Citation Rate:0.00%， Gold OA Rate: 0.00%

Jordan Journal of Chemistry

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